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Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)

 SFTPD_HUMAN             Reviewed;         375 AA.
P35247; Q5T0M3; Q6FH08; Q86YK9; Q8TCD8; Q9UCJ2; Q9UCJ3;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
11-JAN-2011, sequence version 3.
25-OCT-2017, entry version 190.
RecName: Full=Pulmonary surfactant-associated protein D;
Short=PSP-D;
Short=SP-D;
AltName: Full=Collectin-7;
AltName: Full=Lung surfactant protein D;
Flags: Precursor;
Name=SFTPD; Synonyms=COLEC7, PSPD, SFTP4;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 214-243, AND VARIANTS
THR-31 AND ALA-180.
TISSUE=Amniotic fluid, and Lung;
PubMed=1339284; DOI=10.1042/bj2840795;
Lu J., Willis A.C., Reid K.B.M.;
"Purification, characterization and cDNA cloning of human lung
surfactant protein D.";
Biochem. J. 284:795-802(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=8428971;
Crouch E., Rust K., Veile R., Donis-Keller H., Grosso L.;
"Genomic organization of human surfactant protein D (SP-D). SP-D is
encoded on chromosome 10q22.2-23.1.";
J. Biol. Chem. 268:2976-2983(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-31 AND
ALA-180.
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-31; VAL-123;
ALA-180; THR-290 AND LYS-309.
SeattleSNPs variation discovery resource;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 46-72 AND 223-260.
PubMed=8424457;
Crouch E., Persson A., Chang D.;
"Accumulation of surfactant protein D in human pulmonary alveolar
proteinosis.";
Am. J. Pathol. 142:241-248(1993).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-375, AND PARTIAL PROTEIN
SEQUENCE.
TISSUE=Lung;
PubMed=1898081; DOI=10.1016/0003-9861(91)90597-C;
Rust K., Grosso L., Zhang V., Chang D., Persson A., Longmore W.,
Cai G.-Z., Crouch E.;
"Human surfactant protein D: SP-D contains a C-type lectin
carbohydrate recognition domain.";
Arch. Biochem. Biophys. 290:116-126(1991).
[9]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=23478426; DOI=10.1038/ijo.2013.23;
Ortega F.J., Pueyo N., Moreno-Navarrete J.M., Sabater M.,
Rodriguez-Hermosa J.I., Ricart W., Tinahones F.J.,
Fernandez-Real J.M.;
"The lung innate immune gene surfactant protein-D is expressed in
adipose tissue and linked to obesity status.";
Int. J. Obes. Relat. Metab. Disord. 37:1532-1538(2013).
[10]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
PubMed=10368295; DOI=10.1016/S0969-2126(99)80036-7;
Hakansson K., Lim N.K., Hoppe H.-J., Reid K.B.M.;
"Crystal structure of the trimeric alpha-helical coiled-coil and the
three lectin domains of human lung surfactant protein D.";
Structure 7:255-264(1999).
[11]
VARIANTS THR-31; VAL-123; ALA-180 AND THR-290.
PubMed=19100526; DOI=10.1016/j.ajhg.2008.11.010;
Wang Y., Kuan P.J., Xing C., Cronkhite J.T., Torres F.,
Rosenblatt R.L., DiMaio J.M., Kinch L.N., Grishin N.V., Garcia C.K.;
"Genetic defects in surfactant protein A2 are associated with
pulmonary fibrosis and lung cancer.";
Am. J. Hum. Genet. 84:52-59(2009).
-!- FUNCTION: Contributes to the lung's defense against inhaled
microorganisms, organic antigens and toxins. Interacts with
compounds such as bacterial lipopolysaccharides, oligosaccharides
and fatty acids and modulates leukocyte action in immune response.
May participate in the extracellular reorganization or turnover of
pulmonary surfactant. Binds strongly maltose residues and to a
lesser extent other alpha-glucosyl moieties.
{ECO:0000269|PubMed:23478426}.
-!- SUBUNIT: Oligomeric complex of 4 set of homotrimers.
-!- INTERACTION:
O00322:UPK1A; NbExp=3; IntAct=EBI-11316157, EBI-14031976;
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix. Secreted, extracellular space, surface film.
-!- TISSUE SPECIFICITY: Expressed in lung, brain, pancreas and adipose
tissue (mainly mature adipocytes). {ECO:0000269|PubMed:23478426}.
-!- PTM: The N-terminus is blocked.
-!- PTM: Hydroxylation on proline residues within the sequence motif,
GXPG, is most likely to be 4-hydroxy as this fits the requirement
for 4-hydroxylation in vertebrates. {ECO:0000250}.
-!- PTM: S-nitrosylation at Cys-35 and Cys-40 alters the quaternary
structure which results in a pro-inflammatory chemoattractive
signaling activity with macrophages. {ECO:0000250}.
-!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
protein. There are 4 surfactant-associated proteins: 2
collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D)
and 2 small hydrophobic proteins (SP-B and SP-C).
-!- SIMILARITY: Belongs to the SFTPD family. {ECO:0000305}.
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/sftpd/";
-!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
Note=Pulmonary surfactant protein SP-D;
URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_228";
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EMBL; X65018; CAA46152.1; -; mRNA.
EMBL; L05485; AAB59450.1; -; Genomic_DNA.
EMBL; L05483; AAB59450.1; JOINED; Genomic_DNA.
EMBL; L05484; AAB59450.1; JOINED; Genomic_DNA.
EMBL; CR541948; CAG46746.1; -; mRNA.
EMBL; AY216721; AAO22991.1; -; Genomic_DNA.
EMBL; AL512662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC022318; AAH22318.1; -; mRNA.
CCDS; CCDS7362.1; -.
PIR; A45225; A45225.
RefSeq; NP_003010.4; NM_003019.4.
RefSeq; XP_011538389.1; XM_011540087.1.
UniGene; Hs.253495; -.
PDB; 1B08; X-ray; 2.30 A; A/B/C=218-375.
PDB; 1M7L; NMR; -; A/B/C=220-257.
PDB; 1PW9; X-ray; 1.60 A; A/B/C=199-375.
PDB; 1PWB; X-ray; 1.40 A; A/B/C=199-375.
PDB; 2GGU; X-ray; 1.90 A; A/B/C=223-375.
PDB; 2GGX; X-ray; 1.90 A; A/B/C=223-375.
PDB; 2ORJ; X-ray; 1.80 A; A/B/C=223-375.
PDB; 2ORK; X-ray; 1.89 A; A/B/C=223-375.
PDB; 2OS9; X-ray; 1.70 A; A/B/C=223-375.
PDB; 2RIA; X-ray; 1.80 A; A/B/C=223-375.
PDB; 2RIB; X-ray; 1.80 A; A/B/C=223-375.
PDB; 2RIC; X-ray; 1.80 A; A/B/C=223-375.
PDB; 2RID; X-ray; 1.80 A; A/B/C=223-375.
PDB; 2RIE; X-ray; 1.60 A; A/B/C=223-375.
PDB; 3DBZ; X-ray; 1.80 A; A/B/C=223-375.
PDB; 3G81; X-ray; 1.80 A; A/B/C=223-375.
PDB; 3G83; X-ray; 1.90 A; A/B/C=223-375.
PDB; 3G84; X-ray; 2.30 A; A/B/C=223-375.
PDB; 3IKN; X-ray; 1.60 A; A/B/C=199-375.
PDB; 3IKP; X-ray; 1.75 A; A/B/C=199-375.
PDB; 3IKQ; X-ray; 2.25 A; A/B/C=199-375.
PDB; 3IKR; X-ray; 1.65 A; A/B/C=199-375.
PDB; 4E52; X-ray; 1.70 A; A/B/C=201-375.
PDB; 4M17; X-ray; 2.10 A; A/B/C/D/E/F/G/H/I/J/K/L=229-375.
PDB; 4M18; X-ray; 3.20 A; A/B/C/D/E/F/G/H/I/J/K/L=229-375.
PDBsum; 1B08; -.
PDBsum; 1M7L; -.
PDBsum; 1PW9; -.
PDBsum; 1PWB; -.
PDBsum; 2GGU; -.
PDBsum; 2GGX; -.
PDBsum; 2ORJ; -.
PDBsum; 2ORK; -.
PDBsum; 2OS9; -.
PDBsum; 2RIA; -.
PDBsum; 2RIB; -.
PDBsum; 2RIC; -.
PDBsum; 2RID; -.
PDBsum; 2RIE; -.
PDBsum; 3DBZ; -.
PDBsum; 3G81; -.
PDBsum; 3G83; -.
PDBsum; 3G84; -.
PDBsum; 3IKN; -.
PDBsum; 3IKP; -.
PDBsum; 3IKQ; -.
PDBsum; 3IKR; -.
PDBsum; 4E52; -.
PDBsum; 4M17; -.
PDBsum; 4M18; -.
ProteinModelPortal; P35247; -.
SMR; P35247; -.
BioGrid; 112339; 4.
IntAct; P35247; 3.
STRING; 9606.ENSP00000361366; -.
ChEMBL; CHEMBL2176857; -.
DrugBank; DB02379; Beta-D-Glucose.
iPTMnet; P35247; -.
PhosphoSitePlus; P35247; -.
BioMuta; SFTPD; -.
DMDM; 317373510; -.
PaxDb; P35247; -.
PeptideAtlas; P35247; -.
PRIDE; P35247; -.
DNASU; 6441; -.
Ensembl; ENST00000372292; ENSP00000361366; ENSG00000133661.
GeneID; 6441; -.
KEGG; hsa:6441; -.
UCSC; uc001kbh.4; human.
CTD; 6441; -.
DisGeNET; 6441; -.
EuPathDB; HostDB:ENSG00000133661.15; -.
GeneCards; SFTPD; -.
H-InvDB; HIX0008974; -.
HGNC; HGNC:10803; SFTPD.
HPA; CAB004578; -.
HPA; HPA044582; -.
HPA; HPA056768; -.
MIM; 178635; gene.
neXtProt; NX_P35247; -.
OpenTargets; ENSG00000133661; -.
PharmGKB; PA35715; -.
eggNOG; ENOG410IS48; Eukaryota.
eggNOG; ENOG4110NRD; LUCA.
GeneTree; ENSGT00700000104102; -.
HOVERGEN; HBG108270; -.
InParanoid; P35247; -.
KO; K10068; -.
OMA; AENCVEI; -.
OrthoDB; EOG091G0MYV; -.
PhylomeDB; P35247; -.
TreeFam; TF330481; -.
Reactome; R-HSA-166016; Toll Like Receptor 4 (TLR4) Cascade.
Reactome; R-HSA-168179; Toll Like Receptor TLR1:TLR2 Cascade.
Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-HSA-391160; Signal regulatory protein family interactions.
Reactome; R-HSA-5683678; Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3).
Reactome; R-HSA-5683826; Surfactant metabolism.
Reactome; R-HSA-5686938; Regulation of TLR by endogenous ligand.
Reactome; R-HSA-5687868; Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF).
Reactome; R-HSA-5688849; Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5).
Reactome; R-HSA-5688890; Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4).
SIGNOR; P35247; -.
EvolutionaryTrace; P35247; -.
GeneWiki; Surfactant_protein_D; -.
GenomeRNAi; 6441; -.
PRO; PR:P35247; -.
Proteomes; UP000005640; Chromosome 10.
Bgee; ENSG00000133661; -.
CleanEx; HS_SFTPD; -.
ExpressionAtlas; P35247; baseline and differential.
Genevisible; P35247; HS.
GO; GO:0045334; C:clathrin-coated endocytic vesicle; TAS:Reactome.
GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
GO; GO:0030139; C:endocytic vesicle; TAS:UniProtKB.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
GO; GO:0042599; C:lamellar body; TAS:Reactome.
GO; GO:0005764; C:lysosome; TAS:UniProtKB.
GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO; GO:0030246; F:carbohydrate binding; TAS:UniProtKB.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
GO; GO:0042742; P:defense response to bacterium; TAS:UniProtKB.
GO; GO:0043152; P:induction of bacterial agglutination; IMP:AgBase.
GO; GO:0045087; P:innate immune response; TAS:UniProtKB.
GO; GO:0048286; P:lung alveolus development; IMP:UniProtKB.
GO; GO:0048246; P:macrophage chemotaxis; TAS:UniProtKB.
GO; GO:0052405; P:negative regulation by host of symbiont molecular function; IDA:AgBase.
GO; GO:0045085; P:negative regulation of interleukin-2 biosynthetic process; TAS:UniProtKB.
GO; GO:0042130; P:negative regulation of T cell proliferation; TAS:UniProtKB.
GO; GO:0050766; P:positive regulation of phagocytosis; TAS:UniProtKB.
GO; GO:0072593; P:reactive oxygen species metabolic process; TAS:UniProtKB.
GO; GO:0006898; P:receptor-mediated endocytosis; TAS:UniProtKB.
GO; GO:1905226; P:regulation of adhesion of symbiont to host epithelial cell; IDA:AgBase.
GO; GO:0001817; P:regulation of cytokine production; NAS:UniProtKB.
GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
GO; GO:0007585; P:respiratory gaseous exchange; IEA:UniProtKB-KW.
GO; GO:0043129; P:surfactant homeostasis; IMP:UniProtKB.
GO; GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome.
CDD; cd03591; CLECT_collectin_like; 1.
Gene3D; 2.160.20.50; -; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link.
InterPro; IPR018378; C-type_lectin_CS.
InterPro; IPR008160; Collagen.
InterPro; IPR033990; Collectin_CTLD.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR016133; Insect_cyst_antifreeze_prot.
InterPro; IPR015097; Surfac_D-trimer.
Pfam; PF01391; Collagen; 2.
Pfam; PF00059; Lectin_C; 1.
Pfam; PF09006; Surfac_D-trimer; 1.
SMART; SM00034; CLECT; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
1: Evidence at protein level;
3D-structure; Calcium; Coiled coil; Collagen; Complete proteome;
Direct protein sequencing; Disulfide bond; Extracellular matrix;
Gaseous exchange; Glycoprotein; Hydroxylation; Immunity;
Innate immunity; Lectin; Polymorphism; Reference proteome; Repeat;
S-nitrosylation; Secreted; Signal; Surface film.
SIGNAL 1 20 {ECO:0000250}.
CHAIN 21 375 Pulmonary surfactant-associated protein
D.
/FTId=PRO_0000017465.
DOMAIN 46 222 Collagen-like.
DOMAIN 260 375 C-type lectin. {ECO:0000255|PROSITE-
ProRule:PRU00040}.
COILED 223 252 {ECO:0000255}.
MOD_RES 35 35 S-nitrosocysteine.
{ECO:0000250|UniProtKB:P35248}.
MOD_RES 40 40 S-nitrosocysteine.
{ECO:0000250|UniProtKB:P35248}.
MOD_RES 78 78 4-hydroxyproline. {ECO:0000250}.
MOD_RES 87 87 5-hydroxylysine. {ECO:0000250}.
MOD_RES 96 96 4-hydroxyproline. {ECO:0000250}.
MOD_RES 99 99 5-hydroxylysine. {ECO:0000250}.
MOD_RES 171 171 4-hydroxyproline. {ECO:0000250}.
MOD_RES 177 177 4-hydroxyproline. {ECO:0000250}.
CARBOHYD 90 90 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 281 373
DISULFID 351 365
VARIANT 31 31 M -> T (in dbSNP:rs721917).
{ECO:0000269|PubMed:1339284,
ECO:0000269|PubMed:19100526,
ECO:0000269|Ref.3, ECO:0000269|Ref.4}.
/FTId=VAR_020937.
VARIANT 123 123 L -> V (in dbSNP:rs17878336).
{ECO:0000269|PubMed:19100526,
ECO:0000269|Ref.4}.
/FTId=VAR_020938.
VARIANT 180 180 T -> A (in dbSNP:rs2243639).
{ECO:0000269|PubMed:1339284,
ECO:0000269|PubMed:19100526,
ECO:0000269|Ref.3, ECO:0000269|Ref.4}.
/FTId=VAR_020939.
VARIANT 290 290 S -> T (in dbSNP:rs3088308).
{ECO:0000269|PubMed:19100526,
ECO:0000269|Ref.4}.
/FTId=VAR_020940.
VARIANT 309 309 E -> K (in dbSNP:rs4469829).
{ECO:0000269|Ref.4}.
/FTId=VAR_020941.
CONFLICT 22 22 E -> G (in Ref. 6; AAH22318).
{ECO:0000305}.
CONFLICT 59 59 P -> F (in Ref. 7; AA sequence).
{ECO:0000305}.
CONFLICT 122 122 P -> A (in Ref. 2; AAB59450).
{ECO:0000305}.
CONFLICT 240 240 H -> P (in Ref. 7; AA sequence).
{ECO:0000305}.
CONFLICT 341 341 E -> K (in Ref. 6; AAH22318).
{ECO:0000305}.
CONFLICT 369 369 R -> S (in Ref. 3; CAG46746).
{ECO:0000305}.
HELIX 226 253 {ECO:0000244|PDB:1PWB}.
TURN 254 256 {ECO:0000244|PDB:1PWB}.
STRAND 257 260 {ECO:0000244|PDB:1PWB}.
STRAND 263 273 {ECO:0000244|PDB:1PWB}.
HELIX 274 283 {ECO:0000244|PDB:1PWB}.
STRAND 286 288 {ECO:0000244|PDB:1PWB}.
HELIX 294 307 {ECO:0000244|PDB:1PWB}.
STRAND 311 316 {ECO:0000244|PDB:2RIA}.
STRAND 318 320 {ECO:0000244|PDB:1PWB}.
STRAND 323 325 {ECO:0000244|PDB:2GGX}.
HELIX 345 347 {ECO:0000244|PDB:1PWB}.
STRAND 351 354 {ECO:0000244|PDB:1PWB}.
STRAND 360 363 {ECO:0000244|PDB:1PWB}.
STRAND 367 375 {ECO:0000244|PDB:1PWB}.
SEQUENCE 375 AA; 37728 MW; 298917699FC40F6A CRC64;
MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR DGRDGREGPR
GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG DTGPSGPPGP PGVPGPAGRE
GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP GMQGSAGARG LAGPKGERGV PGERGVPGNT
GAAGSAGAMG PQGSPGARGP PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH
LQAAFSQYKK VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL
QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED CVEIFTNGKW
NDRACGEKRL VVCEF


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U0890h CLIA 35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,COLEC4,Collectin-4,Homo sapiens,Human,PSAP,PSPA,PSP-A,Pulmonary surfactant-associated protein A1,SFTP1,SFTPA,SFTPA1,SFT 96T
E0890h ELISA 35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,COLEC4,Collectin-4,Homo sapiens,Human,PSAP,PSPA,PSP-A,Pulmonary surfactant-associated protein A1,SFTP1,SFTPA,SFTPA1,SF 96T
E0890h ELISA kit 35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,COLEC4,Collectin-4,Homo sapiens,Human,PSAP,PSPA,PSP-A,Pulmonary surfactant-associated protein A1,SFTP1,SFTPA,SFTP 96T
EIAAB38014 35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,COLEC5,Collectin-5,Homo sapiens,Human,PSAP,PSPA,PSP-A,Pulmonary surfactant-associated protein A2,SFTP1,SFTPA,SFTPA2,SFTPA2B,
U1622h CLIA 18 kDa pulmonary-surfactant protein,6 kDa protein,Homo sapiens,Human,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
E1622h ELISA kit 18 kDa pulmonary-surfactant protein,6 kDa protein,Homo sapiens,Human,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
E1622h ELISA 18 kDa pulmonary-surfactant protein,6 kDa protein,Homo sapiens,Human,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTPB,SP-B 96T
U1039b CLIA Bos taurus,Bovine,Lung surfactant protein D,PSP-D,Pulmonary surfactant-associated protein D,SFTP4,SFTPD,SP-D 96T
E1039b ELISA kit Bos taurus,Bovine,Lung surfactant protein D,PSP-D,Pulmonary surfactant-associated protein D,SFTP4,SFTPD,SP-D 96T
E1039b ELISA Bos taurus,Bovine,Lung surfactant protein D,PSP-D,Pulmonary surfactant-associated protein D,SFTP4,SFTPD,SP-D 96T
E1039m ELISA kit Lung surfactant protein D,Mouse,Mus musculus,PSP-D,Pulmonary surfactant-associated protein D,Sftp4,Sftpd,SP-D 96T
E1039r ELISA kit CP4,Lung surfactant protein D,PSP-D,Pulmonary surfactant-associated protein D,Rat,Rattus norvegicus,Sftp4,Sftpd,SP-D 96T
U1039r CLIA CP4,Lung surfactant protein D,PSP-D,Pulmonary surfactant-associated protein D,Rat,Rattus norvegicus,Sftp4,Sftpd,SP-D 96T
U1039m CLIA Lung surfactant protein D,Mouse,Mus musculus,PSP-D,Pulmonary surfactant-associated protein D,Sftp4,Sftpd,SP-D 96T
E1039m ELISA Lung surfactant protein D,Mouse,Mus musculus,PSP-D,Pulmonary surfactant-associated protein D,Sftp4,Sftpd,SP-D 96T
E1039r ELISA CP4,Lung surfactant protein D,PSP-D,Pulmonary surfactant-associated protein D,Rat,Rattus norvegicus,Sftp4,Sftpd,SP-D 96T
U1039p CLIA Lung surfactant protein D,Pig,PSP-D,Pulmonary surfactant-associated protein D,SFTPD,SP-D,Sus scrofa 96T
E1039p ELISA kit Lung surfactant protein D,Pig,PSP-D,Pulmonary surfactant-associated protein D,SFTPD,SP-D,Sus scrofa 96T
E1039p ELISA Lung surfactant protein D,Pig,PSP-D,Pulmonary surfactant-associated protein D,SFTPD,SP-D,Sus scrofa 96T
U1622c CLIA 6 kDa protein,Canis familiaris,Canis lupus familiaris,Dog,Pulmonary surfactant protein 18,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFTP 96T
E1622c ELISA kit 6 kDa protein,Canis familiaris,Canis lupus familiaris,Dog,Pulmonary surfactant protein 18,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP 96T
E1622c ELISA 6 kDa protein,Canis familiaris,Canis lupus familiaris,Dog,Pulmonary surfactant protein 18,Pulmonary surfactant-associated protein B,Pulmonary surfactant-associated proteolipid SPL(Phe),SFTP3,SFT 96T


 

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