Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)

 BTG2_RAT                Reviewed;         158 AA.
P27049;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
23-MAY-2018, entry version 127.
RecName: Full=Protein BTG2;
AltName: Full=BTG family member 2;
AltName: Full=NGF-inducible anti-proliferative protein PC3;
Name=Btg2; Synonyms=Pc3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1849653; DOI=10.1073/pnas.88.8.3353;
Bradbury A., Possenti R., Shooter E.M., Tirone F.;
"Molecular cloning of PC3, a putatively secreted protein whose mRNA is
induced by nerve growth factor and depolarization.";
Proc. Natl. Acad. Sci. U.S.A. 88:3353-3357(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
CHARACTERIZATION.
PubMed=7811636; DOI=10.1016/0925-4773(94)90085-X;
Iacopetti P., Barsacchi G., Tirone F., Maffei L., Cremisi F.;
"Developmental expression of PC3 gene is correlated with neuronal cell
birthday.";
Mech. Dev. 47:127-137(1994).
[4]
CHARACTERIZATION.
PubMed=8891336;
Montagnoli A., Guardavaccaro D., Starace G., Tirone F.;
"Overexpression of the nerve growth factor-inducible PC3 immediate
early gene is associated with growth inhibition.";
Cell Growth Differ. 7:1327-1336(1996).
[5]
INTERACTION WITH PRKCABP.
PubMed=11237868; DOI=10.1042/0264-6021:3540635;
Lin W.-J., Chang Y.-F., Wang W.-L., Huang C.-Y.F.;
"Mitogen-stimulated TIS21 protein interacts with a protein-kinase-
Calpha-binding protein rPICK1.";
Biochem. J. 354:635-643(2001).
-!- FUNCTION: Anti-proliferative protein; the function is mediated by
association with deadenylase subunits of the CCR4-NOT complex.
Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent
manner. In vitro can inhibit deadenylase activity of CNOT7 and
CNOT8. Involved in cell cycle regulation. Could be involved in the
growth arrest and differentiation of the neuronal precursors.
Modulates transcription regulation mediated by ESR1. Involved in
mitochondrial depolarization and neurite outgrowth (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with PRKCABP. Interacts with CNOT7 and CNOT8;
indicative for an association with the CCR4-NOT complex. Interacts
with PIN1, inducing mitochondrial depolarization.
{ECO:0000269|PubMed:11237868}.
-!- INTERACTION:
Q9EP80:Pick1; NbExp=3; IntAct=EBI-78953, EBI-77728;
-!- TISSUE SPECIFICITY: In brain at embryonic day 13.5, placenta,
amnion, and spleen, which are proliferating and/or
differentiating.
-!- INDUCTION: By nerve growth factor. At lower levels by epidermal
growth factor and membrane depolarization. At much lower levels by
fibroblast growth factor and interleukin 6.
-!- PTM: Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and
at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial
depolarization. {ECO:0000250}.
-!- SIMILARITY: Belongs to the BTG family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; M60921; AAB49567.1; -; mRNA.
EMBL; BC072493; AAH72493.1; -; mRNA.
PIR; A40443; A40443.
RefSeq; NP_058955.1; NM_017259.1.
UniGene; Rn.27923; -.
ProteinModelPortal; P27049; -.
SMR; P27049; -.
BioGrid; 248245; 3.
IntAct; P27049; 2.
STRING; 10116.ENSRNOP00000004408; -.
PaxDb; P27049; -.
PRIDE; P27049; -.
Ensembl; ENSRNOT00000004408; ENSRNOP00000004408; ENSRNOG00000003300.
GeneID; 29619; -.
KEGG; rno:29619; -.
UCSC; RGD:2225; rat.
CTD; 7832; -.
RGD; 2225; Btg2.
eggNOG; KOG4006; Eukaryota.
eggNOG; ENOG410ZZC0; LUCA.
GeneTree; ENSGT00550000074461; -.
HOGENOM; HOG000290200; -.
HOVERGEN; HBG004907; -.
InParanoid; P27049; -.
KO; K14443; -.
OMA; PSKNYIM; -.
OrthoDB; EOG091G0RS0; -.
PhylomeDB; P27049; -.
TreeFam; TF105272; -.
Reactome; R-RNO-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
PRO; PR:P27049; -.
Proteomes; UP000002494; Chromosome 13.
Bgee; ENSRNOG00000003300; -.
Genevisible; P27049; RN.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0008306; P:associative learning; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
GO; GO:0030182; P:neuron differentiation; IDA:MGI.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
GO; GO:0006479; P:protein methylation; IEA:Ensembl.
GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
GO; GO:0009612; P:response to mechanical stimulus; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0010033; P:response to organic substance; IEP:RGD.
GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.20.120.1120; -; 1.
InterPro; IPR002087; Anti_prolifrtn.
InterPro; IPR036054; BTG-like_sf.
InterPro; IPR033328; BTG2.
PANTHER; PTHR22978:SF29; PTHR22978:SF29; 1.
Pfam; PF07742; BTG; 1.
PRINTS; PR00310; ANTIPRLFBTG1.
SMART; SM00099; btg1; 1.
SUPFAM; SSF160696; SSF160696; 1.
PROSITE; PS00960; BTG_1; 1.
PROSITE; PS01203; BTG_2; 1.
1: Evidence at protein level;
Complete proteome; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 158 Protein BTG2.
/FTId=PRO_0000143806.
MOD_RES 147 147 Phosphoserine; by MAPK1 and MAPK3.
{ECO:0000250|UniProtKB:P78543}.
MOD_RES 149 149 Phosphoserine; by MAPK14.
{ECO:0000250|UniProtKB:P78543}.
SEQUENCE 158 AA; 17728 MW; F9105D73C3CDF24A CRC64;
MSHGKRTDML PEIAAAVGFL TSLLRTRGCV SEQRLKVFSR ALQDALTDHY KHHWFPEKPS
KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHQLLPSEL TLWVDPYEVS YRIGEDGSIC
VLYEEAPVAT SYGLLTCKNQ MMLGRSSPSK NYVMTVSS


