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Protein gone early

 GOE_DROME               Reviewed;         879 AA.
Q9XZ14;
07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
05-DEC-2018, entry version 132.
RecName: Full=Protein gone early {ECO:0000312|FlyBase:FBgn0027528};
Name=goe {ECO:0000312|FlyBase:FBgn0027528};
ORFNames=CG9634 {ECO:0000312|FlyBase:FBgn0027528};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
[1] {ECO:0000312|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2] {ECO:0000312|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3] {ECO:0000312|EMBL:AAD34757.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley {ECO:0000312|EMBL:AAD34757.1};
TISSUE=Embryo {ECO:0000312|EMBL:AAD34757.1};
PubMed=10731138; DOI=10.1126/science.287.5461.2222;
Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E.,
Stapleton M., Harvey D.A.;
"A Drosophila complementary DNA resource.";
Science 287:2222-2224(2000).
[4] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL
STAGE, AND DISRUPTION PHENOTYPE.
PubMed=25420147; DOI=10.1371/journal.pone.0113423;
Matsuoka S., Gupta S., Suzuki E., Hiromi Y., Asaoka M.;
"gone early, a novel germline factor, ensures the proper size of the
stem cell precursor pool in the Drosophila ovary.";
PLoS ONE 9:E113423-E113423(2014).
-!- FUNCTION: Plays a role in the ovary in limiting the number of
primordial germ cells (PGCs) that develop directly into gametes,
allowing them instead to enter the developmental pathway that
produces germline stem cells (GSCs) from PGCs and ensuring
lifelong production of gametes from these GSCs. Negatively
regulates epidermal growth factor receptor (Egfr) signaling.
Probably down-regulates EGFR signaling on intermingled cells, a
type of somatic stromal cell which contacts PGCs, and the
resultant low level of signaling limits the proportion of PGCs
which start gametogenesis, maintaining them in an undifferentiated
proliferative state. {ECO:0000269|PubMed:25420147}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25420147};
Single-pass type II membrane protein {ECO:0000255}. Note=Not
uniformly present at the cell membrane but is concentrated at the
interface between germ cells. {ECO:0000269|PubMed:25420147}.
-!- TISSUE SPECIFICITY: In late third larval instar ovaries, detected
in germ cells but not in somatic intermingled cells and is
expressed uniformly in the wing disk. In the embryo, expressed in
the ventral midline, tracheal placodes, and cells forming the
anterior-most row in each segment. {ECO:0000269|PubMed:25420147}.
-!- DEVELOPMENTAL STAGE: In the larva, becomes detectable at the late
second larval instar stage and continues to be expressed
throughout the larval period. {ECO:0000269|PubMed:25420147}.
-!- DISRUPTION PHENOTYPE: Increase in the number of differentiating
germ cells. {ECO:0000269|PubMed:25420147}.
-!- SIMILARITY: Belongs to the peptidase M13 family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AE014298; AAF48659.1; -; Genomic_DNA.
EMBL; AE014298; AHN59820.1; -; Genomic_DNA.
EMBL; AF132169; AAD34757.1; -; mRNA.
RefSeq; NP_001285350.1; NM_001298421.1.
RefSeq; NP_573160.1; NM_132932.3.
UniGene; Dm.7732; -.
ProteinModelPortal; Q9XZ14; -.
SMR; Q9XZ14; -.
IntAct; Q9XZ14; 1.
STRING; 7227.FBpp0074133; -.
PaxDb; Q9XZ14; -.
PRIDE; Q9XZ14; -.
EnsemblMetazoa; FBtr0074359; FBpp0074133; FBgn0027528.
EnsemblMetazoa; FBtr0343364; FBpp0310021; FBgn0027528.
GeneID; 32660; -.
KEGG; dme:Dmel_CG9634; -.
UCSC; CG9634-RA; d. melanogaster.
CTD; 32660; -.
FlyBase; FBgn0027528; goe.
eggNOG; KOG3624; Eukaryota.
eggNOG; COG3590; LUCA.
GeneTree; ENSGT00940000164877; -.
InParanoid; Q9XZ14; -.
OrthoDB; EOG091G03QA; -.
PhylomeDB; Q9XZ14; -.
GenomeRNAi; 32660; -.
PRO; PR:Q9XZ14; -.
Proteomes; UP000000803; Chromosome X.
Bgee; FBgn0027528; Expressed in 39 organ(s), highest expression level in imaginal disc.
ExpressionAtlas; Q9XZ14; baseline and differential.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
GO; GO:2000737; P:negative regulation of stem cell differentiation; IMP:FlyBase.
GO; GO:0048477; P:oogenesis; IMP:FlyBase.
Gene3D; 3.40.390.10; -; 1.
InterPro; IPR024079; MetalloPept_cat_dom_sf.
InterPro; IPR000718; Peptidase_M13.
InterPro; IPR008753; Peptidase_M13_N.
PANTHER; PTHR11733; PTHR11733; 1.
Pfam; PF05649; Peptidase_M13_N; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Differentiation; Glycoprotein;
Membrane; Oogenesis; Reference proteome; Signal-anchor; Transmembrane;
Transmembrane helix.
CHAIN 1 879 Protein gone early. {ECO:0000305}.
/FTId=PRO_0000437210.
TOPO_DOM 1 127 Cytoplasmic. {ECO:0000305}.
TRANSMEM 128 148 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 149 879 Extracellular. {ECO:0000305}.
CARBOHYD 180 180 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 539 539 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 701 701 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 853 853 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
SEQUENCE 879 AA; 100068 MW; 5D06C9000BF5BB48 CRC64;
MAINQGKYKP SICAIDEVDD RSFKLHNSQD EIGGKQQLQQ IEGSETAPLT TNQQKLHMDD
GSHLTPKDLE AARQDALNEV AAGGAGGRTP AAITPNSTHP SANGLRALLL PGRRSFDALM
SLSRKRRILY VTTACLCALL LLIIILLLAF WPEVPFYLRA PLCLDKECVE SSRQLLLWAN
TSKSPCHETY EWACGNFASD YANHEYFVIK RGEWNYETYN EYQELNELNR FIAMLPNSQE
GSVESTVSSL YRSCRETDVL DKSQSDLLLK RAINAVYGWQ AFRDSNRLQS WEYKRVLVVL
QAKHGIFPYY RVTVENGFSN PHDYVITLDE GELGLPDKYF YGNDADEEVV RGYKLLLRDF
AINMGIVSRE ADLFADDIFH YERRIVNHIE DAKADANRPI NKLMRLADLK IKAPSLPILE
SLQAIFPKTK ITEDTEVLVR DPEVMHALSV LLSTSDKKPI NNFIVWSLAR KMLPHLSKEY
RTLAETFDHA LYGRTASYPR WLICSKVVRD WLPFAVDALQ QQPPRQQFET MTSKSRGLNK
TQGNEELLKL MFFSLRNQLK DSLEQAKWLE PAARQFIQKK LNEMRLQFGI PDEVLQQPTY
LAQYYNELIL NNVFFVEHLE WIWTFRRSQM EKKLGPLAIL DVIVSEMYTR DNPQAIAYSN
KLNMLLVSKV LISSNYYDYR YPVAVNFARI GTDILEALID NFSTFLLQFN TQSTDISDAA
PEIRYAQPDV NCLAAGQPPR LVHELNELSS NALKSFHVTL SAARTAARAL SNFVNAIDAG
SAIQGSGIDQ ANTYEALGLT RRLRIPGLRS FNENELFTLS YMQQHCSTTI ADKDYARIKP
LVESQLAESY LFNATWQHIQ FLPRSTNCAA AEATCSNLL


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