Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Protein kinase B beta (RAC-beta serine/threonine-protein kinase) (Thymoma viral proto-oncogene 2, isoform CRA_b)

 Q3HSE5_RAT              Unreviewed;       481 AA.
Q3HSE5;
08-NOV-2005, integrated into UniProtKB/TrEMBL.
08-NOV-2005, sequence version 1.
12-SEP-2018, entry version 114.
RecName: Full=Non-specific serine/threonine protein kinase {ECO:0000256|SAAS:SAAS01060667};
EC=2.7.11.1 {ECO:0000256|SAAS:SAAS01060667};
Name=Akt2 {ECO:0000313|EMBL:EDM07942.1,
ECO:0000313|Ensembl:ENSRNOP00000025303, ECO:0000313|RGD:2082};
ORFNames=rCG_53945 {ECO:0000313|EMBL:EDM07942.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:ABA42095.1};
[1] {ECO:0000313|Ensembl:ENSRNOP00000025303, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000025303,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2] {ECO:0000313|EMBL:EDM07942.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDM07942.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[3] {ECO:0000313|EMBL:EDM07942.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDM07942.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:ABA42095.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Sprague-Dawley {ECO:0000313|EMBL:ABA42095.1};
PubMed=16452480; DOI=10.1074/jbc.M510724200;
He L., Simmen F.A., Mehendale H.M., Ronis M.J.J., Badger T.M.;
"Chronic ethanol intake impairs insulin signaling in rats by
disrupting Akt association with the cell membrane. Role of TRB3 in
inhibition of Akt/protein kinase B activation.";
J. Biol. Chem. 281:11126-11134(2006).
[5] {ECO:0000213|PubMed:22673903}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
[6] {ECO:0000313|Ensembl:ENSRNOP00000025303}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000025303};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
{ECO:0000256|SAAS:SAAS00935732}.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AC120811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; DQ198085; ABA42095.1; -; mRNA.
EMBL; CH473979; EDM07942.1; -; Genomic_DNA.
EMBL; CH473979; EDM07943.1; -; Genomic_DNA.
EMBL; CH473979; EDM07944.1; -; Genomic_DNA.
RefSeq; XP_008757331.1; XM_008759109.2.
RefSeq; XP_008757332.1; XM_008759110.2.
RefSeq; XP_008757333.1; XM_008759111.2.
UniGene; Rn.87066; -.
PRIDE; Q3HSE5; -.
Ensembl; ENSRNOT00000025303; ENSRNOP00000025303; ENSRNOG00000018677.
GeneID; 25233; -.
CTD; 208; -.
RGD; 2082; Akt2.
eggNOG; KOG0598; Eukaryota.
eggNOG; ENOG410XNPH; LUCA.
GeneTree; ENSGT00920000148938; -.
HOVERGEN; HBG108317; -.
OMA; EPMEIKF; -.
OrthoDB; EOG091G06FF; -.
TreeFam; TF102004; -.
Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
Reactome; R-RNO-1358803; Downregulation of ERBB2:ERBB3 signaling.
Reactome; R-RNO-165158; Activation of AKT2.
Reactome; R-RNO-165181; Inhibition of TSC complex formation by PKB.
Reactome; R-RNO-198323; AKT phosphorylates targets in the cytosol.
Reactome; R-RNO-198693; AKT phosphorylates targets in the nucleus.
Reactome; R-RNO-199418; Negative regulation of the PI3K/AKT network.
Reactome; R-RNO-211163; AKT-mediated inactivation of FOXO1A.
Reactome; R-RNO-3769402; Deactivation of the beta-catenin transactivating complex.
Reactome; R-RNO-389357; CD28 dependent PI3K/Akt signaling.
Reactome; R-RNO-389513; CTLA4 inhibitory signaling.
Reactome; R-RNO-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-RNO-5218920; VEGFR2 mediated vascular permeability.
Reactome; R-RNO-5628897; TP53 Regulates Metabolic Genes.
Reactome; R-RNO-6804757; Regulation of TP53 Degradation.
Reactome; R-RNO-6804758; Regulation of TP53 Activity through Acetylation.
Reactome; R-RNO-6804759; Regulation of TP53 Activity through Association with Co-factors.
Reactome; R-RNO-69202; Cyclin E associated events during G1/S transition.
Reactome; R-RNO-69656; Cyclin A:Cdk2-associated events at S phase entry.
Reactome; R-RNO-8876198; RAB GEFs exchange GTP for GDP on RABs.
Reactome; R-RNO-8948751; Regulation of PTEN stability and activity.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000018677; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue.
GO; GO:0005938; C:cell cortex; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0071486; P:cellular response to high light intensity; IEA:Ensembl.
GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IEA:Ensembl.
GO; GO:0032287; P:peripheral nervous system myelin maintenance; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:2001275; P:positive regulation of glucose import in response to insulin stimulus; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0010918; P:positive regulation of mitochondrial membrane potential; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO; GO:0031340; P:positive regulation of vesicle fusion; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:InterPro.
GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0097473; P:retinal rod cell apoptotic process; IEA:Ensembl.
CDD; cd01241; PH_PKB; 1.
CDD; cd05595; STKc_PKB_beta; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR034677; Akt2.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
InterPro; IPR039026; PH_PKB.
InterPro; IPR017892; Pkinase_C.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR039027; RAC_alpha/beta.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24356:SF176; PTHR24356:SF176; 1.
Pfam; PF00169; PH; 1.
Pfam; PF00069; Pkinase; 1.
Pfam; PF00433; Pkinase_C; 1.
SMART; SM00233; PH; 1.
SMART; SM00133; S_TK_X; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding {ECO:0000256|RuleBase:RU000304,
ECO:0000256|SAAS:SAAS00593399};
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Kinase {ECO:0000256|RuleBase:RU000304, ECO:0000256|SAAS:SAAS00593706};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304,
ECO:0000256|SAAS:SAAS00593399};
Proteomics identification {ECO:0000213|PeptideAtlas:Q3HSE5};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304,
ECO:0000256|SAAS:SAAS00593706};
Transferase {ECO:0000256|RuleBase:RU000304,
ECO:0000256|SAAS:SAAS00593706}.
DOMAIN 5 108 PH. {ECO:0000259|PROSITE:PS50003}.
DOMAIN 152 409 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DOMAIN 410 481 AGC-kinase C-terminal.
{ECO:0000259|PROSITE:PS51285}.
SEQUENCE 481 AA; 55629 MW; 4738A48046FE8714 CRC64;
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWI RAIQMVANSL KQRGPGEDAM
DYKCGSPSDS STSEMMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH
LSRERVFTED RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE
LILMEEIRFP RTLGPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG SLELDQRTHF PQFSYSASIR
E


