GENTAUR Molecular Products.

 MAB3_CAEEL              Reviewed;         290 AA.
 O18214; Q8I0Z0;
 08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
 01-JAN-1998, sequence version 1.
 28-MAR-2018, entry version 125.
 RecName: Full=Protein male abnormal 3;
 Name=mab-3; ORFNames=Y53C12B.5;
 Caenorhabditis elegans.
 Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
 Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
 NCBI_TaxID=6239;
 [1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A), FUNCTION, AND
 DEVELOPMENTAL STAGE.
 STRAIN=Bristol N2;
 PubMed=9490411; DOI=10.1038/35618;
 Raymond C.S., Shamu C.E., Shen M.M., Seifert K.J., Hirsch B.,
 Hodgkin J., Zarkower D.;
 "Evidence for evolutionary conservation of sex-determining genes.";
 Nature 391:691-695(1998).
 [2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
 SPLICING.
 STRAIN=Bristol N2;
 PubMed=9851916; DOI=10.1126/science.282.5396.2012;
 The C. elegans sequencing consortium;
 "Genome sequence of the nematode C. elegans: a platform for
 investigating biology.";
 Science 282:2012-2018(1998).
 -!- FUNCTION: Promotes male-specific development of two tissues. In
     the peripheral nervous system, directs differentiation of sensory
     ray neuroblasts into peripheral sense organs. In the intestine,
     causes repression of vitellogenin gene transcription. Binds the
     DNA motif 5'-[CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a
     monomer. {ECO:0000269|PubMed:9490411}.
 -!- INTERACTION:
     Q10666:pop-1; NbExp=3; IntAct=EBI-2420993, EBI-317870;
 -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
     ProRule:PRU00070}.
 -!- ALTERNATIVE PRODUCTS:
     Event=Alternative splicing; Named isoforms=2;
     Name=a;
       IsoId=O18214-1; Sequence=Displayed;
     Name=b;
       IsoId=O18214-2; Sequence=VSP_015559, VSP_015560;
       Note=No experimental confirmation available.;
 -!- DEVELOPMENTAL STAGE: Expressed in late larvae of both sexes. In
     the fourth larval stage, expression is approximately six-fold
     higher in males than in hermaphrodites. In adults, expression is
     undetectable in XX hermaphrodites, but persists in XO males.
     {ECO:0000269|PubMed:9490411}.
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 EMBL; AF022388; AAC38956.1; -; Genomic_DNA.
 EMBL; Z99278; CAB16489.1; -; Genomic_DNA.
 EMBL; Z99278; CAD59170.1; -; Genomic_DNA.
 PIR; T27132; T27132.
 RefSeq; NP_001022464.1; NM_001027293.1. [O18214-1]
 RefSeq; NP_871909.2; NM_182109.4.
 UniGene; Cel.14693; -.
 ProteinModelPortal; O18214; -.
 SMR; O18214; -.
 IntAct; O18214; 55.
 STRING; 6239.Y53C12B.5a; -.
 PaxDb; O18214; -.
 EnsemblMetazoa; Y53C12B.5a; Y53C12B.5a; WBGene00003100. [O18214-1]
 GeneID; 174533; -.
 KEGG; cel:CELE_Y53C12B.5; -.
 UCSC; Y53C12B.5a; c. elegans. [O18214-1]
 CTD; 174533; -.
 WormBase; Y53C12B.5a; CE14902; WBGene00003100; mab-3. [O18214-1]
 WormBase; Y53C12B.5b; CE51560; WBGene00003100; mab-3.
 eggNOG; KOG3815; Eukaryota.
 eggNOG; ENOG410XSK9; LUCA.
 GeneTree; ENSGT00900000142474; -.
 HOGENOM; HOG000016185; -.
 InParanoid; O18214; -.
 OMA; RCLNHGE; -.
 OrthoDB; EOG091G0PSC; -.
 SignaLink; O18214; -.
 PRO; PR:O18214; -.
 Proteomes; UP000001940; Chromosome II.
 Bgee; WBGene00003100; -.
 GO; GO:0005634; C:nucleus; IC:WormBase.
 GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:WormBase.
 GO; GO:0001012; F:RNA polymerase II regulatory region DNA binding; IDA:WormBase.
 GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:WormBase.
 GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
 GO; GO:0010628; P:positive regulation of gene expression; IGI:WormBase.
 GO; GO:0007548; P:sex differentiation; IMP:WormBase.
 Gene3D; 4.10.1040.10; -; 2.
 InterPro; IPR001275; DM_DNA-bd.
 InterPro; IPR036407; DM_DNA-bd_sf.
 InterPro; IPR026607; DMRT/dsx/mab-3.
 PANTHER; PTHR12322; PTHR12322; 2.
 Pfam; PF00751; DM; 2.
 SMART; SM00301; DM; 2.
 SUPFAM; SSF82927; SSF82927; 2.
 PROSITE; PS40000; DM_1; 2.
 PROSITE; PS50809; DM_2; 2.
 1: Evidence at protein level;
 Alternative splicing; Complete proteome; Developmental protein;
 Differentiation; DNA-binding; Metal-binding; Nucleus;
 Reference proteome; Repeat; Sexual differentiation; Zinc.
 CHAIN         1    290       Protein male abnormal 3.
                              /FTId=PRO_0000207051.
 DNA_BIND     28     74       DM 1. {ECO:0000255|PROSITE-
                              ProRule:PRU00070}.
 DNA_BIND     94    142       DM 2. {ECO:0000255|PROSITE-
                              ProRule:PRU00070}.
 COMPBIAS    183    209       Pro/Ser-rich.
 COMPBIAS    238    241       Poly-Gln.
 VAR_SEQ       1    133       Missing (in isoform b). {ECO:0000305}.
                              /FTId=VSP_015559.
 VAR_SEQ     281    290       MYLKNYGLQA -> IKIVCFPSLLNFPHNLFLSLVSNSMIF
                              SYFLEFSLFTNFVIFSNFFIHFSPSEPTNLPIFFSSSRPLV
                              LFQKSPFFLNSNNLFVSHQTTYYLSMSLRHLIMSSISSKIP
                              KFHRYSSVCIDFPLSPPKLS (in isoform b).
                              {ECO:0000305}.
                              /FTId=VSP_015560.
 SEQUENCE   290 AA;  32463 MW;  2F324FFB0B8846D5 CRC64;
 MLTEDPVSEI CEAKAVDELA EQEKNYYCQR CLNHGELKPR KGHKPDCRYL KCPCRECTMV
 EQRRQLNNLL SKKKIHCTPA TQTRDGKRVR DPHCARCSAH GVLVPLRGHK RTMCQFVTCE
 CTLCTLVEHR RNLMAAQIKL RRSQQKSRDG KEPKRNSRRK SKDMDMEMMV VTATDGQKII
 GTSASPSPSS TTDTMSPSLS MSPPCSPSPL LAQYTLTLAA PIPIYPPIPM NQQLISLQQQ
 QFLMSIIQNM APSIGQQAPL LPGISAGSVS SAAILNEFWS MYLKNYGLQA

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