Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Protocadherin alpha-4 (PCDH-alpha-4)

 PCDA4_HUMAN             Reviewed;         947 AA.
Q9UN74; O75285; Q2M253;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
20-JUN-2018, entry version 154.
RecName: Full=Protocadherin alpha-4 {ECO:0000305};
Short=PCDH-alpha-4 {ECO:0000305};
Flags: Precursor;
Name=PCDHA4 {ECO:0000312|HGNC:HGNC:8670};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Brain;
PubMed=10380929; DOI=10.1016/S0092-8674(00)80789-8;
Wu Q., Maniatis T.;
"A striking organization of a large family of human neural cadherin-
like cell adhesion genes.";
Cell 97:779-790(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15372022; DOI=10.1038/nature02919;
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
"The DNA sequence and comparative analysis of human chromosome 5.";
Nature 431:268-274(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Calcium-dependent cell-adhesion protein involved in
cells self-recognition and non-self discrimination. Thereby, it is
involved in the establishment and maintenance of specific neuronal
connections in the brain. {ECO:0000250|UniProtKB:O88689}.
-!- SUBUNIT: Forms homodimers in trans (molecules expressed by two
different cells). Forms promiscuous heterodimers in cis (at the
plasma membrane of the same cell) with other protocadherins.
Interacts with FYN. {ECO:0000250|UniProtKB:O88689}.
-!- INTERACTION:
O43765:SGTA; NbExp=3; IntAct=EBI-712273, EBI-347996;
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:O88689}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:O88689}. Note=Detected in dendrites
and synapses. {ECO:0000250|UniProtKB:O88689}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9UN74-1; Sequence=Displayed;
Name=2;
IsoId=Q9UN74-2; Sequence=VSP_000677, VSP_000678;
-!- DOMAIN: Cadherin 1 to cadherin 4 domains mediate homophilic trans-
interaction, the interaction with an identical protocadherin
expressed by a neighboring cell. This is a head-to-tail
interaction, the cadherin 1 domain interacting with the cadherin 4
domain and the cadherin 2 domain interacting the cadherin 3 domain
of the other protocadherin. The cadherin 6 domain mediates
promiscuous interactions with protocadherins on the same cell
membrane. Each cadherin domain binds three calcium ions.
{ECO:0000250|UniProtKB:O88689}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF152312; AAD43706.1; -; mRNA.
EMBL; AF152482; AAD43743.1; -; mRNA.
EMBL; AC005609; AAC34322.1; -; Genomic_DNA.
EMBL; BC112102; AAI12103.1; -; mRNA.
EMBL; BC113609; AAI13610.1; -; mRNA.
CCDS; CCDS54916.1; -. [Q9UN74-1]
RefSeq; NP_061730.1; NM_018907.3. [Q9UN74-1]
RefSeq; NP_113688.1; NM_031500.2. [Q9UN74-2]
UniGene; Hs.199343; -.
ProteinModelPortal; Q9UN74; -.
SMR; Q9UN74; -.
BioGrid; 121084; 41.
IntAct; Q9UN74; 15.
STRING; 9606.ENSP00000435300; -.
iPTMnet; Q9UN74; -.
PhosphoSitePlus; Q9UN74; -.
BioMuta; PCDHA4; -.
DMDM; 13878424; -.
EPD; Q9UN74; -.
PaxDb; Q9UN74; -.
PeptideAtlas; Q9UN74; -.
PRIDE; Q9UN74; -.
ProteomicsDB; 85264; -.
ProteomicsDB; 85265; -. [Q9UN74-2]
TopDownProteomics; Q9UN74-2; -. [Q9UN74-2]
DNASU; 56144; -.
Ensembl; ENST00000530339; ENSP00000435300; ENSG00000204967. [Q9UN74-1]
Ensembl; ENST00000618834; ENSP00000481220; ENSG00000204967. [Q9UN74-2]
GeneID; 56144; -.
KEGG; hsa:56144; -.
UCSC; uc003lhi.4; human. [Q9UN74-1]
CTD; 56144; -.
EuPathDB; HostDB:ENSG00000204967.10; -.
GeneCards; PCDHA4; -.
HGNC; HGNC:8670; PCDHA4.
HPA; HPA043180; -.
HPA; HPA073478; -.
MIM; 604966; gene.
MIM; 606310; gene.
neXtProt; NX_Q9UN74; -.
OpenTargets; ENSG00000204967; -.
PharmGKB; PA33016; -.
eggNOG; KOG3594; Eukaryota.
eggNOG; ENOG410XQHI; LUCA.
GeneTree; ENSGT00920000148958; -.
HOGENOM; HOG000220892; -.
HOVERGEN; HBG054878; -.