Related products :

Catalog number Product name Quantity
18-003-42396 BTG2 protein - NGF-inducible anti-proliferative protein PC3 Polyclonal 0.05 mg Aff Pur
27-887 The protein encoded by BTG2 is a member of the BTG_Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the r 0.05 mg
E2153r ELISA CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153r ELISA kit CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 96T
U2153r CLIA CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
U2153r CLIA kit CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
EIAAB46077 Homo sapiens,Human,Protein WAVE-2,Verprolin homology domain-containing protein 2,WASF2,WASP family protein member 2,WAVE2,Wiskott-Aldrich syndrome protein family member 2
GWB-D54FE7 Anti- BTG2 (BTG family. member 2) Antibody
EIAAB46073 Homo sapiens,Human,KIAA0269,Protein WAVE-1,SCAR1,Verprolin homology domain-containing protein 1,WASF1,WASP family protein member 1,WAVE1,Wiskott-Aldrich syndrome protein family member 1
EIAAB46080 Homo sapiens,Human,KIAA0900,Protein WAVE-3,SCAR3,Verprolin homology domain-containing protein 3,WASF3,WASP family protein member 3,WAVE3,Wiskott-Aldrich syndrome protein family member 3
EIAAB14722 Fermitin family homolog 2,FERMT2,Homo sapiens,Human,KIND2,Kindlin-2,MIG2,MIG-2,Mitogen-inducible gene 2 protein,PH domain-containing family C member 1,Pleckstrin homology domain-containing family C me
EIAAB46370 CCN family member 4,CCN4,Homo sapiens,Human,WISP1,WISP-1,Wnt-1-induced secreted protein,WNT1-inducible-signaling pathway protein 1
EIAAB46074 Mouse,Mus musculus,Protein WAVE-1,Wasf1,WASP family protein member 1,Wave1,Wiskott-Aldrich syndrome protein family member 1
EIAAB46079 Mouse,Mus musculus,Protein WAVE-2,Wasf2,WASP family protein member 2,Wave2,Wiskott-Aldrich syndrome protein family member 2
EIAAB46081 Mouse,Mus musculus,Protein WAVE-3,Wasf3,WASP family protein member 3,Wave3,Wiskott-Aldrich syndrome protein family member 3
EIAAB46076 Protein WAVE-1,Rat,Rattus norvegicus,Wasf1,WASP family protein member 1,Wave1,Wiskott-Aldrich syndrome protein family member 1
EIAAB46075 Bos taurus,Bovine,Protein WAVE-1,WASF1,WASP family protein member 1,Wiskott-Aldrich syndrome protein family member 1
U2153m CLIA kit CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153m ELISA kit CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153m ELISA CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
U2153m CLIA CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
BTG4 BTG2 Gene BTG family, member 2
EIAAB46078 Bos taurus,Bovine,WASF2,WASP family protein member 2,Wiskott-Aldrich syndrome protein family member 2
BTG2_HUMAN ELISA Kit FOR Protein BTG2; organism: Human; gene name: BTG2 96T
BTG2_MOUSE ELISA Kit FOR Protein BTG2; organism: Mouse; gene name: Btg2 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur