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Putative BPIFA4P protein (BPI fold containing family A, member 4, pseudogene) (Breast cancer and salivary gland-expressed protein) (Putative latherin)

 LATH_HUMAN              Reviewed;         179 AA.
Q86YQ2;
07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
25-OCT-2017, entry version 77.
RecName: Full=Putative BPIFA4P protein;
AltName: Full=BPI fold containing family A, member 4, pseudogene;
AltName: Full=Breast cancer and salivary gland-expressed protein;
AltName: Full=Putative latherin;
Flags: Precursor;
Name=BPIFA4P; Synonyms=BASE, LATH;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=12538848; DOI=10.1073/pnas.0337425100;
Egland K.A., Vincent J.J., Strausberg R.L., Lee B., Pastan I.;
"Discovery of the breast cancer gene BASE using a molecular approach
to enrich for genes encoding membrane and secreted proteins.";
Proc. Natl. Acad. Sci. U.S.A. 100:1099-1104(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Major protein in sweat, has surfactant properties.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed in breast cancer and salivary gland.
{ECO:0000269|PubMed:12538848}.
-!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc
family. {ECO:0000305}.
-!- CAUTION: Could be the product of a pseudogene. Unitary pseudogene,
the ortholog in horse is a protein-coding gene which may cause an
allergic reaction in human. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; AY180924; AAO17728.1; -; mRNA.
EMBL; AC018694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC069128; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; BC069315; -; NOT_ANNOTATED_CDS; mRNA.
UniGene; Hs.434194; -.
ProteinModelPortal; Q86YQ2; -.
SMR; Q86YQ2; -.
DMDM; 38257945; -.
PRIDE; Q86YQ2; -.
DisGeNET; 317716; -.
GeneCards; BPIFA4P; -.
HGNC; HGNC:20469; BPIFA4P.
MIM; 607627; gene.
neXtProt; NX_Q86YQ2; -.
HOVERGEN; HBG079669; -.
InParanoid; Q86YQ2; -.
PhylomeDB; Q86YQ2; -.
PRO; PR:Q86YQ2; -.
Proteomes; UP000005640; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008289; F:lipid binding; IEA:InterPro.
GO; GO:0050828; P:regulation of liquid surface tension; IEA:InterPro.
InterPro; IPR032942; BPI/LBP/Plunc.
InterPro; IPR032953; Latherin.
InterPro; IPR017942; Lipid-bd_serum_glycop_N.
PANTHER; PTHR10504; PTHR10504; 1.
PANTHER; PTHR10504:SF83; PTHR10504:SF83; 1.
Pfam; PF01273; LBP_BPI_CETP; 1.
5: Uncertain;
Complete proteome; Reference proteome; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 179 Putative BPIFA4P protein.
/FTId=PRO_0000017191.
SEQUENCE 179 AA; 19456 MW; D4F2B97941CF9DF2 CRC64;
MLNVSGLFVL LCGLLVSSSA QEVLAGVSSQ LLNDLTQGLL RADFLPSLQT TGLQKPLSSA
FDGVSGLLDI FGPPLTNEIN TVSIQVKNPQ LLHVSIESTP QRKEATVQVP FTSELIVQLL
TMKPFTANMQ SDIKVQIRLE KNVGGRYELA FGNCRLLPEA IWIQTGVQLA PAQNLLWQT


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