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Protein DDI1 homolog 1 (EC 3.4.23.-)

 DDI1_CAEEL              Reviewed;         389 AA.
Q17569;
20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 2.
28-FEB-2018, entry version 117.
RecName: Full=Protein DDI1 homolog 1 {ECO:0000250|UniProtKB:Q8WTU0};
EC=3.4.23.- {ECO:0000305|PubMed:27528192};
Name=ddi-1 {ECO:0000303|PubMed:27528192,
ECO:0000312|WormBase:C01G5.6};
ORFNames=C01G5.6 {ECO:0000312|WormBase:C01G5.6};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
[1] {ECO:0000312|Proteomes:UP000001940}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2] {ECO:0000305}
FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF MET-244;
LEU-245; 261-ASP--GLY-263; CYS-277; GLY-293 AND LEU-334.
PubMed=27528192; DOI=10.7554/eLife.17721;
Lehrbach N.J., Ruvkun G.;
"Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the
aspartic protease DDI-1.";
Elife 5:0-0(2016).
-!- FUNCTION: Aspartic protease. Required for the cleavage and
activation of transcription factors such as isoform a of the
transcription factor skn-1, which in turn regulates the expression
of proteasomal subunits such as rpt-3.
{ECO:0000269|PubMed:27528192}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27528192}.
Nucleus {ECO:0000269|PubMed:27528192}. Note=Mainly localizes to
the nucleus during proteasomal disruption.
{ECO:0000269|PubMed:27528192}.
-!- TISSUE SPECIFICITY: Expressed in most tissues.
{ECO:0000269|PubMed:27528192}.
-!- DISRUPTION PHENOTYPE: Increased sensitivity to low doses of
bortezomib which causes proteasome dysfunction. Double knockout
with proteasomal subunit pbs-5 or with rpt-5 knockdown results in
failed expression of the proteasomal subunit rpt-3. Double
knockout with pbs-5 also results in the occasional mis-
localization of the transcription factor skn-1a within gut nuclei.
{ECO:0000269|PubMed:27528192}.
-!- SIMILARITY: Belongs to the DDI1 family. {ECO:0000305}.
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EMBL; BX284604; CCD62447.1; -; Genomic_DNA.
PIR; T30993; T30993.
RefSeq; NP_500992.1; NM_068591.3.
UniGene; Cel.13618; -.
ProteinModelPortal; Q17569; -.
SMR; Q17569; -.
IntAct; Q17569; 2.
MINT; Q17569; -.
STRING; 6239.C01G5.6; -.
MEROPS; A28.A02; -.
EPD; Q17569; -.
PaxDb; Q17569; -.
PeptideAtlas; Q17569; -.
EnsemblMetazoa; C01G5.6; C01G5.6; WBGene00015308.
GeneID; 177413; -.
KEGG; cel:CELE_C01G5.6; -.
UCSC; C01G5.6; c. elegans.
CTD; 177413; -.
WormBase; C01G5.6; CE23513; WBGene00015308; ddi-1.
eggNOG; KOG0012; Eukaryota.
eggNOG; ENOG410XPA0; LUCA.
GeneTree; ENSGT00510000047125; -.
InParanoid; Q17569; -.
KO; K11885; -.
OMA; CCINLKT; -.
OrthoDB; EOG091G0CIP; -.
PhylomeDB; Q17569; -.
PRO; PR:Q17569; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00015308; -.
GO; GO:0005737; C:cytoplasm; IDA:WormBase.
GO; GO:0005634; C:nucleus; IDA:WormBase.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO; GO:0051964; P:negative regulation of synapse assembly; IMP:WormBase.
CDD; cd05479; RP_DDI; 1.
Gene3D; 2.40.70.10; -; 1.
InterPro; IPR019103; Peptidase_aspartic_DDI1-type.
InterPro; IPR021109; Peptidase_aspartic_dom_sf.
Pfam; PF09668; Asp_protease; 1.
SUPFAM; SSF50630; SSF50630; 1.
1: Evidence at protein level;
Aspartyl protease; Complete proteome; Cytoplasm; Hydrolase; Nucleus;
Protease; Reference proteome.
CHAIN 1 389 Protein DDI1 homolog 1.
/FTId=PRO_0000442727.
ACT_SITE 261 261 {ECO:0000305}.
MUTAGEN 244 244 M->I: In mg543; defective expression of
the proteasomal subunit rpt-3 in a pbs-5
(proteasomal subunit) mutant background.
{ECO:0000269|PubMed:27528192}.
MUTAGEN 245 245 L->F: In mg563; defective expression of
the proteasomal subunit rpt-3 in a pbs-5
(proteasomal subunit) mutant background.
{ECO:0000269|PubMed:27528192}.
MUTAGEN 261 263 DSG->NSA: In mg572; fails to cleave
isoform a of the transcription factor
skn-1 (skn-1a). Defective expression of
the proteasomal subunit rpt-3 in a pbs-5
(proteasomal subunit) mutant background.
{ECO:0000269|PubMed:27528192}.
MUTAGEN 277 277 C->S: In mg555; defective expression of
the proteasomal subunit rpt-3 in a pbs-5
(proteasomal subunit) mutant background.
{ECO:0000269|PubMed:27528192}.
MUTAGEN 293 293 G->R: In mg544; defective expression of
the proteasomal subunit rpt-3 in a pbs-5
(proteasomal subunit) mutant background.
{ECO:0000269|PubMed:27528192}.
MUTAGEN 334 334 L->F: In mg557; defective expression of
the proteasomal subunit rpt-3 in a pbs-5
(proteasomal subunit) mutant background.
{ECO:0000269|PubMed:27528192}.
SEQUENCE 389 AA; 43716 MW; CC148E3255C06E40 CRC64;
MSFQVSVAVN DGPFQKKSVT PNTTIGDLNN DAILIWKDTA IVYDISDESK NFGPTVTLEQ
LGVTQISMVY IYTTAFPCPS GDLRSIVPAQ VRLISQFASA ASSIFNGQSS SSAQSAQRTR
RVEQDDEGEK SMFSRKLLDS PATFKALSEN MFFRLKNEPH KLGYGLPELV ERFLAKKDMT
YKEFEQMFRS YVEEEVHKEE IIKNNPNSAE AKMFLEAKRN KELIDEQYLH SMTHHPEDMI
AVTMLYINLT INGVPVKAFI DSGAQKSIMS MACAERCGLN GLIDRRFQSM ARGVGGTEKI
EGKIHLCDVK VEDAHFSCPF EVMARREMDL LIGLNVLRKH GCCINLKTSR LEFGNGTTTP
FLQSNEIDSH LKEIMALPEE EMQFEDGST


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