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Protein Rev (Regulator of expression of viral proteins)

 A0A1S7G7M8_9HIV1        Unreviewed;       116 AA.
A0A1S7G7M8;
10-MAY-2017, integrated into UniProtKB/TrEMBL.
10-MAY-2017, sequence version 1.
28-MAR-2018, entry version 8.
RecName: Full=Protein Rev {ECO:0000256|HAMAP-Rule:MF_04077, ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00407638};
AltName: Full=ART/TRS {ECO:0000256|HAMAP-Rule:MF_04077};
AltName: Full=Anti-repression transactivator {ECO:0000256|HAMAP-Rule:MF_04077};
AltName: Full=Regulator of expression of viral proteins {ECO:0000256|HAMAP-Rule:MF_04077, ECO:0000256|RuleBase:RU364044};
Name=rev {ECO:0000256|HAMAP-Rule:MF_04077,
ECO:0000256|RuleBase:RU364044, ECO:0000313|EMBL:AQY59299.1};
Human immunodeficiency virus 1.
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
Lentivirus; Primate lentivirus group.
NCBI_TaxID=11676 {ECO:0000313|EMBL:AQY59299.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:AQY58442.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Donor8.B6.p9c16 {ECO:0000313|EMBL:AQY58450.1},
Donor8.B6.p9c17 {ECO:0000313|EMBL:AQY58458.1},
Donor8.B6.p9c2 {ECO:0000313|EMBL:AQY58482.1},
Donor8.B6.p9c22 {ECO:0000313|EMBL:AQY58442.1},
Donor8.B6.p9d7 {ECO:0000313|EMBL:AQY58490.1},
Donor8.B8.p5j9 {ECO:0000313|EMBL:AQY58602.1},
Donor8.B8.p8l1 {ECO:0000313|EMBL:AQY58618.1},
Donor8.B8.p8l2 {ECO:0000313|EMBL:AQY58634.1},
Donor8.B8.p8l8 {ECO:0000313|EMBL:AQY58594.1},
Donor8.B8.p9e22 {ECO:0000313|EMBL:AQY58642.1},
Donor8.B8.p9f20 {ECO:0000313|EMBL:AQY58626.1},
Donor8.B8.p9f23 {ECO:0000313|EMBL:AQY58610.1},
Donor8.C2.p8m11 {ECO:0000313|EMBL:AQY58650.1},
Donor8.C2.p8m12 {ECO:0000313|EMBL:AQY58682.1},
Donor8.C2.p8m17 {ECO:0000313|EMBL:AQY58714.1},
Donor8.C2.p8m18 {ECO:0000313|EMBL:AQY58698.1},
Donor8.C2.p8m5 {ECO:0000313|EMBL:AQY58674.1},
Donor8.C2.p8n13 {ECO:0000313|EMBL:AQY58706.1},
Donor8.C2.p8n3 {ECO:0000313|EMBL:AQY58722.1},
Donor8.C2.p8n4 {ECO:0000313|EMBL:AQY58690.1},
Donor8.C2.p8n7 {ECO:0000313|EMBL:AQY58658.1},
Donor8.C6.p6g19 {ECO:0000313|EMBL:AQY58762.1},
Donor8.C6.p6g23 {ECO:0000313|EMBL:AQY58778.1},
Donor8.C6.p6g6 {ECO:0000313|EMBL:AQY58730.1},
Donor8.C6.p6h10 {ECO:0000313|EMBL:AQY58746.1},
Donor8.C6.p6h11 {ECO:0000313|EMBL:AQY58786.1},
Donor8.C6.p6h15 {ECO:0000313|EMBL:AQY58738.1},
Donor8.C6.p6h4 {ECO:0000313|EMBL:AQY58770.1}, and
Donor8.C6.p6h5 {ECO:0000313|EMBL:AQY58754.1};
Bui J.K., Sobolewski M.D., Keele B.F., Spindler J., Musick A.,
Wiegand A., Luke B.T., Shao W., Hughes S.H., Coffin J.M.,
Kearney M.F., Mellors J.W.;
"Clonal Proviruses Comprise a Large Fraction of the Replication-
Competent HIV Reservoir.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:AQY59299.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Donor8.B9.p5k11 {ECO:0000313|EMBL:AQY59323.1},
Donor8.B9.p5k13 {ECO:0000313|EMBL:AQY59307.1},
Donor8.B9.p5k16 {ECO:0000313|EMBL:AQY59347.1},
Donor8.B9.p5k2 {ECO:0000313|EMBL:AQY59339.1},
Donor8.B9.p5k23 {ECO:0000313|EMBL:AQY59291.1},
Donor8.B9.p5k5 {ECO:0000313|EMBL:AQY59283.1},
Donor8.B9.p5k7 {ECO:0000313|EMBL:AQY59355.1},
Donor8.B9.p5k9 {ECO:0000313|EMBL:AQY59331.1},
Donor8.B9.p5l2 {ECO:0000313|EMBL:AQY59315.1},
Donor8.B9.p5l5 {ECO:0000313|EMBL:AQY59299.1},
Donor8.C4.p6c22 {ECO:0000313|EMBL:AQY59625.1},
Donor8.C4.p6d10 {ECO:0000313|EMBL:AQY59641.1},
Donor8.C4.p6d15 {ECO:0000313|EMBL:AQY59617.1},
Donor8.C4.p6d16 {ECO:0000313|EMBL:AQY59649.1}, and
Donor8.C4.p6d24 {ECO:0000313|EMBL:AQY59633.1};
Bui J.K., Sobolewski M.D., Keele B.F., Spindler J., Musick A.,
Wiegand A., Luke B.T., Shao W., Hughes S.H., Coffin J.M.,
Kearney M.F., Mellors J.W.;
"Proviruses with Identical Sequences Comprise a Large Fraction of the
Replication-Competent HIV Reservoir.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
-!- DOMAIN: The RNA-binding motif binds to the RRE, a 240 bp stem-and-
loop structure present in incompletely spliced viral pre-mRNAs.
This region also contains the NLS which mediates nuclear
localization via KPNB1 binding and, when the N-terminal sequence
is present, nucleolar targeting. These overlapping functions
prevent Rev bound to RRE from undesirable return to the nucleus.
When Rev binds the RRE, the NLS becomes masked while the NES
remains accessible. The leucine-rich NES mediates binding to human
XPO1. {ECO:0000256|HAMAP-Rule:MF_04077}.
-!- PTM: Asymmetrically arginine dimethylated at one site by host
PRMT6. Methylation impairs the RNA-binding activity and export of
viral RNA from the nucleus to the cytoplasm. {ECO:0000256|HAMAP-
Rule:MF_04077}.
-!- PTM: Phosphorylated by protein kinase CK2. Presence of, and maybe
binding to the N-terminus of the regulatory beta subunit of CK2 is
necessary for CK2-mediated Rev's phosphorylation.
{ECO:0000256|HAMAP-Rule:MF_04077}.
-!- MISCELLANEOUS: HIV-1 lineages are divided in three main groups, M
(for Major), O (for Outlier), and N (for New, or Non-M, Non-O).
The vast majority of strains found worldwide belong to the group
M. Group O seems to be endemic to and largely confined to Cameroon
and neighboring countries in West Central Africa, where these
viruses represent a small minority of HIV-1 strains. The group N
is represented by a limited number of isolates from Cameroonian
persons. The group M is further subdivided in 9 clades or subtypes
(A to D, F to H, J and K). {ECO:0000256|HAMAP-Rule:MF_04077}.
-!- SIMILARITY: Belongs to the HIV-1 REV protein family.
{ECO:0000256|HAMAP-Rule:MF_04077}.
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EMBL; KY748419; AQY58442.1; -; Genomic_RNA.
EMBL; KY748420; AQY58450.1; -; Genomic_RNA.
EMBL; KY748421; AQY58458.1; -; Genomic_RNA.
EMBL; KY748424; AQY58482.1; -; Genomic_RNA.
EMBL; KY748425; AQY58490.1; -; Genomic_RNA.
EMBL; KY748438; AQY58594.1; -; Genomic_RNA.
EMBL; KY748439; AQY58602.1; -; Genomic_RNA.
EMBL; KY748440; AQY58610.1; -; Genomic_RNA.
EMBL; KY748441; AQY58618.1; -; Genomic_RNA.
EMBL; KY748442; AQY58626.1; -; Genomic_RNA.
EMBL; KY748443; AQY58634.1; -; Genomic_RNA.
EMBL; KY748444; AQY58642.1; -; Genomic_RNA.
EMBL; KY748445; AQY58650.1; -; Genomic_RNA.
EMBL; KY748446; AQY58658.1; -; Genomic_RNA.
EMBL; KY748448; AQY58674.1; -; Genomic_RNA.
