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Protein Tat

 M4TCQ3_9HIV1            Unreviewed;       101 AA.
M4TCQ3;
29-MAY-2013, integrated into UniProtKB/TrEMBL.
29-MAY-2013, sequence version 1.
18-JUL-2018, entry version 16.
RecName: Full=Protein Tat {ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00396010};
Name=tat {ECO:0000313|EMBL:AGH71660.1};
Human immunodeficiency virus 1.
Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
NCBI_TaxID=11676 {ECO:0000313|EMBL:AGH71660.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:AGH71660.1}
NUCLEOTIDE SEQUENCE.
STRAIN=CH0228.w96.e15 {ECO:0000313|EMBL:AGH71614.1},
CH0228.w96.e19 {ECO:0000313|EMBL:AGH71645.1},
CH0228.w96.e20 {ECO:0000313|EMBL:AGH71660.1},
CH0228.w96.e24 {ECO:0000313|EMBL:AGH71689.1},
CH0228.w96.e27 {ECO:0000313|EMBL:AGH71713.1},
CH0228.w96.e31 {ECO:0000313|EMBL:AGH71753.1},
CH0228.w96.e35 {ECO:0000313|EMBL:AGH71783.1}, and
CH0228.w96.e42 {ECO:0000313|EMBL:AGH71827.1};
Song H., Cai F., Chen S., Hoper J., Jiang C., Gao F.;
"Analysis of recombinant viral genomes in individuals infected with
multiple transmitted/founder HIV-1 strains.";
Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:AWD45242.1}
NUCLEOTIDE SEQUENCE.
STRAIN=703010228.3.d0707.ipe025.e15_ambcode
{ECO:0000313|EMBL:AWD45242.1},
703010228.3.d0707.ipe025.e19_ambcode {ECO:0000313|EMBL:AWD45273.1},
703010228.3.d0707.ipe025.e20_ambcode {ECO:0000313|EMBL:AWD45295.1},
703010228.3.d0707.ipe025.e24 {ECO:0000313|EMBL:AWD45324.1},
703010228.3.d0707.ipe025.e27 {ECO:0000313|EMBL:AWD45348.1},
703010228.3.d0707.ipe025.e31 {ECO:0000313|EMBL:AWD45388.1},
703010228.3.d0707.ipe025.e35 {ECO:0000313|EMBL:AWD45418.1}, and
703010228.3.d0707.ipe025.e42_ambcode {ECO:0000313|EMBL:AWD45462.1};
PubMed=29765018;
Song H., Giorgi E.E., Ganusov V.V., Cai F., Athreya G., Yoon H.,
Carja O., Hora B., Hraber P., Jiang C., Wang S., Li H.,
Salazar-Gonzalez J.F., Salazar M.G., Goonetilleke N., Keele B.,
Montefiori D.C., Cohen M.S., Shaw G.M., Hahn B.H., McMichael A.J.,
Haynes B.F., Korber B., Battacharya T., Gao F.;
"Tracking HIV-1 recombination to resolve its contribution to HIV-1
evolution in natural infection.";
Nat. Commun. 9:1928-1928(2018).
-!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
{ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581732}.
-!- SIMILARITY: Belongs to the lentiviruses Tat family.
{ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581731}.
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EMBL; KC149357; AGH71614.1; -; Genomic_DNA.
EMBL; KC149361; AGH71645.1; -; Genomic_DNA.
EMBL; KC149363; AGH71660.1; -; Genomic_DNA.
EMBL; KC149367; AGH71689.1; -; Genomic_DNA.
EMBL; KC149370; AGH71713.1; -; Genomic_DNA.
EMBL; KC149375; AGH71753.1; -; Genomic_DNA.
EMBL; KC149379; AGH71783.1; -; Genomic_DNA.
EMBL; KC149385; AGH71827.1; -; Genomic_DNA.
EMBL; MF500197; AWD45242.1; -; Genomic_RNA.
EMBL; MF500201; AWD45273.1; -; Genomic_RNA.
EMBL; MF500204; AWD45295.1; -; Genomic_RNA.
EMBL; MF500208; AWD45324.1; -; Genomic_RNA.
EMBL; MF500211; AWD45348.1; -; Genomic_RNA.
EMBL; MF500216; AWD45388.1; -; Genomic_RNA.
EMBL; MF500220; AWD45418.1; -; Genomic_RNA.
EMBL; MF500226; AWD45462.1; -; Genomic_RNA.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
GO; GO:0042805; F:actinin binding; IEA:UniProtKB-UniRule.
GO; GO:0030332; F:cyclin binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0019904; F:protein domain specific binding; IEA:UniProtKB-UniRule.
GO; GO:0001070; F:RNA binding transcription regulator activity; IEA:UniProtKB-UniRule.
GO; GO:1990970; F:trans-activation response element binding; IEA:UniProtKB-UniRule.
GO; GO:0039525; P:modulation by virus of host chromatin organization; IEA:UniProtKB-UniRule.
GO; GO:0039586; P:modulation by virus of host PP1 activity; IEA:UniProtKB-UniRule.
GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:UniProtKB-UniRule.
GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
GO; GO:0050434; P:positive regulation of viral transcription; IEA:UniProtKB-UniRule.
GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
Gene3D; 4.10.20.10; -; 1.
HAMAP; MF_04079; HIV_TAT; 1.
InterPro; IPR001831; IV_Tat.
InterPro; IPR036963; Tat_dom_sf.
Pfam; PF00539; Tat; 1.
PRINTS; PR00055; HIVTATDOMAIN.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00111091};
Host nucleus {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00473431};
Host-virus interaction {ECO:0000256|SAAS:SAAS00111166};
RNA-binding {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00111359};
Transcription {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00111074};
Transcription regulation {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00111074}.
SEQUENCE 101 AA; 11478 MW; 4A662FF587A47328 CRC64;
MEPVDPNLEP WNHPGSRPKT ACNNCYCKKC SYHCLVCFQT KGLGISYGRK KRRQRRSTPP
SSEDHQKPVS KQPLPQARGD QTGSEESKKK VESKTETDPF D


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