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Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4)

 CNPY2_HUMAN             Reviewed;         182 AA.
Q9Y2B0; B2R7B9; Q9UHE9;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
25-OCT-2017, entry version 135.
RecName: Full=Protein canopy homolog 2;
AltName: Full=MIR-interacting saposin-like protein;
AltName: Full=Putative secreted protein Zsig9;
AltName: Full=Transmembrane protein 4;
Flags: Precursor;
Name=CNPY2; Synonyms=MSAP, TMEM4, ZSIG9; ORFNames=UNQ1943/PRO4426;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Gastric adenocarcinoma;
PubMed=10072769; DOI=10.1016/S0378-1119(99)00004-9;
Yokoyama-Kobayashi M., Yamaguchi T., Sekine S., Kato S.;
"Selection of cDNAs encoding putative type II membrane proteins on the
cell surface from a human full-length cDNA bank.";
Gene 228:161-167(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MYLIP, AND
TISSUE SPECIFICITY.
PubMed=12826659; DOI=10.1074/jbc.M306271200;
Bornhauser B.C., Olsson P.-A., Lindholm D.;
"MSAP is a novel MIR-interacting protein that enhances neurite
outgrowth and increases myosin regulatory light chain.";
J. Biol. Chem. 278:35412-35420(2003).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J.,
O'Hara P.;
"Homo sapiens putative secreted protein.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Eye, and Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
-!- FUNCTION: Positive regulator of neurite outgrowth by stabilizing
myosin regulatory light chain (MRLC). It prevents MIR-mediated
MRLC ubiquitination and its subsequent proteasomal degradation.
-!- SUBUNIT: Interacts with MYLIP/MIR. {ECO:0000269|PubMed:12826659}.
-!- INTERACTION:
Q8WY64:MYLIP; NbExp=3; IntAct=EBI-1054195, EBI-6952711;
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-
ProRule:PRU10138}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9Y2B0-1; Sequence=Displayed;
Name=2;
IsoId=Q9Y2B0-2; Sequence=VSP_010884, VSP_010885;
-!- TISSUE SPECIFICITY: Expressed in different tissues. Highest levels
are detected in adult placenta, liver and pancreas.
{ECO:0000269|PubMed:12826659}.
-!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
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EMBL; AB015631; BAA76498.1; -; mRNA.
EMBL; AY032624; AAK38148.1; -; mRNA.
EMBL; AF186113; AAF01431.1; -; mRNA.
EMBL; AY359102; AAQ89460.1; -; mRNA.
EMBL; AK312921; BAG35766.1; -; mRNA.
EMBL; CH471054; EAW96926.1; -; Genomic_DNA.
EMBL; BC001027; AAH01027.1; -; mRNA.
EMBL; BC065015; AAH65015.1; -; mRNA.
CCDS; CCDS8914.1; -. [Q9Y2B0-1]
RefSeq; NP_001177920.1; NM_001190991.2. [Q9Y2B0-2]
RefSeq; NP_055070.1; NM_014255.6. [Q9Y2B0-1]
UniGene; Hs.8752; -.
ProteinModelPortal; Q9Y2B0; -.
BioGrid; 115613; 15.
DIP; DIP-50705N; -.
IntAct; Q9Y2B0; 7.
MINT; MINT-3084309; -.
STRING; 9606.ENSP00000273308; -.
iPTMnet; Q9Y2B0; -.
PhosphoSitePlus; Q9Y2B0; -.
BioMuta; CNPY2; -.
DMDM; 50401205; -.
EPD; Q9Y2B0; -.
PaxDb; Q9Y2B0; -.
PeptideAtlas; Q9Y2B0; -.
PRIDE; Q9Y2B0; -.
TopDownProteomics; Q9Y2B0-1; -. [Q9Y2B0-1]
TopDownProteomics; Q9Y2B0-2; -. [Q9Y2B0-2]
DNASU; 10330; -.
Ensembl; ENST00000273308; ENSP00000273308; ENSG00000257727. [Q9Y2B0-1]
GeneID; 10330; -.
KEGG; hsa:10330; -.
UCSC; uc001sku.3; human. [Q9Y2B0-1]
CTD; 10330; -.
DisGeNET; 10330; -.
EuPathDB; HostDB:ENSG00000257727.5; -.
GeneCards; CNPY2; -.
HGNC; HGNC:13529; CNPY2.
HPA; HPA038465; -.
HPA; HPA038466; -.
MIM; 605861; gene.
neXtProt; NX_Q9Y2B0; -.
OpenTargets; ENSG00000257727; -.
PharmGKB; PA162382584; -.
eggNOG; KOG3782; Eukaryota.
eggNOG; ENOG4111XSQ; LUCA.
GeneTree; ENSGT00390000009749; -.
HOGENOM; HOG000233996; -.
HOVERGEN; HBG052514; -.
InParanoid; Q9Y2B0; -.
OrthoDB; EOG091G0HOQ; -.
PhylomeDB; Q9Y2B0; -.
TreeFam; TF318578; -.
ChiTaRS; CNPY2; human.
GenomeRNAi; 10330; -.
PRO; PR:Q9Y2B0; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000257727; -.
CleanEx; HS_CNPY2; -.
ExpressionAtlas; Q9Y2B0; baseline and differential.
Genevisible; Q9Y2B0; HS.
GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0007167; P:enzyme linked receptor protein signaling pathway; IBA:GO_Central.
GO; GO:0010629; P:negative regulation of gene expression; ISS:BHF-UCL.
GO; GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; ISS:BHF-UCL.
GO; GO:0010988; P:regulation of low-density lipoprotein particle clearance; ISS:BHF-UCL.
GO; GO:0009888; P:tissue development; IBA:GO_Central.
Gene3D; 1.10.225.10; -; 1.
InterPro; IPR021852; DUF3456.
InterPro; IPR011001; Saposin-like.
InterPro; IPR008139; SaposinB_dom.
Pfam; PF11938; DUF3456; 1.
PROSITE; PS00014; ER_TARGET; 1.
PROSITE; PS50015; SAP_B; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Disulfide bond;
Endoplasmic reticulum; Phosphoprotein; Reference proteome; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 182 Protein canopy homolog 2.
/FTId=PRO_0000031666.
DOMAIN 24 175 Saposin B-type. {ECO:0000255|PROSITE-
ProRule:PRU00415}.
MOTIF 179 182 Prevents secretion from ER.
{ECO:0000255|PROSITE-ProRule:PRU10138}.
MOD_RES 115 115 Phosphoserine.
{ECO:0000250|UniProtKB:Q9QXT0}.
DISULFID 28 171 {ECO:0000255|PROSITE-ProRule:PRU00415}.
DISULFID 31 164 {ECO:0000255|PROSITE-ProRule:PRU00415}.
DISULFID 86 137 {ECO:0000255|PROSITE-ProRule:PRU00415}.
VAR_SEQ 70 84 PYARSEAHLTELLEE -> TVTVPPNKVAHSGFG (in
isoform 2). {ECO:0000303|PubMed:15489334,
ECO:0000303|Ref.3}.
/FTId=VSP_010884.
VAR_SEQ 85 182 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334,
ECO:0000303|Ref.3}.
/FTId=VSP_010885.
SEQUENCE 182 AA; 20652 MW; BE726D302490733F CRC64;
MKGWGWLALL LGALLGTAWA RRSQDLHCGA CRALVDELEW EIAQVDPKKT IQMGSFRINP
DGSQSVVEVP YARSEAHLTE LLEEICDRMK EYGEQIDPST HRKNYVRVVG RNGESSELDL
QGIRIDSDIS GTLKFACESI VEEYEDELIE FFSREADNVK DKLCSKRTDL CDHALHISHD
EL


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