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Protochlorophyllide reductase A, chloroplastic (PCR A) (EC 1.3.1.33) (NADPH-protochlorophyllide oxidoreductase A) (POR A)

 PORA_ARATH              Reviewed;         405 AA.
Q42536; B9DGY6; Q9FK22;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
06-DEC-2002, sequence version 2.
25-APR-2018, entry version 151.
RecName: Full=Protochlorophyllide reductase A, chloroplastic;
Short=PCR A;
EC=1.3.1.33;
AltName: Full=NADPH-protochlorophyllide oxidoreductase A;
Short=POR A;
Flags: Precursor;
Name=PORA; OrderedLocusNames=At5g54190; ORFNames=K18G13.7;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE, AND
TISSUE SPECIFICITY.
STRAIN=cv. Columbia;
PubMed=7659751; DOI=10.1104/pp.108.4.1505;
Armstrong G.A., Runge S., Frick G., Sperling U., Apel K.;
"Identification of NADPH:protochlorophyllide oxidoreductases A and B:
a branched pathway for light-dependent chlorophyll biosynthesis in
Arabidopsis thaliana.";
Plant Physiol. 108:1505-1517(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=9734815; DOI=10.1093/dnares/5.3.203;
Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. VI.
Sequence features of the regions of 1,367,185 bp covered by 19
physically assigned P1 and TAC clones.";
DNA Res. 5:203-216(1998).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=cv. Columbia;
PubMed=19423640; DOI=10.1093/dnares/dsp009;
Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M.,
Seki M., Shinozaki K.;
"Analysis of multiple occurrences of alternative splicing events in
Arabidopsis thaliana using novel sequenced full-length cDNAs.";
DNA Res. 16:155-164(2009).
[6]
FUNCTION, INDUCTION BY LIGHT, AND DEVELOPMENTAL STAGE.
STRAIN=cv. Columbia;
PubMed=11785941; DOI=10.1023/A:1013699721301;
Su Q., Frick G., Armstrong G., Apel K.;
"POR C of Arabidopsis thaliana: a third light- and NADPH-dependent
protochlorophyllide oxidoreductase that is differentially regulated by
light.";
Plant Mol. Biol. 47:805-813(2001).
[7]
INTERACTION WITH OP161 AND TOC33.
PubMed=15773849; DOI=10.1111/j.1365-313X.2005.02353.x;
Reinbothe S., Pollmann S., Springer A., James R.J., Tichtinsky G.,
Reinbothe C.;
"A role of Toc33 in the protochlorophyllide-dependent plastid import
pathway of NADPH:protochlorophyllide oxidoreductase (POR) A.";
Plant J. 42:1-12(2005).
[8]
SUBCELLULAR LOCATION.
PubMed=15842619; DOI=10.1111/j.1365-313X.2005.02374.x;
Kim C., Ham H., Apel K.;
"Multiplicity of different cell- and organ-specific import routes for
the NADPH-protochlorophyllide oxidoreductases A and B in plastids of
Arabidopsis seedlings.";
Plant J. 42:329-340(2005).
[9]
FUNCTION.
PubMed=20012672; DOI=10.1007/s11103-009-9582-y;
Paddock T.N., Mason M.E., Lima D.F., Armstrong G.A.;
"Arabidopsis protochlorophyllide oxidoreductase A (PORA) restores bulk
chlorophyll synthesis and normal development to a porB porC double
mutant.";
Plant Mol. Biol. 72:445-457(2010).
[10]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=22278767; DOI=10.1007/s11103-012-9873-6;
Paddock T., Lima D., Mason M.E., Apel K., Armstrong G.A.;
"Arabidopsis light-dependent protochlorophyllide oxidoreductase A
(PORA) is essential for normal plant growth and development.";
Plant Mol. Biol. 78:447-460(2012).
[11]
INTERACTION WITH CPP1.
PubMed=25901327; DOI=10.1073/pnas.1506339112;
Reinbothe S., Gray J., Rustgi S., von Wettstein D., Reinbothe C.;
"Cell growth defect factor 1 is crucial for the plastid import of
NADPH:protochlorophyllide oxidoreductase A in Arabidopsis thaliana.";
Proc. Natl. Acad. Sci. U.S.A. 112:5838-5843(2015).
-!- FUNCTION: Phototransformation of protochlorophyllide (Pchlide) to
chlorophyllide (Chlide). PORA may also function as a
photoprotectant during the transitory stage from dark to light.
Functions in skotomorphogenesis, photomorphogenesis and throughout
the plant life under specific light conditions.
{ECO:0000269|PubMed:11785941, ECO:0000269|PubMed:20012672,
ECO:0000269|PubMed:22278767}.
-!- CATALYTIC ACTIVITY: Chlorophyllide a + NADP(+) =
protochlorophyllide + NADPH.
-!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
biosynthesis.
-!- SUBUNIT: Forms large complexes including TOC33, pPORA and OEP161
during pPORA import into plastids at the plastid envelope
membrane. Interacts with CPP1 during plastid import
(PubMed:25901327). {ECO:0000269|PubMed:25901327}.
-!- SUBCELLULAR LOCATION: Plastid, chloroplast
{ECO:0000269|PubMed:15842619}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q42536-1; Sequence=Displayed;
Name=2;
IsoId=Q42536-2; Sequence=VSP_046548;
-!- TISSUE SPECIFICITY: Expressed in young seedlings. Not detected in
leaves. {ECO:0000269|PubMed:7659751}.
-!- DEVELOPMENTAL STAGE: Etiolated seedlings.
{ECO:0000269|PubMed:11785941, ECO:0000269|PubMed:7659751}.
-!- INDUCTION: Down-regulated by light. {ECO:0000269|PubMed:11785941}.
-!- DISRUPTION PHENOTYPE: Lethal under normal growth conditions and
light-green stunted plants when grown in presence of sucrose.
{ECO:0000269|PubMed:22278767}.
-!- MISCELLANEOUS: The presence of TOC33 is not required for the
import of PORA into plastids. {ECO:0000305|PubMed:15842619}.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
(SDR) family. POR subfamily. {ECO:0000305}.
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EMBL; U29699; AAC49043.1; -; mRNA.
EMBL; AB013387; BAB11581.1; -; Genomic_DNA.
EMBL; CP002688; AED96464.1; -; Genomic_DNA.
EMBL; CP002688; AED96465.1; -; Genomic_DNA.
EMBL; BT003853; AAO41903.1; -; mRNA.
EMBL; BT005080; AAO50613.1; -; mRNA.
EMBL; AK317329; BAH20003.1; -; mRNA.
RefSeq; NP_001032072.1; NM_001036995.1. [Q42536-2]
RefSeq; NP_200230.1; NM_124799.4. [Q42536-1]
UniGene; At.23877; -.
ProteinModelPortal; Q42536; -.
SMR; Q42536; -.
BioGrid; 20751; 6.
IntAct; Q42536; 1.
STRING; 3702.AT5G54190.1; -.
PaxDb; Q42536; -.
PRIDE; Q42536; -.
EnsemblPlants; AT5G54190.1; AT5G54190.1; AT5G54190. [Q42536-1]
EnsemblPlants; AT5G54190.2; AT5G54190.2; AT5G54190. [Q42536-2]
GeneID; 835507; -.
Gramene; AT5G54190.1; AT5G54190.1; AT5G54190. [Q42536-1]
Gramene; AT5G54190.2; AT5G54190.2; AT5G54190. [Q42536-2]
KEGG; ath:AT5G54190; -.
Araport; AT5G54190; -.
TAIR; locus:2153438; AT5G54190.
eggNOG; KOG1208; Eukaryota.
eggNOG; COG1028; LUCA.
InParanoid; Q42536; -.
KO; K00218; -.
OMA; WSWGNRQ; -.
OrthoDB; EOG09360CR9; -.
PhylomeDB; Q42536; -.
BioCyc; ARA:AT5G54190-MONOMER; -.
BRENDA; 1.3.1.33; 399.
UniPathway; UPA00668; -.
PRO; PR:Q42536; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; Q42536; baseline and differential.
Genevisible; Q42536; AT.
GO; GO:0009507; C:chloroplast; NAS:TAIR.
GO; GO:0009941; C:chloroplast envelope; IDA:TAIR.
GO; GO:0009534; C:chloroplast thylakoid; IDA:TAIR.
GO; GO:0016630; F:protochlorophyllide reductase activity; IMP:UniProtKB.
GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0009640; P:photomorphogenesis; IMP:UniProtKB.
GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
GO; GO:0009723; P:response to ethylene; IEP:TAIR.
GO; GO:0009647; P:skotomorphogenesis; IMP:UniProtKB.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR005979; Prochl_reduct.
InterPro; IPR002347; SDR_fam.
PANTHER; PTHR44419; PTHR44419; 1.
Pfam; PF00106; adh_short; 1.
PRINTS; PR00081; GDHRDH.
SUPFAM; SSF51735; SSF51735; 2.
TIGRFAMs; TIGR01289; LPOR; 1.
1: Evidence at protein level;
Alternative splicing; Chlorophyll biosynthesis; Chloroplast;
Complete proteome; NADP; Oxidoreductase; Photosynthesis; Plastid;
Reference proteome; Transit peptide.
TRANSIT 1 69 Chloroplast. {ECO:0000255}.
CHAIN 70 405 Protochlorophyllide reductase A,
chloroplastic.
/FTId=PRO_0000023287.
VAR_SEQ 1 121 Missing (in isoform 2).
{ECO:0000303|PubMed:19423640}.
/FTId=VSP_046548.
CONFLICT 37 37 V -> I (in Ref. 1; AAC49043).
{ECO:0000305}.
SEQUENCE 405 AA; 43863 MW; EB82F2CEF0480D2E CRC64;
MALQAASLVS SAFSVRKDGK LNASASSSFK ESSLFGVSLS EQSKADFVSS SLRCKREQSL
RNNKAIIRAQ AIATSTPSVT KSSLDRKKTL RKGNVVVTGA SSGLGLATAK ALAETGKWHV
IMACRDFLKA ERAAQSAGMP KDSYTVMHLD LASLDSVRQF VDNFRRAEMP LDVLVCNAAV
YQPTANQPTF TAEGFELSVG INHLGHFLLS RLLIDDLKNS DYPSKRLIIV GSITGNTNTL
AGNVPPKANL GDLRGLAGGL NGLNSSAMID GGDFVGAKAY KDSKVCNMLT MQEFHRRFHE
DTGITFASLY PGCIATTGLF REHIPLFRTL FPPFQKYITK GYVSESEAGK RLAQVVADPS
LTKSGVYWSW NKTSASFENQ LSQEASDVEK ARRVWEVSEK LVGLA


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