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Protein Tube

 TUBE_DROVI              Reviewed;         514 AA.
Q08171;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
12-SEP-2018, entry version 83.
RecName: Full=Protein Tube;
Name=tub; Synonyms=tube;
Drosophila virilis (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila.
NCBI_TaxID=7244;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8253071;
Letsou A., Alexander S., Wasserman S.A.;
"Domain mapping of tube, a protein essential for dorsoventral
patterning of the Drosophila embryo.";
EMBO J. 12:3449-3458(1993).
-!- FUNCTION: Required for the determination of embryonic dorsoventral
polarity. Is involved in transduction of information regulating
nuclear import of dorsal protein.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- TISSUE SPECIFICITY: Maternal and zygotic gene product.
-!- DEVELOPMENTAL STAGE: Expressed maximally early in embryogenesis,
and in late larval development.
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EMBL; L20449; AAA28995.1; -; Genomic_DNA.
ProteinModelPortal; Q08171; -.
SMR; Q08171; -.
FlyBase; FBgn0013148; Dvir\tub.
eggNOG; ENOG410J7N2; Eukaryota.
eggNOG; ENOG410Z3IC; LUCA.
OrthoDB; EOG091G0Q4E; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR000488; Death_domain.
InterPro; IPR029397; Tube_Death.
Pfam; PF14786; Death_2; 1.
SMART; SM00005; DEATH; 1.
SUPFAM; SSF47986; SSF47986; 1.
2: Evidence at transcript level;
Cytoplasm; Developmental protein; Repeat; Transducer.
CHAIN 1 514 Protein Tube.
/FTId=PRO_0000065695.
SEQUENCE 514 AA; 54541 MW; D8DE8A0F8019E699 CRC64;
MEMAKANGWA VVCTSTNTNT VPIYSKYTRC TELRRVDDND IYKLATILDV NGCWRKLMSI
IPKRLDAQAC SAPGALNYQE IAAKVGLKYT AQQISLIDGT AERLTPGQSI SQVMIDEWKT
SGKLNERPTV GVLLQLLVHA EIYSAADFVA LHFLNEPKPE RPTDGPAAHI SLDLCSEDLS
EDMDVEDGAS YQPNTSALNA AVEQARGTGM NLDYFDKHMV RRDKSVPQQL ENGTSSTVPV
PPPRAARSSR LLKATASNVA PTTASNAPSA SNTANVPNLS ILNASSKKLA ASSEQTLQPQ
NIPNLSILNG SSEAVLMATT STTLDAGKSD NASNGRSSAS TSTATIPNVP LITLLIENSS
CEISDASDAT QITSKSTATK TVPDMSTASY NNLPAISALN LNIASGAGEL DGNGAKARGD
NADNNSSGTN SLSNDDDEQK EDDDDDDDDD VVDVDDEEAD VSLPNLSNSD HNDSSLTTVT
CTSGENSFEF TNDSSSASND DYTNNIPNLS ELQQ


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