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Protein DETOXIFICATION 48 (AtDTX48) (Multidrug and toxic compound extrusion protein 48) (MATE protein 48) (Protein ABNORMAL SHOOT 4) (Protein BUSH-AND-CHLOROTIC-DWARF 1) (Protein BCD1) (Protein ZRIZI)

 DTX48_ARATH             Reviewed;         532 AA.
Q9SLV0; Q67YZ2;
14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
18-JUL-2018, entry version 118.
RecName: Full=Protein DETOXIFICATION 48 {ECO:0000303|PubMed:11739388};
Short=AtDTX48 {ECO:0000303|PubMed:11739388};
AltName: Full=Multidrug and toxic compound extrusion protein 48 {ECO:0000305};
Short=MATE protein 48 {ECO:0000305};
AltName: Full=Protein ABNORMAL SHOOT 4 {ECO:0000303|PubMed:26160579};
AltName: Full=Protein BUSH-AND-CHLOROTIC-DWARF 1 {ECO:0000303|PubMed:22150160};
Short=Protein BCD1 {ECO:0000303|PubMed:22150160};
AltName: Full=Protein ZRIZI {ECO:0000303|PubMed:21257605};
Name=DTX48 {ECO:0000303|PubMed:11739388};
Synonyms=ABS4 {ECO:0000303|PubMed:26160579},
BCD1 {ECO:0000303|PubMed:22150160},
ZF14 {ECO:0000312|EMBL:BAA87939.1}, ZRZ {ECO:0000303|PubMed:21257605};
OrderedLocusNames=At1g58340 {ECO:0000312|Araport:AT1G58340};
ORFNames=F19C14.5 {ECO:0000312|EMBL:BAA87939.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Columbia;
PubMed=10548732; DOI=10.1016/S0378-1119(99)00403-5;
Kato A., Suzuki M., Kuwahara A., Ooe H., Higano-Inaba K., Komeda Y.;
"Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana
genomic region located around the 100 map unit of chromosome 1.";
Gene 239:309-316(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130712; DOI=10.1038/35048500;
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana.";
Nature 408:816-820(2000).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
Hayashizaki Y., Shinozaki K.;
"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[5]
GENE FAMILY, AND NOMENCLATURE.
PubMed=11739388; DOI=10.1074/jbc.M108777200;
Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
"Functional cloning and characterization of a plant efflux carrier for
multidrug and heavy metal detoxification.";
J. Biol. Chem. 277:5360-5368(2002).
[6]
GENE FAMILY.
PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F.,
Saier M.H. Jr.;
"The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
superfamily.";
Eur. J. Biochem. 270:799-813(2003).
[7]
TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=21257605; DOI=10.1093/pcp/pcr007;
Burko Y., Geva Y., Refael-Cohen A., Shleizer-Burko S., Shani E.,
Berger Y., Halon E., Chuck G., Moshelion M., Ori N.;
"From organelle to organ: ZRIZI MATE-Type transporter is an organelle
transporter that enhances organ initiation.";
Plant Cell Physiol. 52:518-527(2011).
[8]
FUNCTION, INDUCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
PubMed=22150160; DOI=10.1042/BJ20111311;
Seo P.J., Park J., Park M.J., Kim Y.S., Kim S.G., Jung J.H.,
Park C.M.;
"A Golgi-localized MATE transporter mediates iron homoeostasis under
osmotic stress in Arabidopsis.";
Biochem. J. 442:551-561(2012).
[9]
TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=26160579; DOI=10.1093/jxb/erv344;
Wang R., Liu X., Liang S., Ge Q., Li Y., Shao J., Qi Y., An L., Yu F.;
"A subgroup of MATE transporter genes regulates hypocotyl cell
elongation in Arabidopsis.";
J. Exp. Bot. 66:6327-6343(2015).
-!- FUNCTION: Functions as a multidrug and toxin extrusion
transporter. Contributes to iron homeostasis during stress
responses and senescence (PubMed:22150160). Could be involved in
specifying the lateral organ initiation rate (PubMed:21257605).
May act as a negative regulator of hypocotyl cell elongation in
the light (PubMed:26160579). {ECO:0000269|PubMed:21257605,
ECO:0000269|PubMed:22150160, ECO:0000269|PubMed:26160579}.
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane
{ECO:0000269|PubMed:22150160}; Multi-pass membrane protein
{ECO:0000269|PubMed:22150160}. Late endosome membrane
{ECO:0000269|PubMed:26160579}; Multi-pass membrane protein
{ECO:0000269|PubMed:26160579}.
-!- TISSUE SPECIFICITY: Highly expressed in shoot apices relative to
leaves (PubMed:21257605). At vegetative stages, highly expressed
at the stipules. At reproductive stages, most highly expressed in
the mature pollen. Also expressed in the tips of sepals
(PubMed:26160579). {ECO:0000269|PubMed:21257605,
ECO:0000269|PubMed:26160579}.
-!- INDUCTION: Induced by excessive iron, but repressed by iron
deficiency. Induced by heat, darkness, osmotic stresses and acid
abscisic (ABA). {ECO:0000269|PubMed:22150160}.
-!- DISRUPTION PHENOTYPE: No visible phenotype.
{ECO:0000269|PubMed:21257605, ECO:0000269|PubMed:22150160}.
-!- MISCELLANEOUS: Plants overexpressing DTX48 in initiating leaves
are short, produce leaves much faster than wild-type plants and
show enhanced growth of axillary buds (PubMed:21257605).
Overexpression of DTX48 alters shoot developmental programs
leading to a loss of apical dominance phenotype (PubMed:26160579).
