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Protein ovarian tumor locus

 OTU_DROME               Reviewed;         853 AA.
P10383; A4V451; Q8SYF4; Q9GYD8; Q9TWA9; Q9W3E4;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 2.
12-SEP-2018, entry version 161.
RecName: Full=Protein ovarian tumor locus;
Name=otu; ORFNames=CG12743;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
STRAIN=Canton-S; TISSUE=Ovary;
PubMed=2498839; DOI=10.1093/nar/17.8.3304;
Champe M.A., Laird C.D.;
"Nucleotide sequence of a cDNA from the putative ovarian tumor locus
of Drosophila melanogaster.";
Nucleic Acids Res. 17:3304-3304(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Canton-S;
PubMed=2511440; DOI=10.1128/MCB.9.12.5726;
Steinhauer W.R., Walsh R.C., Kalfayan L.J.;
"Sequence and structure of the Drosophila melanogaster ovarian tumor
gene and generation of an antibody specific for the ovarian tumor
protein.";
Mol. Cell. Biol. 9:5726-5732(1989).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B), FUNCTION, AND
SUBCELLULAR LOCATION.
STRAIN=Canton-S;
PubMed=1737618; DOI=10.1101/gad.6.2.233;
Steinhauer W.R., Kalfayan L.J.;
"A specific ovarian tumor protein isoform is required for efficient
differentiation of germ cells in Drosophila oogenesis.";
Genes Dev. 6:233-243(1992).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[5]
GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
STRAIN=Berkeley; TISSUE=Embryo;
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[7]
ACTIVATION BY STIL.
PubMed=10101125;
Sahut-Barnola I., Pauli D.;
"The Drosophila gene stand still encodes a germline chromatin-
associated protein that controls the transcription of the ovarian
tumor gene.";
Development 126:1917-1926(1999).
-!- FUNCTION: Essential for female fertility; germ cell division and
differentiation. {ECO:0000269|PubMed:1737618}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1737618}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=B; Synonyms=C;
IsoId=P10383-1; Sequence=Displayed;
Note=No experimental confirmation available.;
Name=A;
IsoId=P10383-2; Sequence=VSP_004354;
-!- TISSUE SPECIFICITY: Expressed in both oocyte and nurse cells of
the germarium.
-!- INDUCTION: Expression is cooperatively activated by Ovo and Stil.
-!- SEQUENCE CAUTION:
Sequence=AAL49210.1; Type=Frameshift; Positions=308; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X13693; CAA31983.1; -; mRNA.
EMBL; M30825; AAA28740.1; -; Genomic_DNA.
EMBL; M30825; AAF97987.1; -; Genomic_DNA.
EMBL; AE014298; AAF46384.1; -; Genomic_DNA.
EMBL; AE014298; AAN09234.1; -; Genomic_DNA.
EMBL; AE014298; AAS65286.1; -; Genomic_DNA.
EMBL; AY071588; AAL49210.1; ALT_FRAME; mRNA.
PIR; B41760; B41760.
PIR; S04085; S04085.
RefSeq; NP_001259332.1; NM_001272403.1. [P10383-2]
RefSeq; NP_001259333.1; NM_001272404.1. [P10383-2]
RefSeq; NP_511089.2; NM_078534.4. [P10383-1]
RefSeq; NP_727271.1; NM_167158.3. [P10383-2]
RefSeq; NP_996379.1; NM_206656.2. [P10383-1]
UniGene; Dm.7029; -.
ProteinModelPortal; P10383; -.
SMR; P10383; -.
BioGrid; 58248; 17.
DIP; DIP-19612N; -.
IntAct; P10383; 1.
STRING; 7227.FBpp0071181; -.
PaxDb; P10383; -.
PRIDE; P10383; -.
EnsemblMetazoa; FBtr0071236; FBpp0071180; FBgn0003023. [P10383-2]
EnsemblMetazoa; FBtr0071237; FBpp0071181; FBgn0003023. [P10383-1]
EnsemblMetazoa; FBtr0071238; FBpp0089325; FBgn0003023. [P10383-1]
EnsemblMetazoa; FBtr0333146; FBpp0305351; FBgn0003023. [P10383-2]
EnsemblMetazoa; FBtr0333147; FBpp0305352; FBgn0003023. [P10383-2]
GeneID; 31789; -.
KEGG; dme:Dmel_CG12743; -.
CTD; 31789; -.
FlyBase; FBgn0003023; otu.
eggNOG; ENOG410INQ8; Eukaryota.
eggNOG; ENOG4111T74; LUCA.