Related products :

Catalog number Product name Quantity
32-105 Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine_threonine protein kinase family, wh 0.1 mL
G4694 Proto-oncogene serine threonine-protein kinase mos (MOS), Rat, ELISA Kit 96T
G4693 Proto-oncogene serine threonine-protein kinase mos (MOS), Pig, ELISA Kit 96T
G4691 Proto-oncogene serine threonine-protein kinase mos (MOS), Human, ELISA Kit 96T
G4692 Proto-oncogene serine threonine-protein kinase mos (MOS), Mouse, ELISA Kit 96T
G6186 RAF proto-oncogene serine threonine-protein kinase (RAF1), Rat, ELISA Kit 96T
RAF1_HUMAN Human ELISA Kit FOR RAF proto-oncogene serine per threonine-protein kinase 96T
E0812r Mouse ELISA Kit FOR Proto-oncogene serine per threonine-protein kinase mos 96T
G4690 Proto-oncogene serine threonine-protein kinase mos (MOS), Chicken, ELISA Kit 96T
SVOP_BOVIN Bovine ELISA Kit FOR RAF proto-oncogene serine per threonine-protein kinase 96T
G4699 Proto-oncogene serine threonine-protein kinase pim-1 (PIM1), Rat, ELISA Kit 96T
G4696 Proto-oncogene serine threonine-protein kinase pim-1 (PIM1), Cat, ELISA Kit 96T
E0726r Bovine ELISA Kit FOR RAF proto-oncogene serine per threonine-protein kinase 96T
G4698 Proto-oncogene serine threonine-protein kinase pim-1 (PIM1), Mouse, ELISA Kit 96T
G4695 Proto-oncogene serine threonine-protein kinase pim-1 (PIM1), Bovine, ELISA Kit 96T
G4697 Proto-oncogene serine threonine-protein kinase pim-1 (PIM1), Human, ELISA Kit 96T
UT-E05024 Human C-Raf Proto Oncogene Serine Threonine Protein Kinase (CRAF) ELISA Kit 96T
G6182 RAF proto-oncogene serine threonine-protein kinase (RAF1), Bovine, ELISA Kit 96T
E2796Hu Human C-Raf Proto Oncogene Serine-Threonine Protein Kinase (CRAF)ELISA Kit 96T
G6183 RAF proto-oncogene serine threonine-protein kinase (RAF1), Chicken, ELISA Kit 96T
YHB0856Hu Human C-Raf Proto Oncogene Serine-Threonine Protein Kinase (CRAF)ELISA Kit 96T
E2796Hu Human C-Raf Proto Oncogene Serine-Threonine Protein Kinase (CRAF)ELISA Kit 48T
YHB0856Hu Human C-Raf Proto Oncogene Serine-Threonine Protein Kinase (CRAF)ELISA Kit 48T
G6185 RAF proto-oncogene serine threonine-protein kinase (RAF1), Mouse, ELISA Kit 96T
E2796Hu Human C-Raf Proto Oncogene Serine per Threonine Protein Kinase (CRAF)ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur