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Protein Nef (Fragment)

 H9CI54_9HIV1            Unreviewed;       109 AA.
H9CI54;
16-MAY-2012, integrated into UniProtKB/TrEMBL.
16-MAY-2012, sequence version 1.
18-JAN-2017, entry version 21.
RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS00118351};
Flags: Fragment;
Name=nef {ECO:0000313|EMBL:AFE88684.1};
Human immunodeficiency virus 1.
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
Lentivirus; Primate lentivirus group.
NCBI_TaxID=11676 {ECO:0000313|EMBL:AFE88684.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:AFE88684.1}
NUCLEOTIDE SEQUENCE.
STRAIN=F302A11 {ECO:0000313|EMBL:AFE88684.1};
Bachu M., Swaroopa Y., Anjali V., Udaykumar R.;
"Sequence insertions in the HIV-1 subtype C viral promoter
predominantly generate an additional NF-KB binding site.";
Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
-!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00536203}.
-!- SUBCELLULAR LOCATION: Host cell membrane
{ECO:0000256|SAAS:SAAS00536205}; Lipid-anchor
{ECO:0000256|SAAS:SAAS00536205}; Cytoplasmic side
{ECO:0000256|SAAS:SAAS00536205}.
-!- SIMILARITY: Belongs to the lentivirus primate group Nef protein
family. {ECO:0000256|RuleBase:RU000344,
ECO:0000256|SAAS:SAAS00536190}.
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EMBL; JQ321432; AFE88684.1; -; Genomic_DNA.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0005525; F:GTP binding; IEA:InterPro.
GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
Gene3D; 3.30.62.10; -; 1.
InterPro; IPR027481; HIV-1_Nef_core.
InterPro; IPR001558; HIV_Nef.
Pfam; PF00469; F-protein; 1.
SUPFAM; SSF55671; SSF55671; 1.
3: Inferred from homology;
Host cell membrane {ECO:0000256|SAAS:SAAS00004523};
Host membrane {ECO:0000256|SAAS:SAAS00004523};
Host-virus interaction {ECO:0000256|RuleBase:RU000344};
Lipoprotein {ECO:0000256|RuleBase:RU000344};
Membrane {ECO:0000256|SAAS:SAAS00004523};
Myristate {ECO:0000256|RuleBase:RU000344};
Viral immunoevasion {ECO:0000256|RuleBase:RU000344};
Virulence {ECO:0000256|RuleBase:RU000344}.
NON_TER 1 1 {ECO:0000313|EMBL:AFE88684.1}.
SEQUENCE 109 AA; 12953 MW; E737802A0BFBDEDE CRC64;
EGLIYSKKRQ EILDLWVYHT QGFFPDWQNY TPGPGTRPPL TFGWCFKLVP VDPGEVEEAT
KEENNSLLHP VCQHGMEDEH REVLVWKFDS QLARRHLARE QHPEFYRDC


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