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Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT)

 ICMT_MOUSE              Reviewed;         283 AA.
Q9EQK7;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
20-JUN-2001, sequence version 2.
20-DEC-2017, entry version 113.
RecName: Full=Protein-S-isoprenylcysteine O-methyltransferase;
EC=2.1.1.100;
AltName: Full=Isoprenylcysteine carboxylmethyltransferase;
AltName: Full=Prenylated protein carboxyl methyltransferase;
Short=PPMT;
AltName: Full=Prenylcysteine carboxyl methyltransferase;
Short=pcCMT;
Name=Icmt;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] OF 20-283.
PubMed=10649571; DOI=10.1038/72101;
Lin X., Antalffy B., Kang D., Orr H.T., Zoghbi H.Y.;
"Polyglutamine expansion down-regulates specific neuronal genes before
pathologic changes in SCA1.";
Nat. Neurosci. 3:157-163(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-153.
STRAIN=C57BL/6J; TISSUE=Placenta;
Marra M., Hillier L., Allen M., Bowles M., Dietrich N., Dubuque T.,
Geisel S., Kucaba T., Lacy M., Le M., Martin J., Morris M.,
Schellenberg K., Steptoe M., Tan F., Underwood K., Moore B.,
Theising B., Wylie T., Lennon G., Soares B., Wilson R., Waterston R.;
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the post-translational methylation of
isoprenylated C-terminal cysteine residues. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + protein C-terminal
S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-
terminal S-farnesyl-L-cysteine methyl ester. {ECO:0000255|PROSITE-
ProRule:PRU00897}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Divalent metal cations. Probably Zn(2+). {ECO:0000250};
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Highly enriched in adult cerebellum, with a
low level expression in other brain regions.
-!- DEVELOPMENTAL STAGE: During cerebellar development expression was
low before postnatal day P6 and dramatically increased after P12.
-!- SIMILARITY: Belongs to the class VI-like SAM-binding
methyltransferase superfamily. Isoprenylcysteine carboxyl
methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU00897}.
-----------------------------------------------------------------------
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EMBL; AF209926; AAG48552.1; -; mRNA.
EMBL; AA022288; -; NOT_ANNOTATED_CDS; mRNA.
RefSeq; NP_598549.1; NM_133788.2.
UniGene; Mm.277464; -.
ProteinModelPortal; Q9EQK7; -.
SMR; Q9EQK7; -.
BioGrid; 208249; 2.
STRING; 10090.ENSMUSP00000043390; -.
iPTMnet; Q9EQK7; -.
PhosphoSitePlus; Q9EQK7; -.
MaxQB; Q9EQK7; -.
PaxDb; Q9EQK7; -.
PRIDE; Q9EQK7; -.
GeneID; 57295; -.
KEGG; mmu:57295; -.
CTD; 23463; -.
MGI; MGI:1888594; Icmt.
eggNOG; KOG2628; Eukaryota.
eggNOG; COG2020; LUCA.
HOVERGEN; HBG019034; -.
InParanoid; Q9EQK7; -.
KO; K00587; -.
PhylomeDB; Q9EQK7; -.
SABIO-RK; Q9EQK7; -.
PRO; PR:Q9EQK7; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_ICMT; -.
GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0008140; F:cAMP response element binding protein binding; IMP:MGI.
GO; GO:0004671; F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity; IMP:MGI.
GO; GO:0006481; P:C-terminal protein methylation; IMP:MGI.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0001889; P:liver development; IMP:MGI.
GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
GO; GO:0008104; P:protein localization; IMP:MGI.
GO; GO:0006479; P:protein methylation; IMP:MGI.
GO; GO:0046578; P:regulation of Ras protein signal transduction; IGI:MGI.
InterPro; IPR007269; ICMT_MeTrfase.
InterPro; IPR025770; PPMT_MeTrfase.
Pfam; PF04140; ICMT; 1.
PROSITE; PS51564; SAM_ICMT; 1.
2: Evidence at transcript level;
Complete proteome; Endoplasmic reticulum; Membrane; Methyltransferase;
Reference proteome; S-adenosyl-L-methionine; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 283 Protein-S-isoprenylcysteine O-
methyltransferase.
/FTId=PRO_0000209895.
TOPO_DOM 1 15 Cytoplasmic. {ECO:0000255}.
TRANSMEM 16 32 Helical. {ECO:0000255}.
TOPO_DOM 33 40 Lumenal. {ECO:0000255}.
TRANSMEM 41 58 Helical. {ECO:0000255}.
TOPO_DOM 59 68 Cytoplasmic. {ECO:0000255}.
TRANSMEM 69 86 Helical. {ECO:0000255}.
TOPO_DOM 87 91 Lumenal. {ECO:0000255}.
TRANSMEM 92 111 Helical. {ECO:0000255}.
TOPO_DOM 112 130 Cytoplasmic. {ECO:0000255}.
TRANSMEM 131 148 Helical. {ECO:0000255}.
TOPO_DOM 149 153 Lumenal. {ECO:0000255}.
TRANSMEM 154 173 Helical. {ECO:0000255}.
TOPO_DOM 174 211 Cytoplasmic. {ECO:0000255}.
TRANSMEM 212 227 Helical. {ECO:0000255}.
TOPO_DOM 228 228 Lumenal. {ECO:0000255}.
TRANSMEM 229 243 Helical. {ECO:0000255}.
TOPO_DOM 244 283 Cytoplasmic. {ECO:0000255}.
CONFLICT 24 24 A -> D (in Ref. 2; AA022288).
{ECO:0000305}.
CONFLICT 42 42 G -> A (in Ref. 2). {ECO:0000305}.
SEQUENCE 283 AA; 31790 MW; A6C17436EDC27F40 CRC64;
MAAARRGSAG SEARLSLATF LLGASVLALP LLTRAGLQGR TGLALYVAGL NALLLLLYRP
PRYQIAIRAC FLGFVFGCGV LLSFSQSSWN HFGWYVCSLS LFHYSEYLVT AVNNPKSLSL
DSFLLNHSLE YTVAALSSWI EFTLENIFWP ELKQITWLSA TGLLMVVFGE CLRKAAMFTA
GSNFNHVVQS EKSDTHTLVT SGVYAWCRHP SYVGWFYWSI GTQVMLCNPI CGVVYALTVW
RFFRDRTEEE EISLIHFFGE EYLDYKKRVP TGLPFIKGVK VEL


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