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Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)

 ASXL2_MOUSE             Reviewed;        1370 AA.
Q8BZ32; Q3TRU9; Q80TA5;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
28-MAR-2018, entry version 99.
RecName: Full=Putative Polycomb group protein ASXL2;
AltName: Full=Additional sex combs-like protein 2;
Name=Asxl2; Synonyms=Kiaa1685;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Vagina;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 311-1370.
TISSUE=Brain;
PubMed=12693553; DOI=10.1093/dnares/10.1.35;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
Nakajima D., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
II. The complete nucleotide sequences of 400 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 10:35-48(2003).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1121, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney, Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[5]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-594, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryo;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
-!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act
by forming multiprotein complexes, which are required to maintain
the transcriptionally repressive state of homeotic genes
throughout development. PcG proteins are not required to initiate
repression, but to maintain it during later stages of development.
They probably act via methylation of histones, rendering chromatin
heritably changed in its expressibility. Involved in
transcriptional regulation mediated by ligand-bound nuclear
hormone receptors, such as peroxisome proliferator-activated
receptor gamma (PPARG). Acts as coactivator for PPARG and enhances
its adipocyte differentiation-inducing activity; the function
seems to involve differential recruitment of acetylated and
methylated histone H3 (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with PPARA and PPARG. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- DOMAIN: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may
be required for an association with nuclear receptors.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the Asx family. {ECO:0000305}.
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EMBL; AK036839; BAC29602.1; -; mRNA.
EMBL; AK162455; BAE36927.1; -; mRNA.
EMBL; AK122540; BAC65822.1; -; mRNA.
CCDS; CCDS36395.2; -.
RefSeq; NP_001257917.1; NM_001270988.1.
RefSeq; NP_766009.2; NM_172421.5.
UniGene; Mm.120475; -.
ProteinModelPortal; Q8BZ32; -.
SMR; Q8BZ32; -.
BioGrid; 217375; 3.
STRING; 10090.ENSMUSP00000106846; -.
iPTMnet; Q8BZ32; -.
PhosphoSitePlus; Q8BZ32; -.
MaxQB; Q8BZ32; -.
PaxDb; Q8BZ32; -.
PRIDE; Q8BZ32; -.
GeneID; 75302; -.
KEGG; mmu:75302; -.
CTD; 55252; -.
MGI; MGI:1922552; Asxl2.
eggNOG; ENOG410IIF3; Eukaryota.
eggNOG; ENOG4111F3G; LUCA.
HOGENOM; HOG000168836; -.
HOVERGEN; HBG106941; -.
InParanoid; Q8BZ32; -.
KO; K11471; -.
ChiTaRS; Asxl2; mouse.
PRO; PR:Q8BZ32; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_ASXL2; -.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0042975; F:peroxisome proliferator activated receptor binding; ISS:UniProtKB.
GO; GO:0007512; P:adult heart development; IMP:MGI.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0003007; P:heart morphogenesis; IMP:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:MGI.
GO; GO:1900159; P:positive regulation of bone mineralization involved in bone maturation; IMP:MGI.
GO; GO:0045600; P:positive regulation of fat cell differentiation; ISS:UniProtKB.
GO; GO:1902466; P:positive regulation of histone H3-K27 trimethylation; IMP:MGI.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IMP:MGI.
GO; GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR026905; ASX-like_PHD.
InterPro; IPR024811; ASX/ASX-like.
InterPro; IPR028020; ASXH.
InterPro; IPR024817; ASXL2.
InterPro; IPR007759; HB1/Asxl_HTH.
PANTHER; PTHR13578; PTHR13578; 1.
PANTHER; PTHR13578:SF11; PTHR13578:SF11; 1.
Pfam; PF13919; ASXH; 1.
Pfam; PF05066; HARE-HTH; 1.
Pfam; PF13922; PHD_3; 1.
1: Evidence at protein level;
Complete proteome; Metal-binding; Methylation; Nucleus;
Phosphoprotein; Reference proteome; Repressor; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 1370 Putative Polycomb group protein ASXL2.
/FTId=PRO_0000313827.
ZN_FING 1332 1369 PHD-type; atypical.
MOTIF 178 182 Nuclear localization signal.
{ECO:0000255}.
MOTIF 258 262 LXXLL motif.
COMPBIAS 95 166 Ser-rich.
COMPBIAS 176 179 Poly-Gln.
COMPBIAS 258 262 Poly-Leu.
COMPBIAS 607 637 Ala-rich.
COMPBIAS 640 692 Gly-rich.
MOD_RES 150 150 Phosphoserine.
{ECO:0000250|UniProtKB:Q76L83}.
MOD_RES 477 477 Phosphoserine.
{ECO:0000250|UniProtKB:Q76L83}.
MOD_RES 524 524 Phosphoserine.
{ECO:0000250|UniProtKB:Q76L83}.
MOD_RES 553 553 Phosphoserine.
{ECO:0000250|UniProtKB:Q76L83}.
MOD_RES 590 590 Phosphoserine.
{ECO:0000250|UniProtKB:Q76L83}.
MOD_RES 594 594 Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 601 601 Phosphoserine.
{ECO:0000250|UniProtKB:Q76L83}.
MOD_RES 1121 1121 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 1254 1254 Phosphoserine.
{ECO:0000250|UniProtKB:Q76L83}.
CONFLICT 564 564 V -> S (in Ref. 1; BAE36927).
{ECO:0000305}.
CONFLICT 621 621 E -> K (in Ref. 1; BAE36927 and 2;
BAC65822). {ECO:0000305}.
CONFLICT 627 627 A -> P (in Ref. 1; BAE36927).
{ECO:0000305}.
CONFLICT 646 646 P -> L (in Ref. 2; BAC65822).
{ECO:0000305}.
CONFLICT 686 686 G -> V (in Ref. 1; BAE36927).
{ECO:0000305}.
SEQUENCE 1370 AA; 147107 MW; 5E93DCF61F64861B CRC64;
MREKGRRKKG RTWAEAAKTV LEKYPNTPMS HKEILQVIQR EGLKEIRSGT SPLACLNAML
HTNSRGEEGI FYKVPGRMGV YTLKKDVPDG VKELSECSEE SSDGQSDSHS SDNSSSSDGG
SNKEGRKSRW KRKVSSRLSH PPSPPSGCPS PTIPASKVIS PSQKHSKKAL KQALKQQQQK
KKQQQCRPSM SISNQHLSLK TVKAASDSVP AKPGQMKRTK CADIDVETPD SILVNTNLRA
LINKHTFSVL PGDCQQRLLL LLPEVDRQVG PDGLMKLNGS ALNNEFFTSA AQGWKERLSE
GEFTPEMQVR IRQEIEKEKK VELWKEQFFE NYYGQSSGLS LEDSQKLTAS SSDPKAKKTP
AEQPKSILPS EASPVRIVPV VPQSECKEEA VQIPSPSQKE ENQDEARPDS KSPEPVLASA
SNTNELITMK PIKSPKDEGL LEQKPVACAE QESEKENHVT TTSRNNKSEN QEALAISPSK
SKNAGLQKPI IKPVAEASPL NPDMKMPPAT VTDQIQESLK RKSSLTDEEA TSSWEKRPRI
TENRQHQQPF QVSPQPFLNR GDRVQVRKVP PLKIPVSRIS PMLFSTSQVS PRARFPISIT
SPYRTGARTL ADIKAKAQLV EAQKAAAAAA AAAAAAASVG GTIPGPGPGG GQSPREGGER
KIAGGGSAGS DPVSTNGKGP TLELAGTGSR GGTRELLPCG PQPETNMPGQ AQPPGISGAQ
LQQTSSVPTG LASSGACTSV PLPAHIEISN SEKPNLHKAT ATAASPCHLQ DPRSCRLEKA
LSPTGPPLIS GASTVYFVAD GTVEPKAGSN KNAPKPSALA KTTAPAPLDM TSSPVTTASL
EKLPVPQISG TATSTGSAPS SSTLPAASSL KTPGTSANMN GPISRTSSSI PANNPLVTQL
LQGKDVPLEQ ILPKPLTKIE MKTVPLTTKE EKGIGIFPGI SVMESSSREE VNGRQAHLAI
PQLGKPLQSK QLSQVPRPVF TAKDRKDPCI DTHQYREGLS KTTQDQLFQT LIQRAQRQSV
LSFVPPSQFN FAHSGFHLED ISTSQKFMLG FAGRRTSKPA MAGHYLLNIS TYGRGTENIK
RTHSVNPDDR FCLSSPTEAL RMGHADYKNT TGEISSKEDE SDEDRVGDEQ EPISVKEEPW
ASQSSGRHPH HGEASSTNDC LASKNGKTEA PVSEQTTLGQ ENYIFSRGQA SDEKSLPRDF
IPAAHKQMTH AVRGKTVCSS PELFNSTALS LPADSPTHQP LLLPPLQTPK LYGSPTQIGP
SYRGMINVST SSDMDHNSAI PGSQVSSNVG DVMSFSVTVT TIPASQAMNP SSHGQTIPVQ
TFPDDNSIED TPSKCYCRLK AMIMCKGCGA FCHDDCIGPS KLCVSCLVVR


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