GENTAUR Molecular Products.

 W5Q1D2_SHEEP            Unreviewed;       353 AA.
 W5Q1D2;
 16-APR-2014, integrated into UniProtKB/TrEMBL.
 16-APR-2014, sequence version 1.
 07-NOV-2018, entry version 40.
 RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
 Name=WNT5A {ECO:0000313|Ensembl:ENSOARP00000016518};
 Ovis aries (Sheep).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
 Pecora; Bovidae; Caprinae; Ovis.
 NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016518, ECO:0000313|Proteomes:UP000002356};
 [1] {ECO:0000313|Ensembl:ENSOARP00000016518, ECO:0000313|Proteomes:UP000002356}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016518};
 PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
 Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
 Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
 Wang J., Wang W., Xun X.;
 "The sheep genome reference sequence: a work in progress.";
 Anim. Genet. 41:449-453(2010).
 [2] {ECO:0000313|Ensembl:ENSOARP00000016518}
 IDENTIFICATION.
 Ensembl;
 Submitted (FEB-2014) to UniProtKB.
 -!- FUNCTION: Ligand for members of the frizzled family of seven
     transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
 -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
     matrix {ECO:0000256|RuleBase:RU003500,
     ECO:0000256|SAAS:SAAS00681827}.
 -!- SIMILARITY: Belongs to the Wnt family.
     {ECO:0000256|RuleBase:RU003500, ECO:0000256|SAAS:SAAS00681828}.
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 EMBL; AMGL01045428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; AMGL01045429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; AMGL01045430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 RefSeq; XP_004018679.1; XM_004018630.3.
 UniGene; Oar.4783; -.
 SMR; W5Q1D2; -.
 Ensembl; ENSOART00000016754; ENSOARP00000016518; ENSOARG00000015400.
 GeneID; 101109745; -.
 KEGG; oas:101109745; -.
 CTD; 7474; -.
 GeneTree; ENSGT00760000118943; -.
 KO; K00444; -.
 OMA; IVERCHC; -.
 OrthoDB; EOG091G0OFF; -.
 Proteomes; UP000002356; Chromosome 19.
 GO; GO:0009986; C:cell surface; IEA:Ensembl.
 GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
 GO; GO:0005615; C:extracellular space; IEA:Ensembl.
 GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
 GO; GO:0005622; C:intracellular; IEA:GOC.
 GO; GO:0098794; C:postsynapse; IEA:GOC.
 GO; GO:1902379; F:chemoattractant activity involved in axon guidance; IEA:Ensembl.
 GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
 GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
 GO; GO:0005109; F:frizzled binding; IEA:Ensembl.
 GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
 GO; GO:0005115; F:receptor tyrosine kinase-like orphan receptor binding; IEA:Ensembl.
 GO; GO:0044212; F:transcription regulatory region DNA binding; IEA:Ensembl.
 GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
 GO; GO:0007257; P:activation of JUN kinase activity; IEA:Ensembl.
 GO; GO:0032148; P:activation of protein kinase B activity; IEA:Ensembl.
 GO; GO:0008595; P:anterior/posterior axis specification, embryo; IEA:Ensembl.
 GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
 GO; GO:0034613; P:cellular protein localization; IEA:Ensembl.
 GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
 GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl.
 GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
 GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
 GO; GO:0060067; P:cervix development; IEA:Ensembl.
 GO; GO:0036517; P:chemoattraction of serotonergic neuron axon; IEA:Ensembl.
 GO; GO:0036518; P:chemorepulsion of dopaminergic neuron axon; IEA:Ensembl.
 GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl.
 GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
 GO; GO:0060029; P:convergent extension involved in organogenesis; IEA:Ensembl.
 GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
 GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
 GO; GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; IEA:Ensembl.
 GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Ensembl.
 GO; GO:0001736; P:establishment of planar polarity; IEA:Ensembl.
 GO; GO:0060324; P:face development; IEA:Ensembl.
 GO; GO:0001947; P:heart looping; IEA:Ensembl.
 GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
 GO; GO:0007442; P:hindgut morphogenesis; IEA:Ensembl.
 GO; GO:0048850; P:hypophysis morphogenesis; IEA:Ensembl.
 GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
 GO; GO:0060599; P:lateral sprouting involved in mammary gland duct morphogenesis; IEA:Ensembl.
 GO; GO:0030324; P:lung development; IEA:Ensembl.
 GO; GO:0008584; P:male gonad development; IEA:Ensembl.
 GO; GO:0060744; P:mammary gland branching involved in thelarche; IEA:Ensembl.
 GO; GO:0097325; P:melanocyte proliferation; IEA:Ensembl.
 GO; GO:0060638; P:mesenchymal-epithelial cell signaling; IEA:Ensembl.
 GO; GO:0060809; P:mesodermal to mesenchymal transition involved in gastrulation; IEA:Ensembl.
 GO; GO:0007494; P:midgut development; IEA:Ensembl.
 GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
 GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IEA:Ensembl.
 GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
 GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
 GO; GO:1904934; P:negative regulation of cell proliferation in midbrain; IEA:Ensembl.
 GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
 GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
 GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
 GO; GO:0048022; P:negative regulation of melanin biosynthetic process; IEA:Ensembl.
 GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; IEA:Ensembl.
 GO; GO:0060686; P:negative regulation of prostatic bud formation; IEA:Ensembl.
 GO; GO:0051964; P:negative regulation of synapse assembly; IEA:Ensembl.
 GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
 GO; GO:0038031; P:non-canonical Wnt signaling pathway via JNK cascade; IEA:Ensembl.
 GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
 GO; GO:0021891; P:olfactory bulb interneuron development; IEA:Ensembl.
 GO; GO:0048341; P:paraxial mesoderm formation; IEA:Ensembl.
 GO; GO:0003402; P:planar cell polarity pathway involved in axis elongation; IEA:Ensembl.
 GO; GO:1904938; P:planar cell polarity pathway involved in axon guidance; IEA:Ensembl.
 GO; GO:0061350; P:planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; IEA:Ensembl.
 GO; GO:0061349; P:planar cell polarity pathway involved in cardiac right atrium morphogenesis; IEA:Ensembl.
 GO; GO:0060775; P:planar cell polarity pathway involved in gastrula mediolateral intercalation; IEA:Ensembl.
 GO; GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Ensembl.
 GO; GO:0061347; P:planar cell polarity pathway involved in outflow tract morphogenesis; IEA:Ensembl.
 GO; GO:0061354; P:planar cell polarity pathway involved in pericardium morphogenesis; IEA:Ensembl.
 GO; GO:0061348; P:planar cell polarity pathway involved in ventricular septum morphogenesis; IEA:Ensembl.
 GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
 GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
 GO; GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IEA:Ensembl.
 GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
 GO; GO:0002741; P:positive regulation of cytokine secretion involved in immune response; IEA:Ensembl.
 GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
 GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
 GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
 GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
 GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
 GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
 GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
 GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
 GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
 GO; GO:2000484; P:positive regulation of interleukin-8 secretion; IEA:Ensembl.
 GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl.
 GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
 GO; GO:0045836; P:positive regulation of meiotic nuclear division; IEA:Ensembl.
 GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
 GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
 GO; GO:0150012; P:positive regulation of neuron projection arborization; IEA:Ensembl.
 GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
 GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; IEA:Ensembl.
 GO; GO:0045778; P:positive regulation of ossification; IEA:Ensembl.
 GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
 GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
 GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
 GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
 GO; GO:1900020; P:positive regulation of protein kinase C activity; IEA:Ensembl.
 GO; GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
 GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
 GO; GO:0070245; P:positive regulation of thymocyte apoptotic process; IEA:Ensembl.
 GO; GO:0051885; P:positive regulation of timing of anagen; IEA:Ensembl.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
 GO; GO:1904469; P:positive regulation of tumor necrosis factor secretion; IEA:Ensembl.
 GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
 GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
 GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
 GO; GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
 GO; GO:1903827; P:regulation of cellular protein localization; IEA:Ensembl.
 GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
 GO; GO:0099175; P:regulation of postsynapse organization; IEA:Ensembl.
 GO; GO:0099566; P:regulation of postsynaptic cytosolic calcium ion concentration; IEA:Ensembl.
 GO; GO:0062009; P:secondary palate development; IEA:Ensembl.
 GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
 GO; GO:0003323; P:type B pancreatic cell development; IEA:Ensembl.
 GO; GO:0060157; P:urinary bladder development; IEA:Ensembl.
 GO; GO:0060065; P:uterus development; IEA:Ensembl.
 GO; GO:0060068; P:vagina development; IEA:Ensembl.
 GO; GO:1904953; P:Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; IEA:Ensembl.
 GO; GO:0007223; P:Wnt signaling pathway, calcium modulating pathway; IEA:Ensembl.
 GO; GO:0042060; P:wound healing; IEA:Ensembl.
 InterPro; IPR005817; Wnt.
 InterPro; IPR026538; Wnt5a.
 InterPro; IPR018161; Wnt_CS.
 PANTHER; PTHR12027; PTHR12027; 1.
 PANTHER; PTHR12027:SF33; PTHR12027:SF33; 1.
 Pfam; PF00110; wnt; 1.
 PRINTS; PR01349; WNTPROTEIN.
 SMART; SM00097; WNT1; 1.
 PROSITE; PS00246; WNT1; 1.
 3: Inferred from homology;
 Complete proteome {ECO:0000313|Proteomes:UP000002356};
 Developmental protein {ECO:0000256|RuleBase:RU003500,
 ECO:0000256|SAAS:SAAS00083909};
 Disulfide bond {ECO:0000256|SAAS:SAAS00083920};
 Extracellular matrix {ECO:0000256|SAAS:SAAS00083931};
 Reference proteome {ECO:0000313|Proteomes:UP000002356};
 Secreted {ECO:0000256|SAAS:SAAS00083931};
 Wnt signaling pathway {ECO:0000256|RuleBase:RU003500,
 ECO:0000256|SAAS:SAAS00083917}.
 SEQUENCE   353 AA;  38798 MW;  9F4017B68BF7007D CRC64;
 MKKSIGILSP GVAWGTAARA MSSKFFLMAL AIFLSFAQVV IEANSWWSLG MNNPVQMSEV
 YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN
 TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG
 GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YSLADVACKC
 HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV
 YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCGALPP ACRPAPLPGP TYL

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