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Protein downstream neighbor of Son (Protein 3SG)

 DONS_MOUSE              Reviewed;         560 AA.
Q9QXP4; Q80V93; Q8BV55;
11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
24-OCT-2003, sequence version 2.
22-NOV-2017, entry version 107.
RecName: Full=Protein downstream neighbor of Son;
AltName: Full=Protein 3SG;
Name=Donson; Synonyms=ORF60;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-377.
STRAIN=C57BL/6J; TISSUE=Thymus;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 232-560.
STRAIN=129/Sv;
PubMed=10950926; DOI=10.1006/geno.2000.6254;
Wynn S.L., Fisher R.A., Pagel C., Price M., Liu Q.Y., Khan I.M.,
Zammit P., Dadrah K., Mazrani W., Kessling A., Lee J.S., Buluwela L.;
"Organization and conservation of the GART/SON/DONSON locus in mouse
and human genomes.";
Genomics 68:57-62(2000).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[5]
DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
PubMed=28630177; DOI=10.1101/gr.219899.116;
Evrony G.D., Cordero D.R., Shen J., Partlow J.N., Yu T.W., Rodin R.E.,
Hill R.S., Coulter M.E., Lam A.N., Jayaraman D., Gerrelli D.,
Diaz D.G., Santos C., Morrison V., Galli A., Tschulena U., Wiemann S.,
Martel M.J., Spooner B., Ryu S.C., Elhosary P.C., Richardson J.M.,
Tierney D., Robinson C.A., Chibbar R., Diudea D., Folkerth R.,
Wiebe S., Barkovich A.J., Mochida G.H., Irvine J., Lemire E.G.,
Blakley P., Walsh C.A.;
"Integrated genome and transcriptome sequencing identifies a noncoding
mutation in the genome replication factor DONSON as the cause of
microcephaly-micromelia syndrome.";
Genome Res. 27:1323-1335(2017).
-!- FUNCTION: Replisome component that maintains genome stability by
protecting stalled or damaged replication forks. After the
induction of replication stress, required for the stabilization of
stalled replication forks, the efficient activation of the intra-
S-phase and G/2M cell-cycle checkpoints and the maintenance of
genome stability. {ECO:0000250|UniProtKB:Q9NYP3}.
-!- SUBUNIT: Component of the replisome complex composed of at least
MCM2, MCM7, PCNA and TICRR; interaction at least with PCNA occurs
during DNA replication. {ECO:0000250|UniProtKB:Q9NYP3}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NYP3}.
Note=Localizes at DNA replication sites.
{ECO:0000250|UniProtKB:Q9NYP3}.
-!- DEVELOPMENTAL STAGE: At 14.5 dpc, widely expressed, including in
neocortex, cerebellum, lung, liver, hindlimb, intestine, as well
as forelimb, kidney and spinal cord vertebrae.
{ECO:0000269|PubMed:28630177}.
-!- DISRUPTION PHENOTYPE: Early embryonic lethality. Heterozygous mice
show no overt phenotype. {ECO:0000269|PubMed:28630177}.
-!- SIMILARITY: Belongs to the DONSON family. {ECO:0000305}.
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EMBL; BC043316; AAH43316.1; -; mRNA.
EMBL; AK080299; BAC37869.1; -; mRNA.
EMBL; AF193608; AAF23122.1; -; mRNA.
CCDS; CCDS28330.1; -.
RefSeq; NP_068366.1; NM_021720.1.
RefSeq; XP_006523132.1; XM_006523069.3.
UniGene; Mm.328698; -.
ProteinModelPortal; Q9QXP4; -.
SMR; Q9QXP4; -.
STRING; 10090.ENSMUSP00000023682; -.
iPTMnet; Q9QXP4; -.
PhosphoSitePlus; Q9QXP4; -.
EPD; Q9QXP4; -.
MaxQB; Q9QXP4; -.
PaxDb; Q9QXP4; -.
PRIDE; Q9QXP4; -.
Ensembl; ENSMUST00000023682; ENSMUSP00000023682; ENSMUSG00000022960.
GeneID; 60364; -.
KEGG; mmu:60364; -.
UCSC; uc007zyc.1; mouse.
CTD; 29980; -.
MGI; MGI:1890621; Donson.
eggNOG; KOG4734; Eukaryota.
eggNOG; ENOG410ZEEQ; LUCA.
GeneTree; ENSGT00390000000447; -.
HOGENOM; HOG000293183; -.
HOVERGEN; HBG005518; -.
InParanoid; Q9QXP4; -.
OMA; QQSLVYW; -.
OrthoDB; EOG091G0MNB; -.
PhylomeDB; Q9QXP4; -.
TreeFam; TF318976; -.
PRO; PR:Q9QXP4; -.
Proteomes; UP000000589; Chromosome 16.
Bgee; ENSMUSG00000022960; -.
CleanEx; MM_DONSON; -.
ExpressionAtlas; Q9QXP4; baseline and differential.
Genevisible; Q9QXP4; MM.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0033260; P:nuclear DNA replication; IBA:GO_Central.
InterPro; IPR024861; Donson.
PANTHER; PTHR12972; PTHR12972; 1.
PRINTS; PR02064; DONSON.
1: Evidence at protein level;
Complete proteome; Developmental protein; Nucleus; Reference proteome.
CHAIN 1 560 Protein downstream neighbor of Son.
/FTId=PRO_0000079980.
CONFLICT 32 32 A -> D (in Ref. 2; BAC37869).
{ECO:0000305}.
CONFLICT 36 36 S -> L (in Ref. 2; BAC37869).
{ECO:0000305}.
CONFLICT 72 72 R -> M (in Ref. 2; BAC37869).
{ECO:0000305}.
CONFLICT 93 93 L -> V (in Ref. 2; BAC37869).
{ECO:0000305}.
CONFLICT 97 97 Q -> H (in Ref. 2; BAC37869).
{ECO:0000305}.
CONFLICT 100 100 S -> W (in Ref. 2; BAC37869).
{ECO:0000305}.
SEQUENCE 560 AA; 61987 MW; 953AE708BE5686BA CRC64;
MAVSVPGYSP SFKRPPETVR LRRKRSRDHG AAVPASLPEP APRRAALAAG LPLRPFPTAG
GRGGAAATIA RRNPFARLDN RPRVSDEASE EPLRGPQGAS GPLLDSNEEN NLLWEDTSSH
ERTGTELSQS QRVSLSESDT WSSDGTELPV DWSIKTRLLF TSSQPFSWAD HLKAQEEAQG
LVQHCRATEV TLPQSIQDPK LSTALRCAFQ QALVYWLHPA FSWLPLFPRI GADRKMAAKT
SPWSADETLQ HALMSDWSVS FTSLYNLLKT KLCPYFYVCS YQFTVLFRAA GLAGSSVITA
LISPTTRGLR EAMRNEGIEF SLPLLEEIGH KKKVRDPSLE SEEEQAVSDE DEEESFSWLE
EIGVQDQIKK PDVISIKLRK EKHEVQMDHR PESVVLVKGL NTFKLLNFLI NCKSLVATSG
AQAGLPPTLL SPIAFRGASM QMLKARSSNV KTQALSGYRD KFSLDITGPV MPHALHSMSM
LLRSSQRGSF SAGLYAHEPT AVFNVGLSLD KELDRKVARE DLANCGLHPK TLEQLSQRPV
LGKSSLRSVE MSDYILSWRS


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