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Protein Tat (Transactivating regulatory protein)

 M4NTM1_9HIV1            Unreviewed;       101 AA.
29-MAY-2013, integrated into UniProtKB/TrEMBL.
29-MAY-2013, sequence version 1.
18-JUL-2018, entry version 17.
RecName: Full=Protein Tat {ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00396010};
Name=tat {ECO:0000313|EMBL:AGG94573.1};
Human immunodeficiency virus 1.
Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
NCBI_TaxID=11676 {ECO:0000313|EMBL:AGG94573.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:AGG94573.1}
STRAIN=C.703010131.w12.91dps.e13 {ECO:0000313|EMBL:AGG94209.1},
C.703010131.w12.91dps.e14 {ECO:0000313|EMBL:AGG94217.1},
C.703010131.w12.91dps.e8 {ECO:0000313|EMBL:AGG94240.1},
C.703010131.w24.175dps.e1 {ECO:0000313|EMBL:AGG94256.1},
C.703010131.w24.175dps.e10 {ECO:0000313|EMBL:AGG94264.1},
C.703010131.w24.175dps.e11 {ECO:0000313|EMBL:AGG94272.1},
C.703010131.w24.175dps.e2 {ECO:0000313|EMBL:AGG94287.1},
C.703010131.w24.175dps.e3 {ECO:0000313|EMBL:AGG94294.1},
C.703010131.w24.175dps.e4 {ECO:0000313|EMBL:AGG94302.1},
C.703010131.w24.175dps.e5 {ECO:0000313|EMBL:AGG94310.1},
C.703010131.w24.175dps.e6 {ECO:0000313|EMBL:AGG94318.1},
C.703010131.w24.175dps.e7 {ECO:0000313|EMBL:AGG94326.1},
C.703010131.w24.175dps.e8 {ECO:0000313|EMBL:AGG94334.1},
C.703010131.w24.175dps.e9 {ECO:0000313|EMBL:AGG94342.1},
C.703010131.w36.273dps.e1 {ECO:0000313|EMBL:AGG94350.1},
C.703010131.w36.273dps.e2 {ECO:0000313|EMBL:AGG94365.1},
C.703010131.w36.273dps.e3 {ECO:0000313|EMBL:AGG94373.1},
C.703010131.w36.273dps.e5 {ECO:0000313|EMBL:AGG94380.1},
C.703010131.w36.273dps.e6 {ECO:0000313|EMBL:AGG94388.1},
C.703010131.w36.273dps.e7 {ECO:0000313|EMBL:AGG94395.1},
C.703010131.w36.273dps.e9 {ECO:0000313|EMBL:AGG94409.1},
C.703010131.w48.333dps.e1 {ECO:0000313|EMBL:AGG94417.1},
C.703010131.w48.333dps.e10 {ECO:0000313|EMBL:AGG94425.1},
C.703010131.w48.333dps.e3 {ECO:0000313|EMBL:AGG94441.1},
C.703010131.w48.333dps.e5 {ECO:0000313|EMBL:AGG94449.1},
C.703010131.w48.333dps.e7 {ECO:0000313|EMBL:AGG94465.1},
C.703010131.w48.333dps.e8 {ECO:0000313|EMBL:AGG94473.1},
C.703010131.w96.670dps.e10 {ECO:0000313|EMBL:AGG94497.1},
C.703010131.w96.670dps.e11 {ECO:0000313|EMBL:AGG94504.1},
C.703010131.w96.670dps.e12 {ECO:0000313|EMBL:AGG94511.1},
C.703010131.w96.670dps.e14 {ECO:0000313|EMBL:AGG94518.1},
C.703010131.w96.670dps.e16 {ECO:0000313|EMBL:AGG94534.1},
C.703010131.w96.670dps.e17 {ECO:0000313|EMBL:AGG94542.1},
C.703010131.w96.670dps.e19 {ECO:0000313|EMBL:AGG94558.1},
C.703010131.w96.670dps.e20 {ECO:0000313|EMBL:AGG94566.1},
C.703010131.w96.670dps.e23 {ECO:0000313|EMBL:AGG94573.1},
C.703010131.w96.670dps.e24 {ECO:0000313|EMBL:AGG94580.1},
C.703010131.w96.670dps.e25 {ECO:0000313|EMBL:AGG94587.1},
C.703010131.w96.670dps.e3 {ECO:0000313|EMBL:AGG94617.1},
C.703010131.w96.670dps.e31 {ECO:0000313|EMBL:AGG94632.1},
C.703010131.w96.670dps.e33 {ECO:0000313|EMBL:AGG94647.1},
C.703010131.w96.670dps.e35 {ECO:0000313|EMBL:AGG94663.1},
C.703010131.w96.670dps.e36 {ECO:0000313|EMBL:AGG94671.1},
C.703010131.w96.670dps.e8 {ECO:0000313|EMBL:AGG94687.1}, and
C.703010131.w96.670dps.e9 {ECO:0000313|EMBL:AGG94695.1};
PubMed=23221345; DOI=10.1172/JCI65330;
Liu M.K., Hawkins N., Ritchie A.J., Ganusov V.V., Whale V.,
Brackenridge S., Li H., Pavlicek J.W., Cai F., Rose-Abrahams M.,
Treurnicht F., Hraber P., Riou C., Gray C., Ferrari G., Tanner R.,
Ping L.H., Anderson J.A., Swanstrom R., B C.C., Cohen M., Karim S.S.,
Haynes B., Borrow P., Perelson A.S., Shaw G.M., Hahn B.H.,
Williamson C., Korber B.T., Gao F., Self S., McMichael A.,
Goonetilleke N.;
"Vertical T cell immunodominance and epitope entropy determine HIV-1
J. Clin. Invest. 123:380-393(2013).
-!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
{ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581732}.
