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Protein PHYTOCHROME KINASE SUBSTRATE 1

 PKS1_ARATH              Reviewed;         439 AA.
Q9SWI1; O80610;
10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
10-MAY-2002, sequence version 2.
23-MAY-2018, entry version 102.
RecName: Full=Protein PHYTOCHROME KINASE SUBSTRATE 1;
Name=PKS1; OrderedLocusNames=At2g02950; ORFNames=T17M13.12;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PHYA AND PHYB,
PHOSPHORYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
STRAIN=cv. Columbia;
PubMed=10348744; DOI=10.1126/science.284.5419.1539;
Fankhauser C., Yeh K.C., Lagarias J.C., Zhang H., Elich T.D.,
Chory J.;
"PKS1, a substrate phosphorylated by phytochrome that modulates light
signaling in Arabidopsis.";
Science 284:1539-1541(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
FUNCTION, INDUCTION, TISSUE SPECIFICITY, INTERACTION WITH PKS2, AND
DISRUPTION PHENOTYPE.
PubMed=14615593; DOI=10.1105/tpc.014563;
Lariguet P., Boccalandro H.E., Alonso J.M., Ecker J.R., Chory J.,
Casal J.J., Fankhauser C.;
"A growth regulatory loop that provides homeostasis to phytochrome a
signaling.";
Plant Cell 15:2966-2978(2003).
[6]
GENE FAMILY, AND NOMENCLATURE.
PubMed=16170454; DOI=10.1007/s00239-004-0294-2;
Lariguet P., Dunand C.;
"Plant photoreceptors: phylogenetic overview.";
J. Mol. Evol. 61:559-569(2005).
[7]
INDUCTION.
PubMed=16908503; DOI=10.1093/jxb/erl086;
Molas M.L., Kiss J.Z., Correll M.J.;
"Gene profiling of the red light signalling pathways in roots.";
J. Exp. Bot. 57:3217-3229(2006).
[8]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION,
INTERACTION WITH PHOT1 AND RPT3, AND DISRUPTION PHENOTYPE.
PubMed=16777956; DOI=10.1073/pnas.0603799103;
Lariguet P., Schepens I., Hodgson D., Pedmale U.V., Trevisan M.,
Kami C., de Carbonnel M., Alonso J.M., Ecker J.R., Liscum E.,
Fankhauser C.;
"PHYTOCHROME KINASE SUBSTRATE 1 is a phototropin 1 binding protein
required for phototropism.";
Proc. Natl. Acad. Sci. U.S.A. 103:10134-10139(2006).
[9]
FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=18024556; DOI=10.1104/pp.107.106468;
Boccalandro H.E., De Simone S.N., Bergmann-Honsberger A., Schepens I.,
Fankhauser C., Casal J.J.;
"PHYTOCHROME KINASE SUBSTRATE1 regulates root phototropism and
gravitropism.";
Plant Physiol. 146:108-115(2008).
[10]
FUNCTION, INTERACTION WITH PKS1; RPT3; PHOT1 AND PHOT2, SUBCELLULAR
LOCATION, AND DISRUPTION PHENOTYPE.
PubMed=20071603; DOI=10.1104/pp.109.150441;
de Carbonnel M., Davis P., Roelfsema M.R., Inoue S., Schepens I.,
Lariguet P., Geisler M., Shimazaki K., Hangarter R., Fankhauser C.;
"The Arabidopsis PHYTOCHROME KINASE SUBSTRATE2 protein is a
phototropin signaling element that regulates leaf flattening and leaf
positioning.";
Plant Physiol. 152:1391-1405(2010).
-!- FUNCTION: May be responsible for light-regulated cytoplasmic
sequestration of phytochromes or may be a negative regulator of
phytochrome B signaling. Component of the network that modulates
the very low-fluence response (VLFR) branch of phyA signaling.
Acts positively in PHOT1 signaling. Regulates phytochrome-mediated
photomorphogenesis and hypocotyl phototropism. Involved in the
control of leaf flattening and leaf positioning. Promotes negative
root phototropism and negatively regulates root gravitropism. May
act by controlling auxin homeostasis.
{ECO:0000269|PubMed:10348744, ECO:0000269|PubMed:14615593,
ECO:0000269|PubMed:16777956, ECO:0000269|PubMed:18024556,
ECO:0000269|PubMed:20071603}.
-!- SUBUNIT: Interacts with PKS2, RPT3, PHOT1, PHOT2 and the C-termini
of both phytochromes A (phyA) and B (phyB). Binds both spectral
forms of phytochrome, Pr and Pfr. {ECO:0000269|PubMed:10348744,
ECO:0000269|PubMed:14615593, ECO:0000269|PubMed:16777956,
ECO:0000269|PubMed:20071603}.
-!- INTERACTION:
O48963:PHOT1; NbExp=3; IntAct=EBI-626200, EBI-1553849;
P14712:PHYA; NbExp=3; IntAct=EBI-626200, EBI-624446;
P14713:PHYB; NbExp=2; IntAct=EBI-626200, EBI-300727;
Q9FMF5:RPT3; NbExp=2; IntAct=EBI-626200, EBI-1553842;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10348744,
ECO:0000269|PubMed:16777956, ECO:0000269|PubMed:20071603};
Peripheral membrane protein {ECO:0000269|PubMed:10348744,
ECO:0000269|PubMed:16777956, ECO:0000269|PubMed:20071603}.
-!- TISSUE SPECIFICITY: Expressed in young seedlings in both darkness
and light. Moderate in leaves and very low in roots and flowers.
Expressed in the elongation zone of the root and hypocotyl.
{ECO:0000269|PubMed:10348744, ECO:0000269|PubMed:14615593,
ECO:0000269|PubMed:16777956, ECO:0000269|PubMed:18024556}.
-!- DEVELOPMENTAL STAGE: Decreases with development.
{ECO:0000269|PubMed:10348744}.
-!- INDUCTION: Up-regulated by white, red, far-red and blue light.
{ECO:0000269|PubMed:14615593, ECO:0000269|PubMed:16908503}.
-!- PTM: Phosphorylated on Ser and to a lower extent on Thr by
phytochromes. Phosphorylation is stimulated twofold by red light.
{ECO:0000269|PubMed:10348744, ECO:0000269|PubMed:16777956}.
-!- DISRUPTION PHENOTYPE: Increased hypocotyl growth inhibition and
cotyledon unfolding responses in the very low fluence response
(VLFR) mode. Reduced phototropic response. Reduced hyponasty when
grown under blue light. Loss of negative root phototropism. Auxin
accumulation in protoplasts. {ECO:0000269|PubMed:14615593,
ECO:0000269|PubMed:16777956, ECO:0000269|PubMed:18024556,
ECO:0000269|PubMed:20071603}.
-!- MISCELLANEOUS: PKS1, PKS2 and/or PKS4 are essential for
phototropism but not for inhibition of gravitropism under long-
term blue light irradiation.
-!- SIMILARITY: Belongs to the PKS family. {ECO:0000305}.
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EMBL; AF149053; AAD38033.1; -; mRNA.
EMBL; AC004138; AAC32913.1; -; Genomic_DNA.
EMBL; CP002685; AEC05643.1; -; Genomic_DNA.
EMBL; AF325064; AAK17132.1; -; mRNA.
EMBL; AY052708; AAK96612.1; -; mRNA.
EMBL; AY063721; AAL36071.1; -; mRNA.
PIR; E84442; E84442.
PIR; T52304; T52304.
RefSeq; NP_565292.1; NM_126347.3.
UniGene; At.24751; -.
ProteinModelPortal; Q9SWI1; -.
BioGrid; 225; 6.
DIP; DIP-34783N; -.
IntAct; Q9SWI1; 7.
STRING; 3702.AT2G02950.1; -.
iPTMnet; Q9SWI1; -.
PaxDb; Q9SWI1; -.
EnsemblPlants; AT2G02950.1; AT2G02950.1; AT2G02950.
GeneID; 814823; -.
Gramene; AT2G02950.1; AT2G02950.1; AT2G02950.
KEGG; ath:AT2G02950; -.
Araport; AT2G02950; -.
TAIR; locus:2056695; AT2G02950.
eggNOG; ENOG410IXAU; Eukaryota.
eggNOG; ENOG4111ACR; LUCA.
HOGENOM; HOG000115571; -.
InParanoid; Q9SWI1; -.
OMA; FLMSCKS; -.
OrthoDB; EOG09360DBV; -.
PhylomeDB; Q9SWI1; -.
PRO; PR:Q9SWI1; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; Q9SWI1; differential.
Genevisible; Q9SWI1; AT.
GO; GO:0005737; C:cytoplasm; NAS:TAIR.
GO; GO:0005886; C:plasma membrane; IDA:TAIR.
GO; GO:0009638; P:phototropism; IGI:TAIR.
GO; GO:0009958; P:positive gravitropism; IMP:TAIR.
GO; GO:0010017; P:red or far-red light signaling pathway; IMP:TAIR.
GO; GO:0009585; P:red, far-red light phototransduction; IMP:TAIR.
GO; GO:0010218; P:response to far red light; IEP:TAIR.
GO; GO:0010114; P:response to red light; IEP:TAIR.
1: Evidence at protein level;
Cell membrane; Complete proteome; Membrane; Phosphoprotein;
Phytochrome signaling pathway; Reference proteome.
CHAIN 1 439 Protein PHYTOCHROME KINASE SUBSTRATE 1.
/FTId=PRO_0000058450.
COMPBIAS 31 34 Poly-Ser.
COMPBIAS 365 369 Poly-Ser.
MOD_RES 238 238 Phosphoserine.
{ECO:0000250|UniProtKB:Q9M9T4}.
MOD_RES 244 244 Phosphoserine.
{ECO:0000250|UniProtKB:Q9M9T4}.
CONFLICT 196 196 E -> D (in Ref. 1; AAD38033).
{ECO:0000305}.
SEQUENCE 439 AA; 48085 MW; 7A0A825FF7D3F3FC CRC64;
MVTLTPSSAS TPKTSFDFMK NNNSHSSLYV SSSSYLSSKE DALVTTKKLM EPSKTLNMSI
NPKQEEFGDE KKMVKKAPED PEIGVFGAEK YFNGDMDSDQ GSSVLSLTNP EVERTVVDSK
QSAKKSTGTP SVRSESSWNS QSVLLQNKLV NSCNSSFKEK KNSNGQIQKV TNNKKSFLAN
LGCKCACSDG DSVDVEEKTS VKRSADPNIS VITMRSSADM NTELIKIQKQ EELSQRKSLE
VFGSPVAIEK KSSVVQKKLP LPPWKSRTEE DDTKSEGSDS SSDLFEIEGL TGNPKPFLTR
QGSDPASPTC YAPSEVSVEW SIVTASAADF SVMSECATSP VRRNRPTQIP RIPITAKSAP
QRRKSSSSSG GNGFLMSCKS HKSVMVSGDL DRRSSMNKTQ PSYVPRFPME TTKPKSFETR
RRISNSSISH TQSSLLYSQ


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