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Protein atonal homolog 7 (Helix-loop-helix protein cATH-5) (cATH5) (Protein atonal homolog 5)

 ATOH7_CHICK             Reviewed;         151 AA.
O57598;
26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 2.
12-SEP-2018, entry version 99.
RecName: Full=Protein atonal homolog 7;
AltName: Full=Helix-loop-helix protein cATH-5;
Short=cATH5;
AltName: Full=Protein atonal homolog 5;
Name=ATOH7; Synonyms=ATH5;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, AND
FUNCTION.
TISSUE=Blood, and Neuroretina;
PubMed=11124117;
Matter-Sadzinski L., Matter J.-M., Ong M.-T., Hernandez J.,
Ballivet M.;
"Specification of neurotransmitter receptor identity in developing
retina: the chick ATH5 promoter integrates the positive and negative
effects of several bHLH proteins.";
Development 128:217-231(2001).
[2]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=11172005; DOI=10.1073/pnas.98.4.1649;
Liu W., Mo Z., Xiang M.;
"The Ath5 proneural genes function upstream of Brn3 POU domain
transcription factor genes to promote retinal ganglion cell
development.";
Proc. Natl. Acad. Sci. U.S.A. 98:1649-1654(2001).
[3]
FUNCTION, AND DNA-BINDING.
PubMed=15342472; DOI=10.1242/dev.01302;
Skowronska-Krawczyk D., Ballivet M., Dynlacht B.D., Matter J.-M.;
"Highly specific interactions between bHLH transcription factors and
chromatin during retina development.";
Development 131:4447-4454(2004).
[4]
INDUCTION.
PubMed=16079155; DOI=10.1242/dev.01960;
Matter-Sadzinski L., Puzianowska-Kuznicka M., Hernandez J.,
Ballivet M., Matter J.-M.;
"A bHLH transcriptional network regulating the specification of
retinal ganglion cells.";
Development 132:3907-3921(2005).
[5]
FUNCTION.
PubMed=16260616; DOI=10.1128/MCB.25.22.10029-10039.2005;
Skowronska-Krawczyk D., Matter-Sadzinski L., Ballivet M.,
Matter J.-M.;
"The basic domain of ATH5 mediates neuron-specific promoter activity
during retina development.";
Mol. Cell. Biol. 25:10029-10039(2005).
-!- FUNCTION: Transcription factor involved in the differentiation of
retinal ganglion cells. During retinal neurogenesis, activates its
own transcription, as well as the transcription of CHRNB3 and
BRN3. {ECO:0000269|PubMed:11124117, ECO:0000269|PubMed:11172005,
ECO:0000269|PubMed:15342472, ECO:0000269|PubMed:16260616}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- DEVELOPMENTAL STAGE: Expressed in the developing retina, and in a
tiny population of ventricular cells located in the ventral domain
of the spinal cord and hindbrain. Retinal expression peaks at
stage 29 (E6). {ECO:0000269|PubMed:11124117,
ECO:0000269|PubMed:11172005}.
-!- INDUCTION: Up-regulated by NGN2 and ATOH7. Down-regulated by HES1.
{ECO:0000269|PubMed:16079155}.
-!- DOMAIN: The basic motif confers specificity for the CHRNB3
promoter.
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EMBL; AJ001178; CAA04572.1; -; mRNA.
EMBL; AJ630209; CAF34420.1; -; Genomic_DNA.
RefSeq; NP_989999.1; NM_204668.1.
UniGene; Gga.199; -.
ProteinModelPortal; O57598; -.
SMR; O57598; -.
STRING; 9031.ENSGALP00000040088; -.
PaxDb; O57598; -.
Ensembl; ENSGALT00000006264; ENSGALP00000040088; ENSGALG00000003931.
GeneID; 395388; -.
KEGG; gga:395388; -.
CTD; 220202; -.
eggNOG; KOG4395; Eukaryota.
eggNOG; ENOG411269K; LUCA.
GeneTree; ENSGT00680000099860; -.
HOGENOM; HOG000034180; -.
HOVERGEN; HBG096161; -.
InParanoid; O57598; -.
KO; K09083; -.
OMA; HYLPFAG; -.
OrthoDB; EOG091G0R1N; -.
PhylomeDB; O57598; -.
TreeFam; TF315153; -.
PRO; PR:O57598; -.
Proteomes; UP000000539; Chromosome 6.
Bgee; ENSGALG00000003931; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
GO; GO:0009649; P:entrainment of circadian clock; IEA:Ensembl.
GO; GO:0003407; P:neural retina development; IMP:AgBase.
GO; GO:0030182; P:neuron differentiation; IMP:AgBase.
GO; GO:0048663; P:neuron fate commitment; TAS:AgBase.
GO; GO:0021554; P:optic nerve development; IEA:Ensembl.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR032663; Atoh7.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
PANTHER; PTHR19290:SF99; PTHR19290:SF99; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation;
DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription;
Transcription regulation.
INIT_MET 1 1 Removed. {ECO:0000305}.
CHAIN 2 151 Protein atonal homolog 7.
/FTId=PRO_5000064266.
DOMAIN 39 91 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
SITE 42 43 Required for CHRNB3 transcription
activation but not for DNA binding.
SITE 49 49 Required for CHRNB3 transcription
activation but not for DNA binding.
SEQUENCE 151 AA; 17540 MW; 1D4F2F9D225A5319 CRC64;
MKTCQSSHLD SGVESDIQCR SGSGCVVKCS TERMESAAKR RLAANARERR RMQGLNTAFD
RLRKVVPQWG QDKKLSKYET LQMALSYIMA LTRILAEAER YSTEREWINL HCEHFHPESY
HHYTGQKVAT DSDPYAQRIF SYHPEHFQIA N


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