Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Protein argonaute-1 (Argonaute1) (mAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Piwi/argonaute family protein meIF2C1)

 AGO1_MOUSE              Reviewed;         857 AA.
Q8CJG1; A1L365;
14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
25-OCT-2017, entry version 112.
RecName: Full=Protein argonaute-1;
Short=Argonaute1;
Short=mAgo1;
AltName: Full=Argonaute RISC catalytic component 1;
AltName: Full=Eukaryotic translation initiation factor 2C 1;
Short=eIF-2C 1;
Short=eIF2C 1;
AltName: Full=Piwi/argonaute family protein meIF2C1;
Name=Ago1; Synonyms=Eif2c1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=12526743; DOI=10.1016/S0960-9822(02)01394-5;
Doi N., Zenno S., Ueda R., Ohki-Hamazaki H., Ui-Tei K., Saigo K.;
"Short-interfering-RNA-mediated gene silencing in mammalian cells
requires Dicer and eIF2C translation initiation factors.";
Curr. Biol. 13:41-46(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION.
PubMed=19174539; DOI=10.1101/gad.1749809;
Su H., Trombly M.I., Chen J., Wang X.;
"Essential and overlapping functions for mammalian Argonautes in
microRNA silencing.";
Genes Dev. 23:304-317(2009).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds
to short RNAs such as microRNAs (miRNAs) or short interfering RNAs
(siRNAs), and represses the translation of mRNAs which are
complementary to them. Lacks endonuclease activity and does not
appear to cleave target mRNAs. May also be required for
transcriptional gene silencing (TGS) of promoter regions which are
complementary to bound short antigene RNAs (agRNAs).
{ECO:0000269|PubMed:19174539}.
-!- SUBUNIT: Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47,
DICER1, AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10,
PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with
polysomes and messenger ribonucleoproteins (mNRPs) (By
similarity). Interacts with LIMD1, WTIP and AJUBA (By similarity).
Interacts with APOBEC3F, APOBEC3G and APOBEC3H (By similarity).
{ECO:0000250}.
-!- INTERACTION:
Q8CH72:Trim32; NbExp=2; IntAct=EBI-2291996, EBI-773837;
-!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}.
-!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB081471; BAC15766.1; -; mRNA.
EMBL; AL606935; CAM17423.1; -; Genomic_DNA.
EMBL; AL606976; CAM17423.1; JOINED; Genomic_DNA.
EMBL; AL606976; CAM45874.1; -; Genomic_DNA.
EMBL; AL606935; CAM45874.1; JOINED; Genomic_DNA.
EMBL; BC129914; AAI29915.1; -; mRNA.
CCDS; CCDS18653.1; -.
RefSeq; NP_001304102.1; NM_001317173.1.
RefSeq; NP_700452.2; NM_153403.3.
UniGene; Mm.30800; -.
ProteinModelPortal; Q8CJG1; -.
SMR; Q8CJG1; -.
BioGrid; 231767; 1.
IntAct; Q8CJG1; 2.
MINT; MINT-4098243; -.
STRING; 10090.ENSMUSP00000095498; -.
iPTMnet; Q8CJG1; -.
PhosphoSitePlus; Q8CJG1; -.
EPD; Q8CJG1; -.
MaxQB; Q8CJG1; -.
PaxDb; Q8CJG1; -.
PRIDE; Q8CJG1; -.
Ensembl; ENSMUST00000097888; ENSMUSP00000095498; ENSMUSG00000041530.
GeneID; 236511; -.
KEGG; mmu:236511; -.
UCSC; uc008utj.2; mouse.
CTD; 26523; -.
MGI; MGI:2446630; Ago1.
eggNOG; KOG1041; Eukaryota.
eggNOG; ENOG410XP07; LUCA.
GeneTree; ENSGT00760000119148; -.
HOGENOM; HOG000116043; -.
HOVERGEN; HBG006101; -.
InParanoid; Q8CJG1; -.
KO; K11593; -.
OMA; TNPNNIE; -.
OrthoDB; EOG091G020J; -.
TreeFam; TF101510; -.
Reactome; R-MMU-426496; Post-transcriptional silencing by small RNAs.
Reactome; R-MMU-5578749; Transcriptional regulation by small RNAs.
PRO; PR:Q8CJG1; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000041530; -.
CleanEx; MM_EIF2C1; -.
ExpressionAtlas; Q8CJG1; baseline and differential.
Genevisible; Q8CJG1; MM.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005829; C:cytosol; IDA:MGI.
GO; GO:0030529; C:intracellular ribonucleoprotein complex; ISS:UniProtKB.
GO; GO:0035068; C:micro-ribonucleoprotein complex; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0000932; C:P-body; IDA:MGI.
GO; GO:0005844; C:polysome; ISS:UniProtKB.
GO; GO:0016442; C:RISC complex; ISO:MGI.
GO; GO:0070578; C:RISC-loading complex; ISO:MGI.
GO; GO:0001047; F:core promoter binding; ISO:MGI.
GO; GO:0003725; F:double-stranded RNA binding; ISO:MGI.
GO; GO:0035198; F:miRNA binding; IDA:MGI.
GO; GO:0003723; F:RNA binding; IDA:MGI.
GO; GO:0000993; F:RNA polymerase II core binding; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:MGI.
GO; GO:0003727; F:single-stranded RNA binding; ISO:MGI.
GO; GO:0044212; F:transcription regulatory region DNA binding; IMP:BHF-UCL.
GO; GO:0035280; P:miRNA loading onto RISC involved in gene silencing by miRNA; ISO:MGI.
GO; GO:0035278; P:miRNA mediated inhibition of translation; ISS:UniProtKB.
GO; GO:0010586; P:miRNA metabolic process; IDA:MGI.
GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL.
GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IMP:BHF-UCL.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0031054; P:pre-miRNA processing; ISO:MGI.
GO; GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; ISO:MGI.
GO; GO:0010501; P:RNA secondary structure unwinding; ISO:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 3.30.420.10; -; 1.
InterPro; IPR014811; ArgoL1.
InterPro; IPR032472; ArgoL2.
InterPro; IPR032473; Argonaute_Mid_dom.
InterPro; IPR032474; Argonaute_N.
InterPro; IPR003100; PAZ_dom.
InterPro; IPR036085; PAZ_dom_sf.
InterPro; IPR003165; Piwi.
InterPro; IPR012337; RNaseH-like_sf.
InterPro; IPR036397; RNaseH_sf.
Pfam; PF08699; ArgoL1; 1.
Pfam; PF16488; ArgoL2; 1.
Pfam; PF16487; ArgoMid; 1.
Pfam; PF16486; ArgoN; 1.
Pfam; PF02170; PAZ; 1.
Pfam; PF02171; Piwi; 1.
SMART; SM01163; DUF1785; 1.
SMART; SM00949; PAZ; 1.
SMART; SM00950; Piwi; 1.
SUPFAM; SSF101690; SSF101690; 1.
SUPFAM; SSF53098; SSF53098; 1.
PROSITE; PS50821; PAZ; 1.
PROSITE; PS50822; PIWI; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Reference proteome; Repressor;
Ribonucleoprotein; RNA-binding; RNA-mediated gene silencing;
Transcription; Transcription regulation; Translation regulation.
CHAIN 1 857 Protein argonaute-1.
/FTId=PRO_0000194056.
DOMAIN 226 346 PAZ. {ECO:0000255|PROSITE-
ProRule:PRU00142}.
DOMAIN 515 816 Piwi. {ECO:0000255|PROSITE-
ProRule:PRU00150}.
REGION 309 314 Interaction with guide RNA.
{ECO:0000250}.
REGION 522 564 Interaction with guide RNA.
{ECO:0000250}.
REGION 670 675 Impairs access of bound RNA to the active
site. {ECO:0000250}.
REGION 708 712 Interaction with guide RNA.
{ECO:0000250}.
REGION 751 759 Interaction with guide RNA.
{ECO:0000250}.
REGION 788 813 Interaction with guide RNA.
{ECO:0000250}.
CONFLICT 96 96 K -> E (in Ref. 1; BAC15766).
{ECO:0000305}.
CONFLICT 309 309 Y -> H (in Ref. 1; BAC15766).
{ECO:0000305}.
CONFLICT 386 386 Y -> C (in Ref. 1; BAC15766).
{ECO:0000305}.
CONFLICT 550 550 V -> A (in Ref. 1; BAC15766).
{ECO:0000305}.
SEQUENCE 857 AA; 97214 MW; 1DBB524AE7CBAF66 CRC64;
MEAGPSGAAA GAYLPPLQQV FQAPRRPGIG TVGKPIKLLA NYFEVDIPKI DVYHYEVDIK
PDKCPRRVNR EVVEYMVQHF KPQIFGDRKP VYDGKKNIYT VTALPIGNER VDFEVTIPGE
GKDRIFKVSI KWLAIVSWRM LHEALVSGQI PVPLESVQAL DVAMRHLASM RYTPVGRSFF
SPPEGYYHPL GGGREVWFGF HQSVRPAMWK MMLNIDVSAT AFYKAQPVIE FMCEVLDIRN
IDEQPKPLTD SQRVRFTKEI KGLKVEVTHC GQMKRKYRVC NVTRRPASHQ TFPLQLESGQ
TVECTVAQYF KQKYNLQLKY PHLPCLQVGQ EQKHTYLPLE VCNIVAGQRC IKKLTDNQTS
TMIKATARSA PDRQEEISRL MKNASYNLDP YIQEFGIKVK DDMTEVTGRV LPAPILQYGG
RNRAIATPNQ GVWDMRGKQF YNGIEIKVWA IACFAPQKQC REEVLKNFTD QLRKISKDAG
MPIQGQPCFC KYAQGADSVE PMFRHLKNTY SGLQLIIVIL PGKTPVYAEV KRVGDTLLGM
ATQCVQVKNV VKTSPQTLSN LCLKINVKLG GINNILVPHQ RSAVFQQPVI FLGADVTHPP
AGDGKKPSIT AVVGSMDAHP SRYCATVRVQ RPRQEIIEDL SYMVRELLIQ FYKSTRFKPT
RIIFYRDGVP EGQLPQILHY ELLAIRDACI KLEKDYQPGI TYIVVQKRHH TRLFCADKNE
RIGKSGNIPA GTTVDTNITH PFEFDFYLCS HAGIQGTSRP SHYYVLWDDN RFTADELQIL
TYQLCHTYVR CTRSVSIPAP AYYARLVAFR ARYHLVDKEH DSGEGSHISG QSNGRDPQAL
AKAVQVHQDT LRTMYFA


Related products :

Catalog number Product name Quantity
YF-PA22643 anti-Argonaute 3 eIF2C 3 100 ug
YF-PA26955 anti-Argonaute 3 eIF2C 3 type: Primary antibodies host: Mouse 50 ul
YF-PA22643 anti-Argonaute 3 eIF2C 3 type: Primary antibodies host: Rabbit 100 ug
25-619 EIF3G belongs to the eIF-3 subunit G family. It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synth 0.05 mg
26-291 EIF3E belongs to the eIF-3 subunit E family.It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthe 0.05 mg
YF-PA22643 Rabbit polyclonal to Argonaute 3 _ eIF2C 3, Host Rabbit 100 ug
YF-PA26955 Mouse polyclonal to Argonaute 3 _ eIF2C 3, Host Mouse 50 uL
18-003-42779 Probable ATP-dependent RNA helicase DDX48 - EC 3.6.1.-; DEAD box protein 48; Eukaryotic initiation factor 4A-like NUK-34; Nuclear matrix protein 265; hNMP 265; Eukaryotic translation initiation factor 0.1 mg Protein A
15-288-22403A Eukaryotic translation initiation factor 4E type 3 - eIF4E type 3; eIF-4E type 3; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.1 mg
18-003-43602 Eukaryotic translation initiation factor 4E type 2 - eIF4E type 2; eIF-4E type 2; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.1 mg Protein A
10-288-22403F Eukaryotic translation initiation factor 4E type 3 - eIF4E type 3; eIF-4E type 3; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.05 mg
10-288-22403F Eukaryotic translation initiation factor 4E type 3 - eIF4E type 3; eIF-4E type 3; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.1 mg
15-288-22403A Eukaryotic translation initiation factor 4E type 3 - eIF4E type 3; eIF-4E type 3; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.05 mg
AGO1_MOUSE Mouse ELISA Kit FOR Protein argonaute-1 96T
E10828r Mouse ELISA Kit FOR Protein argonaute-3 96T
G2411 Protein argonaute-2 (EIF2C2), Rat, ELISA Kit 96T
E2027d Mouse ELISA Kit FOR Protein argonaute-4 96T
CSB-EL007520RA Rat Protein argonaute-2(EIF2C2) ELISA kit 96T
E10828Rb Chicken ELISA Kit FOR Protein argonaute-4 96T
PC-Ergo Endogenous RNA-I deficient argonaute family 1, WB control 100-150ul
CSB-EL007522CH Chicken Protein argonaute-4(EIF2C4) ELISA kit 96T
abx109351 Polyclonal Rabbit Protein argonaute-2 Antibody 100 μg
CSB-EL007521CH Chicken Protein argonaute-3(EIF2C3) ELISA kit 96T
G2412 Protein argonaute-3 (EIF2C3), Bovine, ELISA Kit 96T
CSB-EL007520RA Rat Protein argonaute-2(EIF2C2) ELISA kit SpeciesRat 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur