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Protoheme IX farnesyltransferase (EC 2.5.1.-) (Heme B farnesyltransferase) (Heme O synthase)

 A0A069QCG9_PSEAI        Unreviewed;       304 AA.
A0A069QCG9;
01-OCT-2014, integrated into UniProtKB/TrEMBL.
01-OCT-2014, sequence version 1.
05-DEC-2018, entry version 46.
RecName: Full=Protoheme IX farnesyltransferase {ECO:0000256|HAMAP-Rule:MF_00154};
EC=2.5.1.141 {ECO:0000256|HAMAP-Rule:MF_00154};
AltName: Full=Heme B farnesyltransferase {ECO:0000256|HAMAP-Rule:MF_00154};
AltName: Full=Heme O synthase {ECO:0000256|HAMAP-Rule:MF_00154};
Name=cyoE1 {ECO:0000313|EMBL:CEH97508.1};
Synonyms=ctaB {ECO:0000313|EMBL:SOV26643.1},
ctaB_1 {ECO:0000313|EMBL:CRR23488.1},
cyoE {ECO:0000256|HAMAP-Rule:MF_00154};
ORFNames=C0044_00835 {ECO:0000313|EMBL:PXC04039.1},
C0046_00805 {ECO:0000313|EMBL:PXB96739.1},
CAZ10_15765 {ECO:0000313|EMBL:OTI61331.1},
CGU42_21650 {ECO:0000313|EMBL:OZO15593.1},
CW299_00700 {ECO:0000313|EMBL:PXC01571.1},
DI492_12160 {ECO:0000313|EMBL:PWH93011.1},
DN070_15560 {ECO:0000313|EMBL:RCH60847.1},
NCTC13719_06321 {ECO:0000313|EMBL:SUD06744.1},
PAERUG_E15_London_28_01_14_08421 {ECO:0000313|EMBL:CRR23488.1},
PAMH19_0112 {ECO:0000313|EMBL:CEH97508.1},
RW109_RW109_00716 {ECO:0000313|EMBL:SOV26643.1};
Pseudomonas aeruginosa.
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
Pseudomonadaceae; Pseudomonas.
NCBI_TaxID=287 {ECO:0000313|EMBL:CEH97508.1, ECO:0000313|Proteomes:UP000043988};
[1] {ECO:0000313|EMBL:CEH97508.1, ECO:0000313|Proteomes:UP000043988}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MH19 {ECO:0000313|EMBL:CEH97508.1,
ECO:0000313|Proteomes:UP000043988};
Wibberg Daniel;
Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:CRR23488.1}
NUCLEOTIDE SEQUENCE.
STRAIN=E15_London_28_01_14 {ECO:0000313|EMBL:CRR23488.1};
Radhakrishnan Rajesh, Underwood Anthony, Al-Shahib Ali;
Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:OTI61331.1, ECO:0000313|Proteomes:UP000194857}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=S567_C10_BS {ECO:0000313|EMBL:OTI61331.1,
ECO:0000313|Proteomes:UP000194857};
Song R., Chenine A.L., Ruprecht R.M.;
Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:OZO15593.1, ECO:0000313|Proteomes:UP000216659}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Ocean-1187 {ECO:0000313|EMBL:OZO15593.1,
ECO:0000313|Proteomes:UP000216659};
Kumagai Y., Yoshizawa S., Kogure K.;
"Genome sequencing of oceanic Pseudomonas aeruginosa.";
Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:SOV26643.1, ECO:0000313|Proteomes:UP000233777}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=RW109 {ECO:0000313|EMBL:SOV26643.1};
Hurst M.R.H.;
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|EMBL:PWH93011.1, ECO:0000313|Proteomes:UP000245486}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PAL0.1 {ECO:0000313|EMBL:PWH93011.1,
ECO:0000313|Proteomes:UP000245486};
Grandjean T., Le Guern R., Bauduin M., Dessein R., Kipnis E.,
Faure K., Duployez C.;
"In vivo anti-infectious effect of lectins inhibitors.";
Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|Proteomes:UP000246712, ECO:0000313|Proteomes:UP000246728, ECO:0000313|Proteomes:UP000247072}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=LIM1410 {ECO:0000313|EMBL:PXC04039.1,
ECO:0000313|Proteomes:UP000247072},