GeneTree; ENSGT00530000063508; -.
InParanoid; P10383; -.
KO; K13718; -.
OMA; NMGVDMH; -.
OrthoDB; EOG091G0MOZ; -.
PhylomeDB; P10383; -.
Reactome; R-DME-446193; Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.
GenomeRNAi; 31789; -.
PRO; PR:P10383; -.
Proteomes; UP000000803; Chromosome X.
Bgee; FBgn0003023; Expressed in 9 organ(s), highest expression level in female gonad.
ExpressionAtlas; P10383; baseline and differential.
Genevisible; P10383; DM.
GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
GO; GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; ISS:FlyBase.
GO; GO:0019099; P:female germ-line sex determination; NAS:FlyBase.
GO; GO:0007281; P:germ cell development; TAS:FlyBase.
GO; GO:0048477; P:oogenesis; TAS:FlyBase.
GO; GO:0032877; P:positive regulation of DNA endoreduplication; IMP:FlyBase.
GO; GO:0016579; P:protein deubiquitination; ISS:FlyBase.
InterPro; IPR003323; OTU_dom.
InterPro; IPR038765; Papain_like_cys_pep_sf.
InterPro; IPR002999; Tudor.
Pfam; PF02338; OTU; 1.
SMART; SM00333; TUDOR; 1.
SUPFAM; SSF54001; SSF54001; 1.
PROSITE; PS50802; OTU; 1.
PROSITE; PS50304; TUDOR; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Cytoplasm;
Reference proteome.
CHAIN 1 853 Protein ovarian tumor locus.
/FTId=PRO_0000058104.
DOMAIN 29 150 OTU. {ECO:0000255|PROSITE-
ProRule:PRU00139}.
DOMAIN 336 396 Tudor. {ECO:0000255|PROSITE-
ProRule:PRU00211}.
VAR_SEQ 340 381 Missing (in isoform A).
{ECO:0000303|PubMed:12537569,
ECO:0000303|PubMed:2498839}.
/FTId=VSP_004354.
CONFLICT 300 300 K -> Q (in Ref. 1; CAA31983).
{ECO:0000305}.
CONFLICT 831 831 T -> P (in Ref. 3; AAA28740/AAF97987).
{ECO:0000305}.
SEQUENCE 853 AA; 97452 MW; D7C1F9453377B075 CRC64;
MDMQVQRPIT SGSRQAPDPY DQYLESRGLY RKHTARDASS LFRVIAEQMY DTQMLHYEIR
LECVRFMTLK RRIFEKEIPG DFDSYMQDMS KPKTYGTMTE LRAMSCLYRR NVILYEPYNM
GTSVVFNRRY AENFRVFFNN ENHFDSVYDV EYIERAAICQ SIAFKLLYQK LFKLPDVSFA
VEIMLHPHTF NWDRFNVEFD DKGYMVRIHC TDGRVFKLDL PGDTNCILEN YKLCNFHSTN
GNQSINARKG GRLEIKNQEE RKASGSSGHE PNDLLPMCPN RLESCVRQLL DDGISPFPYK
VAKSMDPYMY RNIEFDCWND MRKEAKLYNV YINDYNFKVG AKCKVELPNE TEMYTCHVQN
ISKDKNYCHV FVERIGKEIV VPYESLHPLP PDEYRPWSLP FRYHRQMPRL PLPKYAGKAN
KSSKWKKNKL FEMDQYFEHS KCDLMPYMPV DNCYQGVHIQ DDEQRDHNDP EQNDQNPTTE
QRDREEPQAQ KQHQRTKASR VQPQNSSSSQ NQEVSGSAAP PPTQYMNYVP MIPSRPGHLP
PPWPASPMAI AEEFPFPISG TPHPPPTEGC VYMPFGGYGP PPPGAVALSG PHPFMPLPSP
PLNVTGIGEP RRSLHPNGED LPVDMVTLRY FYNMGVDLHW RMSHHTPPDE LGMFGYHQQN
NTDQQAGRTV VIGATEDNLT AVESTPPPSP EVANATEQSP LEKSAYAKRN LNSVKVRGKR
PEQLQDIKDS LGPAAFLPTP TPSPSSNGSQ FSFYTTPSPH HHLITPPRLL QPPPPPPIFY
HKAGPPQLGG AAQGQTPYAW GMPAPVVSPY EVINNYNMDP SAQPQQQQPA TLQPAPLSVQ
SQPAAVYAAT RHH


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