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Protein Tat (Transactivating regulatory protein)

 I7EY66_9HIV1            Unreviewed;       102 AA.
I7EY66;
03-OCT-2012, integrated into UniProtKB/TrEMBL.
03-OCT-2012, sequence version 1.
18-JUL-2018, entry version 24.
RecName: Full=Protein Tat {ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00396010};
Name=tat {ECO:0000313|EMBL:AFP25797.1};
Human immunodeficiency virus 1.
Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
NCBI_TaxID=11676 {ECO:0000313|EMBL:AFP25797.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:AFP25797.1}
NUCLEOTIDE SEQUENCE.
STRAIN=703010256.e1 {ECO:0000313|EMBL:AFP25733.1},
703010256.e14 {ECO:0000313|EMBL:AFP25769.1},
703010256.e19 {ECO:0000313|EMBL:AFP25797.1},
703010256.e20 {ECO:0000313|EMBL:AFP25811.1},
703010256.e21 {ECO:0000313|EMBL:AFP25818.1},
703010256.e6 {ECO:0000313|EMBL:AFP25873.1}, and
703010256.e9 {ECO:0000313|EMBL:AFP25894.1};
PubMed=22693444; DOI=10.1371/journal.ppat.1002686;
Parrish N.F., Wilen C.B., Banks L.B., Iyer S.S., Pfaff J.M.,
Salazar-Gonzalez J.F., Salazar M.G., Decker J.M., Parrish E.H.,
Berg A., Hopper J., Hora B., Kumar A., Mahlokozera T., Yuan S.,
Coleman C., Vermeulen M., Ding H., Ochsenbauer C., Tilton J.C.,
Permar S.R., Kappes J.C., Betts M.R., Busch M.P., Gao F.,
Montefiori D., Haynes B.F., Shaw G.M., Hahn B.H., Doms R.W.;
"Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5
receptors with equal efficiency and are not inhibited by blocking the
integrin alpha4beta7.";
PLoS Pathog. 8:E1002686-E1002686(2012).
[2] {ECO:0000313|EMBL:AGF30953.1, ECO:0000313|Proteomes:UP000150399}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CH256.w96 {ECO:0000313|EMBL:AGF30953.1};
Hora B., Berg A., Cai F., Kumar A., Chen S., Gao F.;
"Infectious HIV-1 molecular clones generated for clonally expanded
viruses in chronically infected individuals.";
Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:AGG96222.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C.703010256.w60.426dps.e10 {ECO:0000313|EMBL:AGG96222.1},
C.703010256.w60.426dps.e11 {ECO:0000313|EMBL:AGG96229.1},
C.703010256.w60.426dps.e6 {ECO:0000313|EMBL:AGG96289.1},
C.703010256.w96.684dps.e1 {ECO:0000313|EMBL:AGG96317.1},
C.703010256.w96.684dps.e14 {ECO:0000313|EMBL:AGG96351.1},
C.703010256.w96.684dps.e19 {ECO:0000313|EMBL:AGG96379.1},
C.703010256.w96.684dps.e20 {ECO:0000313|EMBL:AGG96393.1},
C.703010256.w96.684dps.e21 {ECO:0000313|EMBL:AGG96400.1},
C.703010256.w96.684dps.e6 {ECO:0000313|EMBL:AGG96455.1}, and
C.703010256.w96.684dps.e9 {ECO:0000313|EMBL:AGG96475.1};
PubMed=23221345; DOI=10.1172/JCI65330;
CHAVI Core B;
Liu M.K., Hawkins N., Ritchie A.J., Ganusov V.V., Whale V.,
Brackenridge S., Li H., Pavlicek J.W., Cai F., Rose-Abrahams M.,
Treurnicht F., Hraber P., Riou C., Gray C., Ferrari G., Tanner R.,
Ping L.H., Anderson J.A., Swanstrom R., B C.C., Cohen M., Karim S.S.,
Haynes B., Borrow P., Perelson A.S., Shaw G.M., Hahn B.H.,
Williamson C., Korber B.T., Gao F., Self S., McMichael A.,
Goonetilleke N.;
"Vertical T cell immunodominance and epitope entropy determine HIV-1
escape.";
J. Clin. Invest. 123:380-393(2013).
-!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
{ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581732}.
-!- SIMILARITY: Belongs to the lentiviruses Tat family.
{ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581731}.
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EMBL; JQ779074; AFP25733.1; -; Genomic_RNA.
EMBL; JQ779079; AFP25769.1; -; Genomic_RNA.
EMBL; JQ779083; AFP25797.1; -; Genomic_RNA.
EMBL; JQ779085; AFP25811.1; -; Genomic_RNA.
EMBL; JQ779086; AFP25818.1; -; Genomic_RNA.
EMBL; JQ779094; AFP25873.1; -; Genomic_RNA.
EMBL; JQ779097; AFP25894.1; -; Genomic_RNA.
EMBL; KC156214; AGF30953.1; -; Genomic_RNA.
EMBL; JX972800; AGG96222.1; -; Genomic_RNA.
EMBL; JX972801; AGG96229.1; -; Genomic_RNA.
EMBL; JX972810; AGG96289.1; -; Genomic_RNA.
EMBL; JX972814; AGG96317.1; -; Genomic_RNA.
EMBL; JX972819; AGG96351.1; -; Genomic_RNA.
EMBL; JX972823; AGG96379.1; -; Genomic_RNA.
EMBL; JX972825; AGG96393.1; -; Genomic_RNA.
EMBL; JX972826; AGG96400.1; -; Genomic_RNA.
EMBL; JX972834; AGG96455.1; -; Genomic_RNA.
EMBL; JX972837; AGG96475.1; -; Genomic_RNA.
Proteomes; UP000150399; Genome.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
GO; GO:0042805; F:actinin binding; IEA:UniProtKB-UniRule.
GO; GO:0030332; F:cyclin binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0019904; F:protein domain specific binding; IEA:UniProtKB-UniRule.
GO; GO:0001070; F:RNA binding transcription regulator activity; IEA:UniProtKB-UniRule.
GO; GO:1990970; F:trans-activation response element binding; IEA:UniProtKB-UniRule.
GO; GO:0039525; P:modulation by virus of host chromatin organization; IEA:UniProtKB-UniRule.
GO; GO:0039586; P:modulation by virus of host PP1 activity; IEA:UniProtKB-UniRule.
GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:UniProtKB-UniRule.
GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
GO; GO:0050434; P:positive regulation of viral transcription; IEA:UniProtKB-UniRule.
GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
Gene3D; 4.10.20.10; -; 1.
HAMAP; MF_04079; HIV_TAT; 1.
InterPro; IPR001831; IV_Tat.
InterPro; IPR036963; Tat_dom_sf.
Pfam; PF00539; Tat; 1.
PRINTS; PR00055; HIVTATDOMAIN.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00111091};
Complete proteome {ECO:0000313|Proteomes:UP000150399};
Host nucleus {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00473431};
Host-virus interaction {ECO:0000256|SAAS:SAAS00111166};
RNA-binding {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00111359};
Transcription {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00111074};
Transcription regulation {ECO:0000256|RuleBase:RU003311,
ECO:0000256|SAAS:SAAS00111074}.
SEQUENCE 102 AA; 11645 MW; C602D61B777F2259 CRC64;
MEPIDPKLEP WNHPGSQPKT ACNKCYCKKC SYHCLVCFQT KGLGISYGRK KRRQRRSAPP
SSKDHQNPLP KQPLSQTRGN PTGSEESKKK VESQTETDPF DW


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