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Protein Wnt

 W5Q1D2_SHEEP            Unreviewed;       353 AA.
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
16-JAN-2019, entry version 42.
RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
Name=WNT5A {ECO:0000313|Ensembl:ENSOARP00000016518};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016518, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000016518, ECO:0000313|Proteomes:UP000002356}
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016518};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
Wang J., Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000016518}
Submitted (FEB-2014) to UniProtKB.
-!- FUNCTION: Ligand for members of the frizzled family of seven
transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix {ECO:0000256|RuleBase:RU003500,
-!- SIMILARITY: Belongs to the Wnt family.
{ECO:0000256|RuleBase:RU003500, ECO:0000256|SAAS:SAAS00681828}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AMGL01045428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01045429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01045430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_004018679.1; XM_004018630.3.
UniGene; Oar.4783; -.
SMR; W5Q1D2; -.
Ensembl; ENSOART00000016754; ENSOARP00000016518; ENSOARG00000015400.
GeneID; 101109745; -.
KEGG; oas:101109745; -.
CTD; 7474; -.
GeneTree; ENSGT00940000158894; -.
KO; K00444; -.
OrthoDB; 695671at2759; -.
Proteomes; UP000002356; Chromosome 19.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:1902379; F:chemoattractant activity involved in axon guidance; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0005109; F:frizzled binding; IEA:Ensembl.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0005115; F:receptor tyrosine kinase-like orphan receptor binding; IEA:Ensembl.
GO; GO:0044212; F:transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0007257; P:activation of JUN kinase activity; IEA:Ensembl.
GO; GO:0032148; P:activation of protein kinase B activity; IEA:Ensembl.
GO; GO:0008595; P:anterior/posterior axis specification, embryo; IEA:Ensembl.
GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0034613; P:cellular protein localization; IEA:Ensembl.
GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0060067; P:cervix development; IEA:Ensembl.
GO; GO:0036517; P:chemoattraction of serotonergic neuron axon; IEA:Ensembl.
GO; GO:0036518; P:chemorepulsion of dopaminergic neuron axon; IEA:Ensembl.
GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl.
GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
GO; GO:0060029; P:convergent extension involved in organogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
GO; GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; IEA:Ensembl.
GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Ensembl.
GO; GO:0001736; P:establishment of planar polarity; IEA:Ensembl.
GO; GO:0060324; P:face development; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
GO; GO:0007442; P:hindgut morphogenesis; IEA:Ensembl.
GO; GO:0048850; P:hypophysis morphogenesis; IEA:Ensembl.
GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
GO; GO:0060599; P:lateral sprouting involved in mammary gland duct morphogenesis; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0060744; P:mammary gland branching involved in thelarche; IEA:Ensembl.
GO; GO:0097325; P:melanocyte proliferation; IEA:Ensembl.
GO; GO:0060638; P:mesenchymal-epithelial cell signaling; IEA:Ensembl.
GO; GO:0060809; P:mesodermal to mesenchymal transition involved in gastrulation; IEA:Ensembl.
GO; GO:0007494; P:midgut development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:1904934; P:negative regulation of cell proliferation in midbrain; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0048022; P:negative regulation of melanin biosynthetic process; IEA:Ensembl.
GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:0060686; P:negative regulation of prostatic bud formation; IEA:Ensembl.
GO; GO:0051964; P:negative regulation of synapse assembly; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0038031; P:non-canonical Wnt signaling pathway via JNK cascade; IEA:Ensembl.
GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
GO; GO:0021891; P:olfactory bulb interneuron development; IEA:Ensembl.
GO; GO:0048341; P:paraxial mesoderm formation; IEA:Ensembl.
GO; GO:0003402; P:planar cell polarity pathway involved in axis elongation; IEA:Ensembl.
GO; GO:1904938; P:planar cell polarity pathway involved in axon guidance; IEA:Ensembl.
GO; GO:0061350; P:planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0061349; P:planar cell polarity pathway involved in cardiac right atrium morphogenesis; IEA:Ensembl.
GO; GO:0060775; P:planar cell polarity pathway involved in gastrula mediolateral intercalation; IEA:Ensembl.
GO; GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Ensembl.
GO; GO:0061347; P:planar cell polarity pathway involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061354; P:planar cell polarity pathway involved in pericardium morphogenesis; IEA:Ensembl.
GO; GO:0061348; P:planar cell polarity pathway involved in ventricular septum morphogenesis; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
GO; GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:0002741; P:positive regulation of cytokine secretion involved in immune response; IEA:Ensembl.
GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:2000484; P:positive regulation of interleukin-8 secretion; IEA:Ensembl.
GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
GO; GO:0045836; P:positive regulation of meiotic nuclear division; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0150012; P:positive regulation of neuron projection arborization; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0045778; P:positive regulation of ossification; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
GO; GO:1900020; P:positive regulation of protein kinase C activity; IEA:Ensembl.
GO; GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
GO; GO:0070245; P:positive regulation of thymocyte apoptotic process; IEA:Ensembl.
GO; GO:0051885; P:positive regulation of timing of anagen; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1904469; P:positive regulation of tumor necrosis factor secretion; IEA:Ensembl.
GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
GO; GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
GO; GO:1903827; P:regulation of cellular protein localization; IEA:Ensembl.
GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0099175; P:regulation of postsynapse organization; IEA:Ensembl.
GO; GO:0099566; P:regulation of postsynaptic cytosolic calcium ion concentration; IEA:Ensembl.
GO; GO:0062009; P:secondary palate development; IEA:Ensembl.
GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
GO; GO:0003323; P:type B pancreatic cell development; IEA:Ensembl.
GO; GO:0060157; P:urinary bladder development; IEA:Ensembl.
GO; GO:0060065; P:uterus development; IEA:Ensembl.
GO; GO:0060068; P:vagina development; IEA:Ensembl.
GO; GO:1904953; P:Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; IEA:Ensembl.
GO; GO:0007223; P:Wnt signaling pathway, calcium modulating pathway; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
InterPro; IPR005817; Wnt.
InterPro; IPR026538; Wnt5a.
InterPro; IPR018161; Wnt_CS.
PANTHER; PTHR12027; PTHR12027; 1.
PANTHER; PTHR12027:SF33; PTHR12027:SF33; 1.
Pfam; PF00110; wnt; 1.
SMART; SM00097; WNT1; 1.
PROSITE; PS00246; WNT1; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002356};
Developmental protein {ECO:0000256|RuleBase:RU003500,
Disulfide bond {ECO:0000256|SAAS:SAAS00083920};
Extracellular matrix {ECO:0000256|SAAS:SAAS00083931};
Reference proteome {ECO:0000313|Proteomes:UP000002356};
Secreted {ECO:0000256|SAAS:SAAS00083931};
Wnt signaling pathway {ECO:0000256|RuleBase:RU003500,
SEQUENCE 353 AA; 38798 MW; 9F4017B68BF7007D CRC64;

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