Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Protein NIS1 (Jumonji domain-interacting protein 1) (Neck protein interacting with septins protein 1)

 NIS1_YEAST              Reviewed;         407 AA.
P53939; D6W1A1;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
18-JUL-2018, entry version 130.
RecName: Full=Protein NIS1;
AltName: Full=Jumonji domain-interacting protein 1;
AltName: Full=Neck protein interacting with septins protein 1;
Name=NIS1; Synonyms=JIP1; OrderedLocusNames=YNL078W; ORFNames=N2337;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=8701611;
DOI=10.1002/(SICI)1097-0061(19960330)12:4<391::AID-YEA921>3.3.CO;2-E;
Poehlmann R., Philippsen P.;
"Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV
reveals 12 new open reading frames (ORFs) and an ancient duplication
of six ORFs.";
Yeast 12:391-402(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169873;
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F.,
Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M.,
Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N.,
Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D.,
Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A.,
Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A.,
Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C.,
Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M.,
Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J.,
Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L.,
Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M.,
Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P.,
Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A.,
Wambutt R., Wedler H., Zollner A., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV
and its evolutionary implications.";
Nature 387:93-98(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
SUBCELLULAR LOCATION, PHOSPHORYLATION, AND INTERACTION WITH SHS1 AND
NAP1.
PubMed=11817649; DOI=10.1266/ggs.76.335;
Iwase M., Toh-e A.;
"Nis1 encoded by YNL078W: a new neck protein of Saccharomyces
cerevisiae.";
Genes Genet. Syst. 76:335-343(2001).
[5]
INDUCTION.
PubMed=11309124; DOI=10.1046/j.1365-2958.2001.02388.x;
Doolin M.-T., Johnson A.L., Johnston L.H., Butler G.;
"Overlapping and distinct roles of the duplicated yeast transcription
factors Ace2p and Swi5p.";
Mol. Microbiol. 40:422-432(2001).
[6]
INTERACTION WITH PRM8.
PubMed=12101299;
Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S.,
Souciet J.-L., Jauniaux J.-C.;
"Functional analysis of the Saccharomyces cerevisiae DUP240 multigene
family reveals membrane-associated proteins that are not essential for
cell viability.";
Microbiology 148:2111-2123(2002).
[7]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[8]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[9]
INTERACTION WITH REI1, AND FUNCTION.
PubMed=15107529; DOI=10.1247/csf.29.1;
Iwase M., Toh-e A.;
"Ybr267w is a new cytoplasmic protein belonging to the mitotic
signaling network of Saccharomyces cerevisiae.";
Cell Struct. Funct. 29:1-15(2004).
[10]
INTERACTION WITH CBF2.
PubMed=16923829; DOI=10.1083/jcb.200605019;
Montpetit B., Hazbun T.R., Fields S., Hieter P.;
"Sumoylation of the budding yeast kinetochore protein Ndc10 is
required for Ndc10 spindle localization and regulation of anaphase
spindle elongation.";
J. Cell Biol. 174:653-663(2006).
[11]
DOMAIN, AND INTERACTION WITH SUMOYLATED PROTEINS.
PubMed=17728242; DOI=10.1074/jbc.M706505200;
Uzunova K., Goettsche K., Miteva M., Weisshaar S.R., Glanemann C.,
Schnellhardt M., Niessen M., Scheel H., Hofmann K., Johnson E.S.,
Praefcke G.J.K., Dohmen R.J.;
"Ubiquitin-dependent proteolytic control of SUMO conjugates.";
J. Biol. Chem. 282:34167-34175(2007).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=ADR376;
PubMed=17330950; DOI=10.1021/pr060559j;
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
Elias J.E., Gygi S.P.;
"Large-scale phosphorylation analysis of alpha-factor-arrested
Saccharomyces cerevisiae.";
J. Proteome Res. 6:1190-1197(2007).
[13]
INTERACTION WITH GIS1.
PubMed=17043893; DOI=10.1007/s00438-006-0171-3;
Tronnersjoe S., Hanefalk C., Balciunas D., Hu G.-Z., Nordberg N.,
Muren E., Ronne H.;
"The jmjN and jmjC domains of the yeast zinc finger protein Gis1
interact with 19 proteins involved in transcription, sumoylation and
DNA repair.";
Mol. Genet. Genomics 277:57-70(2007).
[14]
INTERACTION WITH NAP1, AND IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=18086883; DOI=10.1128/MCB.01035-07;
Calvert M.E.K., Keck K.M., Ptak C., Shabanowitz J., Hunt D.F.,
Pemberton L.F.;
"Phosphorylation by casein kinase 2 regulates Nap1 localization and
function.";
Mol. Cell. Biol. 28:1313-1325(2008).
[15]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=18407956; DOI=10.1074/mcp.M700468-MCP200;
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth
phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260; SER-264 AND
SER-302, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides
insights into evolution.";
Science 325:1682-1686(2009).
-!- FUNCTION: May be involved in a mitotic signaling network. Binds
sumoylated proteins and may stabilize SUMO chains.
{ECO:0000269|PubMed:15107529}.
-!- SUBUNIT: Interacts with CBF2, GIS1, NAP1, PRM8, REI1, SHS1 and
SMT3. {ECO:0000269|PubMed:11817649, ECO:0000269|PubMed:12101299,
ECO:0000269|PubMed:15107529, ECO:0000269|PubMed:16923829,
ECO:0000269|PubMed:17043893, ECO:0000269|PubMed:17728242,
ECO:0000269|PubMed:18086883}.
-!- INTERACTION:
Q99299:AIM44; NbExp=5; IntAct=EBI-28760, EBI-29423;
P25293:NAP1; NbExp=8; IntAct=EBI-28760, EBI-11850;
Q08229:NBA1; NbExp=6; IntAct=EBI-28760, EBI-36841;
-!- SUBCELLULAR LOCATION: Bud neck {ECO:0000269|PubMed:11817649}.
Cytoplasm, cell cortex {ECO:0000269|PubMed:14562095}.
-!- INDUCTION: Expression is regulated by the ACE2 and SWI5
transcription factors. {ECO:0000269|PubMed:11309124}.
-!- MISCELLANEOUS: Present with 504 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X86470; CAA60180.1; -; Genomic_DNA.
EMBL; Z71354; CAA95952.1; -; Genomic_DNA.
EMBL; BK006947; DAA10467.1; -; Genomic_DNA.
PIR; S53900; S53900.
RefSeq; NP_014321.3; NM_001182916.3.
ProteinModelPortal; P53939; -.
BioGrid; 35745; 129.
DIP; DIP-1980N; -.
IntAct; P53939; 18.
MINT; P53939; -.
STRING; 4932.YNL078W; -.
iPTMnet; P53939; -.
MaxQB; P53939; -.
PaxDb; P53939; -.
PRIDE; P53939; -.
EnsemblFungi; YNL078W; YNL078W; YNL078W.
GeneID; 855646; -.
KEGG; sce:YNL078W; -.
EuPathDB; FungiDB:YNL078W; -.
SGD; S000005022; NIS1.
InParanoid; P53939; -.
OMA; DDSHITH; -.
OrthoDB; EOG092C3OCO; -.
BioCyc; YEAST:G3O-33107-MONOMER; -.
PRO; PR:P53939; -.
Proteomes; UP000002311; Chromosome XIV.
GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO; GO:0005935; C:cellular bud neck; IDA:SGD.
GO; GO:0005634; C:nucleus; IDA:SGD.
GO; GO:0007088; P:regulation of mitotic nuclear division; IPI:SGD.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome.
CHAIN 1 407 Protein NIS1.
/FTId=PRO_0000203447.
MOTIF 391 398 SUMO-binding.
MOD_RES 260 260 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
MOD_RES 264 264 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
MOD_RES 300 300 Phosphoserine.
{ECO:0000244|PubMed:17330950}.
MOD_RES 302 302 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
SEQUENCE 407 AA; 45908 MW; 925C7B6063BCE4F1 CRC64;
METYETSIGT QSYPPTLFPP PLGTGGFTTS GYIHALVDST SNSNSNSNTN SNTNSNTNSN
SDTKIPIVQI SDDSHITHDS FKPYMEYHDA SHLRNRNISK ADQVESTEVM EQFTQWSNYK
MRSRSPTINA KPIRHTSQRR TDFTSKNELS KFSKNHNFIF HKGFLKRQHS IRREDRQAKV
RSRFRSKKEL TSVLNYIELE QMDIANVLAS QPVNLHAIRN LTSRDPAVTP IPFLRSQMYA
TSSRPPYLRN RSISRKLPKS QPGSLPTTMP ATATKTIKQN STTPTTRSVY NKNVGRSNTS
PSVLYHPKRR GKLNTKSHAR KEQLLLELWR EYLMLVITQR TQLRLTLLCS PGSASNESSV
CSSNASDLDM SLLSTPSSLF QMAGETKSNP IIIPDSQDDS ILSSDPF


Related products :

Catalog number Product name Quantity
EIAAB39603 54 kDa VacA-interacting protein,90 kDa N-WASP-interacting protein,90 kDa SH3 protein interacting with Nck,Mouse,Mus musculus,NCK-interacting protein with SH3 domain,Nckipsd,N-WASP-binding protein,SH3
EIAAB27017 45 kDa NF-AT-interacting protein,45 kDa NFAT-interacting protein,Homo sapiens,Human,NFATC2-interacting protein,NFATC2IP,NIP45,Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
EIAAB27018 45 kDa NF-AT-interacting protein,45 kDa NFAT-interacting protein,Mouse,Mus musculus,NFATC2-interacting protein,Nfatc2ip,Nip45,Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
15-288-22308F GIPC PDZ domain-containing protein 1 - RGS19-interacting protein 1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; Tax interaction protein 2; TIP-2 Polyclonal 0.1 mg
15-288-22308F GIPC PDZ domain-containing protein 1 - RGS19-interacting protein 1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; Tax interaction protein 2; TIP-2 Polyclonal 0.05 mg
18-003-44197 PDZ domain-containing protein GIPC1 - RGS19-interacting protein 1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; Tax interaction protein 2; TIP-2 Polyclonal 0.05 mg Aff Pur
