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Putative NAD(P)H nitroreductase acg (EC 1.-.-.-)

 ACG_MYCTU               Reviewed;         331 AA.
P9WIZ9; L0TB56; O53476; Q7D7L2;
16-APR-2014, integrated into UniProtKB/Swiss-Prot.
16-APR-2014, sequence version 1.
07-JUN-2017, entry version 21.
RecName: Full=Putative NAD(P)H nitroreductase acg;
EC=1.-.-.-;
Name=acg; OrderedLocusNames=Rv2032;
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=83332;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
PubMed=9634230; DOI=10.1038/31159;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence.";
Nature 393:537-544(1998).
[2]
INDUCTION BY HYPOXIA.
STRAIN=ATCC 25618 / H37Rv;
PubMed=11416222; DOI=10.1073/pnas.121172498;
Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
Schoolnik G.K.;
"Regulation of the Mycobacterium tuberculosis hypoxic response gene
encoding alpha -crystallin.";
Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
[3]
DISCUSSION OF SEQUENCE.
PubMed=11854240; DOI=10.1128/IAI.70.3.1518-1529.2002;
Purkayastha A., McCue L.A., McDonough K.A.;
"Identification of a Mycobacterium tuberculosis putative classical
nitroreductase gene whose expression is coregulated with that of the
acr gene within macrophages, in standing versus shaking cultures, and
under low oxygen conditions.";
Infect. Immun. 70:1518-1529(2002).
[4]
INDUCTION BY NITRIC OXIDE (NO); BY HYPOXIA; IN MOUSE MODEL AND
DORMANCY REGULON.
PubMed=12953092; DOI=10.1084/jem.20030205;
Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I.,
Dolganov G.M., Sherman D.R., Schoolnik G.K.;
"Inhibition of respiration by nitric oxide induces a Mycobacterium
tuberculosis dormancy program.";
J. Exp. Med. 198:705-713(2003).
[5]
INDUCTION BY CARBON MONOXIDE (CO).
STRAIN=ATCC 35801 / TMC 107 / Erdman;
PubMed=18474359; DOI=10.1016/j.chom.2008.03.007;
Shiloh M.U., Manzanillo P., Cox J.S.;
"Mycobacterium tuberculosis senses host-derived carbon monoxide during
macrophage infection.";
Cell Host Microbe 3:323-330(2008).
[6]
INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
STRAIN=ATCC 25618 / H37Rv;
PubMed=18400743; DOI=10.1074/jbc.M802274200;
Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S.,
Kramnik I., Agarwal A., Steyn A.J.;
"Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
tuberculosis dormancy regulon.";
J. Biol. Chem. 283:18032-18039(2008).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=ATCC 25618 / H37Rv;
PubMed=21969609; DOI=10.1074/mcp.M111.011627;
Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
Dash D., Pandey A.;
"Proteogenomic analysis of Mycobacterium tuberculosis by high
resolution mass spectrometry.";
Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
-!- COFACTOR:
Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000305};
-!- INDUCTION: A member of the dormancy regulon. Induced in response
to reduced oxygen tension (hypoxia), low levels of nitric oxide
(NO) and carbon monoxide (CO). It is hoped that this regulon will
give insight into the latent, or dormant phase of infection.
Induced in C57BL/6 mouse lungs 3 weeks after low dose aerosol
infection with H37Rv bacteria. {ECO:0000269|PubMed:11416222,
ECO:0000269|PubMed:12953092, ECO:0000269|PubMed:18400743,
ECO:0000269|PubMed:18474359}.
-!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; AL123456; CCP44805.1; -; Genomic_DNA.
PIR; G70942; G70942.
RefSeq; NP_216548.1; NC_000962.3.
RefSeq; WP_003410193.1; NZ_KK339370.1.
ProteinModelPortal; P9WIZ9; -.
SMR; P9WIZ9; -.
STRING; 83332.Rv2032; -.
PaxDb; P9WIZ9; -.
EnsemblBacteria; CCP44805; CCP44805; Rv2032.
GeneID; 887582; -.
KEGG; mtu:Rv2032; -.
TubercuList; Rv2032; -.
eggNOG; ENOG4108DYU; Bacteria.
eggNOG; ENOG410ZYU8; LUCA.
OMA; WEIGEPH; -.
PhylomeDB; P9WIZ9; -.
Proteomes; UP000001584; Chromosome.
GO; GO:0005618; C:cell wall; IDA:MTBBASE.
GO; GO:0005829; C:cytosol; IDA:MTBBASE.
GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO; GO:0052572; P:response to host immune response; IGI:MTBBASE.
GO; GO:0001666; P:response to hypoxia; IGI:MTBBASE.
Gene3D; 3.40.109.10; -; 1.
InterPro; IPR000415; Nitroreductase-like.
SUPFAM; SSF55469; SSF55469; 2.
1: Evidence at protein level;
Complete proteome; Flavoprotein; FMN; NAD; NADP; Oxidoreductase;
Reference proteome.
CHAIN 1 331 Putative NAD(P)H nitroreductase acg.
/FTId=PRO_0000392626.
NP_BIND 28 32 FMN. {ECO:0000255}.
BINDING 316 316 FMN. {ECO:0000255}.
SEQUENCE 331 AA; 36559 MW; 8FF2A825CE90C6EB CRC64;
MPDTMVTTDV IKSAVQLACR APSLHNSQPW RWIAEDHTVA LFLDKDRVLY ATDHSGREAL
LGCGAVLDHF RVAMAAAGTT ANVERFPNPN DPLHLASIDF SPADFVTEGH RLRADAILLR
RTDRLPFAEP PDWDLVESQL RTTVTADTVR IDVIADDMRP ELAAASKLTE SLRLYDSSYH
AELFWWTGAF ETSEGIPHSS LVSAAESDRV TFGRDFPVVA NTDRRPEFGH DRSKVLVLST
YDNERASLLR CGEMLSAVLL DATMAGLATC TLTHITELHA SRDLVAALIG QPATPQALVR
VGLAPEMEEP PPATPRRPID EVFHVRAKDH R


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