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Putative nonstructural polyprotein

 Q9WIJ1_EEVVT            Unreviewed;      1879 AA.
Q9WIJ1;
01-NOV-1999, integrated into UniProtKB/TrEMBL.
01-NOV-1999, sequence version 1.
25-APR-2018, entry version 101.
SubName: Full=Putative nonstructural polyprotein {ECO:0000313|EMBL:AAC19323.2};
Name=NS {ECO:0000313|EMBL:AAC19323.2};
Venezuelan equine encephalitis virus (strain Trinidad donkey) (VEEV).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Togaviridae; Alphavirus.
NCBI_TaxID=11038 {ECO:0000313|EMBL:AAC19323.2, ECO:0000313|Proteomes:UP000127220};
NCBI_TaxID=9913; Bos taurus (Bovine).
NCBI_TaxID=9268; Didelphis marsupialis (Southern opossum).
NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
NCBI_TaxID=9796; Equus caballus (Horse).
NCBI_TaxID=9606; Homo sapiens (Human).
NCBI_TaxID=53535; Melanoconion.
NCBI_TaxID=9272; Philander opossum (Gray four-eyed opossum).
NCBI_TaxID=10162; Proechimys.
NCBI_TaxID=42415; Sigmodon hispidus (Hispid cotton rat).
[1] {ECO:0000313|EMBL:AAC19323.2, ECO:0000313|Proteomes:UP000127220}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Trinidad donkey {ECO:0000313|EMBL:AAC19323.2,
ECO:0000313|Proteomes:UP000127220};
PubMed=3755750;
Johnson B.J.B., Kinney R.M., Kost C.L., Trent D.W.;
"Molecular determinants of alphavirus neurovirulence: nucleotide and
deduced protein sequence changes during attenuation of Venezuelan
equine encephalitis virus.";
J. Gen. Virol. 67:1951-1960(1986).
[2] {ECO:0000313|EMBL:AAC19323.2, ECO:0000313|Proteomes:UP000127220}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Trinidad donkey {ECO:0000313|EMBL:AAC19323.2,
ECO:0000313|Proteomes:UP000127220};
PubMed=3088830; DOI=10.1016/0042-6822(86)90142-X;
Kinney R.M., Johnson B.J.B., Brown V.L., Trent D.W.;
"Nucleotide sequence of the 26 S mRNA of the virulent Trinidad donkey
strain of Venezuelan equine encephalitis virus and deduced sequence of
the encoded structural proteins.";
Virology 152:400-413(1986).
[3] {ECO:0000313|EMBL:AAC19323.2, ECO:0000313|Proteomes:UP000127220}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Trinidad donkey {ECO:0000313|EMBL:AAC19323.2,
ECO:0000313|Proteomes:UP000127220};
PubMed=2524126; DOI=10.1016/0042-6822(89)90347-4;
Kinney R.M., Johnson B.J.B., Welch J.B., Tsuchiya K.R., Trent D.W.;
"The full-length nucleotide sequences of the virulent Trinidad donkey
strain of Venezuelan equine encephalitis virus and its attenuated
vaccine derivative, strain TC-83.";
Virology 170:19-30(1989).
[4] {ECO:0000213|PDB:2HWK}
X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 1003-1322.
PubMed=16962975; DOI=10.1016/j.str.2006.07.010;
Russo A.T., White M.A., Watowich S.J.;
"The crystal structure of the Venezuelan equine encephalitis
alphavirus nsP2 protease.";
Structure 14:1449-1458(2006).
-!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
{ECO:0000256|SAAS:SAAS00580605}.
-!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
+ RNA(n+1). {ECO:0000256|SAAS:SAAS00580430}.
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EMBL; L01442; AAC19323.2; -; Genomic_RNA.
PDB; 2HWK; X-ray; 2.45 A; A=1003-1322.
PDBsum; 2HWK; -.
ProteinModelPortal; Q9WIJ1; -.
SMR; Q9WIJ1; -.
Proteomes; UP000127220; Genome.
GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0006396; P:RNA processing; IEA:InterPro.
InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
InterPro; IPR002588; Alphavirus-like_MT_dom.
InterPro; IPR002620; Alphavirus_nsp2pro.
InterPro; IPR002589; Macro_dom.
InterPro; IPR027417; P-loop_NTPase.
Pfam; PF01661; Macro; 1.
Pfam; PF01707; Peptidase_C9; 1.
Pfam; PF01443; Viral_helicase1; 1.
Pfam; PF01660; Vmethyltransf; 1.
SMART; SM00506; A1pp; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS51743; ALPHAVIRUS_MT; 1.
PROSITE; PS51154; MACRO; 1.
PROSITE; PS51520; NSP2PRO; 1.
PROSITE; PS51657; PSRV_HELICASE; 1.
1: Evidence at protein level;
3D-structure {ECO:0000213|PDB:2HWK};
ATP-binding {ECO:0000256|SAAS:SAAS00581494};
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000127220};
Helicase {ECO:0000256|SAAS:SAAS00581494};
Host membrane {ECO:0000256|SAAS:SAAS00539966};
Hydrolase {ECO:0000256|SAAS:SAAS00539752,
ECO:0000256|SAAS:SAAS00581494};
Membrane {ECO:0000256|SAAS:SAAS00539966};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00581494};
Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00580306};
Protease {ECO:0000256|SAAS:SAAS00539752};
RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00580306};
Thiol protease {ECO:0000256|SAAS:SAAS00539752};
Transferase {ECO:0000256|SAAS:SAAS00580306};
Viral RNA replication {ECO:0000256|SAAS:SAAS00580355}.
DOMAIN 28 259 Alphavirus-like MT.
{ECO:0000259|PROSITE:PS51743}.
DOMAIN 690 990 (+)RNA virus helicase C-terminal.
{ECO:0000259|PROSITE:PS51657}.
DOMAIN 1003 1322 Peptidase C9.
{ECO:0000259|PROSITE:PS51520}.
DOMAIN 1320 1489 Macro. {ECO:0000259|PROSITE:PS51154}.
COILED 487 507 {ECO:0000256|SAM:Coils}.
ACT_SITE 1012 1012 For cysteine protease nsP2 activity.
{ECO:0000256|PROSITE-ProRule:PRU00853}.
ACT_SITE 1081 1081 For cysteine protease nsP2 activity.
{ECO:0000256|PROSITE-ProRule:PRU00853}.
SEQUENCE 1879 AA; 209435 MW; DE351B27E463ACF6 CRC64;
MEKVHVDIEE DSPFLRALQR SFPQFEVEAK QVTDNDHANA RAFSHLASKL IETEVDPSDT
ILDIGSAPAR RMYSKHKYHC ICPMRCAEDP DRLYKYATKL KKNCKEITDK ELDKKMKELA
AVMSDPDLET ETMCLHDDES CRYEGQVAVY QDVYAVDGPT SLYHQANKGV RVAYWIGFDT
TPFMFKNLAG AYPSYSTNWA DETVLTARNI GLCSSDVMER SRRGMSILRK KYLKPSNNVL
FSVGSTIYHE KRDLLRSWHL PSVFHLRGKQ NYTCRCETIV SCDGYVVKRI AISPGLYGKP
SGYAATMHRE GFLCCKVTDT LNGERVSFPV CTYVPATLCD QMTGILATDV SADDAQKLLV
GLNQRIVVNG RTQRNTNTMK NYLLPVVAQA FARWAKEYKE DQEDERPLGL RDRQLVMGCC
WAFRRHKITS IYKRPDTQTI IKVNSDFHSF VLPRIGSNTL EIGLRTRIRK MLEEHKEPSP
LITAEDVQEA KCAADEAKEV REAEELRAAL PPLAADVEEP TLEADVDLML QEAGAGSVET
PRGLIKVTSY AGEDKIGSYA VLSPQAVLKS EKLSCIHPLA EQVIVITHSG RKGRYAVEPY
HGKVVVPEGH AIPVQDFQAL SESATIVYNE REFVNRYLHH IATHGGALNT DEEYYKTVKP
SEHDGEYLYD IDRKQCVKKE LVTGLGLTGE LVDPPFHEFA YESLRTRPAA PYQVPTIGVY
GVPGSGKSGI IKSAVTKKDL VVSAKKENCA EIIRDVKKMK GLDVNARTVD SVLLNGCKHP
VETLYIDEAF ACHAGTLRAL IAIIRPKKAV LCGDPKQCGF FNMMCLKVHF NHEICTQVFH
KSISRRCTKS VTSVVSTLFY DKKMRTTNPK ETKIVIDTTG STKPKQDDLI LTCFRGWVKQ
LQIDYKGNEI MTAAASQGLT RKGVYAVRYK VNENPLYAPT SEHVNVLLTR TEDRIVWKTL
AGDPWIKTLT AKYPGNFTAT IEEWQAEHDA IMRHILERPD PTDVFQNKAN VCWAKALVPV
LKTAGIDMTT EQWNTVDYFE TDKAHSAEIV LNQLCVRFFG LDLDSGLFSA PTVPLSIRNN
HWDNSPSPNM YGLNKEVVRQ LSRRYPQLPR AVATGRVYDM NTGTLRNYDP RINLVPVNRR
LPHALVLHHN EHPQSDFSSF VSKLKGRTVL VVGEKLSVPG KMVDWLSDRP EATFRARLDL
GIPGDVPKYD IIFVNVRTPY KYHHYQQCED HAIKLSMLTK KACLHLNPGG TCVSIGYGYA
DRASESIIGA IARQFKFSRV CKPKSSLEET EVLFVFIGYD RKARTHNPYK LSSTLTNIYT
GSRLHEAGCA PSYHVVRGDI ATATEGVIIN AANSKGQPGG GVCGALYKKF PESFDLQPIE
VGKARLVKGA AKHIIHAVGP NFNKVSEVEG DKQLAEAYES IAKIVNDNNY KSVAIPLLST
GIFSGNKDRL TQSLNHLLTA LDTTDADVAI YCRDKKWEMT LKEAVARREA VEEICISDDS
SVTEPDAELV RVHPKSSLAG RKGYSTSDGK TFSYLEGTKF HQAAKDIAEI NAMWPVATEA
NEQVCMYILG ESMSSIRSKC PVEESEASTP PSTLPCLCIH AMTPERVQRL KASRPEQITV
CSSFPLPKYR ITGVQKIQCS QPILFSPKVP AYIHPRKYLV ETPPVDETPE PSAENQSTEG
TPEQPPLITE DETRTRTPEP IIIEEEEEDS ISLLSDGPTH QVLQVEADIH GPPSVSSSSW
SIPHASDFDV DSLSILDTLE GASVTSGATS AETNSYFAKS MEFLARPVPA PRTVFRNPPH
PAPRTRTPSL APSRACSRTS LVSTPPGVNR VITREELEAL TPSRTPSRSV SRTSLVSNPP
GVNRVITREE FEAFVAQQQ


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