EIAAB31218 Homo sapiens,hPIP1,Human,p21-activated protein kinase-interacting protein 1,PAK_PLC-interacting protein 1,PAK1-interacting protein 1,PAK1IP1,PIP1,WD repeat-containing protein 84,WDR84
EIAAB46349 Homo sapiens,Human,Protein PRPL-2,WAS_WASL-interacting protein family member 1,WASP-interacting protein,WASPIP,WIP,WIPF1,Wiskott-Aldrich syndrome protein-interacting protein
EIAAB39347 Mouse,Mus musculus,Spata24,Spermatogenesis-associated protein 24,TATA-binding protein-like factor-interacting protein,Testis protein T6441 homolog,Tipt,Tipt2,TLF-interacting protein,TRF2-interacting p
EIAAB07420 Cdc42-interacting protein 4,CIP4,Homo sapiens,hSTP,Human,Protein Felic,Salt tolerant protein,STOT,STP,Thyroid receptor-interacting protein 10,TR-interacting protein 10,TRIP10,TRIP-10
10-288-22308F GIPC PDZ domain-containing protein 1 - RGS19-interacting protein 1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; Tax interaction protein 2; TIP-2 0.05 mg
10-288-22308F GIPC PDZ domain-containing protein 1 - RGS19-interacting protein 1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; Tax interaction protein 2; TIP-2 0.1 mg
EIAAB31034 Androgen receptor-interacting protein 3,ARIP3,DAB2-interacting protein,DIP,E3 SUMO-protein ligase PIAS2,Homo sapiens,Human,Miz1,Msx-interacting zinc finger protein,PIAS2,PIAS-NY protein,PIASX,Protein
EIAAB35575 Mouse,Mus musculus,RING finger protein 37,Rnf37,Ubce7ip5,UbcM4-interacting protein 5,Ubiquitin-conjugating enzyme 7-interacting protein 5,U-box domain-containing protein 5,Ubox5,Uip5
EIAAB31325 Casein kinase 2-interacting protein 1,C-Jun-binding protein,CK2-interacting protein 1,CKIP1,CKIP-1,Homo sapiens,HQ0024c,Human,JBP,OC120,Osteoclast maturation-associated gene 120 protein,PH domain-cont
EIAAB39604 54 kDa VacA-interacting protein,54 kDa vimentin-interacting protein,90 kDa SH3 protein interacting with Nck,AF3p21,AF3P21,Dia-interacting protein 1,Diaphanous protein-interacting protein,DIP-1,Homo sa
EIAAB32252 Addicsin,ADP-ribosylation factor-like protein 6-interacting protein 5,Aip5,Aip-5,ARL-6-interacting protein 5,Arl6ip5,Glutamate transporter EAAC1-interacting protein,GTRAP3-18,Jwa,Mouse,Mus musculus,PR
EIAAB46351 Rat,Rattus norvegicus,WAS_WASL-interacting protein family member 1,WASP-interacting protein,Waspip,Wip,Wipf1,Wiskott-Aldrich syndrome protein-interacting protein
EIAAB46350 Mouse,Mus musculus,WAS_WASL-interacting protein family member 1,WASP-interacting protein,Waspip,Wip,Wipf1,Wiskott-Aldrich syndrome protein-interacting protein
EIAAB30253 Aip1,ALG-2-interacting protein 1,ALG-2-interacting protein X,Alix,E2F1-inducible protein,Eig2,Mouse,Mus musculus,Pdcd6ip,Programmed cell death 6-interacting protein
EIAAB07421 Cdc42-interacting protein 4,Cip4,Rat,Rattus norvegicus,Salt tolerant protein,Stp,Thyroid receptor-interacting protein 10,TR-interacting protein 10,Trip10,TRIP-10
EIAAB44012 Homo sapiens,Human,OIP1,OIP-1,Opa-interacting protein 1,Thyroid receptor-interacting protein 6,TR-interacting protein 6,TRIP6,TRIP-6,ZRP-1,Zyxin-related protein 1
EIAAB31033 Androgen receptor-interacting protein 3,ARIP3,DAB2-interacting protein,DIP,E3 SUMO-protein ligase PIAS2,Miz1,Mouse,Msx-interacting zinc finger protein,Mus musculus,Pias2,Piasx,Protein inhibitor of act
EIAAB31032 Androgen receptor-interacting protein 3,ARIP3,DAB2-interacting protein,DIP,E3 SUMO-protein ligase PIAS2,Miz1,Msx-interacting-zinc finger protein,Pias2,Piasx,Protein inhibitor of activated STAT x,Prote
EIAAB29754 Homo sapiens,HSPC218,Human,PABP-interacting protein 2,PAIP2,PAIP-2,PAIP2A,Poly(A)-binding protein-interacting protein 2,Polyadenylate-binding protein-interacting protein 2


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur