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Protein Wnt-10a

 WN10A_HUMAN             Reviewed;         417 AA.
Q9GZT5; Q53S44; Q96TA7; Q9H7S8;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
20-JUN-2018, entry version 151.
RecName: Full=Protein Wnt-10a;
Flags: Precursor;
Name=WNT10A;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y.,
Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A.,
Culbert A.A., Reith A.D., Barnes M.R.;
"Molecular cloning and characterization of six novel human WNT
genes.";
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Rump A., Hayes C., Brown S.D.M., Rosenthal A.;
"Genomic sequence of the Wnt6 gene and the Wnt10a gene from human
2q35.";
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11350055; DOI=10.1006/bbrc.2001.4855;
Kirikoshi H., Sekihara H., Katoh M.;
"WNT10A and WNT6, clustered in human chromosome 2q35 region with head-
to-tail manner, are strongly co-expressed in SW480 cells.";
Biochem. Biophys. Res. Commun. 283:798-805(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta, and Thymus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
INVOLVEMENT IN OODD, AND FUNCTION.
PubMed=17847007; DOI=10.1086/520064;
Adaimy L., Chouery E., Megarbane H., Mroueh S., Delague V.,
Nicolas E., Belguith H., de Mazancourt P., Megarbane A.;
"Mutation in WNT10A is associated with an autosomal recessive
ectodermal dysplasia: the odonto-onycho-dermal dysplasia.";
Am. J. Hum. Genet. 81:821-828(2007).
[9]
INTERACTION WITH AFM, AND SUBCELLULAR LOCATION.
PubMed=26902720; DOI=10.7554/eLife.11621;
Mihara E., Hirai H., Yamamoto H., Tamura-Kawakami K., Matano M.,
Kikuchi A., Sato T., Takagi J.;
"Active and water-soluble form of lipidated Wnt protein is maintained
by a serum glycoprotein afamin/alpha-albumin.";
Elife 5:0-0(2016).
[10]
INVOLVEMENT IN STHAG4, AND VARIANT STHAG4 SER-213.
PubMed=27657131; DOI=10.3390/genes7090065;
Zeng B., Xiao X., Li S., Lu H., Lu J., Zhu L., Yu D., Zhao W.;
"Eight mutations of three genes (EDA, EDAR, and WNT10A) identified in
seven hypohidrotic ectodermal dysplasia patients.";
Genes (Basel) 7:0-0(2016).
[11]
VARIANTS OODD GLN-128 AND ILE-228, AND INVOLVEMENT IN SSPS.
PubMed=19559398; DOI=10.1016/j.ajhg.2009.06.001;
Bohring A., Stamm T., Spaich C., Haase C., Spree K., Hehr U.,
Hoffmann M., Ledig S., Sel S., Wieacker P., Ropke A.;
"WNT10A mutations are a frequent cause of a broad spectrum of
ectodermal dysplasias with sex-biased manifestation pattern in
heterozygotes.";
Am. J. Hum. Genet. 85:97-105(2009).
[12]
INVOLVEMENT IN STHAG4, VARIANTS STHAG4 TYR-143; MET-145 AND ILE-228,
AND VARIANT CYS-360.
PubMed=20979233; DOI=10.1002/humu.21384;
Cluzeau C., Hadj-Rabia S., Jambou M., Mansour S., Guigue P.,
Masmoudi S., Bal E., Chassaing N., Vincent M.C., Viot G., Clauss F.,
Maniere M.C., Toupenay S., Le Merrer M., Lyonnet S., Cormier-Daire V.,
Amiel J., Faivre L., de Prost Y., Munnich A., Bonnefont J.P.,
Bodemer C., Smahi A.;
"Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of
hypohidrotic/anhidrotic ectodermal dysplasia cases.";
Hum. Mutat. 32:70-72(2011).
[13]
VARIANT OODD VAL-131.
PubMed=19471313; DOI=10.1038/ejhg.2009.81;
Nawaz S., Klar J., Wajid M., Aslam M., Tariq M., Schuster J.,
Baig S.M., Dahl N.;
"WNT10A missense mutation associated with a complete odonto-onycho-
dermal dysplasia syndrome.";
Eur. J. Hum. Genet. 17:1600-1605(2009).
[14]
VARIANTS STHAG4 ASN-217 AND ILE-228.
PubMed=21484994; DOI=10.1002/ajmg.a.33840;
Kantaputra P., Sripathomsawat W.;
"WNT10A and isolated hypodontia.";
Am. J. Med. Genet. A 155:1119-1122(2011).
[15]
VARIANTS SSPS THR-131 AND CYS-266.
PubMed=21143469; DOI=10.1111/j.1399-0004.2010.01513.x;
Castori M., Castiglia D., Brancati F., Foglio M., Heath S.,
Floriddia G., Madonna S., Fischer J., Zambruno G.;
"Two families confirm Schoepf-Schulz-Passarge syndrome as a discrete
entity within the WNT10A phenotypic spectrum.";
Clin. Genet. 79:92-95(2011).
[16]
VARIANTS STHAG4 LYS-95; GLN-128; MET-145; TRP-163; CYS-277 AND
LYS-306.
PubMed=22581971; DOI=10.1136/jmedgenet-2012-100750;
van den Boogaard M.J., Creton M., Bronkhorst Y., van der Hout A.,
Hennekam E., Lindhout D., Cune M., Ploos van Amstel H.K.;
"Mutations in WNT10A are present in more than half of isolated
hypodontia cases.";
J. Med. Genet. 49:327-331(2012).
[17]
VARIANTS STHAG4 SER-126; SER-213; SER-266; ILE-357 AND CYS-379, AND
FUNCTION.
PubMed=23401279; DOI=10.1002/ajmg.a.35747;
Plaisancie J., Bailleul-Forestier I., Gaston V., Vaysse F.,
Lacombe D., Holder-Espinasse M., Abramowicz M., Coubes C., Plessis G.,
Faivre L., Demeer B., Vincent-Delorme C., Dollfus H., Sigaudy S.,
Guillen-Navarro E., Verloes A., Jonveaux P., Martin-Coignard D.,
Colin E., Bieth E., Calvas P., Chassaing N.;
"Mutations in WNT10A are frequently involved in oligodontia associated
with minor signs of ectodermal dysplasia.";
Am. J. Med. Genet. A 161A:671-678(2013).
[18]
VARIANTS STHAG4 TRP-70; 107-CYS--LYS-417 DEL; CYS-113; SER-213;
CYS-223 AND ILE-228.
PubMed=24449199; DOI=10.1002/ajmg.a.36243;
Arzoo P.S., Klar J., Bergendal B., Norderyd J., Dahl N.;
"WNT10A mutations account for 1/4 of population-based isolated
oligodontia and show phenotypic correlations.";
Am. J. Med. Genet. A 164A:353-359(2014).
[19]
VARIANTS STHAG4 CYS-171 AND SER-213.
PubMed=24311251; DOI=10.1002/ajmg.a.36280;
Kantaputra P., Kaewgahya M., Kantaputra W.;
"WNT10A mutations also associated with agenesis of the maxillary
permanent canines, a separate entity.";
Am. J. Med. Genet. A 164A:360-363(2014).
[20]
VARIANTS OODD SER-213 AND CYS-356.
PubMed=24458874; DOI=10.1002/ajmg.a.36388;
Kantaputra P., Kaewgahya M., Jotikasthira D., Kantaputra W.;
"Tricho-odonto-onycho-dermal dysplasia and WNT10A mutations.";
Am. J. Med. Genet. A 164A:1041-1048(2014).
[21]
VARIANTS STHAG4 SER-213 AND ILE-357, AND FUNCTION.
PubMed=29178643; DOI=10.1002/mgg3.332;
Yuan Q., Zhao M., Tandon B., Maili L., Liu X., Zhang A., Baugh E.H.,
Tran T., Silva R.M., Hecht J.T., Swindell E.C., Wagner D.S., Letra A.;
"Role of WNT10A in failure of tooth development in humans and
zebrafish.";
Mol. Genet. Genomic Med. 5:730-741(2017).
[22]
INVOLVEMENT IN OODD, AND FUNCTION.
PubMed=28589954; DOI=10.1038/ncomms15397;
Xu M., Horrell J., Snitow M., Cui J., Gochnauer H., Syrett C.M.,
Kallish S., Seykora J.T., Liu F., Gaillard D., Katz J.P.,
Kaestner K.H., Levin B., Mansfield C., Douglas J.E., Cowart B.J.,
Tordoff M., Liu F., Zhu X., Barlow L.A., Rubin A.I., McGrath J.A.,
Morrisey E.E., Chu E.Y., Millar S.E.;
"WNT10A mutation causes ectodermal dysplasia by impairing progenitor
cell proliferation and KLF4-mediated differentiation.";
Nat. Commun. 8:15397-15397(2017).
-!- FUNCTION: Ligand for members of the frizzled family of seven
transmembrane receptors (Probable). Functions in the canonical
Wnt/beta-catenin signaling pathway (By similarity). Plays a role
in normal ectoderm development (PubMed:17847007, PubMed:28589954).
Required for normal tooth development (PubMed:17847007,
PubMed:29178643, PubMed:28589954). Required for normal postnatal
development and maintenance of tongue papillae and sweat ducts
(PubMed:28589954). Required for normal proliferation of basal
cells in tongue filiform papillae, plantar epithelium and sweat
ducts. Required for normal expression of keratins in tongue
papillae (By similarity). Required for normal expression of KRT9
in foot plant epithelium (PubMed:28589954). Required for normal
hair follicle function (PubMed:28589954).
{ECO:0000250|UniProtKB:P70701, ECO:0000269|PubMed:17847007,
ECO:0000269|PubMed:28589954, ECO:0000269|PubMed:29178643,
ECO:0000305}.
-!- SUBUNIT: Forms a soluble 1:1 complex with AFM; this prevents
oligomerization and is required for prolonged biological activity
(PubMed:26902720). The complex with AFM may represent the
physiological form in body fluids (PubMed:26902720).
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
-!- PTM: Palmitoleoylation is required for efficient binding to
frizzled receptors. Depalmitoleoylation leads to Wnt signaling
pathway inhibition. {ECO:0000250|UniProtKB:P27467,
ECO:0000250|UniProtKB:P56704}.
-!- DISEASE: Odonto-onycho-dermal dysplasia (OODD) [MIM:257980]: A
rare autosomal recessive ectodermal dysplasia characterized by dry
hair, severe hypodontia, smooth tongue with marked reduction of
fungiform and filiform papillae, onychodysplasia, keratoderma and
hyperhidrosis of palms and soles, and hyperkeratosis of the skin.
{ECO:0000269|PubMed:17847007, ECO:0000269|PubMed:19471313,
ECO:0000269|PubMed:19559398, ECO:0000269|PubMed:24458874,
ECO:0000269|PubMed:28589954}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- DISEASE: Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]: A
rare ectodermal dysplasia, characterized chiefly by cysts of the
eyelid margins, palmoplantar keratoderma, hypodontia,
hypotrichosis and nail dystrophy. Multiple eyelid apocrine
hidrocystomas are the hallmark of this condition, although they
usually appear in adulthood. The concomitant presence of eccrine
syringofibroadenoma in most patients and of other adnexal skin
tumors in some affected subjects indicates that Schopf-Schulz-
Passarge syndrome is a genodermatosis with skin appendage
neoplasms. {ECO:0000269|PubMed:19559398,
ECO:0000269|PubMed:21143469}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- DISEASE: Tooth agenesis, selective, 4 (STHAG4) [MIM:150400]: A
form of selective tooth agenesis, a common anomaly characterized
by the congenital absence of one or more teeth. Selective tooth
agenesis without associated systemic disorders has sometimes been
divided into 2 types: oligodontia, defined as agenesis of 6 or
more permanent teeth, and hypodontia, defined as agenesis of less
than 6 teeth. The number in both cases does not include absence of
third molars (wisdom teeth). In STHAG4, the upper lateral incisors
are absent or peg-shaped. Some STHAG4 patients manifest mild
features of ectodermal dysplasia, including sparse hair, sparse
eyebrows, short eyelashes, abnormalities of the nails, sweating
anomalies and dry skin. STHAG4 inheritance is autosomal dominant
or autosomal recessive. {ECO:0000269|PubMed:20979233,
ECO:0000269|PubMed:21484994, ECO:0000269|PubMed:22581971,
ECO:0000269|PubMed:23401279, ECO:0000269|PubMed:24311251,
ECO:0000269|PubMed:24449199, ECO:0000269|PubMed:27657131,
ECO:0000269|PubMed:29178643}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}.
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EMBL; AY009400; AAG38660.1; -; mRNA.
EMBL; AF315943; AAG45153.1; -; Genomic_DNA.
EMBL; AB059569; BAB55602.1; -; mRNA.
EMBL; AK024363; BAB14898.1; -; mRNA.
EMBL; AK315081; BAG37548.1; -; mRNA.
EMBL; AC073128; AAY24175.1; -; Genomic_DNA.
EMBL; CH471063; EAW70659.1; -; Genomic_DNA.
EMBL; BC052234; AAH52234.1; -; mRNA.
CCDS; CCDS2426.1; -.
PIR; JC7693; JC7693.
RefSeq; NP_079492.2; NM_025216.2.
UniGene; Hs.121540; -.
ProteinModelPortal; Q9GZT5; -.
BioGrid; 123238; 1.
IntAct; Q9GZT5; 1.
STRING; 9606.ENSP00000258411; -.
PhosphoSitePlus; Q9GZT5; -.
BioMuta; WNT10A; -.
DMDM; 14424011; -.
PaxDb; Q9GZT5; -.
PeptideAtlas; Q9GZT5; -.
PRIDE; Q9GZT5; -.
ProteomicsDB; 80132; -.
DNASU; 80326; -.
Ensembl; ENST00000258411; ENSP00000258411; ENSG00000135925.
GeneID; 80326; -.
KEGG; hsa:80326; -.
UCSC; uc002vjd.2; human.
CTD; 80326; -.
DisGeNET; 80326; -.
EuPathDB; HostDB:ENSG00000135925.8; -.
GeneCards; WNT10A; -.
HGNC; HGNC:13829; WNT10A.
HPA; HPA013898; -.
MalaCards; WNT10A; -.
MIM; 150400; phenotype.
MIM; 224750; phenotype.
MIM; 257980; phenotype.
MIM; 606268; gene.
neXtProt; NX_Q9GZT5; -.
OpenTargets; ENSG00000135925; -.
Orphanet; 248; Autosomal recessive hypohidrotic ectodermal dysplasia.
Orphanet; 2227; Hypodontia.
Orphanet; 2721; Odonto-onycho-dermal dysplasia.
Orphanet; 99798; Oligodontia.
Orphanet; 50944; Schopf-Schulz-Passarge syndrome.
PharmGKB; PA37817; -.
eggNOG; KOG3913; Eukaryota.
eggNOG; ENOG410XQZ1; LUCA.
GeneTree; ENSGT00690000101857; -.
HOGENOM; HOG000039528; -.
HOVERGEN; HBG001595; -.
InParanoid; Q9GZT5; -.
KO; K01357; -.
OMA; CSHNMDF; -.
OrthoDB; EOG091G0OFF; -.
PhylomeDB; Q9GZT5; -.
TreeFam; TF105310; -.
Reactome; R-HSA-3238698; WNT ligand biogenesis and trafficking.
Reactome; R-HSA-373080; Class B/2 (Secretin family receptors).
SIGNOR; Q9GZT5; -.
GeneWiki; WNT10A; -.
GenomeRNAi; 80326; -.
PRO; PR:Q9GZT5; -.
Proteomes; UP000005640; Chromosome 2.
Bgee; ENSG00000135925; -.
CleanEx; HS_WNT10A; -.
ExpressionAtlas; Q9GZT5; baseline and differential.
Genevisible; Q9GZT5; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
GO; GO:0048018; F:receptor ligand activity; IDA:WormBase.
GO; GO:0060070; P:canonical Wnt signaling pathway; IDA:WormBase.
GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.
GO; GO:0048730; P:epidermis morphogenesis; IMP:BHF-UCL.
GO; GO:0001942; P:hair follicle development; IMP:BHF-UCL.
GO; GO:0031069; P:hair follicle morphogenesis; IMP:BHF-UCL.
GO; GO:0014033; P:neural crest cell differentiation; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
GO; GO:0042476; P:odontogenesis; IMP:BHF-UCL.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0048733; P:sebaceous gland development; IMP:BHF-UCL.
GO; GO:0043588; P:skin development; IMP:BHF-UCL.
GO; GO:0043586; P:tongue development; IMP:BHF-UCL.
GO; GO:0016055; P:Wnt signaling pathway; IBA:GO_Central.
InterPro; IPR005817; Wnt.
InterPro; IPR013302; Wnt10.
InterPro; IPR018161; Wnt_CS.
PANTHER; PTHR12027; PTHR12027; 1.
Pfam; PF00110; wnt; 1.
PRINTS; PR01893; WNT10PROTEIN.
PRINTS; PR01349; WNTPROTEIN.
SMART; SM00097; WNT1; 1.
PROSITE; PS00246; WNT1; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Disease mutation;
Disulfide bond; Ectodermal dysplasia; Extracellular matrix;
Glycoprotein; Hypotrichosis; Lipoprotein; Palmoplantar keratoderma;
Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal;
Wnt signaling pathway.
SIGNAL 1 35 {ECO:0000255}.
CHAIN 36 417 Protein Wnt-10a.
/FTId=PRO_0000041460.
MOD_RES 59 59 Phosphothreonine.
{ECO:0000250|UniProtKB:O00744}.
LIPID 268 268 O-palmitoleoyl serine; by PORCN.
{ECO:0000250|UniProtKB:P56704}.
CARBOHYD 106 106 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 363 363 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 96 107 {ECO:0000250|UniProtKB:P28026}.
DISULFID 149 157 {ECO:0000250|UniProtKB:P28026}.
DISULFID 159 214 {ECO:0000250|UniProtKB:P28026}.
DISULFID 262 276 {ECO:0000250|UniProtKB:P28026}.
DISULFID 264 271 {ECO:0000250|UniProtKB:P28026}.
DISULFID 362 377 {ECO:0000250|UniProtKB:P28026}.
DISULFID 392 407 {ECO:0000250|UniProtKB:P28026}.
DISULFID 394 404 {ECO:0000250|UniProtKB:P28026}.
DISULFID 399 400 {ECO:0000250|UniProtKB:P28026}.
VARIANT 70 70 R -> W (in STHAG4; unknown pathological
significance; dbSNP:rs146460077).
{ECO:0000269|PubMed:24449199}.
/FTId=VAR_079418.
VARIANT 95 95 E -> K (in STHAG4; dbSNP:rs318240759).
{ECO:0000269|PubMed:22581971}.
/FTId=VAR_069171.
VARIANT 107 417 Missing (in STHAG4).
{ECO:0000269|PubMed:24449199}.
/FTId=VAR_079419.
VARIANT 113 113 R -> C (in STHAG4; unknown pathological
significance; dbSNP:rs141074983).
{ECO:0000269|PubMed:24449199}.
/FTId=VAR_079420.
VARIANT 126 126 G -> S (in STHAG4; unknown pathological
significance).
{ECO:0000269|PubMed:23401279}.
/FTId=VAR_077446.
VARIANT 128 128 R -> Q (in OODD and STHAG4;
dbSNP:rs121908121).
{ECO:0000269|PubMed:19559398,
ECO:0000269|PubMed:22581971}.
/FTId=VAR_062510.
VARIANT 131 131 A -> T (in SSPS; dbSNP:rs372993798).
{ECO:0000269|PubMed:21143469}.
/FTId=VAR_077447.
VARIANT 131 131 A -> V (in OODD).
{ECO:0000269|PubMed:19471313}.
/FTId=VAR_077448.
VARIANT 143 143 H -> Y (in STHAG4; unknown pathological
significance; dbSNP:rs202024965).
{ECO:0000269|PubMed:20979233}.
/FTId=VAR_064837.
VARIANT 145 145 V -> M (in STHAG4; unknown pathological
significance; dbSNP:rs543063101).
{ECO:0000269|PubMed:20979233,
ECO:0000269|PubMed:22581971}.
/FTId=VAR_064838.
VARIANT 163 163 R -> W (in STHAG4; unknown pathological
significance; dbSNP:rs368280129).
{ECO:0000269|PubMed:22581971}.
/FTId=VAR_069172.
VARIANT 171 171 R -> C (in STHAG4; unknown pathological
significance; dbSNP:rs116998555).
{ECO:0000269|PubMed:24311251}.
/FTId=VAR_077449.
VARIANT 213 213 G -> S (in STHAG4 and OODD; unknown
pathological significance;
dbSNP:rs147680216).
{ECO:0000269|PubMed:23401279,
ECO:0000269|PubMed:24311251,
ECO:0000269|PubMed:24449199,
ECO:0000269|PubMed:24458874,
ECO:0000269|PubMed:27657131,
ECO:0000269|PubMed:29178643}.
/FTId=VAR_077450.
VARIANT 217 217 D -> N (in STHAG4; unknown pathological
significance; dbSNP:rs146902156).
{ECO:0000269|PubMed:21484994}.
/FTId=VAR_069173.
VARIANT 223 223 R -> C (in STHAG4; unknown pathological
significance; dbSNP:rs149245953).
{ECO:0000269|PubMed:24449199}.
/FTId=VAR_079421.
VARIANT 228 228 F -> I (in OODD and STHAG4; also found in
patients with an unclassified form of
ectodermal dysplasia; dbSNP:rs121908120).
{ECO:0000269|PubMed:19559398,
ECO:0000269|PubMed:20979233,
ECO:0000269|PubMed:21484994,
ECO:0000269|PubMed:24449199}.
/FTId=VAR_062511.
VARIANT 266 266 G -> C (in SSPS).
{ECO:0000269|PubMed:21143469}.
/FTId=VAR_077451.
VARIANT 266 266 G -> S (in STHAG4; unknown pathological
significance; dbSNP:rs778752861).
{ECO:0000269|PubMed:23401279}.
/FTId=VAR_077452.
VARIANT 277 277 W -> C (in STHAG4).
{ECO:0000269|PubMed:22581971}.
/FTId=VAR_069174.
VARIANT 302 302 P -> T (in dbSNP:rs1057306).
/FTId=VAR_013239.
VARIANT 306 306 N -> K (in STHAG4; unknown pathological
significance; dbSNP:rs745513263).
{ECO:0000269|PubMed:22581971}.
/FTId=VAR_069175.
VARIANT 356 356 G -> C (in OODD; unknown pathological
significance).
{ECO:0000269|PubMed:24458874}.
/FTId=VAR_077453.
VARIANT 357 357 T -> I (in STHAG4; unknown pathological
significance; dbSNP:rs750190755).
{ECO:0000269|PubMed:23401279,
ECO:0000269|PubMed:29178643}.
/FTId=VAR_077454.
VARIANT 360 360 R -> C (probable disease-associated
mutation found in patients with an
unclassified form of ectodermal
dysplasia).
{ECO:0000269|PubMed:20979233}.
/FTId=VAR_064839.
VARIANT 379 379 R -> C (in STHAG4; unknown pathological
significance).
{ECO:0000269|PubMed:23401279}.
/FTId=VAR_077455.
CONFLICT 52 52 E -> G (in Ref. 3; BAB55602 and 4;
BAB14898). {ECO:0000305}.
SEQUENCE 417 AA; 46444 MW; 868DF5146A895319 CRC64;
MGSAHPRPWL RLRPQPQPRP ALWVLLFFLL LLAAAMPRSA PNDILDLRLP PEPVLNANTV
CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF RDQRWNCSSL ETRNKIPYES
PIFSRGFRES AFAYAIAAAG VVHAVSNACA LGKLKACGCD ASRRGDEEAF RRKLHRLQLD
ALQRGKGLSH GVPEHPALPT ASPGLQDSWE WGGCSPDMGF GERFSKDFLD SREPHRDIHA
RMRLHNNRVG RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RSRFHRATLI
RPHNRNGGQL EPGPAGAPSP APGAPGPRRR ASPADLVYFE KSPDFCEREP RLDSAGTVGR
LCNKSSAGSD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC FVVCEECRIT EWVSVCK


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