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Protoheme IX farnesyltransferase (EC 2.5.1.-) (Heme B farnesyltransferase) (Heme O synthase)

 COXX_RHOS4              Reviewed;         310 AA.
Q3J5F9; Q66LN7;
08-APR-2008, integrated into UniProtKB/Swiss-Prot.
08-NOV-2005, sequence version 1.
05-DEC-2018, entry version 78.
RecName: Full=Protoheme IX farnesyltransferase;
EC=2.5.1.141;
AltName: Full=Heme B farnesyltransferase;
AltName: Full=Heme O synthase;
Name=ctaB; Synonyms=cox10; OrderedLocusNames=RHOS4_04070;
ORFNames=RSP_1827;
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM
158).
Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
Rhodobacteraceae; Rhodobacter.
NCBI_TaxID=272943;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INTERACTION.
PubMed=15491161;
Brown B.M., Wang Z., Brown K.R., Cricco J.A., Hegg E.L.;
"Heme O synthase and heme A synthase from Bacillus subtilis and
Rhodobacter sphaeroides interact in Escherichia coli.";
Biochemistry 43:13541-13548(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158;
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J.,
Kaplan S.;
"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
of the vinyl group on carbon 2 of heme B porphyrin ring with a
hydroxyethyl farnesyl side group. {ECO:0000269|PubMed:15491161}.
-!- CATALYTIC ACTIVITY:
Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate
+ Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377,
ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530,
ChEBI:CHEBI:175763; EC=2.5.1.141;
-!- PATHWAY: Porphyrin-containing compound metabolism; heme O
biosynthesis; heme O from protoheme: step 1/1.
-!- SUBUNIT: Interacts with CtaA. {ECO:0000269|PubMed:15491161}.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-
pass membrane protein {ECO:0000305}.
-!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
according to the Fischer nomenclature.
-!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
Protoheme IX farnesyltransferase subfamily. {ECO:0000305}.
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EMBL; AY692270; AAU04882.1; -; Genomic_DNA.
EMBL; CP000143; ABA77975.1; -; Genomic_DNA.
RefSeq; WP_002722694.1; NZ_CP030271.1.
RefSeq; YP_351876.1; NC_007493.2.
IntAct; Q3J5F9; 1.
STRING; 272943.RSP_1827; -.
EnsemblBacteria; ABA77975; ABA77975; RSP_1827.
GeneID; 3719074; -.
KEGG; rsp:RSP_1827; -.
PATRIC; fig|272943.9.peg.713; -.
eggNOG; ENOG4105F1R; Bacteria.
eggNOG; COG0109; LUCA.
HOGENOM; HOG000237291; -.
KO; K02257; -.
OMA; WQFPHFW; -.
OrthoDB; POG091H05F2; -.
PhylomeDB; Q3J5F9; -.
BRENDA; 2.5.1.B36; 5383.
UniPathway; UPA00834; UER00712.
Proteomes; UP000002703; Chromosome 1.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-UniRule.
CDD; cd13957; PT_UbiA_Cox10; 1.
HAMAP; MF_00154; CyoE_CtaB; 1.
InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
InterPro; IPR000537; UbiA_prenyltransferase.
InterPro; IPR030470; UbiA_prenylTrfase_CS.
PANTHER; PTHR43448; PTHR43448; 1.
Pfam; PF01040; UbiA; 1.
TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
PROSITE; PS00943; UBIA; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Complete proteome;
Heme biosynthesis; Membrane; Reference proteome; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 310 Protoheme IX farnesyltransferase.
/FTId=PRO_0000327134.
TRANSMEM 26 45 Helical. {ECO:0000255}.
TRANSMEM 49 71 Helical. {ECO:0000255}.
TRANSMEM 95 115 Helical. {ECO:0000255}.
TRANSMEM 118 138 Helical. {ECO:0000255}.
TRANSMEM 147 167 Helical. {ECO:0000255}.
TRANSMEM 174 194 Helical. {ECO:0000255}.
TRANSMEM 220 240 Helical. {ECO:0000255}.
TRANSMEM 243 263 Helical. {ECO:0000255}.
TRANSMEM 289 309 Helical. {ECO:0000255}.
SEQUENCE 310 AA; 33357 MW; 2FECC8D6F66CB477 CRC64;
MTDIRITGIP KEAGFGDYVA LLKPRVMSLV VFTALVGLLV APVTVHPMIA LTGILFIALG
AGASGALNMW WDEDIDRVMK RTRNRPVPSG TVAPGEALGI GLALSGIAVV MLGLATNLFA
AGLLAFTIFF YAVVYSMWLK RTTPQNIVIG GAAGAFPPMI GWAVATGGVS VESLFMFALI
FMWTPPHFWS LALFMKSDYS DAGVPMLTVT HGRRVTRAHV LVYSLLLAPL AVAGAFTGIG
GPLYLATALA LNGWLLVGAV RIWRRDEAQA EADRYRVEKG FFRFSLYYLF LHFGAILAEA
ALKPYGLGGW


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