EMBL; KY748449; AQY58682.1; -; Genomic_RNA.
EMBL; KY748450; AQY58690.1; -; Genomic_RNA.
EMBL; KY748451; AQY58698.1; -; Genomic_RNA.
EMBL; KY748452; AQY58706.1; -; Genomic_RNA.
EMBL; KY748453; AQY58714.1; -; Genomic_RNA.
EMBL; KY748454; AQY58722.1; -; Genomic_RNA.
EMBL; KY748455; AQY58730.1; -; Genomic_RNA.
EMBL; KY748456; AQY58738.1; -; Genomic_RNA.
EMBL; KY748457; AQY58746.1; -; Genomic_RNA.
EMBL; KY748458; AQY58754.1; -; Genomic_RNA.
EMBL; KY748459; AQY58762.1; -; Genomic_RNA.
EMBL; KY748460; AQY58770.1; -; Genomic_RNA.
EMBL; KY748461; AQY58778.1; -; Genomic_RNA.
EMBL; KY748462; AQY58786.1; -; Genomic_RNA.
EMBL; KY748576; AQY59283.1; -; Genomic_RNA.
EMBL; KY748577; AQY59291.1; -; Genomic_RNA.
EMBL; KY748578; AQY59299.1; -; Genomic_RNA.
EMBL; KY748579; AQY59307.1; -; Genomic_RNA.
EMBL; KY748580; AQY59315.1; -; Genomic_RNA.
EMBL; KY748581; AQY59323.1; -; Genomic_RNA.
EMBL; KY748582; AQY59331.1; -; Genomic_RNA.
EMBL; KY748583; AQY59339.1; -; Genomic_RNA.
EMBL; KY748584; AQY59347.1; -; Genomic_RNA.
EMBL; KY748585; AQY59355.1; -; Genomic_RNA.
EMBL; KY748644; AQY59617.1; -; Genomic_RNA.
EMBL; KY748645; AQY59625.1; -; Genomic_RNA.
EMBL; KY748646; AQY59633.1; -; Genomic_RNA.
EMBL; KY748647; AQY59641.1; -; Genomic_RNA.
EMBL; KY748648; AQY59649.1; -; Genomic_RNA.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-UniRule.
GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-UniRule.
GO; GO:0003700; F:DNA binding transcription factor activity; IEA:UniProtKB-UniRule.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-UniRule.
GO; GO:0016032; P:viral process; IEA:UniProtKB-UniRule.
HAMAP; MF_04077; REV_HIV1; 1.
InterPro; IPR000625; REV_protein.
Pfam; PF00424; REV; 1.
3: Inferred from homology;
Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04077,
ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00486079};
Host nucleus {ECO:0000256|HAMAP-Rule:MF_04077,
ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00486044};
Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04077};
Methylation {ECO:0000256|HAMAP-Rule:MF_04077};
mRNA transport {ECO:0000256|HAMAP-Rule:MF_04077,
ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00486068};
Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_04077};
RNA-binding {ECO:0000256|HAMAP-Rule:MF_04077,
ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00486057};
Transport {ECO:0000256|HAMAP-Rule:MF_04077,
ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00486068}.
REGION 18 26 Homomultimerization. {ECO:0000256|HAMAP-
Rule:MF_04077}.
MOTIF 34 50 Nuclear localization signal and RNA-
binding (RRE). {ECO:0000256|HAMAP-
Rule:MF_04077}.
MOTIF 73 84 Nuclear export signal and binding to
XPO1. {ECO:0000256|HAMAP-Rule:MF_04077}.
MOD_RES 5 5 Phosphoserine; by host CK2.
{ECO:0000256|HAMAP-Rule:MF_04077}.
MOD_RES 8 8 Phosphoserine; by host CK2.
{ECO:0000256|HAMAP-Rule:MF_04077}.
MOD_RES 92 92 Phosphoserine; by host.
{ECO:0000256|HAMAP-Rule:MF_04077}.
MOD_RES 99 99 Phosphoserine; by host.
{ECO:0000256|HAMAP-Rule:MF_04077}.
SEQUENCE 116 AA; 13263 MW; 4E9CCA41E1E4F705 CRC64;
MAGRSGDSDE ELLKTVRLVK FLYQSNPPPS SEGTRQARRN RRRRWRERQR QIRWISERIL
STYLDRSTEP LPLHLPPLER LTLDCSEDCG TSGTEGVGSP QILVESPTVL ESGTKE


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