Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pulmonary surfactant-associated protein A1 (PSP-A) (PSPA) (SP-A) (SP-A1) (35 kDa pulmonary surfactant-associated protein) (Alveolar proteinosis protein) (Collectin-4)

 SFTA1_HUMAN             Reviewed;         248 AA.
Q8IWL2; A8K3T8; B7ZW50; E3VLD8; E3VLD9; E3VLE0; E3VLE1; G5E9J3;
P07714; Q14DV4; Q5RIR5; Q5RIR7; Q6PIT0; Q8TC19;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-MAR-2005, sequence version 2.
23-MAY-2018, entry version 157.
RecName: Full=Pulmonary surfactant-associated protein A1;
Short=PSP-A;
Short=PSPA;
Short=SP-A;
Short=SP-A1;
AltName: Full=35 kDa pulmonary surfactant-associated protein;
AltName: Full=Alveolar proteinosis protein;
AltName: Full=Collectin-4;
Flags: Precursor;
Name=SFTPA1; Synonyms=COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2995821; DOI=10.1038/317361a0;
White R.T., Damm D., Miller J., Spratt K., Schilling J., Hawgood S.,
Benson B., Cordell B.;
"Isolation and characterization of the human pulmonary surfactant
apoprotein gene.";
Nature 317:361-363(1985).
[2]
NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-19, AND ACETYLATION.
PubMed=3755136;
Floros J., Steinbrink R., Jacobs K., Phelps D., Kriz R., Recny M.,
Sultzman L., Jones S., Taeusch H.W., Frank H.A., Fritsch E.F.;
"Isolation and characterization of cDNA clones for the 35-kDa
pulmonary surfactant-associated protein.";
J. Biol. Chem. 261:9029-9033(1986).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ALA-19; VAL-50 AND TRP-219.
PubMed=20693318; DOI=10.1152/ajplung.00113.2010;
Silveyra P., Wang G., Floros J.;
"Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail
differentially affect the in vitro translation of a reporter gene.";
Am. J. Physiol. 299:L523-L534(2010).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-9; ALA-19; VAL-50
AND TRP-219.
SeattleSNPs variation discovery resource;
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
DISULFIDE BONDS, AND SUBUNIT.
PubMed=2610270;
Haagsman H.P., White R.T., Schilling J., Lau K., Benson B.J.,
Golden J., Hawgood S., Clements J.A.;
"Studies of the structure of lung surfactant protein SP-A.";
Am. J. Physiol. 257:L421-L429(1989).
[10]
DEFINITION OF SFTPA1 ALLELES.
PubMed=9813381; DOI=10.1016/S0925-4439(98)00077-5;
Floros J., Hoover R.R.;
"Genetics of the hydrophilic surfactant proteins A and D.";
Biochim. Biophys. Acta 1408:312-322(1998).
[11]
INVOLVEMENT IN RDS.
PubMed=10762543; DOI=10.1086/302906;
Raemet M., Haataja R., Marttila R., Floros J., Hallman M.;
"Association between the surfactant protein A (SP-A) gene locus and
respiratory-distress syndrome in the Finnish population.";
Am. J. Hum. Genet. 66:1569-1579(2000).
[12]
FUNCTION (MICROBIAL INFECTION), AND INTERACTION WITH M.BOVIS APA.
PubMed=17158455; DOI=10.1074/jbc.M610183200;
Ragas A., Roussel L., Puzo G., Riviere M.;
"The Mycobacterium tuberculosis cell-surface glycoprotein Apa as a
potential adhesin to colonize target cells via the innate immune
system pulmonary C-type lectin surfactant protein A.";
J. Biol. Chem. 282:5133-5142(2007).
[13]
FUNCTION (MICROBIAL INFECTION).
PubMed=21203928; DOI=10.1007/s13238-010-0101-3;
Carroll M.V., Sim R.B., Bigi F., Jaekel A., Antrobus R.,
Mitchell D.A.;
"Identification of four novel DC-SIGN ligands on Mycobacterium bovis
BCG.";
Protein Cell 1:859-870(2010).
