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Protein E7

 C0KXQ5_HPV16            Unreviewed;        98 AA.
C0KXQ5;
05-MAY-2009, integrated into UniProtKB/TrEMBL.
05-MAY-2009, sequence version 1.
22-NOV-2017, entry version 35.
RecName: Full=Protein E7 {ECO:0000256|HAMAP-Rule:MF_04004, ECO:0000256|PIRNR:PIRNR003407, ECO:0000256|SAAS:SAAS00614352};
Name=E7 {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000313|EMBL:ACN22555.1};
Human papillomavirus type 16.
Viruses; dsDNA viruses, no RNA stage; Papillomaviridae;
Alphapapillomavirus.
NCBI_TaxID=333760 {ECO:0000313|EMBL:ACN22555.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:ACN22555.1}
NUCLEOTIDE SEQUENCE.
STRAIN=TV302a {ECO:0000313|EMBL:ACN22555.1};
PubMed=19626616; DOI=10.1002/jmv.21552;
Cento V., Ciccozzi M., Ronga L., Perno C.F., Ciotti M.;
"Genetic diversity of human papillomavirus type 16 E6, E7, and L1
genes in Italian women with different grades of cervical lesions.";
J. Med. Virol. 81:1627-1634(2009).
-!- FUNCTION: E7 protein has both transforming and trans-activating
activities. {ECO:0000256|PIRNR:PIRNR003407}.
-!- FUNCTION: Plays a role in viral genome replication by driving
entry of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to efficiently use
the cellular DNA replicating machinery to achieve viral genome
replication. E7 protein has both transforming and trans-activating
activities. Induces the disassembly of the E2F1 transcription
factor from RB1, with subsequent transcriptional activation of
E2F1-regulated S-phase genes. Interferes with host histone
deacetylation mediated by HDAC1 and HDAC2, leading to
transcription activation. Plays also a role in the inhibition of
both antiviral and antiproliferative functions of host interferon
alpha. Interaction with host TMEM173/STING impairs the ability of
TMEM173/STING to sense cytosolic DNA and promote the production of
type I interferon (IFN-alpha and IFN-beta). {ECO:0000256|HAMAP-
Rule:MF_04004, ECO:0000256|SAAS:SAAS00955501}.
-!- SUBUNIT: Homodimer. Homooligomer. Interacts with host RB1; this
interaction induces dissociation of RB1-E2F1 complex thereby
disrupting RB1 activity. Interacts with host EP300; this
interaction represses EP300 transcriptional activity. Interacts
with protein E2; this interaction inhibits E7 oncogenic activity.
Interacts with host TMEM173/STING; this interaction impairs the
ability of TMEM173/STING to sense cytosolic DNA and promote the
production of type I interferon (IFN-alpha and IFN-beta).
{ECO:0000256|HAMAP-Rule:MF_04004}.
-!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|HAMAP-
Rule:MF_04004}. Host nucleus {ECO:0000256|HAMAP-Rule:MF_04004}.
Note=Predominantly found in the host nucleus. {ECO:0000256|HAMAP-
Rule:MF_04004}.
-!- SUBCELLULAR LOCATION: Host nucleus
{ECO:0000256|SAAS:SAAS00614351}.
-!- PTM: Highly phosphorylated. {ECO:0000256|HAMAP-Rule:MF_04004}.
-!- SIMILARITY: Belongs to the papillomaviridae E7 protein family.
{ECO:0000256|HAMAP-Rule:MF_04004, ECO:0000256|PIRNR:PIRNR003407,
ECO:0000256|SAAS:SAAS00614358}.
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EMBL; FJ645017; ACN22555.1; -; Genomic_DNA.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0019904; F:protein domain specific binding; IEA:UniProtKB-UniRule.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-UniRule.
GO; GO:0039645; P:modulation by virus of host G1/S transition checkpoint; IEA:UniProtKB-UniRule.
GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
HAMAP; MF_04004; PPV_E7; 1.
InterPro; IPR000148; Papilloma_E7.
Pfam; PF00527; E7; 1.
PIRSF; PIRSF003407; Papvi_E7; 1.
3: Inferred from homology;
Activator {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|PIRNR:PIRNR003407, ECO:0000256|SAAS:SAAS00614356};
DNA-binding {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|PIRNR:PIRNR003407, ECO:0000256|SAAS:SAAS00614350};
Early protein {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|PIRNR:PIRNR003407};
G1/S host cell cycle checkpoint dysregulation by virus
{ECO:0000256|HAMAP-Rule:MF_04004, ECO:0000256|SAAS:SAAS00614340};
Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|SAAS:SAAS00614345};
Host nucleus {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|SAAS:SAAS00614349};
Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|SAAS:SAAS00614340, ECO:0000256|SAAS:SAAS00614353};
Inhibition of host innate immune response by virus {ECO:0000256|HAMAP-
Rule:MF_04004, ECO:0000256|SAAS:SAAS00614353};
Inhibition of host interferon signaling pathway by virus
{ECO:0000256|HAMAP-Rule:MF_04004, ECO:0000256|SAAS:SAAS00614353};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|SAAS:SAAS00614342};
Modulation of host cell cycle by virus {ECO:0000256|HAMAP-
Rule:MF_04004, ECO:0000256|SAAS:SAAS00614340};
Transcription {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|PIRNR:PIRNR003407, ECO:0000256|SAAS:SAAS00614344};
Transcription regulation {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|PIRNR:PIRNR003407, ECO:0000256|SAAS:SAAS00614344};
Viral immunoevasion {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|SAAS:SAAS00614353};
Zinc {ECO:0000256|HAMAP-Rule:MF_04004, ECO:0000256|SAAS:SAAS00614342};
Zinc-finger {ECO:0000256|HAMAP-Rule:MF_04004,
ECO:0000256|SAAS:SAAS00614342}.
ZN_FING 58 94 {ECO:0000256|HAMAP-Rule:MF_04004}.
REGION 1 40 Disordered. {ECO:0000256|HAMAP-
Rule:MF_04004}.
MOTIF 22 26 LXCXE motif; interaction with host RB1
and TMEM173/STING. {ECO:0000256|HAMAP-
Rule:MF_04004}.
MOTIF 76 84 Nuclear export signal.
{ECO:0000256|HAMAP-Rule:MF_04004}.
SEQUENCE 98 AA; 11008 MW; 606C12438668B921 CRC64;
MHGDTPTLHE YMLDVQPETT DLYCYEQLND SSEEEDEIDG PAGQAEPDRA HYNIVTFCCK
CDSTLRLCVQ STHVDIRTLE DLLMGTLGIV CPICSQKP


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