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Protein phosphatase 1 regulatory subunit 3B (33 kDa glycogen-binding protein) (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL)

 PPR3B_RAT               Reviewed;         284 AA.
Q6IN01; Q63759;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
25-OCT-2017, entry version 87.
RecName: Full=Protein phosphatase 1 regulatory subunit 3B;
AltName: Full=33 kDa glycogen-binding protein;
AltName: Full=Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL;
AltName: Full=Protein phosphatase 1 regulatory subunit 4;
Short=PP1 subunit R4;
AltName: Full=Protein phosphatase 1 subunit GL;
Name=Ppp1r3b; Synonyms=Ppp1r4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 42-56; 61-98; 150-157;
161-169; 181-199; 201-220; 238-259 AND 280-284, FUNCTION, INTERACTION
WITH PYGL, AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley; TISSUE=Liver;
PubMed=7498521; DOI=10.1016/0014-5793(95)01184-G;
Doherty M.J., Moorhead G., Morrice N., Cohen P., Cohen P.T.W.;
"Amino acid sequence and expression of the hepatic glycogen-binding
(GL)-subunit of protein phosphatase-1.";
FEBS Lett. 375:294-298(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 61-76 AND 150-157, INTERACTION WITH PPP1CC AND
PYGL, AND ASSOCIATION WITH GLYCOGEN.
PubMed=7720853; DOI=10.1016/0014-5793(95)00197-H;
Moorhead G., MacKintosh C., Morrice N., Cohen P.;
"Purification of the hepatic glycogen-associated form of protein
phosphatase-1 by microcystin-Sepharose affinity chromatography.";
FEBS Lett. 362:101-105(1995).
[4]
INTERACTION WITH GLYCOGEN; PPP1CC AND PYGL.
PubMed=9841883; DOI=10.1042/bj3360699;
Armstrong C.G., Doherty M.J., Cohen P.T.W.;
"Identification of the separate domains in the hepatic glycogen-
targeting subunit of protein phosphatase 1 that interact with
phosphorylase a, glycogen and protein phosphatase 1.";
Biochem. J. 336:699-704(1998).
[5]
FUNCTION.
PubMed=10862764; DOI=10.1074/jbc.M002427200;
Gasa R., Jensen P.B., Berman H.K., Brady M.J., DePaoli-Roach A.A.,
Newgard C.B.;
"Distinctive regulatory and metabolic properties of glycogen-targeting
subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in
hepatocytes.";
J. Biol. Chem. 275:26396-26403(2000).
[6]
TISSUE SPECIFICITY.
PubMed=11872655; DOI=10.2337/diabetes.51.3.591;
Munro S., Cuthbertson D.J., Cunningham J., Sales M., Cohen P.T.W.;
"Human skeletal muscle expresses a glycogen-targeting subunit of PP1
that is identical to the insulin-sensitive glycogen-targeting subunit
G(L) of liver.";
Diabetes 51:591-598(2002).
[7]
FUNCTION.
PubMed=17555403; DOI=10.1042/BJ20061572;
Montori-Grau M., Guitart M., Lerin C., Andreu A.L., Newgard C.B.,
Garcia-Martinez C., Gomez-Foix A.M.;
"Expression and glycogenic effect of glycogen-targeting protein
phosphatase 1 regulatory subunit GL in cultured human muscle.";
Biochem. J. 405:107-113(2007).
-!- FUNCTION: Acts as a glycogen-targeting subunit for phosphatase
PP1. Facilitates interaction of the PP1 with enzymes of the
glycogen metabolism and regulates its activity. Suppresses the
rate at which PP1 dephosphorylates (inactivates) glycogen
phosphorylase and enhances the rate at which it activates glycogen
synthase and therefore limits glycogen breakdown. Its activity is
inhibited by PYGL, resulting in inhibition of the glycogen
synthase and glycogen phosphorylase phosphatase activities of PP1.
Dramatically increases basal and insulin-stimulated glycogen
synthesis upon overexpression in hepatocytes.
{ECO:0000269|PubMed:10862764, ECO:0000269|PubMed:17555403,
ECO:0000269|PubMed:7498521}.
-!- SUBUNIT: Interacts with glycogen, PPP1CC catalytic subunit of PP1
and PYGL. Associates with glycogen particles. Forms complexes with
debranching enzyme, glycogen phosphorylase, glycogen synthase and
phosphorylase kinase which is necessary for its regulation of PP1
activity. {ECO:0000269|PubMed:7498521, ECO:0000269|PubMed:7720853,
ECO:0000269|PubMed:9841883}.
-!- TISSUE SPECIFICITY: Highly expressed in liver. Moderately
expressed in kidney, heart, testis, spleen and lung. Weakly
expressed in skeletal muscle (at protein level). Expressed
predominantly in liver. Expressed moderately in heart. Expressed
weakly in lung, kidney, spleen and skeletal muscle.
{ECO:0000269|PubMed:11872655, ECO:0000269|PubMed:7498521}.
-!- DOMAIN: The PP1-binding domain is located between residues 59 and
94. The glycogen-binding domain is located between residues 94 and
257. The PYGL-binding site lies in the C-terminal 16 amino acids.
-----------------------------------------------------------------------
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EMBL; Y18208; CAA77083.1; -; mRNA.
EMBL; BC072514; AAH72514.1; -; mRNA.
PIR; S68216; S68216.
RefSeq; NP_620267.2; NM_138912.2.
RefSeq; XP_006253277.1; XM_006253215.2.
RefSeq; XP_006253278.1; XM_006253216.3.
UniGene; Rn.30046; -.
ProteinModelPortal; Q6IN01; -.
SMR; Q6IN01; -.
IntAct; Q6IN01; 1.
STRING; 10116.ENSRNOP00000042713; -.
CAZy; CBM21; Carbohydrate-Binding Module Family 21.
iPTMnet; Q6IN01; -.
PhosphoSitePlus; Q6IN01; -.
PaxDb; Q6IN01; -.
PRIDE; Q6IN01; -.
DNASU; 192280; -.
Ensembl; ENSRNOT00000051720; ENSRNOP00000042713; ENSRNOG00000011474.
Ensembl; ENSRNOT00000082091; ENSRNOP00000070738; ENSRNOG00000011474.
GeneID; 192280; -.
KEGG; rno:192280; -.
UCSC; RGD:621600; rat.
CTD; 79660; -.
RGD; 621600; Ppp1r3b.
eggNOG; KOG3986; Eukaryota.
eggNOG; ENOG4111FT1; LUCA.
GeneTree; ENSGT00530000062978; -.
HOGENOM; HOG000026799; -.
HOVERGEN; HBG052744; -.
InParanoid; Q6IN01; -.
KO; K07189; -.
OMA; MVKVFSE; -.
PhylomeDB; Q6IN01; -.
TreeFam; TF105537; -.
PRO; PR:Q6IN01; -.
Proteomes; UP000002494; Chromosome 16.
Bgee; ENSRNOG00000011474; -.
Genevisible; Q6IN01; RN.
GO; GO:0042587; C:glycogen granule; IDA:RGD.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
GO; GO:0000164; C:protein phosphatase type 1 complex; IDA:RGD.
GO; GO:0019899; F:enzyme binding; IDA:RGD.
GO; GO:0019888; F:protein phosphatase regulator activity; IDA:RGD.
GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
GO; GO:0006470; P:protein dephosphorylation; IEA:GOC.
GO; GO:0005979; P:regulation of glycogen biosynthetic process; IDA:RGD.
GO; GO:0005981; P:regulation of glycogen catabolic process; IDA:RGD.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR005036; CBM21_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR017434; Pase-1_reg-su_3B/C/D_met.
InterPro; IPR030682; PP1_3B.
PANTHER; PTHR12307:SF13; PTHR12307:SF13; 1.
Pfam; PF03370; CBM_21; 1.
PIRSF; PIRSF038207; PP1_GT_animal; 1.
PROSITE; PS51159; CBM21; 1.
1: Evidence at protein level;
Carbohydrate metabolism; Complete proteome; Direct protein sequencing;
Glycogen metabolism; Phosphoprotein; Reference proteome.
CHAIN 1 284 Protein phosphatase 1 regulatory subunit
3B.
/FTId=PRO_0000324545.
DOMAIN 124 232 CBM21. {ECO:0000255|PROSITE-
ProRule:PRU00491}.
MOTIF 61 64 PP1-binding motif.
MOD_RES 260 260 Phosphoserine.
{ECO:0000250|UniProtKB:Q8C767}.
CONFLICT 162 162 R -> S (in Ref. 1; CAA77083).
{ECO:0000305}.
SEQUENCE 284 AA; 32626 MW; 8E64443CCE0EFE83 CRC64;
MAVDIEYSYS SMAPSLRRER FTFKISPKLN KPLRPCIQLG SKDEAGRMVA PTVQEKKVKK
RVSFADNQGL ALTMVKVFSE FDDPLDIPFN ITELLDNIVS LTTAESESFV LDFPQPSADY
LDFRNRLQTN HVCLENCVLK EKAIAGTVKV QNLAFEKVVK IRMTFDTWKS FTDFPCQYVK
DTYAGSDRDT FSFDISLPEK IQSYERMEFA VCYECNGQSY WDSNKGKNYR ITRAELRSTQ
GMTEPYNGPD FGISFDQFGS PRCSFGLFPE WPSYLGYEKL GPYY


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