Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Protocadherin beta-15 (PCDH-beta-15)

 PCDBF_HUMAN             Reviewed;         787 AA.
Q9Y5E8; Q8IUX5;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
20-JUN-2018, entry version 153.
RecName: Full=Protocadherin beta-15;
Short=PCDH-beta-15;
Flags: Precursor;
Name=PCDHB15;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10380929; DOI=10.1016/S0092-8674(00)80789-8;
Wu Q., Maniatis T.;
"A striking organization of a large family of human neural cadherin-
like cell adhesion genes.";
Cell 97:779-790(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11322959; DOI=10.1016/S0014-5793(01)02372-9;
Vanhalst K., Kools P., Vanden Eynde E., van Roy F.;
"The human and murine protocadherin-beta one-exon gene families show
high evolutionary conservation, despite the difference in gene
number.";
FEBS Lett. 495:120-125(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-474 AND
GLN-494.
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
VARIANTS [LARGE SCALE ANALYSIS] VAL-719 AND VAL-758.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May
be involved in the establishment and maintenance of specific
neuronal connections in the brain.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF152494; AAD43755.1; -; mRNA.
EMBL; AF217742; AAK51610.1; -; mRNA.
EMBL; BC038797; AAH38797.1; -; mRNA.
CCDS; CCDS4257.1; -.
RefSeq; NP_061758.1; NM_018935.3.
UniGene; Hs.130757; -.
ProteinModelPortal; Q9Y5E8; -.
SMR; Q9Y5E8; -.
BioGrid; 121061; 25.
IntAct; Q9Y5E8; 25.
STRING; 9606.ENSP00000231173; -.
iPTMnet; Q9Y5E8; -.
PhosphoSitePlus; Q9Y5E8; -.
BioMuta; PCDHB15; -.
DMDM; 13431379; -.
EPD; Q9Y5E8; -.
PaxDb; Q9Y5E8; -.
PeptideAtlas; Q9Y5E8; -.
PRIDE; Q9Y5E8; -.
ProteomicsDB; 86347; -.
DNASU; 56121; -.
Ensembl; ENST00000231173; ENSP00000231173; ENSG00000113248.
GeneID; 56121; -.
KEGG; hsa:56121; -.
UCSC; uc003lje.5; human.
CTD; 56121; -.
EuPathDB; HostDB:ENSG00000113248.5; -.
GeneCards; PCDHB15; -.
HGNC; HGNC:8686; PCDHB15.
HPA; CAB026471; -.
HPA; HPA007172; -.
HPA; HPA074676; -.
MIM; 604967; gene.
MIM; 606341; gene.
neXtProt; NX_Q9Y5E8; -.
OpenTargets; ENSG00000113248; -.
PharmGKB; PA33031; -.
eggNOG; KOG3594; Eukaryota.
eggNOG; ENOG410XQHI; LUCA.
GeneTree; ENSGT00900000140770; -.
HOGENOM; HOG000220892; -.
HOVERGEN; HBG054878; -.
InParanoid; Q9Y5E8; -.
KO; K16494; -.
OMA; RVVSEDN; -.
OrthoDB; EOG091G024L; -.
PhylomeDB; Q9Y5E8; -.
TreeFam; TF332299; -.
GeneWiki; PCDHB15; -.
GenomeRNAi; 56121; -.
PRO; PR:Q9Y5E8; -.
Proteomes; UP000005640; Chromosome 5.
Bgee; ENSG00000113248; -.
CleanEx; HS_PCDHB15; -.
ExpressionAtlas; Q9Y5E8; baseline and differential.
Genevisible; Q9Y5E8; HS.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
GO; GO:0007399; P:nervous system development; TAS:ProtInc.
GO; GO:0007416; P:synapse assembly; IBA:GO_Central.
InterPro; IPR002126; Cadherin.
InterPro; IPR015919; Cadherin-like.
InterPro; IPR032455; Cadherin_C.
InterPro; IPR020894; Cadherin_CS.
InterPro; IPR013164; Cadherin_N.
InterPro; IPR030733; PCDHB15.
PANTHER; PTHR24028:SF97; PTHR24028:SF97; 1.
Pfam; PF00028; Cadherin; 5.
Pfam; PF08266; Cadherin_2; 1.
Pfam; PF16492; Cadherin_C_2; 1.
PRINTS; PR00205; CADHERIN.
SMART; SM00112; CA; 5.
SUPFAM; SSF49313; SSF49313; 6.
PROSITE; PS00232; CADHERIN_1; 5.
PROSITE; PS50268; CADHERIN_2; 6.
2: Evidence at transcript level;
Calcium; Cell adhesion; Cell membrane; Complete proteome;
Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat;
Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 26 {ECO:0000255}.
CHAIN 27 787 Protocadherin beta-15.
/FTId=PRO_0000003942.
TOPO_DOM 27 690 Extracellular. {ECO:0000255}.
TRANSMEM 691 711 Helical. {ECO:0000255}.
TOPO_DOM 712 787 Cytoplasmic. {ECO:0000255}.
DOMAIN 35 133 Cadherin 1. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 138 242 Cadherin 2. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 247 347 Cadherin 3. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 352 451 Cadherin 4. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 456 561 Cadherin 5. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
DOMAIN 568 671 Cadherin 6. {ECO:0000255|PROSITE-
ProRule:PRU00043}.
CARBOHYD 418 418 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 567 567 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 474 474 S -> R (in dbSNP:rs618506).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_019633.
VARIANT 494 494 R -> Q (in dbSNP:rs618096).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_019634.
VARIANT 719 719 A -> V (in a breast cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036106.
VARIANT 758 758 G -> V (in a breast cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036107.
SEQUENCE 787 AA; 86329 MW; 8DE8D3A07B0B6A56 CRC64;
MEPAGERFPE QRQVLILLLL LEVTLAGWEP RRYSVMEETE RGSFVANLAN DLGLGVGELA
ERGARVVSED NEQGLQLDLQ TGQLILNEKL DREKLCGPTE PCIMHFQVLL KKPLEVFRAE
LLVTDINDHS PEFPEREMTL KIPETSSLGT VFPLKKARDL DVGSNNVQNY NISPNSHFHV
STRTRGDGRK YPELVLDTEL DREEQAELRL TLTAVDGGSP PRSGTVQILI LVLDANDNAP
EFVQALYEVQ VPENSPVGSL VVKVSARDLD TGTNGEISYS LYYSSQEIDK PFELSSLSGE
IRLIKKLDFE TMSSYDLDIE ASDGGGLSGK CSVSVKVLDV NDNFPELSIS SLTSPIPENS
PETEVALFRI RDRDSGENGK MICSIQDDVP FKLKPSVENF YRLVTEGALD RETRAEYNIT
ITITDLGTPR LKTEQSITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS
GTNAQVTYSL LPPRDPHLPL TSLVSINTDN GHLFALQSLD YEALQAFEFR VGATDRGFPA
LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDVAKHRL VVLVKDNGEP PRSATATLQV
LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVFLFVA VRLCRRSRAA
SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSE SNDFKFLKPI FPNIVSQDSR
RKSEFLE


Related products :

Catalog number Product name Quantity
EIAAB30094 Homo sapiens,Human,PCDHB18,PCDH-beta-18,PCDH-psi2,Putative protocadherin beta-18
EIAAB30093 Homo sapiens,Human,KIAA1621,PCDH3X,PCDHB16,PCDH-beta-16,Protocadherin beta-16,Protocadherin-3X
EIAAB30084 Homo sapiens,Human,PCDH3I,PCDHB8,PCDH-beta-8,Protocadherin beta-8,Protocadherin-3I
EIAAB30085 Homo sapiens,Human,PCDH3H,PCDHB9,PCDH-beta-9,Protocadherin beta-9,Protocadherin-3H
EIAAB30077 Homo sapiens,Human,PCDHB1,PCDH-beta-1,Protocadherin beta-1
EIAAB30083 Homo sapiens,Human,PCDHB7,PCDH-beta-7,Protocadherin beta-7
EIAAB30087 Homo sapiens,Human,PCDHB11,PCDH-beta-11,Protocadherin beta-11
EIAAB30078 Homo sapiens,Human,PCDHB2,PCDH-beta-2,Protocadherin beta-2
EIAAB30079 Homo sapiens,Human,PCDHB3,PCDH-beta-3,Protocadherin beta-3
EIAAB30088 Homo sapiens,Human,PCDHB12,PCDH-beta-12,Protocadherin beta-12
EIAAB30081 Homo sapiens,Human,PCDHB5,PCDH-beta-5,Protocadherin beta-5
EIAAB30082 Homo sapiens,Human,PCDHB6,PCDH-beta-6,Protocadherin beta-6
EIAAB30092 Homo sapiens,Human,PCDHB15,PCDH-beta-15,Protocadherin beta-15
EIAAB30080 Homo sapiens,Human,PCDHB4,PCDH-beta-4,Protocadherin beta-4
EIAAB30090 Homo sapiens,Human,PCDHB14,PCDH-beta-14,Protocadherin beta-14
EIAAB30091 Mouse,Mus musculus,Pcdhb14,PCDH-beta-14,Protocadherin beta-14
EIAAB30089 Homo sapiens,Human,PCDHB13,PCDH-beta-13,Protocadherin beta-13,UNQ332_PRO531
EIAAB30086 Homo sapiens,Human,PCDHB10,PCDH-beta-10,Protocadherin beta-10,UNQ1906_PRO4352
EIAAB30019 Homo sapiens,Human,PCDH11,PCDH11Y,PCDH22,PCDHY,PCDH-Y,Protocadherin on the Y chromosome,Protocadherin prostate cancer,Protocadherin-11,Protocadherin-11 Y-linked,Protocadherin-22,Protocadherin-PC
EIAAB30017 Homo sapiens,Human,KIAA1326,PCDH11,PCDH11X,PCDHX,PCDH-X,Protocadherin on the X chromosome,Protocadherin-11,Protocadherin-11 X-linked,Protocadherin-S
EIAAB30018 PCDH11,PCDH11X,PCDHX,PCDH-X,Pig,Protocadherin on the X chromosome,Protocadherin-11,Protocadherin-11 X-linked,Sus scrofa
EIAAB30116 Homo sapiens,Human,PC-43,PCDH2,PCDH-gamma-C3,PCDHGC3,Protocadherin gamma-C3,Protocadherin-2,Protocadherin-43
TD2007PA-1 Stem Cell Products 5 Wernig Factor Set (pCDH-CMV-mAscl1, pCDH-CMV-mBrn2, pCDH-CMV-mMyt1l, pCDH-CMV-mOlig2 , pCDH-CMV-mZic1) 10 ug each
TD2007PA-1 5 Wernig Factor Set (pCDH-CMV-mAscl1, pCDH-CMV-mBrn2, pCDH-CMV-mMyt1l, pCDH-CMV-mOlig2 , pCDH-CMV-mZic1) 10 ug each
EIAAB30120 BHPCDH,BH-Pcdh,Brain-heart protocadherin,Homo sapiens,Human,PCDH7,Protocadherin-7


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur