Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Protein kinase C-like 1 (PKC) (EC 2.7.11.13) (Tetradecanoyl phorbol acetate-resistant protein 1)

 KPC1_CAEEL              Reviewed;         704 AA.
P34722;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
22-NOV-2017, entry version 166.
RecName: Full=Protein kinase C-like 1;
Short=PKC;
EC=2.7.11.13;
AltName: Full=Tetradecanoyl phorbol acetate-resistant protein 1;
Name=tpa-1; ORFNames=B0545.1;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
STRAIN=Bristol N2;
PubMed=7658466; DOI=10.1006/jmbi.1995.0449;
Sano T., Tabuse Y., Nishiwaki K., Miwa J.;
"The tpa-1 gene of Caenorhabditis elegans encodes two proteins similar
to Ca(2+)-independent protein kinase Cs: evidence by complete genomic
and complementary DNA sequences of the tpa-1 gene.";
J. Mol. Biol. 251:477-485(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 148-704.
PubMed=2538925; DOI=10.1126/science.2538925;
Tabuse Y., Nishiwaki K., Miwa J.;
"Mutations in a protein kinase C homolog confer phorbol ester
resistance on Caenorhabditis elegans.";
Science 243:1713-1716(1989).
[4]
SEQUENCE REVISION.
Miwa J.;
Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases.
[5]
FUNCTION.
PubMed=17891142; DOI=10.1038/nn1981;
Van Buskirk C., Sternberg P.W.;
"Epidermal growth factor signaling induces behavioral quiescence in
Caenorhabditis elegans.";
Nat. Neurosci. 10:1300-1307(2007).
[6]
FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF PRO-544.
PubMed=19380113; DOI=10.1016/j.chom.2009.03.006;
Ziegler K., Kurz C.L., Cypowyj S., Couillault C., Pophillat M.,
Pujol N., Ewbank J.J.;
"Antifungal innate immunity in C. elegans: PKCdelta links G protein
signaling and a conserved p38 MAPK cascade.";
Cell Host Microbe 5:341-352(2009).
[7]
FUNCTION, AND MUTAGENESIS OF LYS-404.
PubMed=23072806; DOI=10.1038/ncomms2136;
Pastuhov S.I., Fujiki K., Nix P., Kanao S., Bastiani M., Matsumoto K.,
Hisamoto N.;
"Endocannabinoid-Goalpha signalling inhibits axon regeneration in
Caenorhabditis elegans by antagonizing Gqalpha-PKC-JNK signalling.";
Nat. Commun. 3:1136-1136(2012).
[8]
FUNCTION, AND MUTAGENESIS OF GLY-384.
PubMed=22470487; DOI=10.1371/journal.pone.0033887;
Labed S.A., Omi S., Gut M., Ewbank J.J., Pujol N.;
"The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide
gene expression.";
PLoS ONE 7:E33887-E33887(2012).
-!- FUNCTION: Diacylglycerol (DAG)-dependent serine/threonine-protein
kinase that phosphorylates a range of cellular proteins
(Probable). Phosphorylates mlk-1, a component of the JNK pathway.
Involved in axon regeneration after injury probably by activating
the JNK pathway (PubMed:23072806). Plays a role in resistance to
fungal infection and in wound healing by promoting expression of
antimicrobial peptide nlp-29 in the epidermis downstream of gpa-12
and plc-3 and upstream of tir-1-p38-like pathway (PubMed:22470487,
PubMed:19380113). Probably by regulating neuronal transmission in
ALA neurons, regulates the decrease in pharyngeal pumping during
the quiescent state that precedes each larval molt, downstream of
lin-3 and receptor let-23 and phospholipase plc-3
(PubMed:17891142). {ECO:0000269|PubMed:17891142,
ECO:0000269|PubMed:19380113, ECO:0000269|PubMed:22470487,
ECO:0000269|PubMed:23072806, ECO:0000305}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=a;
IsoId=P34722-1; Sequence=Displayed;
Name=b;
IsoId=P34722-2; Sequence=VSP_004744;
-!- DISRUPTION PHENOTYPE: Up-regulation of nlp-29 is severely impaired
in the hyp7 and vulva epidermal cells following fungal infection
by D.coniospora or physical injury. {ECO:0000269|PubMed:19380113}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
protein kinase family. PKC subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; D49525; BAA08470.1; -; Genomic_DNA.
EMBL; D49525; BAA08471.1; -; Genomic_DNA.
EMBL; FO080226; CCD62171.1; -; Genomic_DNA.
EMBL; FO080226; CCD62172.1; -; Genomic_DNA.
EMBL; D14815; BAA03556.1; -; mRNA.
PIR; S60117; S60117.
PIR; T33400; T33400.
RefSeq; NP_499860.1; NM_067459.3. [P34722-1]
RefSeq; NP_499861.1; NM_067460.4. [P34722-2]
UniGene; Cel.12259; -.
ProteinModelPortal; P34722; -.
SMR; P34722; -.
STRING; 6239.B0545.1a; -.
iPTMnet; P34722; -.
EPD; P34722; -.
PaxDb; P34722; -.
PeptideAtlas; P34722; -.
PRIDE; P34722; -.
EnsemblMetazoa; B0545.1a; B0545.1a; WBGene00006599. [P34722-1]
GeneID; 176825; -.
KEGG; cel:CELE_B0545.1; -.
UCSC; B0545.1a; c. elegans. [P34722-1]
CTD; 176825; -.
WormBase; B0545.1a; CE17353; WBGene00006599; tpa-1. [P34722-1]
WormBase; B0545.1b; CE17354; WBGene00006599; tpa-1. [P34722-2]
eggNOG; KOG0694; Eukaryota.
eggNOG; ENOG410XNPH; LUCA.
GeneTree; ENSGT00820000126964; -.
HOGENOM; HOG000233022; -.
InParanoid; P34722; -.
KO; K06068; -.
OMA; FIFHKVL; -.
OrthoDB; EOG091G0QRS; -.
PhylomeDB; P34722; -.
BRENDA; 2.7.11.13; 1045.
Reactome; R-CEL-111933; Calmodulin induced events.
Reactome; R-CEL-114508; Effects of PIP2 hydrolysis.
Reactome; R-CEL-1489509; DAG and IP3 signaling.
Reactome; R-CEL-202424; Downstream TCR signaling.
Reactome; R-CEL-2029485; Role of phospholipids in phagocytosis.
Reactome; R-CEL-2871837; FCERI mediated NF-kB activation.
Reactome; R-CEL-373752; Netrin-1 signaling.
Reactome; R-CEL-450520; HuR (ELAVL1) binds and stabilizes mRNA.
Reactome; R-CEL-5218921; VEGFR2 mediated cell proliferation.
Reactome; R-CEL-5607764; CLEC7A (Dectin-1) signaling.
Reactome; R-CEL-6798695; Neutrophil degranulation.
SignaLink; P34722; -.
PRO; PR:P34722; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00006599; -.
GO; GO:0005622; C:intracellular; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:UniProtKB.
GO; GO:0004697; F:protein kinase C activity; IEA:UniProtKB-EC.
GO; GO:0004674; F:protein serine/threonine kinase activity; IMP:UniProtKB.
GO; GO:0050832; P:defense response to fungus; IMP:WormBase.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IMP:UniProtKB.
GO; GO:1904922; P:positive regulation of MAPK cascade involved in axon regeneration; IMP:UniProtKB.
GO; GO:0009611; P:response to wounding; IMP:WormBase.
CDD; cd00029; C1; 2.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR035892; C2_domain_sf.
InterPro; IPR020454; DAG/PE-bd.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR002219; PE/DAG-bd.
InterPro; IPR017892; Pkinase_C.
InterPro; IPR014376; Prot_kin_PKC_delta.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00130; C1_1; 2.
Pfam; PF00069; Pkinase; 1.
Pfam; PF00433; Pkinase_C; 1.
PIRSF; PIRSF000551; PKC_delta; 1.
PRINTS; PR00008; DAGPEDOMAIN.
SMART; SM00109; C1; 2.
SMART; SM00133; S_TK_X; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF49562; SSF49562; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PROSITE; PS00479; ZF_DAG_PE_1; 2.
PROSITE; PS50081; ZF_DAG_PE_2; 2.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Complete proteome; Kinase;
Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
Repeat; Serine/threonine-protein kinase; Transferase; Zinc;
Zinc-finger.
CHAIN 1 704 Protein kinase C-like 1.
/FTId=PRO_0000055734.
DOMAIN 375 634 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
DOMAIN 635 704 AGC-kinase C-terminal.
ZN_FING 165 215 Phorbol-ester/DAG-type 1.
{ECO:0000255|PROSITE-ProRule:PRU00226}.
ZN_FING 237 287 Phorbol-ester/DAG-type 2.
{ECO:0000255|PROSITE-ProRule:PRU00226}.
NP_BIND 381 389 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 499 499 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 404 404 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 89 89 Phosphothreonine; by autocatalysis.
{ECO:0000255}.
MOD_RES 139 139 Phosphothreonine; by autocatalysis.
{ECO:0000255}.
MOD_RES 324 324 Phosphothreonine; by autocatalysis.
{ECO:0000255}.
VAR_SEQ 1 137 Missing (in isoform b). {ECO:0000305}.
/FTId=VSP_004744.
MUTAGEN 384 384 G->E: Severe loss of nlp-29 expression
upon D.coniospora infection.
{ECO:0000269|PubMed:22470487}.
MUTAGEN 404 404 K->R: Probable loss of kinase activity.
Loss of mlk-1 phosphorylation.
{ECO:0000269|PubMed:23072806}.
MUTAGEN 544 544 P->S: In k501; normal up-regulation of
nlp-29 upon D.coniospora infection or
physical injury.
{ECO:0000269|PubMed:19380113}.
SEQUENCE 704 AA; 80298 MW; C44F2E25F58057E3 CRC64;
MAQAENACRL KLLRADVPVD LLPAGCSATD LQPAVNVKEK IEVNGESRLV QKKKTLYPEW
EKCWDTAVAE GRILQIVLMF NQTPVVEATM RLEDIISKCK SDAITHIWIN TKPNGRILAQ
TRHLKNAPDD DHPVEDIMTS RSNSGPGIQR RRGAIKHARV HEIRGHQFVA TFFRQPHFCS
LCSDFMWGLN KQGYQCQLCS AAVHKKCHEK VIMQCPGSAK NTKETMALKE RFKVDIPHRF
KTYNFKSPTF CDHCGSMLYG LFKQGLRCEV CNVACHHKCE RLMSNLCGVN QKQLSEMYHE
IKRGTHATAS CPPNIANLHL NGETSKNNGS LPNKLKNLFK SHQYSVEEQK ETDEYMDNIW
GGGDGPVKKF ALPHFNLLKV LGKGSFGKVM LVELKGKNEF YAMKCLKKDV ILEDDDTECT
YIERRVLILA SQCPFLCQLF CSFQTNEYLF FVMEYLNGGD LMHHIQQIKK FDEARTRFYA
CEIVVALQFL HTNNIIYRDL KLDNVLLDCD GHIKLADFGM AKTEMNRENG MASTFCGTPD
YISPEIIKGQ LYNEAVDFWS FGVLMYEMLV GQSPFHGEGE DELFDSILNE RPYFPKTISK
EAAKCLSALF DRNPNTRLGM PECPDGPIRQ HCFFRGVDWK RFENRQVPPP FKPNIKSNSD
ASNFDDDFTN EKAALTPVHD KNLLASIDPE AFLNFSYTNP HFSK


Related products :

Catalog number Product name Quantity
EH1496 Phorbol-12-myristate-13-acetate-induced protein 1 Elisa Kit 96T
APR_RAT Rat ELISA Kit FOR Phorbol-12-myristate-13-acetate-induced protein 1 96T
CSB-EL018229RA Rat Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) ELISA kit 96T
CSB-EL018229DO Dog Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) ELISA kit 96T
PMEPA1 PMAIP1 Gene phorbol-12-myristate-13-acetate-induced protein 1
CSB-EL018229MO Mouse Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) ELISA kit 96T
CSB-EL018229RA Rat Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) ELISA kit SpeciesRat 96T
CSB-EL018229DO Dog Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) ELISA kit SpeciesDog 96T
CSB-EL018229HU Human Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) ELISA kit 96T
1544-5 Phorbol-12-myristate 13-acetate (PMA) PMA, 12-O-Tetradecanoylphorbol 13-acetate,TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate 5 mg
CSB-EL018229MO Mouse Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) ELISA kit SpeciesMouse 96T
CSB-EL018229HU Human Phorbol-12-myristate-13-acetate-induced protein 1(PMAIP1) ELISA kit SpeciesHuman 96T
APR_RAT ELISA Kit FOR Phorbol-12-myristate-13-acetate-induced protein 1; organism: Rat; gene name: Pmaip1 96T
APR_MOUSE ELISA Kit FOR Phorbol-12-myristate-13-acetate-induced protein 1; organism: Mouse; gene name: Pmaip1 96T
orb61074 Phorbol 12-Myristate 13-Acetate Phorbol 12-Myristate 13-Acetate For research use only. 1 mg
CSB-EL018229RA Rat phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
GWB-7E3FD1 Phorbol-12-myristate-13-acetate-induced Protein 1 (PMAIP1) Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
CSB-EL018229DO Dog phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) ELISA kit, Species Dog, Sample Type serum, plasma 96T
GWB-71AECB Phorbol-12-myristate-13-acetate-induced Protein 1 (PMAIP1) Rabbit anti-Mouse Polyclonal (aa51-66) Antibody
67395-95-3 N-Tetradecanoyl-alanine mono sodium s N-tetradecanoyl-alanin 1g
orb61087 4alpha-Phorbol 12-Myristate 13-Acetate 4alpha-Phorbol 12-Myristate 13-Acetate For research use only. 1 mg
36577-41-0 N-Tetradecanoyl-phenlyalanine mono so N-tetradecanoyl-phenly 1g
68792-49-4 N-Tetradecanoyl-phenlyalanine N-tetradecanoyl-phenly 1g
848390-99-8 N-Tetradecanoyl-hydroxyproline N-tetradecanoyl-Hydrox 1g
71448-29-8 N-Tetradecanoyl-alanine N-tetradecanoyl-alanin 1g


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur