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Protein S100-A14 (S100 calcium-binding protein A14) (S114)

 S10AE_HUMAN             Reviewed;         104 AA.
16-APR-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
16-JAN-2019, entry version 148.
RecName: Full=Protein S100-A14;
AltName: Full=S100 calcium-binding protein A14;
Name=S100A14; Synonyms=S100A15;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
PubMed=11944983; DOI=10.1006/geno.2002.6744;
Pietas A., Schluns K., Marenholz I., Schafer B.W., Heizmann C.W.,
Petersen I.;
"Molecular cloning and characterization of the human S100A14 gene
encoding a novel member of the S100 family.";
Genomics 79:513-522(2002).
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
PubMed=21559403; DOI=10.1371/journal.pone.0019375;
Jin Q., Chen H., Luo A., Ding F., Liu Z.;
"S100A14 stimulates cell proliferation and induces cell apoptosis at
different concentrations via receptor for advanced glycation end
products (RAGE).";
PLoS ONE 6:E19375-E19375(2011).
PubMed=22451655; DOI=10.1074/jbc.M111.326975;
Chen H., Yuan Y., Zhang C., Luo A., Ding F., Ma J., Yang S., Tian Y.,
Tong T., Zhan Q., Liu Z.;
"Involvement of S100A14 protein in cell invasion by affecting
expression and function of matrix metalloproteinase (MMP)-2 via p53-
dependent transcriptional regulation.";
J. Biol. Chem. 287:17109-17119(2012).
PubMed=22032898; DOI=10.1016/j.oraloncology.2011.10.001;
Sapkota D., Costea D.E., Blo M., Bruland O., Lorens J.B.,
Vasstrand E.N., Ibrahim S.O.;
"S100A14 inhibits proliferation of oral carcinoma derived cells
through G1-arrest.";
Oral Oncol. 48:219-225(2012).
PubMed=23197251; DOI=10.1007/s00775-012-0963-3;
Bertini I., Borsi V., Cerofolini L., Das Gupta S., Fragai M.,
Luchinat C.;
"Solution structure and dynamics of human S100A14.";
J. Biol. Inorg. Chem. 18:183-194(2013).
-!- FUNCTION: Modulates P53/TP53 protein levels, and thereby plays a
role in the regulation of cell survival and apoptosis. Depending
on the context, it can promote cell proliferation or apoptosis.
Plays a role in the regulation of cell migration by modulating the
levels of MMP2, a matrix protease that is under transcriptional
control of P53/TP53. Does not bind calcium.
{ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898,
-!- SUBUNIT: Homodimer. Interacts with AGER.
{ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:23197251}.
P43360:MAGEA6; NbExp=3; IntAct=EBI-751842, EBI-1045155;
Q96FQ6:S100A16; NbExp=8; IntAct=EBI-751842, EBI-751850;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11944983}.
-!- TISSUE SPECIFICITY: Expressed at highest levels in colon and at
moderate levels in thymus, kidney, liver, small intestine, and
lung. Low expression in heart and no expression is seen in brain,
skeletal muscle, spleen, placenta and peripheral blood leukocytes.
-!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
-!- CAUTION: Part of the residues that are essential for calcium
binding are not conserved, resulting in loss of calcium binding at
physiological calcium concentrations.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AY007220; AAG01893.1; -; mRNA.
EMBL; AF426828; AAM19206.1; -; Genomic_DNA.
EMBL; BX470102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC005019; AAH05019.1; -; mRNA.
CCDS; CCDS1046.1; -.
RefSeq; NP_065723.1; NM_020672.2.
RefSeq; XP_005245419.1; XM_005245362.1.
RefSeq; XP_016857364.1; XM_017001875.1.
UniGene; Hs.288998; -.
PDB; 2M0R; NMR; -; A/B=1-104.
PDBsum; 2M0R; -.
ProteinModelPortal; Q9HCY8; -.
SMR; Q9HCY8; -.
BioGrid; 121504; 22.
IntAct; Q9HCY8; 13.
MINT; Q9HCY8; -.
