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Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1 homolog) (Protein GCP-WD)

 NEDD1_ARATH             Reviewed;         782 AA.
B3H5K9; B6EUA6; Q9FI89;
24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
22-JUL-2008, sequence version 1.
23-MAY-2018, entry version 83.
RecName: Full=Protein NEDD1 {ECO:0000303|PubMed:19383896};
AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 1 homolog {ECO:0000303|PubMed:19383896};
AltName: Full=Protein GCP-WD {ECO:0000303|PubMed:25438942};
Name=NEDD1 {ECO:0000303|PubMed:19383896};
Synonyms=GCP-WD {ECO:0000303|PubMed:25438942};
OrderedLocusNames=At5g05970 {ECO:0000312|Araport:AT5G05970};
ORFNames=K18J17.16 {ECO:0000312|EMBL:BAB10802.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10470850; DOI=10.1093/dnares/6.3.183;
Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
Miyajima N., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. IX.
Sequence features of the regions of 1,011,550 bp covered by seventeen
P1 and TAC clones.";
DNA Res. 6:183-195(1999).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[4]
FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND DISRUPTION
PHENOTYPE.
PubMed=19383896; DOI=10.1105/tpc.109.065953;
Zeng C.J., Lee Y.R., Liu B.;
"The WD40 repeat protein NEDD1 functions in microtubule organization
during cell division in Arabidopsis thaliana.";
Plant Cell 21:1129-1140(2009).
[5]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=25438942; DOI=10.1016/j.cub.2014.09.013;
Walia A., Nakamura M., Moss D., Kirik V., Hashimoto T., Ehrhardt D.W.;
"GCP-WD mediates gamma-TuRC recruitment and the geometry of
microtubule nucleation in interphase arrays of Arabidopsis.";
Curr. Biol. 24:2548-2555(2014).
-!- FUNCTION: Regulates microtubules organization in a centrosome-
independent manner. Required for the spindle to be positioned
correctly and for the function of gamma-tubulin in organizing
phragmoplast microtubules (PubMed:19383896). Component of active
gamma-tubulin ring complexes (gamma-TuRCs) associated with
cortical microtubules in interphase cells (PubMed:25438942).
Mediates gamma-TuRC recruitment to the nucleation sites and is
important for determining the ratio of branched to parallel
nucleation (PubMed:25438942). May mediate the localization of GCP2
and GCP3 to the nuclear envelope (PubMed:19383896).
{ECO:0000269|PubMed:19383896, ECO:0000269|PubMed:25438942}.
-!- SUBCELLULAR LOCATION: Nucleus envelope
{ECO:0000269|PubMed:19383896, ECO:0000269|PubMed:25438942}.
Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19383896}.
Cytoplasm, cytoskeleton, phragmoplast
{ECO:0000269|PubMed:19383896}. Cytoplasm, cytoskeleton,
microtubule organizing center {ECO:0000269|PubMed:25438942}.
Note=First detected in prophase on the nuclear envelope, where it
appeared to cap the future spindle poles. Later detected along
kinetochore microtubules (MTs) of the metaphase spindle, with more
prominent signals toward the poles. In anaphase, detected with the
shortening kinetochore fibers. In the developing phragmoplast,
localized mainly toward the minus end of MTs.
{ECO:0000269|PubMed:19383896}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=B3H5K9-1; Sequence=Displayed;
Note=No experimental confirmation available. Derived from EST
data. {ECO:0000305};
Name=2;
IsoId=B3H5K9-2; Sequence=VSP_057697;
Note=No experimental confirmation available. {ECO:0000305};
-!- TISSUE SPECIFICITY: Expressed in root meristematic cells.
{ECO:0000269|PubMed:19383896}.
-!- DISRUPTION PHENOTYPE: Lethal when homozygous. Compromised
asymmetric mitotic division in dividing microspores resulting in
abortion of gametogenesis. {ECO:0000269|PubMed:19383896}.
-!- SEQUENCE CAUTION:
Sequence=AY093770; Type=Frameshift; Positions=413; Evidence={ECO:0000305};
Sequence=BAB10802.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AB017060; BAB10802.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002688; AED90947.1; -; Genomic_DNA.
EMBL; CP002688; AED90948.1; -; Genomic_DNA.
EMBL; AY093770; -; NOT_ANNOTATED_CDS; mRNA.
RefSeq; NP_001119176.1; NM_001125704.1. [B3H5K9-1]
RefSeq; NP_196216.2; NM_120679.3. [B3H5K9-2]
UniGene; At.32924; -.
UniGene; At.66718; -.
ProteinModelPortal; B3H5K9; -.
STRING; 3702.AT5G05970.2; -.
iPTMnet; B3H5K9; -.
PaxDb; B3H5K9; -.
PRIDE; B3H5K9; -.
EnsemblPlants; AT5G05970.1; AT5G05970.1; AT5G05970. [B3H5K9-2]
EnsemblPlants; AT5G05970.2; AT5G05970.2; AT5G05970. [B3H5K9-1]
GeneID; 830483; -.
Gramene; AT5G05970.1; AT5G05970.1; AT5G05970. [B3H5K9-2]
Gramene; AT5G05970.2; AT5G05970.2; AT5G05970. [B3H5K9-1]
KEGG; ath:AT5G05970; -.
Araport; AT5G05970; -.
TAIR; locus:2153629; AT5G05970.
eggNOG; KOG4378; Eukaryota.
eggNOG; ENOG410ZQNY; LUCA.
HOGENOM; HOG000243035; -.
InParanoid; B3H5K9; -.
KO; K16547; -.
OMA; RYSVNES; -.
OrthoDB; EOG093603UI; -.
PhylomeDB; B3H5K9; -.
PRO; PR:B3H5K9; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; B3H5K9; baseline and differential.
GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
GO; GO:0005828; C:kinetochore microtubule; IDA:TAIR.
GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO; GO:0009524; C:phragmoplast; IEA:UniProtKB-SubCell.
GO; GO:0000919; P:cell plate assembly; IMP:TAIR.
GO; GO:0009553; P:embryo sac development; IMP:TAIR.
GO; GO:0009555; P:pollen development; IMP:TAIR.
GO; GO:0032467; P:positive regulation of cytokinesis; IMP:TAIR.
GO; GO:0060236; P:regulation of mitotic spindle organization; IMP:TAIR.
GO; GO:2000694; P:regulation of phragmoplast microtubule organization; IMP:TAIR.
Gene3D; 2.130.10.10; -; 2.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
Pfam; PF00400; WD40; 2.
SMART; SM00320; WD40; 6.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 1.
PROSITE; PS50082; WD_REPEATS_2; 1.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
2: Evidence at transcript level;
Alternative splicing; Centromere; Chromosome; Coiled coil;
Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Nucleus;
Reference proteome; Repeat; WD repeat.
CHAIN 1 782 Protein NEDD1.
/FTId=PRO_0000433252.
REPEAT 1 34 WD 1. {ECO:0000255}.
REPEAT 41 80 WD 2. {ECO:0000255}.
REPEAT 90 130 WD 3. {ECO:0000255}.
REPEAT 133 172 WD 4. {ECO:0000255}.
REPEAT 176 216 WD 5. {ECO:0000255}.
REPEAT 220 260 WD 6. {ECO:0000255}.
REPEAT 262 301 WD 7. {ECO:0000255}.
REPEAT 307 358 WD 8. {ECO:0000255}.
COILED 753 782 {ECO:0000255}.
COMPBIAS 445 558 Ser-rich. {ECO:0000255|PROSITE-
ProRule:PRU00016}.
VAR_SEQ 689 689 Missing (in isoform 2).
/FTId=VSP_057697.
SEQUENCE 782 AA; 84757 MW; 384F0F6A5DC5EFCD CRC64;
MMSNLVEPSW RLLAASGGDT VKLFDVSADS GDPCVLSYTP SPGCAVNSVK WNHTNLVVAS
TGEDKKISLW RKNGQSLGTV PVTGKDGGDS AEECLSAISF SKKGSRYICS GGTGQIVKIW
DLQRKLCIKK LKGHTSTITG VMYNCKDEHL ASVSVGGDLI VHNLASGARA TELKDPNGQV
LRLLDYSRSS RHLLVTAGDD GTVHLWDTTG RSPKMSWLKQ HSAPTAGVCF SPSNEKIIAS
VGMDKKLYTY DSGSRRSSSC IAYEAPFSSL AFGDNGYILV AGTSNGRVVF YDIRGKPQPV
TVLHAFSNSE DVTSLSWQTS KPVIVNEKNY TSEMALLGST VEDSVVIPDP LPSTTPSASQ
SAMAPGSRGV SASTVNASSV EQTPNRNHLW PSGPLGRLHA LRANDSYNDD MGVFSPIIDV
SSVEKWADSE GYNNKDHLVV DNKPSSLLFP SSSKGYSFGD NGSKEHPIFD WKPSSTSKQD
DPRAAFSSFG SITPTASSKS EDSALTPPEA WGGDKFSEKF NQLANEKFSD KFSHLHAPSR
LAVSSTGAST SGSMFSSSRD FPLSHGQTNF ANASLEFPRI RDFSSTFETS STQTDNNLPS
SPLFTKGITA PGNIDSLRLS PNFTRRFSTY AERISTTSSF SDGASLSLGG SPKIKKTGSE
TREEVLNHLL ARPETVVATE AGAMPLMNQG GLKQSQTDQQ QVMGSSNFTL QLFQRTLEGT
LDSFQNSIHD DVRNLHIEIL RQFHMHEMEM SKVLSSILEN QAEQMKELKL LRKENQELRQ
RL


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