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Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 72)

 F1MEN8_BOVIN            Unreviewed;       643 AA.
F1MEN8;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
03-MAY-2011, sequence version 1.
28-MAR-2018, entry version 69.
RecName: Full=Protein disulfide-isomerase A4 {ECO:0000256|PIRNR:PIRNR036862};
EC=5.3.4.1 {ECO:0000256|PIRNR:PIRNR036862};
AltName: Full=Endoplasmic reticulum resident protein 72 {ECO:0000256|PIRNR:PIRNR036862};
Name=PDIA4 {ECO:0000313|Ensembl:ENSBTAP00000022782,
ECO:0000313|VGNC:VGNC:32698};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000022782, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|Ensembl:ENSBTAP00000022782, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022782,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[2] {ECO:0000313|Ensembl:ENSBTAP00000022782}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022782};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
-!- CATALYTIC ACTIVITY: Catalyzes the rearrangement of -S-S- bonds in
proteins. {ECO:0000256|PIRNR:PIRNR036862,
ECO:0000256|RuleBase:RU361130}.
-!- SUBUNIT: Part of a large chaperone multiprotein complex comprising
DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1,
UGT1A1 and very small amounts of ERP29, but not, or at very low
levels, CALR nor CANX. {ECO:0000256|PIRNR:PIRNR036862}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
{ECO:0000256|PIRNR:PIRNR036862}.
-!- SIMILARITY: Belongs to the protein disulfide isomerase family.
{ECO:0000256|PIRNR:PIRNR036862, ECO:0000256|RuleBase:RU004208,
ECO:0000256|SAAS:SAAS00569802}.
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EMBL; DAAA02011930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; F1MEN8; -.
Ensembl; ENSBTAT00000022782; ENSBTAP00000022782; ENSBTAG00000017143.
VGNC; VGNC:32698; PDIA4.
eggNOG; KOG0190; Eukaryota.
eggNOG; COG0526; LUCA.
GeneTree; ENSGT00860000133691; -.
OMA; YRAATQF; -.
OrthoDB; EOG091G05J9; -.
TreeFam; TF106382; -.
Proteomes; UP000009136; Chromosome 4.
Bgee; ENSBTAG00000017143; -.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0015037; F:peptide disulfide oxidoreductase activity; IEA:Ensembl.
GO; GO:0003756; F:protein disulfide isomerase activity; IEA:InterPro.
GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
InterPro; IPR005788; Disulphide_isomerase.
InterPro; IPR005792; Prot_disulphide_isomerase.
InterPro; IPR017068; Protein_diS-isomerase_A4.
InterPro; IPR036249; Thioredoxin-like_sf.
InterPro; IPR017937; Thioredoxin_CS.
InterPro; IPR013766; Thioredoxin_domain.
Pfam; PF00085; Thioredoxin; 3.
PIRSF; PIRSF036862; Disulphide_isom_A4; 1.
SUPFAM; SSF52833; SSF52833; 5.
TIGRFAMs; TIGR01130; ER_PDI_fam; 1.
TIGRFAMs; TIGR01126; pdi_dom; 3.
PROSITE; PS00194; THIOREDOXIN_1; 3.
PROSITE; PS51352; THIOREDOXIN_2; 3.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000009136};
Disulfide bond {ECO:0000256|PIRSR:PIRSR605792-51,
ECO:0000256|SAAS:SAAS00903405};
Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR036862};
Isomerase {ECO:0000256|PIRNR:PIRNR036862,
ECO:0000256|RuleBase:RU361130};
Redox-active center {ECO:0000256|PIRSR:PIRSR605792-51,
ECO:0000256|SAAS:SAAS00903442};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
Repeat {ECO:0000256|SAAS:SAAS00435042};
Signal {ECO:0000256|RuleBase:RU361130}.
SIGNAL 1 24 {ECO:0000256|RuleBase:RU361130}.
CHAIN 25 643 Protein disulfide-isomerase A4.
{ECO:0000256|RuleBase:RU361130}.
/FTId=PRO_5005128840.
DOMAIN 20 168 Thioredoxin.
{ECO:0000259|PROSITE:PS51352}.
DOMAIN 170 300 Thioredoxin.
{ECO:0000259|PROSITE:PS51352}.
DOMAIN 503 634 Thioredoxin.
{ECO:0000259|PROSITE:PS51352}.
DISULFID 205 208 Redox-active.
{ECO:0000256|PIRSR:PIRSR605792-51}.
DISULFID 553 556 Redox-active.
{ECO:0000256|PIRSR:PIRSR605792-51}.
SEQUENCE 643 AA; 72498 MW; A50B3276E0ED54C0 CRC64;
MRPRKAWMLV LLLALVQLLA VASAGAPDED SSDKEDAIEE DEEEDEDDDD DDDDLEVKEE
NGVLILNDAN FDNFVADKDT VLLEFYAPWC GHCKQFAPEY EKIAATLKEN DPPIPVAKID
ATSESALASR FDVSGYPTIK ILKKGQEVDY EGSRTQEEIV AKVKEVSQPN WTPPPEVTLV
LTKDNFDEVV NDADIILVEF YAPWCGHCKK LAPEYEKAAK ELSKSSPPIP LAKVDAIAET
DLAKRFDVSS YPTLKIFRKG KAFSYNGPRE KYGIVDYMME QSGPPSKQIL ALKQVQEFLK
DGDDVIIIGV FKSESDPAYQ LYQDAANSLR EDYKFHHTFS TEIAKFLKVS LGKLVVMQPE
KFQSKYEPKS YVMDIKDSTE AAAITEHVVK HTLPLVGHRK AADAKRYTRR PLVVVYYSVD
FSFDYRAATQ FWRNKVLEVA KDFPEYTFAV ADEEDFATEL KDLGLSESGE EVNAAILDEG
GRRFAMEPDD FDADALRDFV TAFKKGKLKP VIKSQPVPKN NKGPVKVVVG KTFDSIVMDP
KKDVLIEFYA PWCGHCKQLE PVYTSLGKKY KGHKNLVIAK MDATANDVTS DRYKVEGFPT
IYFAPSGDKK NPIKFEDGNR DLEHLSKFIE EHATKLSRTK EEL


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