STRING; 9606.ENSP00000340463; -.
iPTMnet; Q9HCY8; -.
PhosphoSitePlus; Q9HCY8; -.
SwissPalm; Q9HCY8; -.
BioMuta; S100A14; -.
DMDM; 20178118; -.
EPD; Q9HCY8; -.
jPOST; Q9HCY8; -.
MaxQB; Q9HCY8; -.
PaxDb; Q9HCY8; -.
PeptideAtlas; Q9HCY8; -.
ProteomicsDB; 81807; -.
TopDownProteomics; Q9HCY8; -.
DNASU; 57402; -.
Ensembl; ENST00000344616; ENSP00000340463; ENSG00000189334.
Ensembl; ENST00000368701; ENSP00000357690; ENSG00000189334.
Ensembl; ENST00000368702; ENSP00000357691; ENSG00000189334.
Ensembl; ENST00000476873; ENSP00000420296; ENSG00000189334.
GeneID; 57402; -.
KEGG; hsa:57402; -.
UCSC; uc001fce.4; human.
CTD; 57402; -.
DisGeNET; 57402; -.
EuPathDB; HostDB:ENSG00000189334.8; -.
GeneCards; S100A14; -.
HGNC; HGNC:18901; S100A14.
HPA; HPA027613; -.
MIM; 607986; gene.
neXtProt; NX_Q9HCY8; -.
OpenTargets; ENSG00000189334; -.
PharmGKB; PA134905502; -.
eggNOG; ENOG410IZKB; Eukaryota.
eggNOG; ENOG4111EF5; LUCA.
GeneTree; ENSGT00940000161706; -.
HOGENOM; HOG000246968; -.
HOVERGEN; HBG001479; -.
InParanoid; Q9HCY8; -.
OrthoDB; 1506806at2759; -.
PhylomeDB; Q9HCY8; -.
TreeFam; TF332727; -.
ChiTaRS; S100A14; human.
GenomeRNAi; 57402; -.
PRO; PR:Q9HCY8; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000189334; Expressed in 153 organ(s), highest expression level in lower esophagus mucosa.
CleanEx; HS_S100A14; -.
Genevisible; Q9HCY8; HS.
GO; GO:0030054; C:cell junction; IDA:HPA.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0016604; C:nuclear body; IDA:HPA.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:HPA.
GO; GO:0005509; F:calcium ion binding; NAS:UniProtKB.
GO; GO:0042379; F:chemokine receptor binding; IMP:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0055074; P:calcium ion homeostasis; NAS:UniProtKB.
GO; GO:0042742; P:defense response to bacterium; IEP:UniProtKB.
GO; GO:0071624; P:positive regulation of granulocyte chemotaxis; IDA:UniProtKB.
GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:UniProtKB.
GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IDA:UniProtKB.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR013787; S100_Ca-bd_sub.
InterPro; IPR028493; S100A14.
PANTHER; PTHR11639:SF4; PTHR11639:SF4; 1.
Pfam; PF01023; S_100; 1.
SMART; SM01394; S_100; 1.
SUPFAM; SSF47473; SSF47473; 1.
1: Evidence at protein level;
3D-structure; Apoptosis; Complete proteome; Cytoplasm;
Reference proteome.
CHAIN 1 104 Protein S100-A14.
DOMAIN 27 61 EF-hand.
STRAND 8 11 {ECO:0000244|PDB:2M0R}.
HELIX 19 32 {ECO:0000244|PDB:2M0R}.
TURN 34 39 {ECO:0000244|PDB:2M0R}.
HELIX 43 53 {ECO:0000244|PDB:2M0R}.
TURN 55 57 {ECO:0000244|PDB:2M0R}.
HELIX 60 62 {ECO:0000244|PDB:2M0R}.
HELIX 65 71 {ECO:0000244|PDB:2M0R}.
HELIX 81 94 {ECO:0000244|PDB:2M0R}.
STRAND 98 100 {ECO:0000244|PDB:2M0R}.
SEQUENCE 104 AA; 11662 MW; 97EF31A46B388E79 CRC64;

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