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Protein FAM90A1

 F90A1_HUMAN             Reviewed;         464 AA.
Q86YD7; D3DUU9; Q9NVZ6;
11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
24-NOV-2009, sequence version 3.
27-SEP-2017, entry version 104.
RecName: Full=Protein FAM90A1;
Name=FAM90A1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-123 AND
ILE-348.
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-348.
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-123; GLU-234;
LEU-334 AND ILE-348.
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- INTERACTION:
Q8N9N5:BANP; NbExp=3; IntAct=EBI-6658203, EBI-744695;
Q13137:CALCOCO2; NbExp=6; IntAct=EBI-6658203, EBI-739580;
Q8N6L0:CCDC155; NbExp=3; IntAct=EBI-6658203, EBI-749265;
Q2TAC2:CCDC57; NbExp=3; IntAct=EBI-6658203, EBI-2808286;
Q53EZ4:CEP55; NbExp=5; IntAct=EBI-6658203, EBI-747776;
Q9P209:CEP72; NbExp=3; IntAct=EBI-6658203, EBI-739498;
Q8TAP6:CEP76; NbExp=5; IntAct=EBI-6658203, EBI-742887;
Q9Y2V7:COG6; NbExp=4; IntAct=EBI-6658203, EBI-3866319;
Q96B26:EXOSC8; NbExp=5; IntAct=EBI-6658203, EBI-371922;
Q13643:FHL3; NbExp=5; IntAct=EBI-6658203, EBI-741101;
Q96C98:FHL3; NbExp=3; IntAct=EBI-6658203, EBI-10229248;
A1L4K1:FSD2; NbExp=5; IntAct=EBI-6658203, EBI-5661036;
P51116:FXR2; NbExp=3; IntAct=EBI-6658203, EBI-740459;
Q06547:GABPB1; NbExp=3; IntAct=EBI-6658203, EBI-618165;
Q3T906:GNPTAB; NbExp=3; IntAct=EBI-6658203, EBI-1104907;
Q08379:GOLGA2; NbExp=7; IntAct=EBI-6658203, EBI-618309;
Q9HD26:GOPC; NbExp=3; IntAct=EBI-6658203, EBI-349832;
Q53G59:KLHL12; NbExp=4; IntAct=EBI-6658203, EBI-740929;
Q15323:KRT31; NbExp=5; IntAct=EBI-6658203, EBI-948001;
O76015:KRT38; NbExp=3; IntAct=EBI-6658203, EBI-1047263;
Q6A162:KRT40; NbExp=5; IntAct=EBI-6658203, EBI-10171697;
O95751:LDOC1; NbExp=5; IntAct=EBI-6658203, EBI-740738;
Q9UJV3-2:MID2; NbExp=5; IntAct=EBI-6658203, EBI-10172526;
Q5JR59:MTUS2; NbExp=3; IntAct=EBI-6658203, EBI-742948;
O43586:PSTPIP1; NbExp=5; IntAct=EBI-6658203, EBI-1050964;
Q15276:RABEP1; NbExp=4; IntAct=EBI-6658203, EBI-447043;
Q6NUQ1:RINT1; NbExp=3; IntAct=EBI-6658203, EBI-726876;
Q8IUQ4:SIAH1; NbExp=3; IntAct=EBI-6658203, EBI-747107;
Q96MF2:STAC3; NbExp=5; IntAct=EBI-6658203, EBI-745680;
O75558:STX11; NbExp=3; IntAct=EBI-6658203, EBI-714135;
O75069-4:TMCC2; NbExp=3; IntAct=EBI-6658203, EBI-10177480;
Q12933:TRAF2; NbExp=5; IntAct=EBI-6658203, EBI-355744;
P36406:TRIM23; NbExp=5; IntAct=EBI-6658203, EBI-740098;
O43829:ZBTB14; NbExp=3; IntAct=EBI-6658203, EBI-10176632;
Q96BR9:ZBTB8A; NbExp=4; IntAct=EBI-6658203, EBI-742740;
Q9UDV6:ZNF212; NbExp=5; IntAct=EBI-6658203, EBI-1640204;
-!- SIMILARITY: Belongs to the FAM90 family. {ECO:0000305}.
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EMBL; AK001270; BAA91593.1; -; mRNA.
EMBL; AC092111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471116; EAW88629.1; -; Genomic_DNA.