InParanoid; Q9UN74; -.
KO; K16493; -.
OMA; DNVPDLE; -.
OrthoDB; EOG091G00KR; -.
PhylomeDB; Q9UN74; -.
TreeFam; TF332299; -.
GeneWiki; PCDHA4; -.
GenomeRNAi; 56144; -.
PRO; PR:Q9UN74; -.
Proteomes; UP000005640; Chromosome 5.
Bgee; ENSG00000204967; -.
ExpressionAtlas; Q9UN74; baseline and differential.
Genevisible; Q9UN74; HS.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0045202; C:synapse; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
GO; GO:0007399; P:nervous system development; TAS:ProtInc.
InterPro; IPR002126; Cadherin.
InterPro; IPR015919; Cadherin-like.
InterPro; IPR031904; Cadherin_CBD.
InterPro; IPR020894; Cadherin_CS.
InterPro; IPR013164; Cadherin_N.
Pfam; PF00028; Cadherin; 5.
Pfam; PF08266; Cadherin_2; 1.
Pfam; PF15974; Cadherin_tail; 1.
PRINTS; PR00205; CADHERIN.
SMART; SM00112; CA; 6.
SUPFAM; SSF49313; SSF49313; 6.
PROSITE; PS00232; CADHERIN_1; 5.
PROSITE; PS50268; CADHERIN_2; 6.
1: Evidence at protein level;
Alternative splicing; Calcium; Cell adhesion; Cell membrane;
Complete proteome; Disulfide bond; Glycoprotein; Membrane;
Metal-binding; Polymorphism; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 29 {ECO:0000255}.
CHAIN 30 947 Protocadherin alpha-4.
/FTId=PRO_0000003890.
TOPO_DOM 30 697 Extracellular.
{ECO:0000250|UniProtKB:O88689}.
TRANSMEM 698 718 Helical. {ECO:0000255}.
TOPO_DOM 719 947 Cytoplasmic.
{ECO:0000250|UniProtKB:O88689}.
DOMAIN 30 133 Cadherin 1. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 134 242 Cadherin 2. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 243 350 Cadherin 3. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 351 455 Cadherin 4. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 456 565 Cadherin 5. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 588 678 Cadherin 6. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
REPEAT 734 737 PXXP 1.
REPEAT 774 777 PXXP 2.
REPEAT 796 799 PXXP 3.
REPEAT 829 832 PXXP 4.
REPEAT 870 873 PXXP 5.
REPEAT 888 891 PXXP 6.
REGION 734 891 6 X 4 AA repeats of P-X-X-P.
REGION 738 947 Required for interaction with FYN.
{ECO:0000250|UniProtKB:O88689}.
COMPBIAS 920 927 Poly-Lys. {ECO:0000255}.
CARBOHYD 139 139 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 257 257 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 265 265 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 548 548 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 96 102 {ECO:0000250|UniProtKB:O88689}.
VAR_SEQ 796 798 PRQ -> VSV (in isoform 2).
{ECO:0000303|PubMed:10380929,
ECO:0000303|PubMed:15489334}.
/FTId=VSP_000677.
VAR_SEQ 799 947 Missing (in isoform 2).
{ECO:0000303|PubMed:10380929,
ECO:0000303|PubMed:15489334}.
/FTId=VSP_000678.
VARIANT 55 55 E -> D (in dbSNP:rs11167605).
/FTId=VAR_059180.
VARIANT 184 184 P -> S (in dbSNP:rs3822346).
/FTId=VAR_024390.
SEQUENCE 947 AA; 102293 MW; 2B06F20872D731D8 CRC64;
MEFSWGSGQE SRRLLLLLLL LAAWEAGNGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV
PRLFRVASKG RGGLLEVNLQ NGILFVNSRI DREELCRRSA ECSIHLEVIV DRPLQVFHVD
VEVRDINDNP PVFPATQKNL SIAESRPLDS RFPLEGASDA DIGENALLTY RLSPNEYFSL
EKPPDDELVK GLGLILRKSL DREEAPEIFL VLTATDGGKP ELTGTVQLLI TVLDANDNAP
AFDRTIYKVR LLENVPNGTL VIKLNASDLD EGLNGDIVYS FSNDISPNVK SKFHIDPITG
QIIVKGYIDF EESKSYEIIV EGIDKGQLPL SGHCRVIVEV EDNNDNVPDL EFKSLSLPIR
EDAPLGTVIA LISVSDKDMG VNGLVTCSLT SHVPFKLVST FKNYYSLVLD SALDRESVSA
YELVVTARDG GSPSLWATAS VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW
DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVTARDA
GVPPLGSNVT LQVFVLDEND NAPALLAPRA GGTGGAVSEL VPWSVGVGHV VAKVRAVDAD
SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDET DAPRHRLLVL VKDHGEPALT
ATATVLVSLV ESGQAPKASS RALVGAVGPD AALVDVNVYL IIAICAVSSL LVLTLLLYTA
LRCSALPTEG ACAPGKPTLV CSSAVGSWSY SQQRRPRVCS GEGPPKTDLM AFSPSLPDSR
DREDQLQTTE ESFAKPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS
SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP
TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ


Related products :

Catalog number Product name Quantity
EIAAB30066 Homo sapiens,Human,PCDHA4,PCDH-alpha-4,Protocadherin alpha-4
EIAAB30075 Homo sapiens,Human,PCDHA12,PCDH-alpha-12,Protocadherin alpha-12
EIAAB30067 Cnr1,Mouse,Mus musculus,Pcdha4,PCDH-alpha-4,Protocadherin alpha-4
EIAAB30063 Homo sapiens,Human,PCDHA2,PCDH-alpha-2,Protocadherin alpha-2
EIAAB30064 Homo sapiens,Human,PCDHA3,PCDH-alpha-3,Protocadherin alpha-3
EIAAB30095 Homo sapiens,Human,PCDHAC1,PCDH-alpha-C1,Protocadherin alpha-C1
EIAAB30071 Homo sapiens,Human,PCDHA8,PCDH-alpha-8,Protocadherin alpha-8
EIAAB30096 Homo sapiens,Human,PCDHAC2,PCDH-alpha-C2,Protocadherin alpha-C2
EIAAB30072 Homo sapiens,Human,KIAA0345,PCDHA9,PCDH-alpha-9,Protocadherin alpha-9
EIAAB30070 CNRS4,Homo sapiens,Human,PCDHA7,PCDH-alpha-7,Protocadherin alpha-7
E1363h ELISA kit Homo sapiens,Human,PCDHA1,PCDH-alpha-1,Protocadherin alpha-1 96T
EIAAB30069 CNRS2,Homo sapiens,Human,PCDHA6,PCDH-alpha-6,Protocadherin alpha-6
EIAAB30073 CNRS8,Homo sapiens,Human,PCDHA10,PCDH-alpha-10,Protocadherin alpha-10
EIAAB30076 CNRS5,Homo sapiens,Human,PCDHA13,PCDH-alpha-13,Protocadherin alpha-13
EIAAB30074 CNRS7,Homo sapiens,Human,PCDHA11,PCDH-alpha-11,Protocadherin alpha-11
E1363h ELISA Homo sapiens,Human,PCDHA1,PCDH-alpha-1,Protocadherin alpha-1 96T
EIAAB30068 CNRS6,Homo sapiens,Human,PCDHA5,PCDH-alpha-5,Protocadherin alpha-5
U1363h CLIA Homo sapiens,Human,PCDHA1,PCDH-alpha-1,Protocadherin alpha-1 96T
EIAAB30065 Cadherin-related neuronal receptor 4,Cnrv4,Pcdha4,PCDH-alpha-4,Protocadherin alpha-4,Rat,Rattus norvegicus
EIAAB30019 Homo sapiens,Human,PCDH11,PCDH11Y,PCDH22,PCDHY,PCDH-Y,Protocadherin on the Y chromosome,Protocadherin prostate cancer,Protocadherin-11,Protocadherin-11 Y-linked,Protocadherin-22,Protocadherin-PC
EIAAB30017 Homo sapiens,Human,KIAA1326,PCDH11,PCDH11X,PCDHX,PCDH-X,Protocadherin on the X chromosome,Protocadherin-11,Protocadherin-11 X-linked,Protocadherin-S
EIAAB30018 PCDH11,PCDH11X,PCDHX,PCDH-X,Pig,Protocadherin on the X chromosome,Protocadherin-11,Protocadherin-11 X-linked,Sus scrofa
EIAAB30116 Homo sapiens,Human,PC-43,PCDH2,PCDH-gamma-C3,PCDHGC3,Protocadherin gamma-C3,Protocadherin-2,Protocadherin-43
TD2007PA-1 Stem Cell Products 5 Wernig Factor Set (pCDH-CMV-mAscl1, pCDH-CMV-mBrn2, pCDH-CMV-mMyt1l, pCDH-CMV-mOlig2 , pCDH-CMV-mZic1) 10 ug each
TD2007PA-1 5 Wernig Factor Set (pCDH-CMV-mAscl1, pCDH-CMV-mBrn2, pCDH-CMV-mMyt1l, pCDH-CMV-mOlig2 , pCDH-CMV-mZic1) 10 ug each


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur