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Protein Tat (Transactivating regulatory protein)

 A0A1L7E787_9HIV1        Unreviewed;       101 AA.
15-MAR-2017, integrated into UniProtKB/TrEMBL.
15-MAR-2017, sequence version 1.
12-SEP-2018, entry version 12.
RecName: Full=Protein Tat {ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00396010};
Name=tat {ECO:0000313|EMBL:APU08448.1};
Human immunodeficiency virus 1.
Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
NCBI_TaxID=11676 {ECO:0000313|EMBL:APU08448.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:APU08448.1}
STRAIN=CH742.PL.091008.UT.8 {ECO:0000313|EMBL:APU05547.1},
CH742.SE.091008.UT.5 {ECO:0000313|EMBL:APU05637.1},
CH742_SGA.1D6 {ECO:0000313|EMBL:APU08243.1},
CH742_SGA.2E6 {ECO:0000313|EMBL:APU08384.1},
CH742_SGA.2F4 {ECO:0000313|EMBL:APU08392.1},
CH831.PL.111408.A2.1 {ECO:0000313|EMBL:APU05700.1},
CH831.PL.111408.A2.2 {ECO:0000313|EMBL:APU05709.1},
CH831.PL.111408.A2.3 {ECO:0000313|EMBL:APU05718.1},
CH831.PL.111408.A2.4 {ECO:0000313|EMBL:APU05727.1},
CH831.PL.111408.BE.1 {ECO:0000313|EMBL:APU05736.1},
CH831.PL.111408.BE.2 {ECO:0000313|EMBL:APU05745.1},
CH831.PL.111408.BE.3 {ECO:0000313|EMBL:APU05754.1},
CH831.PL.111408.BE.4 {ECO:0000313|EMBL:APU05763.1},
CH831.PL.111408.UT.1 {ECO:0000313|EMBL:APU05772.1},
CH831.PL.111408.UT.2 {ECO:0000313|EMBL:APU05781.1},
CH831.PL.111408.UT.3 {ECO:0000313|EMBL:APU05790.1},
CH831.PL.111408.UT.4 {ECO:0000313|EMBL:APU05799.1},
CH831.PL.111408.UT.5 {ECO:0000313|EMBL:APU05808.1},
CH831.PL.111408.UT.6 {ECO:0000313|EMBL:APU05817.1},
CH831.PL.111408.UT.7 {ECO:0000313|EMBL:APU05826.1},
CH831.PL.111408.UT.8 {ECO:0000313|EMBL:APU05835.1},
CH831_SGA.10S50 {ECO:0000313|EMBL:APU08424.1},
CH831_SGA.11S51 {ECO:0000313|EMBL:APU08432.1},
CH831_SGA.12S52 {ECO:0000313|EMBL:APU08440.1},
CH831_SGA.14S54 {ECO:0000313|EMBL:APU08448.1},
CH831_SGA.15S55 {ECO:0000313|EMBL:APU08456.1},
CH831_SGA.17S57 {ECO:0000313|EMBL:APU08464.1},
CH831_SGA.19S59 {ECO:0000313|EMBL:APU08472.1},
CH831_SGA.1S41 {ECO:0000313|EMBL:APU08480.1},
CH831_SGA.20S60 {ECO:0000313|EMBL:APU08487.1},
CH831_SGA.22S62 {ECO:0000313|EMBL:APU08495.1},
CH831_SGA.23S63 {ECO:0000313|EMBL:APU08501.1},
CH831_SGA.25S65 {ECO:0000313|EMBL:APU08509.1},
CH831_SGA.26S66 {ECO:0000313|EMBL:APU08517.1},
CH831_SGA.28S68 {ECO:0000313|EMBL:APU08525.1},
CH831_SGA.29S69 {ECO:0000313|EMBL:APU08532.1},
CH831_SGA.34S74 {ECO:0000313|EMBL:APU08548.1},
CH831_SGA.35S75 {ECO:0000313|EMBL:APU08556.1},
CH831_SGA.36S76 {ECO:0000313|EMBL:APU08564.1},
CH831_SGA.37S77 {ECO:0000313|EMBL:APU08572.1},
CH831_SGA.38S78 {ECO:0000313|EMBL:APU08579.1},
CH831_SGA.3S43 {ECO:0000313|EMBL:APU08594.1},
CH831_SGA.40S80 {ECO:0000313|EMBL:APU08602.1},
CH831_SGA.41S81 {ECO:0000313|EMBL:APU08610.1},
CH831_SGA.42S82 {ECO:0000313|EMBL:APU08618.1},
CH831_SGA.43S83 {ECO:0000313|EMBL:APU08626.1},
CH831_SGA.44S84 {ECO:0000313|EMBL:APU08634.1},
CH831_SGA.45S85 {ECO:0000313|EMBL:APU08642.1},
CH831_SGA.46S86 {ECO:0000313|EMBL:APU08650.1},
CH831_SGA.47S87 {ECO:0000313|EMBL:APU08658.1},
CH831_SGA.48S88 {ECO:0000313|EMBL:APU08666.1},
CH831_SGA.4S44 {ECO:0000313|EMBL:APU08673.1},
CH831_SGA.52S92 {ECO:0000313|EMBL:APU08681.1},
CH831_SGA.53S93 {ECO:0000313|EMBL:APU08689.1},
CH831_SGA.56S96 {ECO:0000313|EMBL:APU08697.1},
CH831_SGA.7S47 {ECO:0000313|EMBL:APU08705.1},
CH831_SGA.8S48 {ECO:0000313|EMBL:APU08713.1}, and
CH831_SGA.9S49 {ECO:0000313|EMBL:APU08721.1};
Iyer S.S., Bibollet-Ruche F., Sherrill-Mix S., Learn G.H.,
Plenderleith L., Smith A.G., Barbian H.J., Russell R.M., Gondim M.V.,
Bahari C.Y., Shaw C.M., Li Y., Decker T., Haynes B.F., Shaw G.M.,
Sharp P.M., Borrow P., Hahn B.H.;
"Resistance to type 1 interferons is a major determinant of HIV-1
transmission fitness.";
Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2017).
-!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
{ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581732}.
-!- SIMILARITY: Belongs to the lentiviruses Tat family.
{ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581731}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; KY112477; APU05547.1; -; Genomic_RNA.
EMBL; KY112487; APU05637.1; -; Genomic_RNA.
EMBL; KY112522; APU05700.1; -; Genomic_RNA.
EMBL; KY112523; APU05709.1; -; Genomic_RNA.
EMBL; KY112524; APU05718.1; -; Genomic_RNA.
EMBL; KY112525; APU05727.1; -; Genomic_RNA.
EMBL; KY112526; APU05736.1; -; Genomic_RNA.
EMBL; KY112527; APU05745.1; -; Genomic_RNA.
EMBL; KY112528; APU05754.1; -; Genomic_RNA.
EMBL; KY112529; APU05763.1; -; Genomic_RNA.
EMBL; KY112530; APU05772.1; -; Genomic_RNA.
EMBL; KY112531; APU05781.1; -; Genomic_RNA.
EMBL; KY112532; APU05790.1; -; Genomic_RNA.
EMBL; KY112533; APU05799.1; -; Genomic_RNA.
EMBL; KY112534; APU05808.1; -; Genomic_RNA.
EMBL; KY112535; APU05817.1; -; Genomic_RNA.
EMBL; KY112536; APU05826.1; -; Genomic_RNA.
EMBL; KY112537; APU05835.1; -; Genomic_RNA.
EMBL; KY112499; APU08243.1; -; Genomic_RNA.
EMBL; KY112517; APU08384.1; -; Genomic_RNA.
EMBL; KY112518; APU08392.1; -; Genomic_RNA.
EMBL; KY112538; APU08424.1; -; Genomic_RNA.
EMBL; KY112539; APU08432.1; -; Genomic_RNA.
EMBL; KY112540; APU08440.1; -; Genomic_RNA.
EMBL; KY112541; APU08448.1; -; Genomic_RNA.
EMBL; KY112542; APU08456.1; -; Genomic_RNA.
EMBL; KY112543; APU08464.1; -; Genomic_RNA.
EMBL; KY112544; APU08472.1; -; Genomic_RNA.
EMBL; KY112545; APU08480.1; -; Genomic_RNA.
EMBL; KY112546; APU08487.1; -; Genomic_RNA.
EMBL; KY112547; APU08495.1; -; Genomic_RNA.
EMBL; KY112548; APU08501.1; -; Genomic_RNA.
EMBL; KY112549; APU08509.1; -; Genomic_RNA.
EMBL; KY112550; APU08517.1; -; Genomic_RNA.
EMBL; KY112551; APU08525.1; -; Genomic_RNA.
EMBL; KY112552; APU08532.1; -; Genomic_RNA.
EMBL; KY112554; APU08548.1; -; Genomic_RNA.
EMBL; KY112555; APU08556.1; -; Genomic_RNA.
EMBL; KY112556; APU08564.1; -; Genomic_RNA.
EMBL; KY112557; APU08572.1; -; Genomic_RNA.
EMBL; KY112558; APU08579.1; -; Genomic_RNA.
EMBL; KY112560; APU08594.1; -; Genomic_RNA.
EMBL; KY112561; APU08602.1; -; Genomic_RNA.
EMBL; KY112562; APU08610.1; -; Genomic_RNA.
EMBL; KY112563; APU08618.1; -; Genomic_RNA.
EMBL; KY112564; APU08626.1; -; Genomic_RNA.
EMBL; KY112565; APU08634.1; -; Genomic_RNA.
EMBL; KY112566; APU08642.1; -; Genomic_RNA.
EMBL; KY112567; APU08650.1; -; Genomic_RNA.
EMBL; KY112568; APU08658.1; -; Genomic_RNA.
EMBL; KY112569; APU08666.1; -; Genomic_RNA.
EMBL; KY112570; APU08673.1; -; Genomic_RNA.
EMBL; KY112571; APU08681.1; -; Genomic_RNA.
EMBL; KY112572; APU08689.1; -; Genomic_RNA.
EMBL; KY112573; APU08697.1; -; Genomic_RNA.
EMBL; KY112574; APU08705.1; -; Genomic_RNA.
EMBL; KY112575; APU08713.1; -; Genomic_RNA.
EMBL; KY112576; APU08721.1; -; Genomic_RNA.
GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0001070; F:RNA-binding transcription regulator activity; IEA:InterPro.
GO; GO:0050434; P:positive regulation of viral transcription; IEA:InterPro.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
Gene3D;; -; 1.
HAMAP; MF_04079; HIV_TAT; 1.
InterPro; IPR001831; IV_Tat.
InterPro; IPR036963; Tat_dom_sf.
Pfam; PF00539; Tat; 1.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU003311,
Host nucleus {ECO:0000256|RuleBase:RU003311,
Host-virus interaction {ECO:0000256|SAAS:SAAS00111166};
RNA-binding {ECO:0000256|RuleBase:RU003311,
Transcription {ECO:0000256|RuleBase:RU003311,
Transcription regulation {ECO:0000256|RuleBase:RU003311,
SEQUENCE 101 AA; 11683 MW; 1E4BFD3DE15BDC7E CRC64;

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