EMBL; CH471116; EAW88630.1; -; Genomic_DNA.
EMBL; BC042608; AAH42608.1; -; mRNA.
CCDS; CCDS31738.1; -.
RefSeq; NP_001306911.1; NM_001319982.1.
RefSeq; NP_060558.3; NM_018088.3.
RefSeq; XP_011519021.1; XM_011520719.1.
RefSeq; XP_016875036.1; XM_017019547.1.
UniGene; Hs.196086; -.
ProteinModelPortal; Q86YD7; -.
SMR; Q86YD7; -.
BioGrid; 120442; 49.
IntAct; Q86YD7; 123.
STRING; 9606.ENSP00000307798; -.
iPTMnet; Q86YD7; -.
PhosphoSitePlus; Q86YD7; -.
BioMuta; FAM90A1; -.
DMDM; 269849691; -.
PaxDb; Q86YD7; -.
PeptideAtlas; Q86YD7; -.
PRIDE; Q86YD7; -.
DNASU; 55138; -.
Ensembl; ENST00000307435; ENSP00000307798; ENSG00000171847.
Ensembl; ENST00000538603; ENSP00000445418; ENSG00000171847.
GeneID; 55138; -.
KEGG; hsa:55138; -.
UCSC; uc001quh.3; human.
CTD; 55138; -.
EuPathDB; HostDB:ENSG00000171847.10; -.
GeneCards; FAM90A1; -.
HGNC; HGNC:25526; FAM90A1.
MIM; 613041; gene.
neXtProt; NX_Q86YD7; -.
OpenTargets; ENSG00000171847; -.
PharmGKB; PA142671796; -.
eggNOG; ENOG410JA2C; Eukaryota.
eggNOG; ENOG4111A8B; LUCA.
GeneTree; ENSGT00530000063065; -.
HOGENOM; HOG000015373; -.
HOVERGEN; HBG107893; -.
InParanoid; Q86YD7; -.
OMA; CDYLRVA; -.
OrthoDB; EOG091G0D9U; -.
PhylomeDB; Q86YD7; -.
TreeFam; TF338572; -.
GenomeRNAi; 55138; -.
PRO; PR:Q86YD7; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000171847; -.
CleanEx; HS_FAM90A1; -.
ExpressionAtlas; Q86YD7; baseline and differential.
Genevisible; Q86YD7; HS.
1: Evidence at protein level;
Complete proteome; Polymorphism; Reference proteome.
CHAIN 1 464 Protein FAM90A1.
/FTId=PRO_0000299592.
VARIANT 123 123 R -> G (in dbSNP:rs9738115).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_060293.
VARIANT 234 234 A -> E (in dbSNP:rs9668582).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_057778.
VARIANT 334 334 P -> L (in dbSNP:rs17855656).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_060294.
VARIANT 343 343 R -> S (in dbSNP:rs9668475).
/FTId=VAR_060154.
VARIANT 348 348 T -> I (in dbSNP:rs9668474).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.3}.
/FTId=VAR_060295.
VARIANT 410 410 T -> A (in dbSNP:rs11044098).
/FTId=VAR_060155.
CONFLICT 254 255 VS -> AR (in Ref. 4; AAH42608).
{ECO:0000305}.
CONFLICT 344 344 T -> TV (in Ref. 1; BAA91593).
{ECO:0000305}.
SEQUENCE 464 AA; 49793 MW; D9E36FCEE5021250 CRC64;
MMARRDPKPG AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCEAF GHTARSTRCP
MKCWKAALVP PNFGEKEGKE NLKPWKPQVE ANPGPLNKDK GEKEERPRPQ DPQRKALLHI
FSRKPPEKPL PNQKGSTESS DYLRVASGPM PVHTTSKRPR VDPVLSDRSA TEMSDRGSVL
ASLSPLRKAS LSSSSSLGPK ERQTGAAADI PQTAVRHQGP EPLLVVKPTH SSPAGGCREV
PQAASKTHGL LQAVSPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRSAPAPIQA
CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPRTSPQTGT RTPAQVLSGD
RQPPHSRPCL PTAQACTMSH HPAASHDGAQ PLRVLFRRLE NGRWSSSLLT APSFHSPEKP
GAFLAQSPHV SEKSEGPCVR VPPSVLYEDL QVPSSSEDSD SDLE


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