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Protein PDF [Cleaved into: PDF precursor-related peptide (PAP); Neuropeptide PDF (Pigment-dispersing factor homolog)]

 PDF_DROME               Reviewed;         102 AA.
O96690; Q7JYY1; Q9VBE9;
06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
06-DEC-2005, sequence version 2.
28-FEB-2018, entry version 104.
RecName: Full=Protein PDF;
Contains:
RecName: Full=PDF precursor-related peptide;
Short=PAP;
Contains:
RecName: Full=Neuropeptide PDF;
AltName: Full=Pigment-dispersing factor homolog;
Flags: Precursor;
Name=Pdf; ORFNames=CG6496;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
STRAIN=Canton-S; TISSUE=Head;
PubMed=9615286; DOI=10.1177/074873098129000066;
Park J.H., Hall J.C.;
"Isolation and chronobiological analysis of a neuropeptide pigment-
dispersing factor gene in Drosophila melanogaster.";
J. Biol. Rhythms 13:219-228(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley; TISSUE=Head;
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[5]
PROTEIN SEQUENCE OF 83-100, IDENTIFICATION BY MASS SPECTROMETRY, MASS
SPECTROMETRY, AND AMIDATION AT ALA-100.
TISSUE=Midgut {ECO:0000303|PubMed:21214272};
PubMed=21214272; DOI=10.1021/pr101116g;
Reiher W., Shirras C., Kahnt J., Baumeister S., Isaac R.E.,
Wegener C.;
"Peptidomics and peptide hormone processing in the Drosophila
midgut.";
J. Proteome Res. 10:1881-1892(2011).
[6]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=10619432; DOI=10.1016/S0092-8674(00)81676-1;
Renn S.C.C., Park J.H., Rosbash M., Hall J.C., Taghert P.H.;
"A pdf neuropeptide gene mutation and ablation of PDF neurons each
cause severe abnormalities of behavioral circadian rhythms in
Drosophila.";
Cell 99:791-802(1999).
[7]
ERRATUM.
Renn S.C.C., Park J.H., Rosbash M., Hall J.C., Taghert P.H.;
Cell 101:114-114(1999).
[8]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=10725392; DOI=10.1073/pnas.97.7.3608;
Park J.H., Helfrich-Foerster C., Lee G., Liu L., Rosbash M.,
Hall J.C.;
"Differential regulation of circadian pacemaker output by separate
clock genes in Drosophila.";
Proc. Natl. Acad. Sci. U.S.A. 97:3608-3613(2000).
[9]
FUNCTION.
PubMed=10777797;
Helfrich-Foerster C., Taueber M., Park J.H., Muehlig-Versen M.,
Schneuwly S., Hofbauer A.;
"Ectopic expression of the neuropeptide pigment-dispersing factor
alters behavioral rhythms in Drosophila melanogaster.";
J. Neurosci. 20:3339-3353(2000).
[10]
FUNCTION.
PubMed=15356209; DOI=10.1523/JNEUROSCI.2370-04.2004;
Lin Y., Stormo G.D., Taghert P.H.;
"The neuropeptide pigment-dispersing factor coordinates pacemaker
interactions in the Drosophila circadian system.";
J. Neurosci. 24:7951-7957(2004).
-!- FUNCTION: Neuropeptide PDF is the main transmitter regulating
circadian locomotor rhythms. Required to maintain behavioral
rhythms under constant conditions by coordinating pacemaker
interactions in the circadian system. Ectopic expression induces
long periods, while its absence leads to short periods.
{ECO:0000269|PubMed:10619432, ECO:0000269|PubMed:10777797,
ECO:0000269|PubMed:15356209}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Predominantly expressed in adult head.
Expressed at higher level in males than in females. In adult
brain, it is specifically expressed in the ventral lateral neurons
(LNvs) as well as in 2-4 tritocerebral cells and 4-6 abdominal
cells. {ECO:0000269|PubMed:10619432, ECO:0000269|PubMed:10725392,
ECO:0000269|PubMed:9615286}.
-!- DEVELOPMENTAL STAGE: Expressed at constant level, without strong
circadian variations. Its amount nevertheless oscillates along day
and night cycles in the termini of dorsally projected axons of
LNvs. {ECO:0000269|PubMed:10725392, ECO:0000269|PubMed:9615286}.
-!- MASS SPECTROMETRY: Mass=1972.02; Method=MALDI; Range=83-100;
Evidence={ECO:0000269|PubMed:21214272};
-!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAL49303.2; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF110059; AAC98309.1; -; Genomic_DNA.
EMBL; AE014297; AAF56593.1; -; Genomic_DNA.
EMBL; AY071681; AAL49303.2; ALT_INIT; mRNA.
RefSeq; NP_524517.1; NM_079793.3.
UniGene; Dm.21687; -.
BioGrid; 68089; 4.
STRING; 7227.FBpp0084396; -.
PaxDb; O96690; -.
EnsemblMetazoa; FBtr0085024; FBpp0084396; FBgn0023178.
GeneID; 43193; -.
KEGG; dme:Dmel_CG6496; -.
CTD; 64146; -.
FlyBase; FBgn0023178; Pdf.
eggNOG; ENOG410KC1M; Eukaryota.
eggNOG; ENOG4110MPR; LUCA.
InParanoid; O96690; -.
OMA; WFNNVGV; -.
OrthoDB; EOG091G1AC3; -.
PhylomeDB; O96690; -.
GenomeRNAi; 43193; -.
PRO; PR:O96690; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0023178; -.
ExpressionAtlas; O96690; differential.
Genevisible; O96690; DM.
GO; GO:0005615; C:extracellular space; IDA:FlyBase.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005184; F:neuropeptide hormone activity; TAS:FlyBase.
GO; GO:0005102; F:receptor binding; IPI:UniProtKB.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:FlyBase.
GO; GO:0007623; P:circadian rhythm; IMP:FlyBase.
GO; GO:0042745; P:circadian sleep/wake cycle; IMP:FlyBase.
GO; GO:0008062; P:eclosion rhythm; TAS:FlyBase.
GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IMP:FlyBase.
GO; GO:0042332; P:gravitaxis; IDA:FlyBase.
GO; GO:0045475; P:locomotor rhythm; IMP:UniProtKB.
GO; GO:0007617; P:mating behavior; IMP:FlyBase.
GO; GO:0007218; P:neuropeptide signaling pathway; IDA:FlyBase.
GO; GO:0010841; P:positive regulation of circadian sleep/wake cycle, wakefulness; IMP:FlyBase.
GO; GO:0042749; P:regulation of circadian sleep/wake cycle; IMP:FlyBase.
GO; GO:1904059; P:regulation of locomotor rhythm; IMP:FlyBase.
InterPro; IPR009396; Pigment_DH.
Pfam; PF06324; Pigment_DH; 1.
1: Evidence at protein level;
Amidation; Biological rhythms; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Reference proteome;
Secreted; Signal.
SIGNAL 1 24 {ECO:0000255}.
PEPTIDE 25 79 PDF precursor-related peptide.
{ECO:0000250}.
/FTId=PRO_0000043162.
PEPTIDE 83 100 Neuropeptide PDF.
{ECO:0000269|PubMed:21214272}.
/FTId=PRO_0000043163.
MOD_RES 100 100 Alanine amide.
{ECO:0000269|PubMed:21214272}.
CONFLICT 4 4 Y -> F (in Ref. 1; AAC98309).
{ECO:0000305}.
SEQUENCE 102 AA; 11545 MW; 7F7E0CAA40AE39C2 CRC64;
MARYTYLVAL VLLAICCQWG YCGAMAMPDE ERYVRKEYNR DLLDWFNNVG VGQFSPGQVA
TLCRYPLILE NSLGPSVPIR KRNSELINSL LSLPKNMNDA GK


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