LIM1680 {ECO:0000313|EMBL:PXB96739.1,
ECO:0000313|Proteomes:UP000246728}, and
LIM4285 {ECO:0000313|EMBL:PXC01571.1,
ECO:0000313|Proteomes:UP000246712};
Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M.,
Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Rusch D.,
Podicherti R., Tsui H.-C.T., Winkler M.E.;
Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|Proteomes:UP000246712, ECO:0000313|Proteomes:UP000246728, ECO:0000313|Proteomes:UP000247072}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=LIM1410 {ECO:0000313|EMBL:PXC04039.1,
ECO:0000313|Proteomes:UP000247072},
LIM1680 {ECO:0000313|EMBL:PXB96739.1,
ECO:0000313|Proteomes:UP000246728}, and
LIM4285 {ECO:0000313|EMBL:PXC01571.1,
ECO:0000313|Proteomes:UP000246712};
Martins R.C.R., Perdigao-Neto L.V., Costa S.F., Levin A.S.S.;
"Pseudomonas aeruginosa genome sequencing and assembly.";
Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
[9] {ECO:0000313|EMBL:SUD06744.1, ECO:0000313|Proteomes:UP000255354}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCTC13719 {ECO:0000313|EMBL:SUD06744.1,
ECO:0000313|Proteomes:UP000255354};
Pathogen Informatics;
Doyle S.;
Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:RCH60847.1, ECO:0000313|Proteomes:UP000252818}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TUEPA7472 {ECO:0000313|EMBL:RCH60847.1,
ECO:0000313|Proteomes:UP000252818};
Miess H., Jahanshah G., Broetz-Oesterhelt H., Willmann M., Peter S.,
Gross H.;
"Draft Genome Sequence of the Extensively Drug-Resistant (XDR / 4MRGN)
Pseudomonas aeruginosa Clinical Isolate TUEPA7472.";
Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
of the vinyl group on carbon 2 of heme B porphyrin ring with a
hydroxyethyl farnesyl side group. {ECO:0000256|HAMAP-
Rule:MF_00154, ECO:0000256|SAAS:SAAS00958916}.
-!- CATALYTIC ACTIVITY:
Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate
+ Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377,
ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530,
ChEBI:CHEBI:175763; EC=2.5.1.141; Evidence={ECO:0000256|HAMAP-
Rule:MF_00154, ECO:0000256|SAAS:SAAS01108303};
-!- PATHWAY: Porphyrin-containing compound metabolism; heme O
biosynthesis; heme O from protoheme: step 1/1. {ECO:0000256|HAMAP-
Rule:MF_00154, ECO:0000256|SAAS:SAAS00958899}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
Rule:MF_00154}; Multi-pass membrane protein {ECO:0000256|HAMAP-
Rule:MF_00154}.
-!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
according to the Fischer nomenclature. {ECO:0000256|HAMAP-
Rule:MF_00154}.
-!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
Protoheme IX farnesyltransferase subfamily. {ECO:0000256|HAMAP-
Rule:MF_00154, ECO:0000256|SAAS:SAAS00958900}.
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EMBL; CDAZ01000001; CEH97508.1; -; Genomic_DNA.
EMBL; CVWF01000466; CRR23488.1; -; Genomic_DNA.
EMBL; NFFZ01000007; OTI61331.1; -; Genomic_DNA.
EMBL; NMRQ01000038; OZO15593.1; -; Genomic_DNA.
EMBL; QFRL01000008; PWH93011.1; -; Genomic_DNA.
EMBL; QHLW01000030; PXB96739.1; -; Genomic_DNA.
EMBL; QHLS01000027; PXC01571.1; -; Genomic_DNA.
EMBL; QHLU01000058; PXC04039.1; -; Genomic_DNA.
EMBL; QOLE01000002; RCH60847.1; -; Genomic_DNA.
EMBL; LT969520; SOV26643.1; -; Genomic_DNA.
EMBL; UGUM01000004; SUD06744.1; -; Genomic_DNA.
RefSeq; WP_003083746.1; NZ_UGUO01000001.1.
EnsemblBacteria; CEH97508; CEH97508; PAMH19_0112.
EnsemblBacteria; CRO58116; CRO58116; PAERUG_P32_London_17_VIM_2_10_11_02604.
EnsemblBacteria; CRR23488; CRR23488; PAERUG_E15_London_28_01_14_08421.
EnsemblBacteria; KSG98985; KSG98985; AO964_32060.
KEGG; paeb:NCGM1900_0105; -.
PATRIC; fig|287.1477.peg.2561; -.
eggNOG; ENOG4105F1R; Bacteria.
eggNOG; COG0109; LUCA.
KO; K02257; -.
UniPathway; UPA00834; UER00712.
Proteomes; UP000043988; Unassembled WGS sequence.
Proteomes; UP000194857; Unassembled WGS sequence.
Proteomes; UP000216659; Unassembled WGS sequence.
Proteomes; UP000233777; Chromosome mainomosome.
Proteomes; UP000245486; Unassembled WGS sequence.
Proteomes; UP000246712; Unassembled WGS sequence.
Proteomes; UP000246728; Unassembled WGS sequence.
Proteomes; UP000247072; Unassembled WGS sequence.
Proteomes; UP000252818; Unassembled WGS sequence.
Proteomes; UP000255354; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-UniRule.
CDD; cd13957; PT_UbiA_Cox10; 1.
HAMAP; MF_00154; CyoE_CtaB; 1.
InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
InterPro; IPR000537; UbiA_prenyltransferase.
InterPro; IPR030470; UbiA_prenylTrfase_CS.
PANTHER; PTHR43448; PTHR43448; 1.
Pfam; PF01040; UbiA; 1.
TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
PROSITE; PS00943; UBIA; 1.
3: Inferred from homology;
Cell membrane {ECO:0000256|HAMAP-Rule:MF_00154,
ECO:0000256|SAAS:SAAS00964118};
Complete proteome {ECO:0000313|Proteomes:UP000043988,
ECO:0000313|Proteomes:UP000194857, ECO:0000313|Proteomes:UP000216659,
ECO:0000313|Proteomes:UP000233777};
Heme biosynthesis {ECO:0000256|HAMAP-Rule:MF_00154,
ECO:0000256|SAAS:SAAS00964124};
Membrane {ECO:0000256|HAMAP-Rule:MF_00154,
ECO:0000256|SAAS:SAAS00415562, ECO:0000256|SAAS:SAAS00964118};
Transferase {ECO:0000256|HAMAP-Rule:MF_00154,
ECO:0000256|SAAS:SAAS00415579, ECO:0000313|EMBL:CEH97508.1};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_00154,
ECO:0000256|SAAS:SAAS00415562};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00154,
ECO:0000256|SAAS:SAAS00415562}.
TRANSMEM 24 44 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
TRANSMEM 50 74 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
TRANSMEM 95 118 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
TRANSMEM 124 142 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
TRANSMEM 149 168 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
TRANSMEM 174 194 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
TRANSMEM 223 240 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
TRANSMEM 246 266 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
TRANSMEM 278 298 Helical. {ECO:0000256|HAMAP-
Rule:MF_00154}.
SEQUENCE 304 AA; 33430 MW; DC278071764B671C CRC64;
MATVIDRHSQ PTWRDFLELT KPKVVVLMLI TSLIGMLLAT KAPLDGFVPW QVLIFGNLGI
GLCAGAAAAV NHVVDRRIDS IMARTHKRPL AEGRVSPSMA LGFALLLALA GMAVLLAFTN
PLTAWLTLAS LLGYAALYTG FLKRATPQNI VIGGLAGAAP PLLGWVAITG HLSAEPLLLV
LIIFAWTPPH FWALCIHRKD EYAKADIPML PVTHGERYTK LHILLYTLVL FAVSLMPFVI
HMSGLVYLLC ALALGARFLD WAWALYCDSR PHAAIKTFKY SIVYLFLLFM ALLVDHYLPL
KLLL


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