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Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT)

 ICMT_DICDI              Reviewed;         237 AA.
Q558K8; Q86AM7; Q8T623;
08-APR-2008, integrated into UniProtKB/Swiss-Prot.
02-MAY-2006, sequence version 2.
28-MAR-2018, entry version 80.
RecName: Full=Protein-S-isoprenylcysteine O-methyltransferase;
EC=2.1.1.100;
AltName: Full=Isoprenylcysteine carboxylmethyltransferase;
AltName: Full=Prenylated protein carboxyl methyltransferase;
Short=PPMT;
AltName: Full=Prenylcysteine carboxyl methyltransferase;
Short=pcCMT;
Name=icmt-1; Synonyms=icmA; ORFNames=DDB_G0272799;
and
Name=icmt-2; Synonyms=icmA; ORFNames=DDB_G0273995;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
Dictyosteliaceae; Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DEVELOPMENTAL STAGE, AND
DISRUPTION PHENOTYPE.
PubMed=17699599; DOI=10.1091/mbc.E06-11-1006;
Chen Y., McQuade K.J., Guan X.-J., Thomason P.A., Wert M.S.,
Stock J.B., Cox E.C.;
"Isoprenylcysteine carboxy methylation is essential for development in
Dictyostelium discoideum.";
Mol. Biol. Cell 18:4106-4118(2007).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=12097910; DOI=10.1038/nature00847;
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A.,
Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G.,
Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A.,
Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
-!- FUNCTION: Methylates the C-terminal cysteine residues of small
GTPases and the heterotrimeric G protein gamma subunit in response
to cAMP. The methylation is required for intercellular signaling
and regulation of cAMP waves propagation. It also seems to induce
the activity of car1, a G protein-coupled receptor which senses
extracellular cAMP during the aggregation phase of development.
{ECO:0000269|PubMed:17699599}.
-!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + protein C-terminal
S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-
terminal S-farnesyl-L-cysteine methyl ester.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Divalent metal cations. Probably Zn(2+). {ECO:0000250};
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- DEVELOPMENTAL STAGE: Induced by starvation and expressed
throughout development, with a peak at 8 hours after starvation.
{ECO:0000269|PubMed:17699599}.
-!- DISRUPTION PHENOTYPE: Cells lacking both icmt-1 and icmt-2 do not
propagate cAMP waves in a sustained manner and fail to aggregate,
affecting differentiation and development.
{ECO:0000269|PubMed:17699599}.
-!- SIMILARITY: Belongs to the class VI-like SAM-binding
methyltransferase superfamily. Isoprenylcysteine carboxyl
methyltransferase family. {ECO:0000305}.
-!- CAUTION: The gene for this protein is duplicated in strains AX3
and AX4. These strains contain a duplication of a segment of 750
kb of chromosome 2 compared to the corresponding sequence in
strain AX2. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF487784; AAL99548.1; -; Genomic_DNA.
EMBL; AAFI02000011; EAL70431.1; -; Genomic_DNA.
EMBL; AAFI02000009; EAL71037.2; -; Genomic_DNA.
RefSeq; XP_644356.1; XM_639264.1.
RefSeq; XP_645058.2; XM_639966.2.
SMR; Q558K8; -.
STRING; 44689.DDB0252724; -.
PaxDb; Q558K8; -.
EnsemblProtists; EAL70431; EAL70431; DDB_G0273995.
EnsemblProtists; EAL71037; EAL71037; DDB_G0272799.
GeneID; 8618733; -.
GeneID; 8619243; -.
KEGG; ddi:DDB_G0272799; -.
KEGG; ddi:DDB_G0273995; -.
dictyBase; DDB_G0272799; icmA-1.
dictyBase; DDB_G0273995; icmA-2.
eggNOG; KOG2628; Eukaryota.
eggNOG; COG2020; LUCA.
InParanoid; Q558K8; -.
KO; K00587; -.
OMA; FHFLEFW; -.
PhylomeDB; Q558K8; -.
Reactome; R-DDI-163841; Gamma carboxylation, hypusine formation and arylsulfatase activation.
PRO; PR:Q558K8; -.
Proteomes; UP000002195; Chromosome 2.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:dictyBase.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0004671; F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity; IDA:dictyBase.
GO; GO:0006481; P:C-terminal protein methylation; IDA:dictyBase.
GO; GO:0030010; P:establishment of cell polarity; IMP:dictyBase.
GO; GO:0006998; P:nuclear envelope organization; IMP:dictyBase.
GO; GO:0034504; P:protein localization to nucleus; IMP:dictyBase.
GO; GO:0060176; P:regulation of aggregation involved in sorocarp development; IMP:dictyBase.
GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IMP:dictyBase.
InterPro; IPR007269; ICMT_MeTrfase.
InterPro; IPR025770; PPMT_MeTrfase.
Pfam; PF04140; ICMT; 1.
PROSITE; PS51564; SAM_ICMT; 1.
2: Evidence at transcript level;
Complete proteome; Endoplasmic reticulum; Membrane; Methyltransferase;
Reference proteome; S-adenosyl-L-methionine; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 237 Protein-S-isoprenylcysteine O-
methyltransferase.
/FTId=PRO_0000328175.
TRANSMEM 26 46 Helical. {ECO:0000255}.
TRANSMEM 53 73 Helical. {ECO:0000255}.
TRANSMEM 92 112 Helical. {ECO:0000255}.
TRANSMEM 116 136 Helical. {ECO:0000255}.
TRANSMEM 184 204 Helical. {ECO:0000255}.
SEQUENCE 237 AA; 27379 MW; 3F6961685B01C5DE CRC64;
MDQSEIVKLN KIKAKSAWLK KGAARSSAIS CGLGIGIGFG IALFIFSQTL RGFGIYLAGL
CTFHMWEYIW VTMYHPDKLS SKSFLLNHSP QFNMALLISF IEFWIEWYFF PSLKTFSLWW
VGAICMVFGQ IVRSVAMDTA GSNFTHLVQE EKRDDHVLVT NGIYQYMRHP SYFGWFVWSV
STQVILMNPI SIIGFGWASW SFFSQRIENE EDYLIQFFGK SYKDYKKSVW SGIPGIH


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