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Protein SPH1 (SPA2 homolog 1)

 SPH1_YEAST              Reviewed;         661 AA.
Q06160; D6VYV7; O13526; Q2VQW2;
18-APR-2006, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 2.
25-OCT-2017, entry version 112.
RecName: Full=Protein SPH1;
AltName: Full=SPA2 homolog 1;
Name=SPH1; OrderedLocusNames=YLR313C;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=ATCC 96099 / S288c / SEY6210;
PubMed=9214378; DOI=10.1083/jcb.138.1.17;
Arkowitz R.A., Lowe N.;
"A small conserved domain in the yeast Spa2p is necessary and
sufficient for its polarized localization.";
J. Cell Biol. 138:17-36(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169871;
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[3]
SEQUENCE REVISION TO 527.
Hong E.L., Cherry J.M.;
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
[4]
GENOME REANNOTATION, AND SEQUENCE REVISION TO 527.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-77.
STRAIN=ATCC 208353 / W303-1A;
PubMed=16012843; DOI=10.1007/s00294-005-0001-x;
Zhang Z., Dietrich F.S.;
"Identification and characterization of upstream open reading frames
(uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces
cerevisiae.";
Curr. Genet. 48:77-87(2005).
[6]
FUNCTION, SUBCELLULAR LOCATION, AND IDENTIFICATION OF FRAMESHIFT.
STRAIN=S288c / Y604;
PubMed=9443897;
Roemer T., Vallier L., Sheu Y.-J., Snyder M.;
"The Spa2-related protein, Sph1p, is important for polarized growth in
yeast.";
J. Cell Sci. 111:479-494(1998).
[7]
FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, AND CONJUGATION TO
HUB1.
PubMed=11923536; DOI=10.1126/science.1069989;
Dittmar G.A.G., Wilkinson C.R.M., Jedrzejewski P.T., Finley D.;
"Role of a ubiquitin-like modification in polarized morphogenesis.";
Science 295:2442-2446(2002).
[8]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[9]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[10]
SUBCELLULAR LOCATION.
PubMed=15282802; DOI=10.1002/yea.1133;
Sundin B.A., Chiu C.-H., Riffle M., Davis T.N., Muller E.G.D.;
"Localization of proteins that are coordinately expressed with Cln2
during the cell cycle.";
Yeast 21:793-800(2004).
-!- FUNCTION: Polarity-determining protein which forms a conjugate
with the ubiquitin-like modifier HUB1. Involved in bud site
selection and cellular morphogenesis during conjugation. Required
for pseudohyphal growth. {ECO:0000269|PubMed:11923536,
ECO:0000269|PubMed:9214378, ECO:0000269|PubMed:9443897}.
-!- SUBUNIT: Conjugated with HUB1. HUB1 has not the classical C-
terminal Gly residue, so it is still unknown how conjugation may
occur.
-!- SUBCELLULAR LOCATION: Bud tip. Bud neck. Cytoplasm, cytoskeleton.
Note=Sites of polarized growth as bud tip, bud neck and mating
projection. Hub1 is necessary for the proper location to mating
projections after pheromone alpha treatment.
-!- MISCELLANEOUS: Present with 672 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SEQUENCE CAUTION:
Sequence=AAB63284.1; Type=Erroneous termination; Positions=649; Note=Translated as Gln.; Evidence={ECO:0000305};
Sequence=DAA09623.2; Type=Frameshift; Positions=527; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF008236; AAB63284.1; ALT_SEQ; Genomic_DNA.
EMBL; U20618; AAB64516.2; -; Genomic_DNA.
EMBL; AY899256; AAX83941.1; -; mRNA.
EMBL; BK006945; DAA09623.2; ALT_FRAME; Genomic_DNA.
PIR; S53392; S53392.
RefSeq; NP_013417.3; NM_001182202.2.
ProteinModelPortal; Q06160; -.
SMR; Q06160; -.
BioGrid; 31578; 79.
DIP; DIP-2337N; -.
IntAct; Q06160; 3.
MINT; MINT-1678722; -.
STRING; 4932.YLR313C; -.
PRIDE; Q06160; -.
GeneID; 851023; -.
KEGG; sce:YLR313C; -.
EuPathDB; FungiDB:YLR313C; -.
SGD; S000004305; SPH1.
InParanoid; Q06160; -.
OrthoDB; EOG092C3TGJ; -.
BioCyc; YEAST:G3O-32399-MONOMER; -.
PRO; PR:Q06160; -.
Proteomes; UP000002311; Chromosome XII.
GO; GO:0005826; C:actomyosin contractile ring; IBA:GO_Central.
GO; GO:1902716; C:cell cortex of growing cell tip; IBA:GO_Central.
GO; GO:0005935; C:cellular bud neck; IDA:SGD.
GO; GO:0005934; C:cellular bud tip; IDA:SGD.
GO; GO:0000131; C:incipient cellular bud site; IDA:SGD.
GO; GO:0005937; C:mating projection; IDA:SGD.
GO; GO:0043332; C:mating projection tip; IBA:GO_Central.
GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO; GO:0005078; F:MAP-kinase scaffold activity; IBA:GO_Central.
GO; GO:0007121; P:bipolar cellular bud site selection; IMP:SGD.
GO; GO:0036267; P:invasive filamentous growth; IGI:SGD.
GO; GO:0031382; P:mating projection assembly; IGI:SGD.
GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
InterPro; IPR013724; GIT_SHD.
Pfam; PF08518; GIT_SHD; 1.
SMART; SM00555; GIT; 2.
1: Evidence at protein level;
Actin-binding; Cell shape; Complete proteome; Conjugation; Cytoplasm;
Cytoskeleton; Reference proteome.
CHAIN 1 661 Protein SPH1.
/FTId=PRO_0000233011.
CONFLICT 141 141 T -> S (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 281 281 D -> H (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 316 316 S -> L (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 377 378 AS -> TF (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 400 400 G -> S (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 431 431 A -> T (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 541 541 F -> Y (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 576 576 S -> C (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 580 580 D -> N (in Ref. 1; AAB63284).
{ECO:0000305}.
CONFLICT 651 651 L -> F (in Ref. 1; AAB63284).
{ECO:0000305}.
SEQUENCE 661 AA; 74007 MW; B5D00F81D1CF7D9D CRC64;
MISSELTNDQ IIDLISDYKN FKRIIEASVP EDDRRRNQNR QNRNKDLTKL SNVQFWQLTT
DVNDELMKRL TDSGADASLN DLDLKRGKAQ SKLSRLKDAK FHKLILDIFT EIERRNLHHL
DMGTHNNGLD EGDLNFYLND TLFESFKIND DFMSVNGIIS IEVFRELKTQ FTLYFQNTLH
RIDPVDTTTT RLPILLETII KIAKLIGDLL PVLSSVSLQS SLENEIVYLK SALSHAITST
RYFLTYGDLI PRIVAQSSIS EVIFAFCNIA QIVKIKSTSR DDISRNEGEL SDIEAGMKPL
KIIEKVKNEK NGKDISSLGD SGSTAVSFPS SGKPITKKSD MPVVVASPSI SIIEKSESSI
RESGKVRNNT SGETNLASVS PLKNTKNSSR ITSEPSPREG LPLKVVSNSR SPSPQGNTLP
LIGKFRQDYQ ASPPKKVITK PVAETAKPYA NIPPAADVLY SPTVTKMRKF REKVQKFAPN
SGLGLRISTS EENLNNSDVN STTHNANINN LVEFVESKSM VVLPMAQGIL NDVQASKSKL
FKSARSVSRL CQNSIEIIPI LESVIDMTTK AMVQKSFKLD LGEHCKEIIE RLTDCSQKLS
ELCTYGCDST KLGKKRFYQK LADILMEVTK RTRELVECVK MANRQTLSQD LSSFFNYRSV
Q


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