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Protein kinase DC2 (EC 2.7.11.1)

 KDC2_DROME              Reviewed;         583 AA.
P16912; Q86BP5; Q8MSN9; Q9VUV5;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
16-AUG-2005, sequence version 2.
23-MAY-2018, entry version 166.
RecName: Full=Protein kinase DC2;
EC=2.7.11.1;
Name=Pka-C3; Synonyms=DC2; ORFNames=CG6117;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
STRAIN=Canton-S;
PubMed=3215511; DOI=10.1101/gad.2.12a.1539;
Kalderon D., Rubin G.M.;
"Isolation and characterization of Drosophila cAMP-dependent protein
kinase genes.";
Genes Dev. 2:1539-1556(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
STRAIN=Berkeley; TISSUE=Testis;
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[5]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=8601490;
Melendez A., Li W., Kalderon D.;
"Activity, expression and function of a second Drosophila protein
kinase A catalytic subunit gene.";
Genetics 141:1507-1520(1995).
-!- FUNCTION: Does not have an essential role in development.
{ECO:0000269|PubMed:8601490}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=B;
IsoId=P16912-1; Sequence=Displayed;
Name=A;
IsoId=P16912-2; Sequence=VSP_015105;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in embryonic mesoderm, and the optic
lamina, wing disk and leg disks of third instar larvae. More
abundant in adult head than adult body.
{ECO:0000269|PubMed:8601490}.
-!- DEVELOPMENTAL STAGE: Expressed throughout development.
-!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
protein kinase family. cAMP subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AE014296; AAF49568.2; -; Genomic_DNA.
EMBL; AE014296; AAN11771.2; -; Genomic_DNA.
EMBL; AY118681; AAM50541.1; -; mRNA.
RefSeq; NP_524097.2; NM_079373.4. [P16912-2]
RefSeq; NP_730083.2; NM_168638.3. [P16912-1]
UniGene; Dm.7805; -.
ProteinModelPortal; P16912; -.
SMR; P16912; -.
BioGrid; 65045; 5.
IntAct; P16912; 2.
STRING; 7227.FBpp0075283; -.
PaxDb; P16912; -.
PRIDE; P16912; -.
EnsemblMetazoa; FBtr0075528; FBpp0075283; FBgn0000489. [P16912-1]
EnsemblMetazoa; FBtr0075529; FBpp0075284; FBgn0000489. [P16912-2]
GeneID; 39733; -.
KEGG; dme:Dmel_CG6117; -.
CTD; 39733; -.
FlyBase; FBgn0000489; Pka-C3.
eggNOG; KOG0616; Eukaryota.
eggNOG; ENOG410XPQQ; LUCA.
GeneTree; ENSGT00810000125385; -.
InParanoid; P16912; -.
KO; K19584; -.
OMA; VSEKYCA; -.
OrthoDB; EOG091G10O8; -.
PhylomeDB; P16912; -.
BRENDA; 2.7.11.1; 1994.
SignaLink; P16912; -.
GenomeRNAi; 39733; -.
PRO; PR:P16912; -.
Proteomes; UP000000803; Chromosome 3L.
Bgee; FBgn0000489; -.
ExpressionAtlas; P16912; baseline and differential.
Genevisible; P16912; DM.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004691; F:cAMP-dependent protein kinase activity; IDA:FlyBase.
GO; GO:0004674; F:protein serine/threonine kinase activity; NAS:FlyBase.
GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
GO; GO:0006468; P:protein phosphorylation; IDA:FlyBase.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00133; S_TK_X; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
Alternative splicing; ATP-binding; Complete proteome; Kinase;
Nucleotide-binding; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 583 Protein kinase DC2.
/FTId=PRO_0000086112.
DOMAIN 274 528 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
DOMAIN 529 583 AGC-kinase C-terminal.
NP_BIND 280 288 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
COMPBIAS 202 252 Asp-rich.
ACT_SITE 397 397 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 303 303 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
VAR_SEQ 1 83 Missing (in isoform A).
{ECO:0000303|PubMed:3215511}.
/FTId=VSP_015105.
CONFLICT 122 122 K -> KKK (in Ref. 1 and 4).
{ECO:0000305}.
CONFLICT 186 186 N -> K (in Ref. 1). {ECO:0000305}.
CONFLICT 217 217 N -> D (in Ref. 1 and 4). {ECO:0000305}.
SEQUENCE 583 AA; 65407 MW; DC52142F06F2625B CRC64;
MDLWHIFLER ILVACRVSAS VFANFGCGLY SSWKLICGDH DSASGLRAGL ATPTQRGKAT
GDNGTTGTPA RTIGKPQARI ATAMSTATCA RFCTPLSSGT AGSTSKLTTG NGSGNTMTSA
YKIPSNNSTT ANDSSNTETT FTFKLGRSNG RSSSNVASSE SSDPLESDYS EEDPEQEQQR
PDPATNSRSS STATTTTTSS ADHDNDVDEE DEEDDENEGE GNGRDADDAT HDSSESIEED
DGNETDDEED DDESEESSSV QTAKGVRKYH LDDYQIIKTV GTGTFGRVCL CRDRISEKYC
AMKILAMTEV IRLKQIEHVK NERNILREIR HPFVISLEWS TKDDSNLYMI FDYVCGGELF
TYLRNAGKFT SQTSNFYAAE IVSALEYLHS LQIVYRDLKP ENLLINRDGH LKITDFGFAK
KLRDRTWTLC GTPEYIAPEI IQSKGHNKAV DWWALGVLIY EMLVGYPPFY DEQPFGIYEK
ILSGKIEWER HMDPIAKDLI KKLLVNDRTK RLGNMKNGAD DVKRHRWFKH LNWNDVYSKK
LKPPILPDVH HDGDTKNFDD YPEKDWKPAK AVDQRDLQYF NDF


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