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Protein YIPF5 (YIP1 family member 5) (YPT-interacting protein 1 A)

 YIPF5_RAT               Reviewed;         257 AA.
Q5XID0;
16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
12-SEP-2018, entry version 86.
RecName: Full=Protein YIPF5;
AltName: Full=YIP1 family member 5;
AltName: Full=YPT-interacting protein 1 A;
Name=Yipf5; Synonyms=Yip1a;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=11489904; DOI=10.1074/jbc.M106189200;
Tang B.L., Ong Y.S., Huang B., Wei S., Wong E.T., Qi R., Horstmann H.,
Hong W.;
"A membrane protein enriched in endoplasmic reticulum exit sites
interacts with COPII.";
J. Biol. Chem. 276:40008-40017(2001).
-!- FUNCTION: Plays a role in transport between endoplasmic reticulum
and Golgi. {ECO:0000269|PubMed:11489904}.
-!- SUBUNIT: Interacts with the COPII coat components Sec23 (SEC23A
and/or SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity).
Interacts with YIF1A (By similarity). May interact with RAB1A (By
similarity). Interacts with YIPF3 and YIPF4 (By similarity).
{ECO:0000250|UniProtKB:Q969M3}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000269|PubMed:11489904}; Multi-pass membrane protein
{ECO:0000269|PubMed:11489904}. Golgi apparatus, cis-Golgi network
membrane {ECO:0000269|PubMed:11489904}; Multi-pass membrane
protein {ECO:0000269|PubMed:11489904}. Cytoplasmic vesicle, COPII-
coated vesicle {ECO:0000269|PubMed:11489904}. Note=Enriched at the
endoplasmic reticulum exit sites. Incorporated into COPII coated
vesicles.
-!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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EMBL; BC083754; AAH83754.1; -; mRNA.
RefSeq; NP_001014172.3; NM_001014150.3.
UniGene; Rn.7575; -.
PRIDE; Q5XID0; -.
Ensembl; ENSRNOT00000020385; ENSRNOP00000020385; ENSRNOG00000014564.
GeneID; 361315; -.
KEGG; rno:361315; -.
UCSC; RGD:1359165; rat.
CTD; 81555; -.
RGD; 1359165; Yipf5.
GeneTree; ENSGT00510000046817; -.
HOGENOM; HOG000037706; -.
HOVERGEN; HBG055241; -.
InParanoid; Q5XID0; -.
KO; K20363; -.
OMA; FDNLNTD; -.
PRO; PR:Q5XID0; -.
Proteomes; UP000002494; Chromosome 18.
Bgee; ENSRNOG00000014564; Expressed in 9 organ(s), highest expression level in Ammon's horn.
ExpressionAtlas; Q5XID0; baseline and differential.
Genevisible; Q5XID0; RN.
GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-SubCell.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
InterPro; IPR006977; Yip1.
Pfam; PF04893; Yip1; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum;
ER-Golgi transport; Golgi apparatus; Membrane; Protein transport;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 257 Protein YIPF5.
/FTId=PRO_0000234332.
TOPO_DOM 1 124 Cytoplasmic.
{ECO:0000250|UniProtKB:Q969M3}.
TRANSMEM 125 145 Helical. {ECO:0000255}.
TOPO_DOM 146 146 Lumenal. {ECO:0000305}.
TRANSMEM 147 167 Helical. {ECO:0000255}.
TOPO_DOM 168 173 Cytoplasmic. {ECO:0000305}.
TRANSMEM 174 194 Helical. {ECO:0000255}.
TOPO_DOM 195 196 Lumenal. {ECO:0000305}.
TRANSMEM 197 217 Helical. {ECO:0000255}.
TOPO_DOM 218 236 Cytoplasmic. {ECO:0000305}.
TRANSMEM 237 257 Helical. {ECO:0000255}.
REGION 75 106 Interaction with Sec23. {ECO:0000250}.
SEQUENCE 257 AA; 27903 MW; 70F867980D62DD38 CRC64;
MSGFDNLNSG FYQTSYSIDE QSQQSYDYGG SGGPYSKQYA GCEYSQQGRF VPPDMMQPQQ
TYTGQIYQPT QAYPPPTPQT FYGDSFEEEP PLLEELGINF DHIWQKTLTV LHPLRASDGS
IMNETDLAGP VVFCLAFGAT LLLAGKIQFG YVYGISAIGC LGMFCLLNLM SMTGVSFGCV
ASVLGYCLLP MILLSSFAVV FSLQGMVGIL LTATIIGWCS FSASKIFISA LAMDGQQLLV
AYPCALLYGV FALISVF


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