-!- SIMILARITY: Belongs to the lentiviruses Tat family.
{ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581731}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; JX972534; AGG94209.1; -; Genomic_RNA.
EMBL; JX972535; AGG94217.1; -; Genomic_RNA.
EMBL; JX972538; AGG94240.1; -; Genomic_RNA.
EMBL; JX972540; AGG94256.1; -; Genomic_RNA.
EMBL; JX972541; AGG94264.1; -; Genomic_RNA.
EMBL; JX972542; AGG94272.1; -; Genomic_RNA.
EMBL; JX972544; AGG94287.1; -; Genomic_RNA.
EMBL; JX972545; AGG94294.1; -; Genomic_RNA.
EMBL; JX972546; AGG94302.1; -; Genomic_RNA.
EMBL; JX972547; AGG94310.1; -; Genomic_RNA.
EMBL; JX972548; AGG94318.1; -; Genomic_RNA.
EMBL; JX972549; AGG94326.1; -; Genomic_RNA.
EMBL; JX972550; AGG94334.1; -; Genomic_RNA.
EMBL; JX972551; AGG94342.1; -; Genomic_RNA.
EMBL; JX972552; AGG94350.1; -; Genomic_RNA.
EMBL; JX972554; AGG94365.1; -; Genomic_RNA.
EMBL; JX972555; AGG94373.1; -; Genomic_RNA.
EMBL; JX972556; AGG94380.1; -; Genomic_RNA.
EMBL; JX972557; AGG94388.1; -; Genomic_RNA.
EMBL; JX972558; AGG94395.1; -; Genomic_RNA.
EMBL; JX972560; AGG94409.1; -; Genomic_RNA.
EMBL; JX972561; AGG94417.1; -; Genomic_RNA.
EMBL; JX972562; AGG94425.1; -; Genomic_RNA.
EMBL; JX972564; AGG94441.1; -; Genomic_RNA.
EMBL; JX972565; AGG94449.1; -; Genomic_RNA.
EMBL; JX972567; AGG94465.1; -; Genomic_RNA.
EMBL; JX972568; AGG94473.1; -; Genomic_RNA.
EMBL; JX972571; AGG94497.1; -; Genomic_RNA.
EMBL; JX972572; AGG94504.1; -; Genomic_RNA.
EMBL; JX972573; AGG94511.1; -; Genomic_RNA.
EMBL; JX972574; AGG94518.1; -; Genomic_RNA.
EMBL; JX972576; AGG94534.1; -; Genomic_RNA.
EMBL; JX972577; AGG94542.1; -; Genomic_RNA.
EMBL; JX972579; AGG94558.1; -; Genomic_RNA.
EMBL; JX972580; AGG94566.1; -; Genomic_RNA.
EMBL; JX972581; AGG94573.1; -; Genomic_RNA.
EMBL; JX972582; AGG94580.1; -; Genomic_RNA.
EMBL; JX972583; AGG94587.1; -; Genomic_RNA.
EMBL; JX972587; AGG94617.1; -; Genomic_RNA.
EMBL; JX972589; AGG94632.1; -; Genomic_RNA.
EMBL; JX972591; AGG94647.1; -; Genomic_RNA.
EMBL; JX972593; AGG94663.1; -; Genomic_RNA.
EMBL; JX972594; AGG94671.1; -; Genomic_RNA.
EMBL; JX972596; AGG94687.1; -; Genomic_RNA.
EMBL; JX972597; AGG94695.1; -; Genomic_RNA.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
GO; GO:0042805; F:actinin binding; IEA:UniProtKB-UniRule.
GO; GO:0030332; F:cyclin binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0019904; F:protein domain specific binding; IEA:UniProtKB-UniRule.
GO; GO:0001070; F:RNA binding transcription regulator activity; IEA:UniProtKB-UniRule.
GO; GO:1990970; F:trans-activation response element binding; IEA:UniProtKB-UniRule.
GO; GO:0039525; P:modulation by virus of host chromatin organization; IEA:UniProtKB-UniRule.
GO; GO:0039586; P:modulation by virus of host PP1 activity; IEA:UniProtKB-UniRule.
GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:UniProtKB-UniRule.
GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
GO; GO:0050434; P:positive regulation of viral transcription; IEA:UniProtKB-UniRule.
GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
Gene3D;; -; 1.
HAMAP; MF_04079; HIV_TAT; 1.
InterPro; IPR001831; IV_Tat.
InterPro; IPR036963; Tat_dom_sf.
Pfam; PF00539; Tat; 1.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU003311,
Host nucleus {ECO:0000256|RuleBase:RU003311,
Host-virus interaction {ECO:0000256|SAAS:SAAS00111166};
RNA-binding {ECO:0000256|RuleBase:RU003311,
Transcription {ECO:0000256|RuleBase:RU003311,
Transcription regulation {ECO:0000256|RuleBase:RU003311,
SEQUENCE 101 AA; 11356 MW; CB080790E54FA3EB CRC64;

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