[14]
FUNCTION (MICROBIAL INFECTION), AND INTERACTION WITH S.AUREUS EPA.
PubMed=21123169; DOI=10.1074/jbc.M110.125567;
Sever-Chroneos Z., Krupa A., Davis J., Hasan M., Yang C.H.,
Szeliga J., Herrmann M., Hussain M., Geisbrecht B.V., Kobzik L.,
Chroneos Z.C.;
"Surfactant protein A (SP-A)-mediated clearance of Staphylococcus
aureus involves binding of SP-A to the staphylococcal adhesin eap and
the macrophage receptors SP-A receptor 210 and scavenger receptor
class A.";
J. Biol. Chem. 286:4854-4870(2011).
[15]
VARIANT TRP-219, AND ASSOCIATION WITH IDIOPATHIC PULMONARY FIBROSIS.
PubMed=13680361; DOI=10.1007/s00439-003-1015-4;
Selman M., Lin H.-M., Montano M., Jenkins A.L., Estrada A., Lin Z.,
Wang G., DiAngelo S.L., Guo X., Umstead T.M., Lang C.M., Pardo A.,
Phelps D.S., Floros J.;
"Surfactant protein A and B genetic variants predispose to idiopathic
pulmonary fibrosis.";
Hum. Genet. 113:542-550(2003).
[16]
VARIANTS LEU-5; THR-9; ALA-19; VAL-50 AND TRP-219.
PubMed=19100526; DOI=10.1016/j.ajhg.2008.11.010;
Wang Y., Kuan P.J., Xing C., Cronkhite J.T., Torres F.,
Rosenblatt R.L., DiMaio J.M., Kinch L.N., Grishin N.V., Garcia C.K.;
"Genetic defects in surfactant protein A2 are associated with
pulmonary fibrosis and lung cancer.";
Am. J. Hum. Genet. 84:52-59(2009).
-!- FUNCTION: In presence of calcium ions, it binds to surfactant
phospholipids and contributes to lower the surface tension at the
air-liquid interface in the alveoli of the mammalian lung and is
essential for normal respiration. Enhances the expression of
MYO18A/SP-R210 on alveolar macrophages (By similarity).
{ECO:0000250|UniProtKB:P35242}.
-!- FUNCTION: (Microbial infection) Recognition of M.tuberculosis by
dendritic cells may occur partially via this molecule
(PubMed:17158455, PubMed:21203928). Can recognize, bind, and
opsonize pathogens to enhance their elimination by alveolar
macrophages (PubMed:21123169). {ECO:0000269|PubMed:17158455,
ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:21203928}.
-!- SUBUNIT: Oligomeric complex of 6 set of homotrimers.
{ECO:0000269|PubMed:2610270}.
-!- SUBUNIT: (Microbial infection) Binds M.bovis cell surface protein
Apa via its glycosylated sites; probably also recognizes other
bacterial moieties. {ECO:0000269|PubMed:17158455}.
-!- SUBUNIT: (Microbial infection) Binds to the S.aureus extracellular
adherence protein, Eap, thereby enhancing phagocytosis and killing
of S.aureus by alveolar macrophages.
{ECO:0000269|PubMed:21123169}.
-!- INTERACTION:
Q9UGM3:DMBT1; NbExp=2; IntAct=EBI-11316418, EBI-1044970;
P75409:MPN_372 (xeno); NbExp=2; IntAct=EBI-11316418, EBI-2259548;
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix. Secreted, extracellular space, surface film.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q8IWL2-1; Sequence=Displayed;
Name=2;
IsoId=Q8IWL2-2; Sequence=VSP_046802;
-!- PTM: N-acetylated. {ECO:0000269|PubMed:3755136}.
-!- POLYMORPHISM: At least 5 allelic variants of SFTPA1 are known: 6A,
6A(2), 6A(3), 6A(4) and 6A(5). The sequence shown is that of
allele 6A(3).
-!- DISEASE: Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung
disease characterized by shortness of breath, radiographically
evident diffuse pulmonary infiltrates, and varying degrees of
inflammation and fibrosis on biopsy. In some cases, the disorder
can be rapidly progressive and characterized by sequential acute
lung injury with subsequent scarring and end-stage lung disease.
Note=Disease susceptibility is associated with variations
affecting the gene represented in this entry.
-!- DISEASE: Respiratory distress syndrome in premature infants (RDS)
[MIM:267450]: A lung disease affecting usually premature newborn
infants. It is characterized by deficient gas exchange, diffuse
atelectasis, high-permeability lung edema and fibrin-rich alveolar
deposits called 'hyaline membranes'.
{ECO:0000269|PubMed:10762543}. Note=Disease susceptibility may be
associated with variations affecting the gene represented in this
entry. The association between SFTPA1 alleles and respiratory
distress syndrome in premature infants is dependent on a variation
Ile to Thr at position 131 in SFTPB.
-!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
protein. There are 4 surfactant-associated proteins: 2
collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D)
and 2 small hydrophobic proteins (SP-B and SP-C).
-!- SIMILARITY: Belongs to the SFTPA family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAI16065.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/sftpa1/";
-!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
Note=Pulmonary surfactant protein SP-A1;
URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_232";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M30838; AAA36510.1; -; Genomic_DNA.
EMBL; M13686; AAA60211.1; -; mRNA.
EMBL; HQ021433; ADO27676.1; -; mRNA.
EMBL; HQ021434; ADO27677.1; -; mRNA.
EMBL; HQ021435; ADO27678.1; -; mRNA.
EMBL; HQ021436; ADO27679.1; -; mRNA.
EMBL; HQ021437; ADO27680.1; -; mRNA.
EMBL; HQ021438; ADO27681.1; -; mRNA.
EMBL; HQ021439; ADO27682.1; -; mRNA.
EMBL; HQ021440; ADO27683.1; -; mRNA.
EMBL; HQ021441; ADO27684.1; -; mRNA.
EMBL; HQ021442; ADO27685.1; -; mRNA.
EMBL; AK290703; BAF83392.1; -; mRNA.
EMBL; AY198391; AAO13486.1; -; Genomic_DNA.
EMBL; BX248123; CAI16065.1; ALT_SEQ; Genomic_DNA.
EMBL; BX248123; CAI16066.1; -; Genomic_DNA.
EMBL; BX248123; CAI16067.1; -; Genomic_DNA.
EMBL; CH471083; EAW54657.1; -; Genomic_DNA.
EMBL; CH471083; EAW54651.1; -; Genomic_DNA.
EMBL; CH471083; EAW54658.1; -; Genomic_DNA.
EMBL; BC029913; AAH29913.1; -; mRNA.
EMBL; BC111570; AAI11571.1; -; mRNA.
EMBL; BC171875; AAI71875.1; -; mRNA.
CCDS; CCDS44444.2; -. [Q8IWL2-2]
CCDS; CCDS44445.1; -. [Q8IWL2-1]
PIR; A24622; LNHUPS.
PIR; A25720; LNHUP6.
RefSeq; NP_001087239.2; NM_001093770.2. [Q8IWL2-2]
RefSeq; NP_001158116.1; NM_001164644.1. [Q8IWL2-1]
RefSeq; NP_001158119.1; NM_001164647.1. [Q8IWL2-1]
RefSeq; NP_005402.3; NM_005411.4. [Q8IWL2-1]
RefSeq; XP_005270119.1; XM_005270062.4. [Q8IWL2-1]
RefSeq; XP_006718016.1; XM_006717953.2. [Q8IWL2-2]
UniGene; Hs.535295; -.
UniGene; Hs.745476; -.
ProteinModelPortal; Q8IWL2; -.
SMR; Q8IWL2; -.
BioGrid; 575839; 4.
IntAct; Q8IWL2; 2.
STRING; 9606.ENSP00000397082; -.
DrugBank; DB03814; 2-(N-Morpholino)-Ethanesulfonic Acid.
iPTMnet; Q8IWL2; -.
PhosphoSitePlus; Q8IWL2; -.
BioMuta; SFTPA1; -.
DMDM; 60416440; -.
PaxDb; Q8IWL2; -.
PeptideAtlas; Q8IWL2; -.
PRIDE; Q8IWL2; -.
Ensembl; ENST00000398636; ENSP00000381633; ENSG00000122852. [Q8IWL2-1]
Ensembl; ENST00000419470; ENSP00000397082; ENSG00000122852. [Q8IWL2-2]
Ensembl; ENST00000428376; ENSP00000411102; ENSG00000122852. [Q8IWL2-1]
GeneID; 653509; -.
KEGG; hsa:653509; -.
UCSC; uc001kap.4; human. [Q8IWL2-1]
CTD; 653509; -.
DisGeNET; 653509; -.
EuPathDB; HostDB:ENSG00000122852.14; -.
GeneCards; SFTPA1; -.
HGNC; HGNC:10798; SFTPA1.
HPA; CAB016793; -.
HPA; HPA042638; -.
HPA; HPA045752; -.
HPA; HPA049368; -.
MalaCards; SFTPA1; -.
MIM; 178500; phenotype.
MIM; 178630; gene.
MIM; 267450; phenotype.
neXtProt; NX_Q8IWL2; -.
OpenTargets; ENSG00000122852; -.
Orphanet; 2032; Idiopathic pulmonary fibrosis.
PharmGKB; PA35710; -.
eggNOG; KOG4297; Eukaryota.
eggNOG; ENOG410XPJ1; LUCA.
GeneTree; ENSGT00700000104102; -.
HOVERGEN; HBG108270; -.
InParanoid; Q8IWL2; -.
KO; K10067; -.
OMA; TWNDKNC; -.
OrthoDB; EOG091G0PU5; -.
PhylomeDB; Q8IWL2; -.
TreeFam; TF330481; -.
Reactome; R-HSA-166016; Toll Like Receptor 4 (TLR4) Cascade.
Reactome; R-HSA-168179; Toll Like Receptor TLR1:TLR2 Cascade.
Reactome; R-HSA-391160; Signal regulatory protein family interactions.
Reactome; R-HSA-5683826; Surfactant metabolism.
Reactome; R-HSA-5686938; Regulation of TLR by endogenous ligand.
Reactome; R-HSA-5688849; Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5).
Reactome; R-HSA-5688890; Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4).
GeneWiki; Pulmonary_surfactant-associated_protein_A1; -.
GenomeRNAi; 653509; -.
PRO; PR:Q8IWL2; -.
Proteomes; UP000005640; Chromosome 10.
Bgee; ENSG00000122852; -.
CleanEx; HS_PSAP; -.
CleanEx; HS_SFTPA1B; -.
ExpressionAtlas; Q8IWL2; baseline and differential.
Genevisible; Q8IWL2; HS.
GO; GO:0045334; C:clathrin-coated endocytic vesicle; TAS:Reactome.
GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
GO; GO:0042599; C:lamellar body; TAS:Reactome.
GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0005319; F:lipid transporter activity; TAS:ProtInc.
GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO; GO:0008228; P:opsonization; IMP:UniProtKB.
GO; GO:0007585; P:respiratory gaseous exchange; IEA:UniProtKB-KW.
GO; GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome.
CDD; cd03591; CLECT_collectin_like; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR018378; C-type_lectin_CS.
InterPro; IPR033990; Collectin_CTLD.
InterPro; IPR016187; CTDL_fold.
Pfam; PF00059; Lectin_C; 1.
SMART; SM00034; CLECT; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Calcium; Collagen;
Complete proteome; Disulfide bond; Extracellular matrix;
Gaseous exchange; Glycoprotein; Hydroxylation; Lectin; Polymorphism;
Reference proteome; Secreted; Signal; Surface film.
SIGNAL 1 20
CHAIN 21 248 Pulmonary surfactant-associated protein
A1.
/FTId=PRO_0000017457.
DOMAIN 28 100 Collagen-like.
DOMAIN 132 248 C-type lectin. {ECO:0000255|PROSITE-
ProRule:PRU00040}.
MOD_RES 30 30 4-hydroxyproline. {ECO:0000250}.
MOD_RES 33 33 4-hydroxyproline. {ECO:0000250}.
MOD_RES 36 36 4-hydroxyproline. {ECO:0000250}.
MOD_RES 42 42 4-hydroxyproline. {ECO:0000250}.
MOD_RES 54 54 4-hydroxyproline. {ECO:0000250}.
MOD_RES 57 57 4-hydroxyproline. {ECO:0000250}.
MOD_RES 63 63 4-hydroxyproline. {ECO:0000250}.
MOD_RES 67 67 4-hydroxyproline. {ECO:0000250}.
MOD_RES 70 70 4-hydroxyproline. {ECO:0000250}.
CARBOHYD 207 207 N-linked (GlcNAc...) asparagine.
{ECO:0000305}.
DISULFID 26 26 Interchain. {ECO:0000305|PubMed:2610270}.
DISULFID 155 246 {ECO:0000255|PROSITE-ProRule:PRU00040,
ECO:0000269|PubMed:2610270}.
DISULFID 224 238 {ECO:0000255|PROSITE-ProRule:PRU00040,
ECO:0000269|PubMed:2610270}.
VAR_SEQ 1 1 M -> MRPCQVPGAATGPRAM (in isoform 2).
{ECO:0000305}.
/FTId=VSP_046802.
VARIANT 5 5 P -> L (in dbSNP:rs72659389).
{ECO:0000269|PubMed:19100526}.
/FTId=VAR_063517.
VARIANT 9 9 N -> T (in dbSNP:rs1059046).
{ECO:0000269|PubMed:19100526,
ECO:0000269|Ref.5}.
/FTId=VAR_004184.
VARIANT 19 19 V -> A (in allele 6A and allele 6A(5);
dbSNP:rs1059047).
{ECO:0000269|PubMed:19100526,
ECO:0000269|PubMed:20693318,
ECO:0000269|PubMed:3755136,
ECO:0000269|Ref.5}.
/FTId=VAR_021292.
VARIANT 50 50 L -> V (in allele 6A(2);
dbSNP:rs1136450).
{ECO:0000269|PubMed:19100526,
ECO:0000269|PubMed:20693318,
ECO:0000269|Ref.5}.
/FTId=VAR_012231.
VARIANT 219 219 R -> W (associated with susceptibility to
idiopathic pulmonary fibrosis in smokers;
allele 6A(4) and allele 6A(5);
dbSNP:rs4253527).
{ECO:0000269|PubMed:13680361,
ECO:0000269|PubMed:19100526,
ECO:0000269|PubMed:20693318,
ECO:0000269|Ref.5}.
/FTId=VAR_012232.
VARIANT 223 223 Q -> K (in dbSNP:rs1965708).
/FTId=VAR_012233.
CONFLICT 45 45 D -> H (in Ref. 1; AAA36510).
{ECO:0000305}.
CONFLICT 54 54 P -> L (in Ref. 1; AAA36510).
{ECO:0000305}.
CONFLICT 100 100 P -> R (in Ref. 1; AAA36510).
{ECO:0000305}.
SEQUENCE 248 AA; 26242 MW; AFFFCF38B87BE081 CRC64;
MWLCPLALNL ILMAASGAVC EVKDVCVGSP GIPGTPGSHG LPGRDGRDGL KGDPGPPGPM
GPPGEMPCPP GNDGLPGAPG IPGECGEKGE PGERGPPGLP AHLDEELQAT LHDFRHQILQ
TRGALSLQGS IMTVGEKVFS SNGQSITFDA IQEACARAGG RIAVPRNPEE NEAIASFVKK
YNTYAYVGLT EGPSPGDFRY SDGTPVNYTN WYRGEPAGRG KEQCVEMYTD GQWNDRNCLY
SRLTICEF


Related products :

Catalog number Product name Quantity
E0890h ELISA 35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,COLEC4,Collectin-4,Homo sapiens,Human,PSAP,PSPA,PSP-A,Pulmonary surfactant-associated protein A1,SFTP1,SFTPA,SFTPA1,SF 96T
E0890h ELISA kit 35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,COLEC4,Collectin-4,Homo sapiens,Human,PSAP,PSPA,PSP-A,Pulmonary surfactant-associated protein A1,SFTP1,SFTPA,SFTP 96T
EIAAB38014 35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,COLEC5,Collectin-5,Homo sapiens,Human,PSAP,PSPA,PSP-A,Pulmonary surfactant-associated protein A2,SFTP1,SFTPA,SFTPA2,SFTPA2B,
U0890h CLIA 35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,COLEC4,Collectin-4,Homo sapiens,Human,PSAP,PSPA,PSP-A,Pulmonary surfactant-associated protein A1,SFTP1,SFTPA,SFTPA1,SFT 96T
U1622h CLIA 18 kDa pulmonary-surfactant protein,6 kDa protein,Homo sapiens,Human,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
E1622h ELISA kit 18 kDa pulmonary-surfactant protein,6 kDa protein,Homo sapiens,Human,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
E1622h ELISA 18 kDa pulmonary-surfactant protein,6 kDa protein,Homo sapiens,Human,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
U1622c CLIA 6 kDa protein,Canis familiaris,Canis lupus familiaris,Dog,Pulmonary surfactant protein 18,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTP 96T
E1039h ELISA COLEC7,Collectin-7,Homo sapiens,Human,Lung surfactant protein D,PSPD,PSP-D,Pulmonary surfactant-associated protein D,SFTP4,SFTPD,SP-D 96T
E1039h ELISA kit COLEC7,Collectin-7,Homo sapiens,Human,Lung surfactant protein D,PSPD,PSP-D,Pulmonary surfactant-associated protein D,SFTP4,SFTPD,SP-D 96T
U1039h CLIA COLEC7,Collectin-7,Homo sapiens,Human,Lung surfactant protein D,PSPD,PSP-D,Pulmonary surfactant-associated protein D,SFTP4,SFTPD,SP-D 96T
E1622c ELISA 6 kDa protein,Canis familiaris,Canis lupus familiaris,Dog,Pulmonary surfactant protein 18,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFT 96T
E1622c ELISA kit 6 kDa protein,Canis familiaris,Canis lupus familiaris,Dog,Pulmonary surfactant protein 18,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP 96T
E1622Rb ELISA kit 6 kDa protein,Oryctolagus cuniculus,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),Rabbit,SFTP3,SFTPB,SP-B 96T
E1622Rb ELISA 6 kDa protein,Oryctolagus cuniculus,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),Rabbit,SFTP3,SFTPB,SP-B 96T
U1622Rb CLIA 6 kDa protein,Oryctolagus cuniculus,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),Rabbit,SFTP3,SFTPB,SP-B 96T
U1622b CLIA 6 kDa protein,Bos taurus,Bovine,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
E1622b ELISA 6 kDa protein,Bos taurus,Bovine,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
E1622b ELISA kit 6 kDa protein,Bos taurus,Bovine,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
U1622p CLIA 8 kDa protein,Pig,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B,Sus scrofa 96T
E1622p ELISA 8 kDa protein,Pig,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B,Sus scrofa 96T
E1622p ELISA kit 8 kDa protein,Pig,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B,Sus scrofa 96T
U1623Rb CLIA Oryctolagus cuniculus,Pulmonary surfactant-associated protein C,Pulmonary surfactant-associated proteolipid SPL(Val),Rabbit,SFTP2,SFTPC,SP-C 96T
E1623Rb ELISA Oryctolagus cuniculus,Pulmonary surfactant-associated protein C,Pulmonary surfactant-associated proteolipid SPL(Val),Rabbit,SFTP2,SFTPC,SP-C 96T
U1623h CLIA Homo sapiens,Human,Pulmonary surfactant-associated protein C,Pulmonary surfactant-associated proteolipid SPL(Val),SFTP2,SFTPC,SP5,SP-C 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur