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Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog)

 LC7L2_MOUSE             Reviewed;         392 AA.
Q7TNC4; Q99LM5; Q99PC3;
10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
07-JUN-2017, entry version 117.
RecName: Full=Putative RNA-binding protein Luc7-like 2;
AltName: Full=CGI-74 homolog;
Name=Luc7l2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=NMRI; TISSUE=Liver;
Utsch B., Albers N., Wickert L., Schubert R., Bidlingmaier F.,
Ludwig M.;
"CGI-74 homolog in the mouse.";
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 222-392 (ISOFORM 3).
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 135-311 (ISOFORMS 1/2/3/4), INTERACTION
WITH SCNM1, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, AND TISSUE
SPECIFICITY.
TISSUE=Embryo;
PubMed=17656373; DOI=10.1093/hmg/ddm206;
Howell V.M., Jones J.M., Bergren S.K., Li L., Billi A.C.,
Avenarius M.R., Meisler M.H.;
"Evidence for a direct role of the disease modifier SCNM1 in
splicing.";
Hum. Mol. Genet. 16:2506-2516(2007).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
"Large scale localization of protein phosphorylation by use of
electron capture dissociation mass spectrometry.";
Mol. Cell. Proteomics 8:904-912(2009).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: May bind to RNA via its Arg/Ser-rich domain.
-!- SUBUNIT: Interacts with SCNM1. {ECO:0000269|PubMed:17656373}.
-!- SUBCELLULAR LOCATION: Isoform 4: Nucleus speckle. Nucleus,
nucleoplasm. Note=Colocalizes with SCNM1 and SNRNP70 in nuclear
speckles.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1;
IsoId=Q7TNC4-1; Sequence=Displayed;
Name=2;
IsoId=Q7TNC4-2; Sequence=VSP_010218, VSP_010219, VSP_010220;
Name=3;
IsoId=Q7TNC4-3; Sequence=VSP_010219, VSP_010220;
Name=4;
IsoId=Q7TNC4-4; Sequence=VSP_010218;
-!- TISSUE SPECIFICITY: All isoforms are expressed in brain, kidney,
heart, thymus, stomach, skeletal muscle, testis and spinal cord.
{ECO:0000269|PubMed:17656373}.
-!- SIMILARITY: Belongs to the Luc7 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF318301; AAK01182.1; -; mRNA.
EMBL; BC002314; AAH02314.1; -; mRNA.
EMBL; BC056354; AAH56354.1; -; mRNA.
EMBL; BC056383; AAH56383.1; -; mRNA.
EMBL; BC056970; AAH56970.1; -; mRNA.
CCDS; CCDS20015.1; -. [Q7TNC4-1]
CCDS; CCDS51751.1; -. [Q7TNC4-2]
RefSeq; NP_001164320.1; NM_001170849.2. [Q7TNC4-2]
RefSeq; NP_619621.2; NM_138680.3. [Q7TNC4-1]
UniGene; Mm.276133; -.
UniGene; Mm.479854; -.
UniGene; Mm.482221; -.
ProteinModelPortal; Q7TNC4; -.
SMR; Q7TNC4; -.
BioGrid; 228673; 2.
IntAct; Q7TNC4; 4.
MINT; MINT-1605815; -.
STRING; 10090.ENSMUSP00000055254; -.
iPTMnet; Q7TNC4; -.
PhosphoSitePlus; Q7TNC4; -.
PaxDb; Q7TNC4; -.
PeptideAtlas; Q7TNC4; -.
PRIDE; Q7TNC4; -.
Ensembl; ENSMUST00000057692; ENSMUSP00000055254; ENSMUSG00000029823. [Q7TNC4-1]
Ensembl; ENSMUST00000161538; ENSMUSP00000124010; ENSMUSG00000029823. [Q7TNC4-2]
GeneID; 192196; -.
KEGG; mmu:192196; -.
UCSC; uc009bkl.2; mouse. [Q7TNC4-2]
UCSC; uc009bkm.2; mouse. [Q7TNC4-1]
CTD; 51631; -.
MGI; MGI:2183260; Luc7l2.
eggNOG; KOG0796; Eukaryota.
eggNOG; COG5200; LUCA.
GeneTree; ENSGT00730000110670; -.
HOGENOM; HOG000215956; -.
HOVERGEN; HBG062167; -.
InParanoid; Q7TNC4; -.
KO; K13212; -.
OMA; DPKVCKS; -.
OrthoDB; EOG091G0PSO; -.
PhylomeDB; Q7TNC4; -.
TreeFam; TF317607; -.
ChiTaRS; Luc7l2; mouse.
PRO; PR:Q7TNC4; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000029823; -.
CleanEx; MM_LUC7L2; -.
ExpressionAtlas; Q7TNC4; baseline and differential.
Genevisible; Q7TNC4; MM.
GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
GO; GO:0019899; F:enzyme binding; ISO:MGI.
GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
GO; GO:0003723; F:RNA binding; ISO:MGI.
GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
InterPro; IPR004882; Luc7-rel.
PANTHER; PTHR12375; PTHR12375; 1.
Pfam; PF03194; LUC7; 1.
1: Evidence at protein level;
Alternative splicing; Coiled coil; Complete proteome; Hydroxylation;
Nucleus; Phosphoprotein; Reference proteome.
CHAIN 1 392 Putative RNA-binding protein Luc7-like 2.
/FTId=PRO_0000187283.
COILED 102 177 {ECO:0000255}.
COMPBIAS 239 387 Arg/Ser-rich.
MOD_RES 18 18 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 266 266 5-hydroxylysine; by JMJD6. {ECO:0000250}.
MOD_RES 269 269 5-hydroxylysine; by JMJD6. {ECO:0000250}.
VAR_SEQ 260 269 Missing (in isoform 2 and isoform 4).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_010218.
VAR_SEQ 335 335 S -> Y (in isoform 2 and isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_010219.
VAR_SEQ 336 392 Missing (in isoform 2 and isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_010220.
CONFLICT 147 147 G -> E (in Ref. 2; AAH56383).
{ECO:0000305}.
CONFLICT 245 245 K -> L (in Ref. 1; AAK01182).
{ECO:0000305}.
CONFLICT 259 259 R -> W (in Ref. 1; AAK01182).
{ECO:0000305}.
SEQUENCE 392 AA; 46583 MW; 1A5202B1F537A7CC CRC64;
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS GTRMDLGECL
KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR TEVSKKRLAE TQEEISAEVA
AKAERVHELN EEIGKLLAKV EQLGAEGNVE ESQKVMDEVE KARAKKREAE EVYRNSMPAS
SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN
QERLKRREER EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASRDR DRSSRDRSPR
DRDRKDKKRS YESANGRSED RRSSEEREAG EI


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