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Proteinase-activated receptor 1 (PAR-1) (Thrombin receptor)

 PAR1_CRILO              Reviewed;         428 AA.
Q00991; Q60461;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
30-AUG-2017, entry version 107.
RecName: Full=Proteinase-activated receptor 1;
Short=PAR-1;
AltName: Full=Thrombin receptor;
Flags: Precursor;
Name=F2R; Synonyms=PAR1;
Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese
hamster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10030;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
PubMed=1652467; DOI=10.1016/0014-5793(91)81017-3;
Rasmussen U.B., Vouret-Craviari V., Jallat S., Schlesinger Y.,
Pages G., Pavirani A., Lecocq J.-P., Pouyssegur J.,
Obberghen-Schilling E.;
"cDNA cloning and expression of a hamster alpha-thrombin receptor
coupled to Ca2+ mobilization.";
FEBS Lett. 288:123-128(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 42-428.
PubMed=7488069; DOI=10.1006/bbrc.1995.2559;
Hartmann T., Grace M.B., Buzard G.S., Ruoss S.J.;
"Thrombin receptor polymorphism in Chinese hamster.";
Biochem. Biophys. Res. Commun. 215:974-980(1995).
-!- FUNCTION: High affinity receptor for activated thrombin coupled to
G proteins that stimulate phosphoinositide hydrolysis.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- DOMAIN: The cleaved signal peptide may not be degraded and may
function as an intracellular angiogenesis inhibitor peptide known
as parstatin. {ECO:0000250}.
-!- PTM: A proteolytic cleavage generates a new N-terminus that
functions as a tethered ligand.
-!- PTM: Phosphorylated in the C-terminal tail; probably mediating
desensitization prior to the uncoupling and internalization of the
receptor. {ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; X61958; CAA43957.1; -; mRNA.
EMBL; U34047; AAA86747.1; -; mRNA.
PIR; S17148; S17148.
ProteinModelPortal; Q00991; -.
SMR; Q00991; -.
HOVERGEN; HBG108233; -.
GO; GO:0005901; C:caveola; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0031094; C:platelet dense tubular network; ISS:UniProtKB.
GO; GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
GO; GO:0001965; F:G-protein alpha-subunit binding; ISS:UniProtKB.
GO; GO:0031681; F:G-protein beta-subunit binding; ISS:UniProtKB.
GO; GO:0004930; F:G-protein coupled receptor activity; ISS:UniProtKB.
GO; GO:0015057; F:thrombin-activated receptor activity; ISS:UniProtKB.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0000186; P:activation of MAPKK activity; ISS:UniProtKB.
GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; ISS:UniProtKB.
GO; GO:0007529; P:establishment of synaptic specificity at neuromuscular junction; ISS:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0003105; P:negative regulation of glomerular filtration; ISS:UniProtKB.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:1900134; P:negative regulation of renin secretion into blood stream; ISS:UniProtKB.
GO; GO:0030168; P:platelet activation; ISS:UniProtKB.
GO; GO:0030194; P:positive regulation of blood coagulation; ISS:UniProtKB.
GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:UniProtKB.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; ISS:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; ISS:UniProtKB.
GO; GO:2000484; P:positive regulation of interleukin-8 secretion; ISS:UniProtKB.
GO; GO:0046427; P:positive regulation of JAK-STAT cascade; ISS:UniProtKB.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
GO; GO:0035025; P:positive regulation of Rho protein signal transduction; ISS:UniProtKB.
GO; GO:0045987; P:positive regulation of smooth muscle contraction; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0045907; P:positive regulation of vasoconstriction; ISS:UniProtKB.
GO; GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0032651; P:regulation of interleukin-1 beta production; ISS:UniProtKB.
GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.
GO; GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.
GO; GO:0009611; P:response to wounding; ISS:UniProtKB.
GO; GO:0007262; P:STAT protein import into nucleus; ISS:UniProtKB.
GO; GO:0070493; P:thrombin-activated receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; ISS:UniProtKB.
CDD; cd15369; 7tmA_PAR1; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR003912; Protea_act_rcpt.
InterPro; IPR000935; Thrmbn_rcpt.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01428; PROTEASEAR.
PRINTS; PR00908; THROMBINR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Blood coagulation; Cell membrane; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Hemostasis; Membrane;
Phosphoprotein; Polymorphism; Receptor; Signal; Transducer;
Transmembrane; Transmembrane helix.
SIGNAL 1 21 {ECO:0000250}.
PROPEP 22 41 Removed for receptor activation.
{ECO:0000250}.
/FTId=PRO_0000012738.
CHAIN 42 428 Proteinase-activated receptor 1.
/FTId=PRO_0000012739.
TOPO_DOM 42 105 Extracellular. {ECO:0000255}.
TRANSMEM 106 131 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 132 140 Cytoplasmic. {ECO:0000255}.
TRANSMEM 141 160 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 161 179 Extracellular. {ECO:0000255}.
TRANSMEM 180 201 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 202 221 Cytoplasmic. {ECO:0000255}.
TRANSMEM 222 242 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 243 271 Extracellular. {ECO:0000255}.
TRANSMEM 272 291 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 292 314 Cytoplasmic. {ECO:0000255}.
TRANSMEM 315 337 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 338 352 Extracellular. {ECO:0000255}.
TRANSMEM 353 377 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 378 428 Cytoplasmic. {ECO:0000255}.
COMPBIAS 60 63 Asp/Glu-rich (acidic).
COMPBIAS 301 304 Poly-Ser.
SITE 41 42 Cleavage; by thrombin. {ECO:0000250}.
MOD_RES 421 421 Phosphoserine.
{ECO:0000250|UniProtKB:P25116}.
CARBOHYD 65 65 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 78 78 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 253 253 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 262 262 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 178 257 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 84 84 Missing (in an allele).
CONFLICT 384 384 H -> T (in Ref. 1; CAA43957).
{ECO:0000305}.
SEQUENCE 428 AA; 47603 MW; E5492AB2CD877E2F CRC64;
MGPQRLLLVA AGLSLCGPLL SSRVPVRQPE SEMTDATVNP RSFFLRNPGE NTFELIPLGD
EEEKNESTLP EGRAIYLNKS HSPPAPLAPF ISEDASGYLT SPWLRLFIPS VYTFVFVVSL
PLNILAIAVF VLKMKVKKPA VVYMLHLAMA DVLFVSVLPL KISYYFSGSD WQFGSGMCRF
ATAAFYCNMY ASIMLMTVIS IDRFLAVVYP IQSLSWRTLG RANFTCLVIW VMAIMGVVPL
LLKEQTTRVP GLNITTCHDV LNETLLQGFY SYYFSAFSAV FFLVPLIIST ICYMSIIRCL
SSSSVANRSK KSRALFLSAA VFCVFIVCFG PTNVLLIMHY LLLSDSPATE KAYFAYLLCV
CVSSVSCCID PLIYYYASSE CQRHLYGILC CKESSDPNSY NSTGQLMPSK MDTCSSHLNN
SIYKKLLA


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