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Proto-oncogene c-Rel

 REL_HUMAN               Reviewed;         619 AA.
Q04864; Q17RU2; Q2PNZ7; Q6LDY0;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
25-OCT-2017, entry version 167.
RecName: Full=Proto-oncogene c-Rel;
Name=REL;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=2666912;
Brownell E., Mittereder N., Rice N.R.;
"A human rel proto-oncogene cDNA containing an Alu fragment as a
potential coding exon.";
Oncogene 4:935-942(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NHLBI resequencing and genotyping service (RS&G);
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 180-284.
PubMed=3016517; DOI=10.1128/MCB.5.10.2826;
Brownell E., O'Brien S.J., Nash W.G., Rice N.R.;
"Genetic characterization of human c-rel sequences.";
Mol. Cell. Biol. 5:2826-2831(1985).
[6]
IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX.
PubMed=1740106;
Hansen S.K., Nerlov C., Zabel U., Verde P., Johnsen M., Baeuerle P.A.,
Blasi F.;
"A novel complex between the p65 subunit of NF-kappa B and c-Rel binds
to a DNA element involved in the phorbol ester induction of the human
urokinase gene.";
EMBO J. 11:205-213(1992).
[7]
IDENTIFICATION IN THE NF-KAPPA-B P50-C-REL COMPLEX, IDENTIFICATION IN
THE NF-KAPPA-B P52-C-REL COMPLEX, AND IDENTIFICATION IN THE NF-KAPPA-B
P65-C-REL COMPLEX.
PubMed=8152812;
Beg A.A., Baldwin A.S. Jr.;
"Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor
necrosis factor.";
Oncogene 9:1487-1492(1994).
[8]
IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX.
PubMed=9056676;
Aoudjit F., Brochu N., Belanger B., Stratowa C., Hiscott J.,
Audette M.;
"Regulation of intercellular adhesion molecule-1 gene by tumor
necrosis factor-alpha is mediated by the nuclear factor-kappaB
heterodimers p65/p65 and p65/c-Rel in the absence of p50.";
Cell Growth Differ. 8:335-342(1997).
[9]
INTERACTION WITH NFKBIE.
PubMed=9315679; DOI=10.1128/MCB.17.10.6184;
Li Z., Nabel G.J.;
"A new member of the IkappaB protein family, IkappaB epsilon, inhibits
RelA (p65)-mediated NF-kappaB transcription.";
Mol. Cell. Biol. 17:6184-6190(1997).
[10]
PHOSPHORYLATION AT SER-503.
PubMed=10823840; DOI=10.1074/jbc.M909396199;
Martin A.G., Fresno M.;
"Tumor necrosis factor-alpha activation of NF-kappa B requires the
phosphorylation of Ser-471 in the transactivation domain of c-Rel.";
J. Biol. Chem. 275:24383-24391(2000).
[11]
IDENTIFICATION IN THE NF-KAPPA-B P50-C-REL COMPLEX.
PubMed=15102766; DOI=10.1128/IAI.72.5.2582-2589.2004;
Guizani-Tabbane L., Ben-Aissa K., Belghith M., Sassi A., Dellagi K.;
"Leishmania major amastigotes induce p50/c-Rel NF-kappa B
transcription factor in human macrophages: involvement in cytokine
synthesis.";
Infect. Immun. 72:2582-2589(2004).
[12]
INTERACTION WITH NKIRAS1.
PubMed=15024091; DOI=10.1128/MCB.24.7.3048-3056.2004;
Chen Y., Vallee S., Wu J., Vu D., Sondek J., Ghosh G.;
"Inhibition of NF-kappaB activity by IkappaBbeta in association with
kappaB-Ras.";
Mol. Cell. Biol. 24:3048-3056(2004).
[13]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
-!- FUNCTION: Proto-oncogene that may play a role in differentiation
and lymphopoiesis. NF-kappa-B is a pleiotropic transcription
factor which is present in almost all cell types and is involved
in many biological processed such as inflammation, immunity,
differentiation, cell growth, tumorigenesis and apoptosis. NF-
kappa-B is a homo- or heterodimeric complex formed by the Rel-like
domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of
their target genes and the individual dimers have distinct
preferences for different kappa-B sites that they can bind with
distinguishable affinity and specificity. Different dimer
combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of
post-translational modification and subcellular
compartmentalization as well as by interactions with other
cofactors or corepressors. NF-kappa-B complexes are held in the
cytoplasm in an inactive state complexed with members of the NF-
kappa-B inhibitor (I-kappa-B) family. In a conventional activation
pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs)
in response to different activators, subsequently degraded thus
liberating the active NF-kappa-B complex which translocates to the
nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a
transcriptional activator.
-!- SUBUNIT: Component of the NF-kappa-B p65-c-Rel complex. Component
of the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B
p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-
Rel complex (By similarity). Interacts with NKIRAS1. Interacts
with NFKBIB (By similarity). Interacts with NFKBIE. {ECO:0000250,
ECO:0000269|PubMed:15024091, ECO:0000269|PubMed:15102766,
ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:8152812,
ECO:0000269|PubMed:9056676, ECO:0000269|PubMed:9315679}.
-!- INTERACTION:
A8K5H9:-; NbExp=3; IntAct=EBI-307352, EBI-10174421;
B2R8Y4:-; NbExp=3; IntAct=EBI-307352, EBI-10175581;
Q96BA4:-; NbExp=3; IntAct=EBI-307352, EBI-10282301;
Q9NQ94:A1CF; NbExp=3; IntAct=EBI-307352, EBI-2809489;
O14734:ACOT8; NbExp=3; IntAct=EBI-307352, EBI-1237371;
Q08117:AES; NbExp=3; IntAct=EBI-307352, EBI-717810;
Q9NRZ5:AGPAT4; NbExp=3; IntAct=EBI-307352, EBI-1754287;
P09917:ALOX5; NbExp=3; IntAct=EBI-307352, EBI-79934;
P29972:AQP1; NbExp=4; IntAct=EBI-10829018, EBI-745213;
O95376:ARIH2; NbExp=3; IntAct=EBI-307352, EBI-711158;
Q8TDY4:ASAP3; NbExp=3; IntAct=EBI-307352, EBI-2609717;
Q7Z3C6:ATG9A; NbExp=3; IntAct=EBI-307352, EBI-727146;
Q8N5M1:ATPAF2; NbExp=3; IntAct=EBI-307352, EBI-1166928;
P54253:ATXN1; NbExp=3; IntAct=EBI-307352, EBI-930964;
Q9NY43:BARHL2; NbExp=3; IntAct=EBI-307352, EBI-10316571;
P55957:BID; NbExp=3; IntAct=EBI-307352, EBI-519672;
P55957-2:BID; NbExp=3; IntAct=EBI-307352, EBI-10215147;
Q96LC9:BMF; NbExp=3; IntAct=EBI-307352, EBI-3919268;
Q9H3H3:C11orf68; NbExp=3; IntAct=EBI-307352, EBI-721765;
Q9NX04:C1orf109; NbExp=3; IntAct=EBI-307352, EBI-8643161;
Q96LT7:C9orf72; NbExp=3; IntAct=EBI-307352, EBI-2961725;
Q9NP86:CABP5; NbExp=3; IntAct=EBI-307352, EBI-10311131;
P24863:CCNC; NbExp=4; IntAct=EBI-10829018, EBI-395261;
F6RF56:CCNJL; NbExp=3; IntAct=EBI-307352, EBI-10177725;
P42773:CDKN2C; NbExp=3; IntAct=EBI-307352, EBI-711290;
A8MT69:CENPX; NbExp=3; IntAct=EBI-307352, EBI-5529694;
Q96LK0:CEP19; NbExp=3; IntAct=EBI-307352, EBI-741885;
Q9UFW8:CGGBP1; NbExp=3; IntAct=EBI-307352, EBI-723153;
Q13111:CHAF1A; NbExp=3; IntAct=EBI-307352, EBI-1020839;
Q9Y6H1:CHCHD2; NbExp=3; IntAct=EBI-307352, EBI-2321769;
Q96Q77:CIB3; NbExp=3; IntAct=EBI-307352, EBI-10292696;
Q9BW66:CINP; NbExp=3; IntAct=EBI-307352, EBI-739784;
P61024:CKS1B; NbExp=3; IntAct=EBI-307352, EBI-456371;
Q9P218-2:COL20A1; NbExp=3; IntAct=EBI-307352, EBI-10318410;
P27658:COL8A1; NbExp=3; IntAct=EBI-307352, EBI-747133;
Q8N668:COMMD1; NbExp=3; IntAct=EBI-307352, EBI-1550112;
Q96FN4:CPNE2; NbExp=3; IntAct=EBI-307352, EBI-7097057;
Q10570:CPSF1; NbExp=3; IntAct=EBI-307352, EBI-347859;
Q9NSA3:CTNNBIP1; NbExp=3; IntAct=EBI-307352, EBI-747082;
P49366:DHPS; NbExp=3; IntAct=EBI-307352, EBI-741925;
Q9NQL9:DMRT3; NbExp=3; IntAct=EBI-307352, EBI-9679045;
P04053:DNTT; NbExp=3; IntAct=EBI-307352, EBI-1220259;
Q9Y6G9:DYNC1LI1; NbExp=3; IntAct=EBI-307352, EBI-2556107;
Q5JVL4:EFHC1; NbExp=6; IntAct=EBI-307352, EBI-743105;
Q9H6Z9:EGLN3; NbExp=4; IntAct=EBI-307352, EBI-1175354;
Q24JU4:EIF3A; NbExp=3; IntAct=EBI-307352, EBI-10239221;
O15371:EIF3D; NbExp=3; IntAct=EBI-307352, EBI-353818;
O60573:EIF4E2; NbExp=3; IntAct=EBI-307352, EBI-398610;
Q13541:EIF4EBP1; NbExp=3; IntAct=EBI-307352, EBI-74090;
P63241:EIF5A; NbExp=3; IntAct=EBI-307352, EBI-373150;
Q9GZV4:EIF5A2; NbExp=3; IntAct=EBI-307352, EBI-748028;
O95834:EML2; NbExp=3; IntAct=EBI-307352, EBI-1054588;
O15197-2:EPHB6; NbExp=3; IntAct=EBI-307352, EBI-10182490;
Q7L775:EPM2AIP1; NbExp=3; IntAct=EBI-307352, EBI-6255981;
Q9Y3B2:EXOSC1; NbExp=4; IntAct=EBI-10829018, EBI-371892;
Q9NQT4:EXOSC5; NbExp=3; IntAct=EBI-307352, EBI-371876;
Q96B26:EXOSC8; NbExp=3; IntAct=EBI-307352, EBI-371922;
Q14192:FHL2; NbExp=3; IntAct=EBI-307352, EBI-701903;
P68106:FKBP1B; NbExp=3; IntAct=EBI-307352, EBI-6693977;
Q8NFF5:FLAD1; NbExp=3; IntAct=EBI-307352, EBI-742815;
P21333-2:FLNA; NbExp=3; IntAct=EBI-307352, EBI-9641086;
Q9BVV2:FNDC11; NbExp=3; IntAct=EBI-307352, EBI-744935;
P98177:FOXO4; NbExp=3; IntAct=EBI-307352, EBI-4481939;
Q495W5:FUT11; NbExp=3; IntAct=EBI-307352, EBI-2907712;
O95257:GADD45G; NbExp=3; IntAct=EBI-307352, EBI-448202;
Q8IVS8:GLYCTK; NbExp=3; IntAct=EBI-307352, EBI-748515;
P62993:GRB2; NbExp=3; IntAct=EBI-307352, EBI-401755;
O14929:HAT1; NbExp=3; IntAct=EBI-307352, EBI-2339359;
Q8WUI4-5:HDAC7; NbExp=3; IntAct=EBI-307352, EBI-10276431;
O00291:HIP1; NbExp=3; IntAct=EBI-307352, EBI-473886;
P06340:HLA-DOA; NbExp=3; IntAct=EBI-307352, EBI-10194851;
Q9UBY9:HSPB7; NbExp=3; IntAct=EBI-307352, EBI-739361;
Q9UBH0:IL36RN; NbExp=3; IntAct=EBI-307352, EBI-465156;
Q08E86:KIAA0100; NbExp=3; IntAct=EBI-307352, EBI-10226057;
Q5THT1:KLHL32; NbExp=3; IntAct=EBI-307352, EBI-10247181;
Q9BYQ2:KRTAP9-4; NbExp=3; IntAct=EBI-307352, EBI-10185730;
Q14847:LASP1; NbExp=3; IntAct=EBI-307352, EBI-742828;
Q8TCE9:LGALS14; NbExp=3; IntAct=EBI-307352, EBI-10274069;
P25800:LMO1; NbExp=3; IntAct=EBI-307352, EBI-8639312;
P25791:LMO2; NbExp=3; IntAct=EBI-307352, EBI-739696;
Q9UIQ6:LNPEP; NbExp=3; IntAct=EBI-307352, EBI-2805360;
Q9Y333:LSM2; NbExp=3; IntAct=EBI-307352, EBI-347416;
Q9UI95:MAD2L2; NbExp=3; IntAct=EBI-307352, EBI-77889;
Q96A72:MAGOHB; NbExp=3; IntAct=EBI-307352, EBI-746778;
P57077-4:MAP3K7CL; NbExp=3; IntAct=EBI-307352, EBI-10215880;
Q9Y316:MEMO1; NbExp=3; IntAct=EBI-307352, EBI-1104564;
Q9BRT3:MIEN1; NbExp=4; IntAct=EBI-10829018, EBI-6137472;
Q9UBU8:MORF4L1; NbExp=3; IntAct=EBI-307352, EBI-399246;
Q7Z7H8:MRPL10; NbExp=3; IntAct=EBI-307352, EBI-723524;
Q9UJ70:NAGK; NbExp=3; IntAct=EBI-307352, EBI-372578;
O43639:NCK2; NbExp=3; IntAct=EBI-307352, EBI-713635;
Q9BU61-2:NDUFAF3; NbExp=3; IntAct=EBI-307352, EBI-10298649;
A8K3C2:NECAP1; NbExp=3; IntAct=EBI-307352, EBI-10174302;
Q14511:NEDD9; NbExp=3; IntAct=EBI-307352, EBI-2108053;
Q969S2:NEIL2; NbExp=3; IntAct=EBI-307352, EBI-10281234;
Q9Y4Z2:NEUROG3; NbExp=3; IntAct=EBI-307352, EBI-10328570;
Q00653:NFKB2; NbExp=3; IntAct=EBI-307352, EBI-307326;
P25963:NFKBIA; NbExp=2; IntAct=EBI-307352, EBI-307386;
Q9NPG2:NGB; NbExp=3; IntAct=EBI-307352, EBI-10311409;
Q9Y5B8:NME7; NbExp=3; IntAct=EBI-307352, EBI-744782;
Q9NWW6:NMRK1; NbExp=4; IntAct=EBI-10829018, EBI-10315485;
Q5SY16:NOL9; NbExp=3; IntAct=EBI-307352, EBI-1055462;
Q86WQ0:NR2C2AP; NbExp=3; IntAct=EBI-307352, EBI-10260040;
O95848:NUDT14; NbExp=3; IntAct=EBI-307352, EBI-536866;
Q9NPJ8:NXT2; NbExp=3; IntAct=EBI-307352, EBI-752122;
Q9UMX2:OAZ3; NbExp=3; IntAct=EBI-307352, EBI-10281601;
Q9UJX0:OSGIN1; NbExp=3; IntAct=EBI-307352, EBI-9057006;
Q92882:OSTF1; NbExp=3; IntAct=EBI-307352, EBI-1051152;
Q96DC9:OTUB2; NbExp=3; IntAct=EBI-307352, EBI-746259;
Q01804:OTUD4; NbExp=3; IntAct=EBI-307352, EBI-1054396;
Q9HBI0:PARVG; NbExp=3; IntAct=EBI-307352, EBI-3921217;
Q8WXA2:PATE1; NbExp=3; IntAct=EBI-307352, EBI-10277790;
Q8WWB5:PIH1D2; NbExp=3; IntAct=EBI-307352, EBI-10232538;
Q15147:PLCB4; NbExp=3; IntAct=EBI-307352, EBI-998637;
Q494U1:PLEKHN1; NbExp=3; IntAct=EBI-307352, EBI-10241513;
P56282:POLE2; NbExp=3; IntAct=EBI-307352, EBI-713847;
O95602:POLR1A; NbExp=3; IntAct=EBI-307352, EBI-359472;
P62875:POLR2L; NbExp=3; IntAct=EBI-307352, EBI-359527;
Q969H6:POP5; NbExp=3; IntAct=EBI-307352, EBI-366525;
Q9NQV6:PRDM10; NbExp=3; IntAct=EBI-307352, EBI-10312448;
P25786:PSMA1; NbExp=3; IntAct=EBI-307352, EBI-359352;
P43115-12:PTGER3; NbExp=3; IntAct=EBI-307352, EBI-10234038;
Q13882:PTK6; NbExp=3; IntAct=EBI-307352, EBI-1383632;
Q9Y2K5-2:R3HDM2; NbExp=3; IntAct=EBI-307352, EBI-10326419;
Q5JT25:RAB41; NbExp=3; IntAct=EBI-307352, EBI-10244509;
P47224:RABIF; NbExp=3; IntAct=EBI-307352, EBI-713992;
Q8WWW0:RASSF5; NbExp=3; IntAct=EBI-307352, EBI-367390;
Q14498-3:RBM39; NbExp=3; IntAct=EBI-307352, EBI-6654703;
Q6P9E2:RECK; NbExp=3; IntAct=EBI-307352, EBI-10253121;
Q04206-3:RELA; NbExp=3; IntAct=EBI-307352, EBI-10223388;
Q8IX06:REXO1L1P; NbExp=3; IntAct=EBI-307352, EBI-10262361;
Q0D2K3:RIPPLY1; NbExp=3; IntAct=EBI-307352, EBI-10226430;
Q63HN8-6:RNF213; NbExp=3; IntAct=EBI-307352, EBI-10248548;
Q9UHP6:RSPH14; NbExp=3; IntAct=EBI-307352, EBI-748350;
P21673:SAT1; NbExp=3; IntAct=EBI-307352, EBI-711613;
O00560:SDCBP; NbExp=3; IntAct=EBI-307352, EBI-727004;
Q9UDX3:SEC14L4; NbExp=3; IntAct=EBI-307352, EBI-10320311;
O94979:SEC31A; NbExp=3; IntAct=EBI-307352, EBI-1767898;
Q16181-2:SEPT7; NbExp=3; IntAct=EBI-307352, EBI-10176094;
Q96H72:SLC39A13; NbExp=3; IntAct=EBI-307352, EBI-10287091;
Q96GZ6:SLC41A3; NbExp=3; IntAct=EBI-307352, EBI-7225508;
P48065:SLC6A12; NbExp=3; IntAct=EBI-307352, EBI-3843589;
Q9H0W8:SMG9; NbExp=4; IntAct=EBI-10829018, EBI-2872322;
Q9BV90:SNRNP25; NbExp=3; IntAct=EBI-307352, EBI-9675976;
O75716:STK16; NbExp=3; IntAct=EBI-307352, EBI-749295;
Q5T011-5:SZT2; NbExp=3; IntAct=EBI-307352, EBI-10245139;
Q96FV9:THOC1; NbExp=4; IntAct=EBI-10829018, EBI-1765605;
Q9HCN3:TMEM8A; NbExp=3; IntAct=EBI-307352, EBI-10310808;
Q63HR2:TNS2; NbExp=3; IntAct=EBI-307352, EBI-949753;
Q9UL33:TRAPPC2L; NbExp=3; IntAct=EBI-307352, EBI-747601;
Q86UV6-2:TRIM74; NbExp=3; IntAct=EBI-307352, EBI-10259086;
Q9Y5U2:TSSC4; NbExp=3; IntAct=EBI-307352, EBI-717229;
Q96PN8:TSSK3; NbExp=3; IntAct=EBI-307352, EBI-3918381;
Q5T7W7:TSTD2; NbExp=3; IntAct=EBI-307352, EBI-8994397;
Q6DKK2:TTC19; NbExp=3; IntAct=EBI-307352, EBI-948354;
A0A0B4J1Y2:TTC21A; NbExp=3; IntAct=EBI-307352, EBI-10220701;
Q9NX01:TXNL4B; NbExp=3; IntAct=EBI-307352, EBI-10309345;
P57075:UBASH3A; NbExp=3; IntAct=EBI-307352, EBI-2105393;
P61086:UBE2K; NbExp=3; IntAct=EBI-307352, EBI-473850;
Q9H832:UBE2Z; NbExp=3; IntAct=EBI-307352, EBI-720977;
Q9BRG1:VPS25; NbExp=3; IntAct=EBI-307352, EBI-741945;
Q8IZ13:ZBED8; NbExp=4; IntAct=EBI-10829018, EBI-7186123;
Q6UX98:ZDHHC24; NbExp=3; IntAct=EBI-307352, EBI-10254561;
Q8TAU3:ZNF417; NbExp=3; IntAct=EBI-307352, EBI-740727;
Q7Z398:ZNF550; NbExp=3; IntAct=EBI-307352, EBI-10256834;
Q8TBZ8:ZNF564; NbExp=3; IntAct=EBI-307352, EBI-10273713;
Q7Z3I7:ZNF572; NbExp=3; IntAct=EBI-307352, EBI-10172590;
Q7L2R6:ZNF765; NbExp=3; IntAct=EBI-307352, EBI-9676069;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q04864-1; Sequence=Displayed;
Name=2;
IsoId=Q04864-2; Sequence=VSP_055857;
Note=No experimental confirmation available.;
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/RELID322.html";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X75042; CAA52954.1; -; mRNA.
EMBL; DQ314888; ABC40747.1; -; Genomic_DNA.
EMBL; AC010733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC117191; AAI17192.1; -; mRNA.
EMBL; BC143885; AAI43886.1; -; mRNA.
EMBL; M11595; AAA52073.1; -; Genomic_DNA.
CCDS; CCDS1864.1; -. [Q04864-1]
CCDS; CCDS74515.1; -. [Q04864-2]
PIR; A60646; A60646.
RefSeq; NP_001278675.1; NM_001291746.1. [Q04864-2]
RefSeq; NP_002899.1; NM_002908.3. [Q04864-1]
UniGene; Hs.631886; -.
UniGene; Hs.633256; -.
ProteinModelPortal; Q04864; -.
SMR; Q04864; -.
BioGrid; 111898; 213.
CORUM; Q04864; -.
DIP; DIP-301N; -.
IntAct; Q04864; 298.
MINT; MINT-1137552; -.
STRING; 9606.ENSP00000295025; -.
iPTMnet; Q04864; -.
PhosphoSitePlus; Q04864; -.
BioMuta; REL; -.
DMDM; 548720; -.
EPD; Q04864; -.
MaxQB; Q04864; -.
PaxDb; Q04864; -.
PeptideAtlas; Q04864; -.
PRIDE; Q04864; -.
DNASU; 5966; -.
Ensembl; ENST00000295025; ENSP00000295025; ENSG00000162924. [Q04864-1]
Ensembl; ENST00000394479; ENSP00000377989; ENSG00000162924. [Q04864-2]
GeneID; 5966; -.
KEGG; hsa:5966; -.
UCSC; uc002sam.2; human. [Q04864-1]
CTD; 5966; -.
DisGeNET; 5966; -.
EuPathDB; HostDB:ENSG00000162924.13; -.
GeneCards; REL; -.
HGNC; HGNC:9954; REL.
HPA; CAB004404; -.
MIM; 164910; gene.
neXtProt; NX_Q04864; -.
OpenTargets; ENSG00000162924; -.
PharmGKB; PA34321; -.
eggNOG; ENOG410IG8F; Eukaryota.
eggNOG; ENOG410XT64; LUCA.
GeneTree; ENSGT00500000044765; -.
HOGENOM; HOG000264257; -.
HOVERGEN; HBG017916; -.
InParanoid; Q04864; -.
KO; K09254; -.
OMA; VTKNDPY; -.
OrthoDB; EOG091G08JD; -.
PhylomeDB; Q04864; -.
TreeFam; TF325632; -.
Reactome; R-HSA-1169091; Activation of NF-kappaB in B cells.
SignaLink; Q04864; -.
SIGNOR; Q04864; -.
GeneWiki; REL; -.
GenomeRNAi; 5966; -.
PRO; PR:Q04864; -.
Proteomes; UP000005640; Chromosome 2.
Bgee; ENSG00000162924; -.
CleanEx; HS_REL; -.
Genevisible; Q04864; HS.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0033256; C:I-kappaB/NF-kappaB complex; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IMP:CACAO.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; NAS:ProtInc.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:NTNU_SB.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0010629; P:negative regulation of gene expression; IDA:CACAO.
GO; GO:0032688; P:negative regulation of interferon-beta production; IDA:CACAO.
GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0038061; P:NIK/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
CDD; cd01177; IPT_NFkappaB; 1.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 2.60.40.340; -; 1.
InterPro; IPR030505; c-Rel.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT.
InterPro; IPR033926; IPT_NFkappaB.
InterPro; IPR000451; NFkB/Dor.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR030492; RHD_CS.
InterPro; IPR032397; RHD_dimer.
InterPro; IPR011539; RHD_DNA_bind_dom.
InterPro; IPR037059; RHD_DNA_bind_dom_sf.
PANTHER; PTHR24169; PTHR24169; 1.
PANTHER; PTHR24169:SF4; PTHR24169:SF4; 1.
Pfam; PF16179; RHD_dimer; 1.
Pfam; PF00554; RHD_DNA_bind; 1.
PRINTS; PR00057; NFKBTNSCPFCT.
SMART; SM00429; IPT; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF81296; SSF81296; 1.
PROSITE; PS01204; REL_1; 1.
PROSITE; PS50254; REL_2; 1.
1: Evidence at protein level;
Acetylation; Activator; Alternative splicing; Complete proteome;
DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene;
Reference proteome; Transcription; Transcription regulation.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:22814378}.
CHAIN 2 619 Proto-oncogene c-Rel.
/FTId=PRO_0000205165.
DOMAIN 8 297 RHD. {ECO:0000255|PROSITE-
ProRule:PRU00265}.
MOTIF 290 295 Nuclear localization signal.
{ECO:0000255}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000244|PubMed:22814378}.
MOD_RES 267 267 Phosphoserine; by PKA. {ECO:0000255}.
MOD_RES 503 503 Phosphoserine.
{ECO:0000269|PubMed:10823840}.
VAR_SEQ 308 339 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_055857.
SEQUENCE 619 AA; 68520 MW; 03E1033BDF7B1B30 CRC64;
MASGAYNPYI EIIEQPRQRG MRFRYKCEGR SAGSIPGEHS TDNNRTYPSI QIMNYYGKGK
VRITLVTKND PYKPHPHDLV GKDCRDGYYE AEFGQERRPL FFQNLGIRCV KKKEVKEAII
TRIKAGINPF NVPEKQLNDI EDCDLNVVRL CFQVFLPDEH GNLTTALPPV VSNPIYDNRA
PNTAELRICR VNKNCGSVRG GDEIFLLCDK VQKDDIEVRF VLNDWEAKGI FSQADVHRQV
AIVFKTPPYC KAITEPVTVK MQLRRPSDQE VSESMDFRYL PDEKDTYGNK AKKQKTTLLF
QKLCQDHVET GFRHVDQDGL ELLTSGDPPT LASQSAGITV NFPERPRPGL LGSIGEGRYF
KKEPNLFSHD AVVREMPTGV SSQAESYYPS PGPISSGLSH HASMAPLPSS SWSSVAHPTP
RSGNTNPLSS FSTRTLPSNS QGIPPFLRIP VGNDLNASNA CIYNNADDIV GMEASSMPSA
DLYGISDPNM LSNCSVNMMT TSSDSMGETD NPRLLSMNLE NPSCNSVLDP RDLRQLHQMS
SSSMSAGANS NTTVFVSQSD AFEGSDFSCA DNSMINESGP SNSTNPNSHG FVQDSQYSGI
GSMQNEQLSD SFPYEFFQV


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