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Protein E6

 Q9IR59_HPV82            Unreviewed;       151 AA.
Q9IR59;
01-OCT-2000, integrated into UniProtKB/TrEMBL.
01-OCT-2000, sequence version 1.
20-JUN-2018, entry version 73.
RecName: Full=Protein E6 {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013181};
Name=E6 {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000313|EMBL:BAA90735.1};
Human papillomavirus type 82.
Viruses; dsDNA viruses, no RNA stage; Papillomaviridae;
Firstpapillomavirinae; Alphapapillomavirus.
NCBI_TaxID=129724 {ECO:0000313|EMBL:BAA90735.1, ECO:0000313|Proteomes:UP000145193};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:BAA90735.1, ECO:0000313|Proteomes:UP000145193}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10618284;
Kino N., Sata T., Sato Y., Sugase M., Matsukura T.;
"Molecular cloning and nucleotide sequence analysis of a novel human
papillomavirus (type 82) associated with vaginal intraepithelial
neoplasia.";
Clin. Diagn. Lab. Immunol. 7:91-95(2000).
[2] {ECO:0000313|Proteomes:UP000102331, ECO:0000313|Proteomes:UP000105977, ECO:0000313|Proteomes:UP000109832}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Qv28313 {ECO:0000313|EMBL:ALJ32313.1},
Qv29261 {ECO:0000313|EMBL:ALJ32273.1},
Qv34162 {ECO:0000313|EMBL:ALJ32281.1},
Qv34571 {ECO:0000313|EMBL:ALJ32265.1},
Rw17 {ECO:0000313|EMBL:ALJ32321.1},
Rw60 {ECO:0000313|EMBL:ALJ32289.1},
Rw643 {ECO:0000313|EMBL:ALJ32297.1}, and
Rw677 {ECO:0000313|EMBL:ALJ32305.1};
PubMed=23998342; DOI=10.1016/j.virol.2013.07.018;
Burk R.D., Harari A., Chen Z.;
"Human papillomavirus genome variants.";
Virology 445:232-243(2013).
[3] {ECO:0000313|EMBL:ARQ82633.1}
NUCLEOTIDE SEQUENCE.
STRAIN=60B {ECO:0000313|EMBL:ARQ82633.1}, and
92B {ECO:0000313|EMBL:ARQ82640.1};
de Oliveira G.R., Siqueira J.D., Finger-Jardim F., Vieira V.C.,
Silva R.L., Goncalves C.V., Soares E., de Martinez A.M.B.,
Soares M.A.;
"Characterization of high and low-risk human papillomavirus complete
genomes isolated from cervical specimens in southern Brazil.";
Mem. Inst. Oswaldo Cruz 0:0-0(2017).
-!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
UBE3A/E6-AP and thus forms a complex with human TP53. Interacts
with human NFX1 and MAGI3. Interacts with human IRF3; this
interaction inhibits the establishment of antiviral state.
Interacts with human TYK2; this interaction inhibits JAK-STAT
activation by interferon alpha. Interacts with host DLG1; this
interaction leads to the proteasomal degradation of DLG1.
{ECO:0000256|HAMAP-Rule:MF_04006}.
-!- SUBCELLULAR LOCATION: Host cytoplasm
{ECO:0000256|RuleBase:RU363123}. Host nucleus
{ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013177}.
-!- MISCELLANEOUS: Belongs to the high risk human alphapapillomavirus
family. The cancer-causing human papillomavirus E6 protein has a
unique carboxy terminal PDZ domain containing substrate.
{ECO:0000256|HAMAP-Rule:MF_04006}.
-!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
{ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013174}.
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EMBL; KF436787; ALJ32265.1; -; Genomic_DNA.
EMBL; KF436788; ALJ32273.1; -; Genomic_DNA.
EMBL; KF436789; ALJ32281.1; -; Genomic_DNA.
EMBL; KF436790; ALJ32289.1; -; Genomic_DNA.
EMBL; KF436791; ALJ32297.1; -; Genomic_DNA.
EMBL; KF436792; ALJ32305.1; -; Genomic_DNA.
EMBL; KF436793; ALJ32313.1; -; Genomic_DNA.
EMBL; KF436794; ALJ32321.1; -; Genomic_DNA.
EMBL; KX514420; ARQ82633.1; -; Genomic_DNA.
EMBL; KX514421; ARQ82640.1; -; Genomic_DNA.
EMBL; AB027021; BAA90735.1; -; Genomic_DNA.
Proteomes; UP000102331; Genome.
Proteomes; UP000105977; Genome.
Proteomes; UP000109832; Genome.
Proteomes; UP000118442; Genome.
Proteomes; UP000141318; Genome.
Proteomes; UP000144397; Genome.
Proteomes; UP000145193; Genome.
Proteomes; UP000148138; Genome.
Proteomes; UP000172479; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IDA:CACAO.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0030165; F:PDZ domain binding; IEA:UniProtKB-UniRule.
GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-UniRule.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
GO; GO:0039548; P:suppression by virus of host IRF3 activity; IEA:UniProtKB-UniRule.
GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
Gene3D; 3.30.240.40; -; 2.
HAMAP; MF_04006; HPV_E6; 1.
InterPro; IPR001334; E6.
InterPro; IPR038575; E6_sf.
Pfam; PF00518; E6; 1.
SUPFAM; SSF161229; SSF161229; 2.
3: Inferred from homology;
Activator {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013178};
Complete proteome {ECO:0000313|Proteomes:UP000102331,
ECO:0000313|Proteomes:UP000105977, ECO:0000313|Proteomes:UP000109832,
ECO:0000313|Proteomes:UP000118442};
DNA-binding {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013184};
Early protein {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|RuleBase:RU363123};
Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|SAAS:SAAS01013183};
Host nucleus {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013175};
Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|SAAS:SAAS01013180};
Inhibition of host innate immune response by virus {ECO:0000256|HAMAP-
Rule:MF_04006};
Inhibition of host IRF3 by virus {ECO:0000256|HAMAP-Rule:MF_04006};
Inhibition of host RLR pathway by virus {ECO:0000256|HAMAP-
Rule:MF_04006};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013170};
Modulation of host cell apoptosis by virus {ECO:0000256|HAMAP-
Rule:MF_04006, ECO:0000256|SAAS:SAAS01013180};
Transcription {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013179};
Transcription regulation {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013179};
Viral immunoevasion {ECO:0000256|HAMAP-Rule:MF_04006};
Zinc {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123,
ECO:0000256|SAAS:SAAS01013170};
Zinc-finger {ECO:0000256|HAMAP-Rule:MF_04006,
ECO:0000256|RuleBase:RU363123, ECO:0000256|SAAS:SAAS01013170}.
ZN_FING 30 66 {ECO:0000256|HAMAP-Rule:MF_04006}.
ZN_FING 103 139 {ECO:0000256|HAMAP-Rule:MF_04006}.
MOTIF 149 151 PDZ-binding domain. {ECO:0000256|HAMAP-
Rule:MF_04006}.
SEQUENCE 151 AA; 18006 MW; 949358742A0375B5 CRC64;
MFEDIRERPR TLHELCEACN TSMHNIQVLC VYCKKELCRA DVYNVAFTEL RIVYRDNTPY
AACKKCLMFY SRIREYRRYS RSVYGATLEA ITNKSLYELL IRCHRCQRPL GPEEKQKVVD
DKKRFHEIAG RWTGQCANCR KPPRQRSETQ V


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