{ECO:0000269|PubMed:21257605, ECO:0000269|PubMed:26160579}.
-!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE)
(TC 2.A.66.1) family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AB028198; BAA87939.1; -; mRNA.
EMBL; AC008051; AAF82254.1; -; Genomic_DNA.
EMBL; CP002684; AEE33537.1; -; Genomic_DNA.
EMBL; AK176206; BAD43969.1; -; mRNA.
EMBL; AK176326; BAD44089.1; -; mRNA.
PIR; T52442; T52442.
RefSeq; NP_564731.1; NM_104614.5.
UniGene; At.447; -.
ProteinModelPortal; Q9SLV0; -.
IntAct; Q9SLV0; 32.
STRING; 3702.AT1G58340.1; -.
TCDB; 2.A.66.1.51; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
PaxDb; Q9SLV0; -.
EnsemblPlants; AT1G58340.1; AT1G58340.1; AT1G58340.
GeneID; 842203; -.
Gramene; AT1G58340.1; AT1G58340.1; AT1G58340.
KEGG; ath:AT1G58340; -.
Araport; AT1G58340; -.
TAIR; locus:2016615; AT1G58340.
eggNOG; KOG1347; Eukaryota.
eggNOG; COG0534; LUCA.
HOGENOM; HOG000177026; -.
KO; K03327; -.
OMA; AMISMIF; -.
OrthoDB; EOG093608PK; -.
PhylomeDB; Q9SLV0; -.
Reactome; R-ATH-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
PRO; PR:Q9SLV0; -.
Proteomes; UP000006548; Chromosome 1.
ExpressionAtlas; Q9SLV0; baseline and differential.
Genevisible; Q9SLV0; AT.
GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0017119; C:Golgi transport complex; IDA:TAIR.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005770; C:late endosome; IDA:UniProtKB.
GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0043226; C:organelle; IDA:TAIR.
GO; GO:0015297; F:antiporter activity; IEA:InterPro.
GO; GO:0015238; F:drug transmembrane transporter activity; IMP:UniProtKB.
GO; GO:0005381; F:iron ion transmembrane transporter activity; IGI:TAIR.
GO; GO:0006855; P:drug transmembrane transport; IMP:UniProtKB.
GO; GO:0015893; P:drug transport; IMP:UniProtKB.
GO; GO:0055072; P:iron ion homeostasis; IMP:TAIR.
GO; GO:0006826; P:iron ion transport; IGI:TAIR.
GO; GO:1905428; P:regulation of plant organ formation; IMP:TAIR.
GO; GO:0009737; P:response to abscisic acid; IEP:UniProtKB.
GO; GO:0009646; P:response to absence of light; IEP:UniProtKB.
GO; GO:0009408; P:response to heat; IEP:UniProtKB.
GO; GO:0009624; P:response to nematode; IEP:TAIR.
GO; GO:0006970; P:response to osmotic stress; IEP:UniProtKB.
GO; GO:0010015; P:root morphogenesis; IMP:UniProtKB.
InterPro; IPR002528; MATE_fam.
Pfam; PF01554; MatE; 2.
TIGRFAMs; TIGR00797; matE; 1.
2: Evidence at transcript level;
Complete proteome; Endosome; Golgi apparatus; Membrane;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 532 Protein DETOXIFICATION 48.
/FTId=PRO_0000434082.
TRANSMEM 65 85 Helical. {ECO:0000255}.
TRANSMEM 95 115 Helical. {ECO:0000255}.
TRANSMEM 136 156 Helical. {ECO:0000255}.
TRANSMEM 174 194 Helical. {ECO:0000255}.
TRANSMEM 211 231 Helical. {ECO:0000255}.
TRANSMEM 235 255 Helical. {ECO:0000255}.
TRANSMEM 279 301 Helical. {ECO:0000255}.
TRANSMEM 322 342 Helical. {ECO:0000255}.
TRANSMEM 363 383 Helical. {ECO:0000255}.
TRANSMEM 397 417 Helical. {ECO:0000255}.
TRANSMEM 437 457 Helical. {ECO:0000255}.
TRANSMEM 464 484 Helical. {ECO:0000255}.
CONFLICT 66 66 S -> P (in Ref. 4; BAD43969/BAD44089).
{ECO:0000305}.
SEQUENCE 532 AA; 57847 MW; 8640D6256B2FAC76 CRC64;
MCNSKPSSAS SSLLSCKDKT HISKLETCDT DNPHYSEFRD TDSLDLKRWP SFLEGLEEVK
AIGKISGPTA MTGLLMYSRA MISMLFLGYL GELELAGGSL SIGFANITGY SVISGLSMGM
EPICGQAYGA KQMKLLGLTL QRTVLLLLSC SVPISFSWLN MRRILLWCGQ DEEISSVAQQ
FLLFAIPDLF LLSLLHPLRI YLRTQNITLP VTYSTAVSVL LHVPLNYLLV VKLEMGVAGV
AIAMVLTNLN LVVLLSSFVY FTSVHSDTWV PITIDSLKGW SALLSLAIPT CVSVCLEWWW
YEFMIILCGL LANPRATVAS MGILIQTTAL VYVFPSSLSL GVSTRISNEL GAKRPAKARV
SMIISLFCAI ALGLMAMVFA VLVRHHWGRL FTTDAEILQL TSIALPIVGL CELGNCPQTT
GCGVLRGCAR PTLGANINLG SFYFVGMPVA ILFGFVFKQG FPGLWFGLLA AQATCASLML
CALLRTDWKV QAERAEELTS QTPGKSPPLL PIASSKSRST SGTEDMMRTM LV


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